The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis?

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMC 1570922)

Published in J Anat on October 01, 2002

Authors

Natalie Hopkins1, Paul McLoughlin

Author Affiliations

1: Department of Human Anatomy and Physiology, Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland.

Articles citing this

Pathophysiology of sleep apnea. Physiol Rev (2010) 4.69

NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation. J Biol Chem (2007) 1.44

Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol (2002) 1.38

Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growth. Respir Res (2011) 1.10

Reactive oxygen species in pulmonary vascular remodeling. Compr Physiol (2013) 1.06

The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB J (2012) 1.01

Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung. Am J Respir Crit Care Med (2008) 0.97

Wall shear stress measured by phase contrast cardiovascular magnetic resonance in children and adolescents with pulmonary arterial hypertension. J Cardiovasc Magn Reson (2013) 0.97

NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice. Am J Physiol Lung Cell Mol Physiol (2011) 0.95

Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries. Am J Physiol Cell Physiol (2011) 0.92

Impact of pulmonary vascular stiffness and vasodilator treatment in pediatric pulmonary hypertension: 21 patient-specific fluid-structure interaction studies. Comput Methods Programs Biomed (2011) 0.86

Remodeling of extra-bronchial lung vasculature following allergic airway inflammation. Respir Res (2008) 0.85

Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro. Am J Physiol Lung Cell Mol Physiol (2008) 0.85

Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep. Pediatr Res (2012) 0.84

Lactate dehydrogenase a expression is necessary to sustain rapid angiogenesis of pulmonary microvascular endothelium. PLoS One (2013) 0.84

Pulmonary hypertension survival effects and treatment options in cystic fibrosis. Curr Opin Pulm Med (2013) 0.83

Balancing the risks and benefits of oxygen therapy in critically III adults. Chest (2013) 0.82

Nitric oxide and pulmonary hypertension. Korean J Anesthesiol (2010) 0.82

Endothelin-1 decreases endothelial PPARγ signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2013) 0.81

Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α. J Biomed Res (2011) 0.81

Study of cardiovascular function using a coupled left ventricle and systemic circulation model. J Biomech (2016) 0.80

Transdifferentiation of endothelial cells to smooth muscle cells play an important role in vascular remodelling. Am J Stem Cells (2015) 0.79

Evaluation of recently validated non- invasive formula using basic lung functions as new screening tool for pulmonary hypertension in idiopathic pulmonary fibrosis patients. Ann Thorac Med (2009) 0.79

Cardiopulmonary coupling in chronic obstructive pulmonary disease: the role of imaging. J Thorac Imaging (2014) 0.79

Rarefaction and blood pressure in systemic and pulmonary arteries. J Fluid Mech (2012) 0.78

Pulmonary intravascular blood volume changes through the cardiac cycle in healthy volunteers studied by cardiovascular magnetic resonance measurements of arterial and venous flow. J Cardiovasc Magn Reson (2009) 0.78

The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance. PLoS One (2013) 0.76

Relationship between polycythemia and in-hospital mortality in chronic obstructive pulmonary disease patients with low-risk pulmonary embolism. J Thorac Dis (2016) 0.75

Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry. Korean J Intern Med (2016) 0.75

Pulmonary Arterial Pressure Response During Exercise in COPD: A Correlation with C-Reactive Protein (hsCRP). Open Respir Med J (2016) 0.75

Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. Am J Physiol Lung Cell Mol Physiol (2015) 0.75

A review of imaging modalities in pulmonary hypertension. Ann Thorac Med (2017) 0.75

Elevated plasma CXCL12α is associated with a poorer prognosis in pulmonary arterial hypertension. PLoS One (2015) 0.75

Effect of propofol and etomidate on normoxic and chronically hypoxic pulmonary artery. BMC Anesthesiol (2006) 0.75

Pulmonary hypertension associated with bronchiolitis obliterans after hematopoietic stem cell transplantation. Bone Marrow Transplant (2015) 0.75

Articles cited by this

(truncated to the top 100)

Mechanisms of angiogenesis and arteriogenesis. Nat Med (2000) 13.88

Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med (1987) 9.79

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS (1988) 8.10

A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med (1996) 8.02

The pathology of hypertensive pulmonary vascular disease; a description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects. Circulation (1958) 7.39

The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS (1988) 6.75

Primary pulmonary hypertension. N Engl J Med (1997) 4.97

A rat model of chronic respiratory infection with Pseudomonas aeruginosa. Am Rev Respir Dis (1979) 4.27

The emerging concept of vascular remodeling. N Engl J Med (1994) 4.27

Flow effects on prostacyclin production by cultured human endothelial cells. Science (1985) 4.15

Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Science (1986) 3.34

Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev (2000) 2.94

Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. N Engl J Med (1991) 2.45

Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am J Physiol (1979) 2.40

The effect of continued hypoxia on rat pulmonary arterial circulation. An ultrastructural study. Lab Invest (1978) 2.32

Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol (1997) 2.21

Pulmonary hypertension in severe acute respiratory failure. N Engl J Med (1977) 2.09

New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol (1976) 2.06

Primary pulmonary hypertension: a vascular biology and translational research "Work in progress". Circulation (2000) 1.97

Effects on the right ventricle, pulmonary vasculature, and carotid bodies of the rat of exposure to, and recovery from, simulated high altitude. Thorax (1973) 1.95

Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J Clin Invest (1991) 1.91

The pulmonary vascular lesions of the adult respiratory distress syndrome. Am J Pathol (1983) 1.88

Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Part One. Am J Respir Crit Care Med (1994) 1.82

Endothelial dysfunction in pulmonary arteries of patients with mild COPD. Am J Physiol (1998) 1.79

Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension (1991) 1.77

Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J Clin Invest (1998) 1.72

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest (1999) 1.71

Hypoxia and incorporation of 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall. Am J Pathol (1979) 1.69

Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds. Thorax (1967) 1.69

Endothelial cellular response to altered shear stress. Am J Physiol Lung Cell Mol Physiol (2001) 1.68

Electrocardiographic signs of chronic cor pulmonale: A negative prognostic finding in chronic obstructive pulmonary disease. Circulation (1999) 1.63

Development of Crotalaria pulmonary hypertension: hemodynamic and structural study. Am J Physiol (1980) 1.55

Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1994) 1.52

Lung morphometry: a new generation of tools and experiments for organ, tissue, cell, and molecular biology. Am J Physiol (1993) 1.49

Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation (1993) 1.47

Compensatory lung growth occurs in adult dogs after right pneumonectomy. J Clin Invest (1994) 1.46

Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation (1997) 1.43

Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis. Lancet (1993) 1.42

Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol (1996) 1.42

The structure and function of the pulmonary vasculature in mild chronic obstructive pulmonary disease. The effect of oxygen and exercise. Am Rev Respir Dis (1983) 1.40

Arterial changes in Crotalaria spectabilis-induced pulmonary hypertension in rats. Br J Exp Pathol (1974) 1.38

Pulmonary vascular structure and function in chronic obstructive pulmonary disease. Thorax (1988) 1.36

Brisket disease. III. Clinical features and hemodynamic observations in altitude-dependent right heart failure of cattle. Am J Med (1962) 1.35

Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium. Am J Physiol (1992) 1.33

Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulation. Circulation (1991) 1.32

High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells. Atherosclerosis (2001) 1.30

The role of inflammation in vascular diseases. J Leukoc Biol (2000) 1.30

Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1999) 1.29

Brain adaptation to chronic hypobaric hypoxia in rats. J Appl Physiol (1985) (1992) 1.28

Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers. Am J Respir Crit Care Med (2001) 1.26

Changes in the pulmonary arteries of the rat during recovery from hypoxia-induced pulmonary hypertension. Br J Exp Pathol (1977) 1.23

Subacute infantile mountain sickness. J Pathol (1988) 1.22

Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension. Am J Pathol (1997) 1.22

Development of pulmonary arterial changes in rats fed Crotalaria spectabilis. Am J Pathol (1979) 1.21

Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP. Proc Natl Acad Sci U S A (1993) 1.20

Shear stress and the endothelium. Kidney Int Suppl (1998) 1.19

Altitude and hypertension. Mayo Clin Proc (1977) 1.19

Lung disease in long-term cigarette smokers with and without chronic air-flow obstruction. Am Rev Respir Dis (1984) 1.18

Changes in pulmonary blood flow affect vascular response to chronic hypoxia in rats. Circ Res (1983) 1.17

Bradycardia, increased cardiac output, and reversal of pulmonary hypertension in altitude natives living at sea level. Br Heart J (1971) 1.17

Cellular and molecular mechanisms in the pathogenesis of severe pulmonary hypertension. Eur Respir J (1995) 1.17

Collagen and elastin metabolism in hypertensive pulmonary arteries of rats. Circ Res (1990) 1.17

Microvascular rarefaction and tissue vascular resistance in hypertension. Am J Physiol (1989) 1.16

The pulmonary circulation in cystic fibrosis. Thorax (1975) 1.16

Pathobiology of pulmonary hypertension. Extracellular matrix. Clin Chest Med (2001) 1.16

Nitric oxide production in the hypoxic lung. Am J Physiol Lung Cell Mol Physiol (2001) 1.15

Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension. Am J Physiol (1999) 1.14

Cigarette smoke causes rapid cell proliferation in small airways and associated pulmonary arteries. Am J Physiol (1994) 1.13

Pulmonary hypertension. Anatomic and physiologic correlates. Clin Chest Med (1983) 1.13

Pulmonary arterial muscularity and right ventricular hypertrophy in chronic bronchitis and emphysema. Br J Dis Chest (1974) 1.12

Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats. Am J Respir Cell Mol Biol (2000) 1.12

Mechanical properties and reactivity of vessels in isolated perfused lungs of chronically hypoxic rats. Clin Sci (Lond) (1981) 1.11

Impairment of pulmonary endothelium-dependent relaxation in patients with Eisenmenger's syndrome. Br J Pharmacol (1990) 1.10

Development of microvascular rarefaction in the spontaneously hypertensive rat. Am J Physiol (1982) 1.10

Changes in arteriole in acute and chronic hypoxic pulmonary hypertension and recovery in rat. J Appl Physiol Respir Environ Exerc Physiol (1983) 1.09

Systemic blood pressure in white men born at sea level: changes after long residence at high altitudes. Am J Cardiol (1969) 1.09

Prostacyclin production by cultured endothelial cell monolayers exposed to step increases in shear stress. J Lab Clin Med (1985) 1.08

Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats. J Clin Invest (1994) 1.07

Morphogenesis of intimal obliterative hyperplasia of small arteries in experimental pulmonary hypertension. An ultrastructural study of the role of smooth-muscle cells. Am J Pathol (1968) 1.06

Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res (1995) 1.06

Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension. Am J Physiol (1997) 1.05

Acute respiratory distress syndrome. Lancet (1999) 1.04

Predictors of survival in patients with chronic obstructive pulmonary disease treated with long-term oxygen therapy. Chest (1991) 1.03

Angiogenesis in ischemic disease. Thromb Haemost (1999) 1.03

Blood supply of pulmonary metastases. J Thorac Imaging (1987) 1.02

Pulmonary vascular remodeling in adult respiratory distress syndrome. Am Rev Respir Dis (1982) 1.01

Capillary remodeling in bleomycin-induced pulmonary fibrosis. Am J Pathol (1986) 1.01

Attentuation of systemic vasoreactivity in chronically hypoxic rats. Am J Physiol (1991) 1.01

Ultrastructural analysis of contractile cell development in lung microvessels in hyperoxic pulmonary hypertension. Fibroblasts and intermediate cells selectively reorganize nonmuscular segments. Am J Pathol (1992) 0.99

Crotalaria-induced pulmonary hypertension. Uptake of 3H-thymidine by the cells of the pulmonary circulation and alveolar walls. Am J Pathol (1982) 0.99

Lipopolysaccharide and interleukin 1 augment the effects of hypoxia and inflammation in human pulmonary arterial tissue. Proc Natl Acad Sci U S A (1996) 0.98

Endothelin-1 and serotonin: mediators of primary and secondary pulmonary hypertension? J Lab Clin Med (1999) 0.98

Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung. J Clin Invest (1998) 0.98

Scanning electron microscopy of arteries. The morphology of aortic endothelium in haemodynamically stressed areas associated with branches. Atherosclerosis (1977) 0.98

Reactivity of small blood vessels in hypertension: relation with structural changes. State of the art lecture. Hypertension (1992) 0.98

Gene transfer of endothelial nitric oxide synthase to the lung of the mouse in vivo. Effect on agonist-induced and flow-mediated vascular responses. Circ Res (1999) 0.97

Repeated Escherichia coli endotoxin-induced pulmonary inflammation causes chronic pulmonary hypertension in sheep. Structural and functional changes. Lab Invest (1986) 0.96

Lung capillary changes in hepatic cirrhosis in rats. Am J Physiol (1997) 0.95

The sequence of cellular and hemodynamic changes of chronic pulmonary hypertension induced by hypoxia and other stimuli. Am Rev Respir Dis (1989) 0.94

Endothelin-1 in primary pulmonary hypertension and the Eisenmenger syndrome. Am J Cardiol (1993) 0.94

Articles by these authors

Atelectasis causes alveolar injury in nonatelectatic lung regions. Am J Respir Crit Care Med (2006) 2.56

Hypercapnic acidosis attenuates endotoxin-induced acute lung injury. Am J Respir Crit Care Med (2003) 2.31

Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury. Crit Care Med (2008) 1.93

Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res (2005) 1.81

Exercise-related changes in umbilical and uterine artery waveforms as assessed by Doppler ultrasound scans. Am J Obstet Gynecol (2002) 1.47

Statistics: all together now, one step at a time. Microcirculation (2011) 1.38

Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol (2002) 1.38

Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2008) 1.15

NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells. J Immunol (2010) 1.12

Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation (2012) 1.11

Permissive hypercapnia--role in protective lung ventilatory strategies. Intensive Care Med (2004) 1.10

The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally. Exp Physiol (2012) 1.08

Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis. Crit Care Med (2009) 1.04

Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway. Am J Physiol Lung Cell Mol Physiol (2004) 1.00

Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation. Transplantation (2004) 0.98

Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung. Am J Respir Crit Care Med (2008) 0.97

Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis. Am J Respir Crit Care Med (2012) 0.97

Role of gremlin in the lung: development and disease. Am J Respir Cell Mol Biol (2009) 0.95

Chronic systemic hypoxia causes intra-retinal angiogenesis. J Anat (2004) 0.93

Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury. Crit Care Med (2005) 0.93

Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling. J Biol Chem (2012) 0.92

Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury? Am J Respir Cell Mol Biol (2012) 0.88

A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease. Eur Respir J (2011) 0.88

Fetal heart rate response to strenuous maternal exercise: not a predictor of fetal distress. Am J Obstet Gynecol (2002) 0.82

Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung. Respir Res (2011) 0.81

Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis. Chest (2002) 0.81

Airway nitric oxide output is reduced in bronchiectasis. Respir Med (2007) 0.80

Structural basis of hypoxic pulmonary hypertension: the modifying effect of chronic hypercapnia. Exp Physiol (2004) 0.79

Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury. Anesthesiology (2010) 0.78

Type 2 nitric oxide synthase and protein nitration in chronic lung infection. J Pathol (2003) 0.77

Pulmonary hypertension. N Engl J Med (2005) 0.77

Do gender differences exist in the ventilatory response to progressive exercise in males and females of average fitness? Eur J Appl Physiol (2003) 0.76

Last Word on Point:Counterpoint "Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature". J Appl Physiol (1985) (2007) 0.75

Repeated measurement of the gas exchange threshold: relative size of measurement and biological variabilities. Comput Biol Med (2005) 0.75