Published in PLoS One on December 09, 2013
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05
Multiple comparison procedures updated. Clin Exp Pharmacol Physiol (1998) 3.92
The physiologic basis of high-altitude diseases. Ann Intern Med (2004) 3.64
Disruption of CREB function in brain leads to neurodegeneration. Nat Genet (2002) 3.54
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci U S A (1994) 2.24
Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci U S A (1998) 2.02
Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol (2004) 1.90
Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res (2005) 1.81
Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells. Circulation (2003) 1.81
Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol (1998) 1.80
Transcriptional regulation by cyclic AMP-responsive factors. Prog Nucleic Acid Res Mol Biol (2000) 1.68
Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol (2003) 1.61
Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A (2003) 1.52
cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration. J Biol Chem (2001) 1.51
Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc Natl Acad Sci U S A (2004) 1.49
Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. EMBO J (1996) 1.47
Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc Natl Acad Sci U S A (2000) 1.46
NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation. J Biol Chem (2007) 1.44
The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res (1995) 1.43
Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol (2002) 1.38
The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis? J Anat (2002) 1.35
Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat. Br J Pharmacol (2000) 1.27
Effect of lung inflation on pulmonary vascular resistance by arterial and venous occlusion. J Appl Physiol Respir Environ Exerc Physiol (1982) 1.24
Attenuation of bleomycin-induced pulmonary fibrosis by follistatin. Am J Respir Crit Care Med (2005) 1.15
Endothelin receptor blockers in cardiovascular disease. Circulation (2003) 1.14
Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells. J Biol Chem (2002) 1.13
Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation (2012) 1.11
ATP-induced mitogenesis is mediated by cyclic AMP response element-binding protein-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol (2004) 1.09
The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally. Exp Physiol (2012) 1.08
Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism. J Biol Chem (1998) 1.06
A 16-month study of the development of genetic emphysema in tight-skin mice. Am Rev Respir Dis (1989) 1.03
Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway. Am J Physiol Lung Cell Mol Physiol (2004) 1.00
Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung. Am J Respir Crit Care Med (2008) 0.97
L-Arginine promotes angiogenesis in the chronically hypoxic lung: a novel mechanism ameliorating pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2009) 0.96
NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice. Am J Physiol Lung Cell Mol Physiol (2011) 0.95
The activin A antagonist follistatin inhibits asthmatic airway remodelling. Thorax (2012) 0.94
cAMP-response element-binding protein (CREB) and NF-κB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. J Biol Chem (2013) 0.94
Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells. J Cardiovasc Pharmacol (2011) 0.92
The transcription of a mammalian voltage-gated potassium channel is regulated by cAMP in a cell-specific manner. J Biol Chem (1993) 0.92
Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells. Cell Physiol Biochem (2009) 0.92
Transcriptional regulation of follistatin expression by GnRH in mouse gonadotroph cell lines: evidence for a role for cAMP signaling. Mol Cell Endocrinol (2007) 0.91
Endothelin in pulmonary fibrosis. Am J Respir Cell Mol Biol (2010) 0.91
A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. Mol Cancer Res (2008) 0.88
The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive. Kidney Int (1997) 0.88
Mineralocorticoid receptor inhibits CREB signaling by calcineurin activation. FASEB J (2010) 0.88
Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury? Am J Respir Cell Mol Biol (2012) 0.88
Thromboxane-induced actin polymerization in hypoxic pulmonary artery is independent of Rho. Am J Physiol Lung Cell Mol Physiol (2011) 0.87
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension. Am J Pathol (2012) 0.87
Nuclear factor-kappaB and cAMP response element binding protein mediate opposite transcriptional effects on the Flk-1/KDR gene promoter. Circ Res (2000) 0.87
CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect. Thromb Haemost (2007) 0.84
Elevated levels of activin A in clinical and experimental pulmonary hypertension. J Appl Physiol (1985) (2009) 0.83
An expanded latch-bridge model of protein kinase C-mediated smooth muscle contraction. J Appl Physiol (1985) (2004) 0.81
Thiazolidinediones prevent PDGF-BB-induced CREB depletion in pulmonary artery smooth muscle cells by preventing upregulation of casein kinase 2 alpha' catalytic subunit. J Cardiovasc Pharmacol (2010) 0.80
Tsk mice with genetic emphysema. Right ventricular hypertrophy occurs without hypertrophy of muscular pulmonary arteries or muscularization of arterioles. Am Rev Respir Dis (1990) 0.79
Mechanisms of dexamethasone-mediated inhibition of cAMP-induced tPA expression in rat mesangial cells. Kidney Int (2002) 0.78
Enhanced expression of inducible nitric oxide synthase without vasodilator effect in chronically infected lungs. Am J Physiol (1999) 0.78
Physiological and pathological angiogenesis in the adult pulmonary circulation. Compr Physiol (2011) 0.77
Ectopic expression of the cAMP-responsive element binding protein inhibits phorbol ester-mediated induction of tissue-type plasminogen activator gene expression. Eur J Biochem (2001) 0.77