Published in Proc Natl Acad Sci U S A on November 13, 2002
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
A gene-driven ENU-based approach to generating an allelic series in any gene. Mamm Genome (2004) 1.82
Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res (2011) 1.56
N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express. Microbiol Mol Biol Rev (2005) 1.54
Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens. Mamm Genome (2006) 1.24
Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice. Genetics (2004) 1.23
Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis. BMC Mol Biol (2007) 1.17
Moving forward with chemical mutagenesis in the mouse. J Physiol (2004) 1.03
Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem (2010) 1.01
Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease. Mamm Genome (2007) 0.92
Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice. BMC Genomics (2005) 0.92
Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics (2004) 0.84
Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes. Mol Imaging (2012) 0.82
A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels. Mamm Genome (2006) 0.81
Genomewide two-generation screens for recessive mutations by ES cell mutagenesis. Mamm Genome (2004) 0.78
ENU Mutagenesis in the Mouse. Curr Protoc Hum Genet (2014) 0.77
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature (1996) 5.21
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev (1999) 5.13
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc Natl Acad Sci U S A (1979) 4.14
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell (1998) 3.86
Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature (1998) 3.65
Denaturing high-performance liquid chromatography: A review. Hum Mutat (2001) 3.58
A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature (1997) 3.29
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev (1997) 3.28
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature (1997) 3.12
Vascular endothelial cell lineage-specific promoter in transgenic mice. Development (1995) 2.76
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev (1998) 2.72
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr Biol (1997) 2.61
Target-selected inactivation of the zebrafish rag1 gene. Science (2002) 2.60
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell (1998) 2.60
SpliceDB: database of canonical and non-canonical mammalian splice sites. Nucleic Acids Res (2001) 2.55
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A (1998) 2.51
Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mamm Genome (1997) 2.47
Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells. Nat Genet (2000) 2.24
Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. Cytokine Growth Factor Rev (2000) 1.81
A gene-driven approach to the identification of ENU mutants in the mouse. Nat Genet (2002) 1.76
The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J Biol Chem (2000) 1.70
Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol Cell Biol (2000) 1.51
Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet (2000) 1.51
Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development (1998) 1.44
Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway. J Biol Chem (2000) 1.35
Formation of the definitive endoderm in mouse is a Smad2-dependent process. Development (2000) 1.31
Sequence-based analysis of mutagenized mice. Mamm Genome (2000) 1.22
Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development. Mol Cell Biol (2001) 1.20
Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability. J Biol Chem (2001) 1.08
Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea. Proc Natl Acad Sci U S A (1992) 1.00
Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo. Mol Cell Endocrinol (2001) 0.96
Calmodulin differentially modulates Smad1 and Smad2 signaling. J Biol Chem (2000) 0.89
The knockout mouse project. Nat Genet (2004) 7.80
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol (2005) 4.52
Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency. Stem Cells (2008) 3.81
Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet (2003) 2.97
Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev (2006) 2.29
The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation. PLoS Genet (2006) 2.08
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol (2006) 1.97
Topoisomerases facilitate transcription of long genes linked to autism. Nature (2013) 1.93
Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res (2004) 1.86
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev (2005) 1.81
UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet (2012) 1.67
The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J Exp Med (2003) 1.64
We screen newborns, don't we?: realizing the promise of public health genomics. Genet Med (2013) 1.60
Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3. Dev Biol (2005) 1.57
Site-specific silencing of regulatory elements as a mechanism of X inactivation. Cell (2012) 1.54
The mouse PcG gene eed is required for Hox gene repression and extraembryonic development. Mamm Genome (2002) 1.50
Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature (2009) 1.49
An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell (2006) 1.49
The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development (2007) 1.49
Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol (2008) 1.44
A new model for random X chromosome inactivation. Development (2008) 1.35
Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A (2005) 1.30
A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10. EMBO J (2008) 1.27
Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Mol Biol Cell (2002) 1.24
Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. J Clin Invest (2006) 1.22
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol Cell Biol (2005) 1.21
The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A (2011) 1.21
Dynamic morphogenetic events characterize the mouse visceral endoderm. Dev Biol (2003) 1.19
Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites. Biochemistry (2007) 1.16
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. Proc Natl Acad Sci U S A (2006) 1.13
Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev (2009) 1.08
TLR3-involved modulation of pregnancy tolerance in double-stranded RNA-stimulated NOD/SCID mice. J Immunol (2006) 1.07
Nature versus nurture: developing enzymes that function under extreme conditions. Annu Rev Chem Biomol Eng (2012) 1.07
Juxtaposed Polycomb complexes co-regulate vertebral identity. Development (2006) 1.06
ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol (2012) 1.03
Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem (2010) 1.01
The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas. Oncogene (2002) 0.99
Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass. Development (2011) 0.98
Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation. J Mol Biol (2007) 0.94
Centralized mouse repositories. Mamm Genome (2012) 0.92
An essential role for a mammalian SWI/SNF chromatin-remodeling complex during male meiosis. Development (2012) 0.91
Lymphocyte phenotyping and NK cell activity analysis in pregnant NOD/SCID mice. J Reprod Immunol (2005) 0.90
Drosophila CTCF is required for Fab-8 enhancer blocking activity in S2 cells. J Mol Biol (2007) 0.90
fourSig: a method for determining chromosomal interactions in 4C-Seq data. Nucleic Acids Res (2014) 0.89
Genomic imprinting and epigenetic control of development. Cold Spring Harb Perspect Biol (2012) 0.89
Nucleolar association and transcriptional inhibition through 5S rDNA in mammals. PLoS Genet (2012) 0.88
Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed. J Cell Biol (2007) 0.88
TSLP-induced placental DC activation and IL-10(+) NK cell expansion: comparative study based on BALB/c x C57BL/6 and NOD/SCID x C57BL/6 pregnant models. Clin Immunol (2007) 0.86
A novel selection marker for efficient DNA cloning and recombineering in E. coli. PLoS One (2013) 0.86
The mouse DXZ4 homolog retains Ctcf binding and proximity to Pls3 despite substantial organizational differences compared to the primate macrosatellite. Genome Biol (2012) 0.85
Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation. Development (2012) 0.85
Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy. Fertil Steril (2008) 0.84
Preterm delivery induced by LPS in syngeneically impregnated BALB/c and NOD/SCID mice. J Reprod Immunol (2006) 0.82
Effects of parenting style and parent-related weight and diet on adolescent weight status. J Pediatr Psychol (2012) 0.82
Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes. Mol Imaging (2012) 0.82
Differentiation-driven nucleolar association of the mouse imprinted Kcnq1 locus. G3 (Bethesda) (2012) 0.82
A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels. Mamm Genome (2006) 0.81
Identification of testis 14-3-3 binding proteins by tandem affinity purification. Spermatogenesis (2011) 0.81
Mitochondrial hydrogen peroxide and defective cholesterol efflux prevent in vitro fertilization by cryopreserved inbred mouse sperm. Biol Reprod (2013) 0.80
Distribution of a primary care office information system. AMIA Annu Symp Proc (2003) 0.78
Two-Step Enzymatic Modification of Solid-Supported Bergenin in Aqueous and Organic Media. Tetrahedron Lett (2010) 0.77
Gene-based chemical mutagenesis in mouse embryonic stem cells. Methods Enzymol (2003) 0.76
The traditional Chinese medicinal formula BDL301 suppresses tumor growth by inhibiting STAT3 pathway and inducing apoptosis in colorectal cancer cells. DNA Cell Biol (2015) 0.76
Inhibitory act of selenoprotein P on Cu(+)/Cu(2+)-induced tau aggregation and neurotoxicity. Inorg Chem (2014) 0.76
All-optical switching in a symmetric three-waveguide coupler with phase-mismatched absorptive central waveguide. Appl Opt (2013) 0.75
Corrigendum: Charge Transfer Through Dithieno[2,3-a:3',2'-c]phenazine: Effect of Substitution Pattern on the Optoelectronic Properties of Regioisomeric Luminophores. Chem Asian J (2016) 0.75
The 2007 Thomas Hunt Morgan Medal. Oliver Smithies. Genetics (2007) 0.75
[Postoperative radiography for cochlear implantation]. Lin Chuang Er Bi Yan Hou Ke Za Zhi (2003) 0.75
Transvaginal Ultrasonography Numbers Reported by Graduating Residents in Obstetrics and Gynecology Training Programs. Obstet Gynecol (1) 0.75
Hospital library foreign language labs: the experiences of two hospital libraries. Med Ref Serv Q (2006) 0.75
Distortion-free femtosecond laser inscription in free-standing optical fiber. Appl Opt (2016) 0.75
A simple enzymatic method for parietal yolk sac removal in early postimplantation mouse embryos. Dev Dyn (2007) 0.75
Realization of ultrafast all-optical switching with switching gain in a single semiconductor waveguide. Opt Lett (2014) 0.75