Published in Mamm Genome on August 01, 2004
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet (2009) 2.68
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood (2007) 2.30
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol (2007) 1.77
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models. Open Biol (2012) 1.65
Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling. Nat Rev Genet (2009) 1.59
N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express. Microbiol Mol Biol Rev (2005) 1.54
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest (2012) 1.35
ENU-induced phenovariance in mice: inferences from 587 mutations. BMC Res Notes (2012) 1.28
Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens. Mamm Genome (2006) 1.24
Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Genome Res (2007) 1.20
Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy. Proc Natl Acad Sci U S A (2009) 1.19
Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis. BMC Mol Biol (2007) 1.17
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. PLoS Genet (2013) 1.14
Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals. BMC Genomics (2008) 1.14
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet (2010) 1.13
Mutation discovery in the mouse using genetically guided array capture and resequencing. Mamm Genome (2009) 1.13
Efficient and fast targeted production of murine models based on ENU mutagenesis. Mamm Genome (2005) 1.11
Finding the molecular basis of complex genetic variation in humans and mice. Philos Trans R Soc Lond B Biol Sci (2006) 1.06
The mouse genetics toolkit: revealing function and mechanism. Genome Biol (2011) 1.05
Modifier genes and the plasticity of genetic networks in mice. PLoS Genet (2012) 1.05
Conserved role of unc-79 in ethanol responses in lightweight mutant mice. PLoS Genet (2010) 1.00
Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS One (2012) 0.99
Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease. Am J Physiol Gastrointest Liver Physiol (2010) 0.99
Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited. Mamm Genome (2007) 0.95
Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes (2008) 0.95
Mouse models of ciliopathies: the state of the art. Dis Model Mech (2012) 0.94
Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nat Commun (2013) 0.94
Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein. PLoS One (2009) 0.94
A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learn Mem (2006) 0.93
Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice. BMC Genomics (2005) 0.92
Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease. Mamm Genome (2007) 0.92
ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development (2014) 0.90
Whole genome profiling of spontaneous and chemically induced mutations in Toxoplasma gondii. BMC Genomics (2014) 0.89
Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. J Neurosci (2011) 0.88
ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2. PLoS One (2010) 0.87
Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity. Dis Model Mech (2011) 0.87
A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity. Hum Mol Genet (2014) 0.85
Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing. Mamm Genome (2015) 0.84
Going forward with genetics: recent technological advances and forward genetics in mice. Am J Pathol (2013) 0.83
N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models. PLoS One (2015) 0.83
A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse. Diabetologia (2010) 0.83
Sexually dimorphic expression of secreted frizzled-related (SFRP) genes in the developing mouse Müllerian duct. Mol Reprod Dev (2006) 0.82
Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7. Mamm Genome (2005) 0.82
Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. PLoS One (2013) 0.81
Foxf2: a novel locus for anterior segment dysgenesis adjacent to the Foxc1 gene. PLoS One (2011) 0.80
New insights into behaviour using mouse ENU mutagenesis. Hum Mol Genet (2012) 0.80
An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance. Exp Hematol (2008) 0.79
Mouse models and type 2 diabetes: translational opportunities. Mamm Genome (2011) 0.79
An ENU-induced mutation in the lymphotoxin alpha gene impairs organogenesis of lymphoid tissues in C57BL/6 mice. Biochem Biophys Res Commun (2008) 0.79
A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. PLoS One (2014) 0.78
A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation. PLoS One (2012) 0.78
A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis. PLoS One (2012) 0.78
Variant mapping and mutation discovery in inbred mice using next-generation sequencing. BMC Genomics (2015) 0.78
ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice. J Biomed Biotechnol (2011) 0.78
Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease. Am J Pathol (2016) 0.77
Lighting the fat furnace without SFRP5. J Clin Invest (2012) 0.77
A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment. Springerplus (2015) 0.76
The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes. Kidney Int (2015) 0.76
Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice. Genes Environ (2016) 0.76
High throughput sequencing approaches to mutation discovery in the mouse. Mamm Genome (2012) 0.76
Point mutation of Hoxd12 in mice. Yonsei Med J (2008) 0.75
Identification of Mouse Cytomegalovirus Resistance Loci by ENU Mutagenesis. Viruses (2009) 0.75
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet (2000) 3.63
Mouse ENU mutagenesis. Hum Mol Genet (1999) 2.72
Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet (2002) 2.30
Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells. Nat Genet (2000) 2.24
Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc Natl Acad Sci U S A (1985) 2.22
A gene-driven approach to the identification of ENU mutants in the mouse. Nat Genet (2002) 1.76
Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet (2000) 1.51
Large numbers of mice established by in vitro fertilization with cryopreserved spermatozoa: implications and applications for genetic resource banks, mutagenesis screens, and mouse backcrosses. Mamm Genome (1999) 1.19
An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells. Proc Natl Acad Sci U S A (2002) 1.05
Comparison of fluorescent single-strand conformation polymorphism analysis and denaturing high-performance liquid chromatography for detection of EXT1 and EXT2 mutations in hereditary multiple exostoses. Eur J Hum Genet (2000) 1.02
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
Averting biodiversity collapse in tropical forest protected areas. Nature (2012) 4.46
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med (2008) 4.28
Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa. AIDS (2009) 4.07
Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res (2008) 3.45
Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol (2008) 3.43
Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement. Nat Biotechnol (2013) 3.41
Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet (2005) 3.39
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol (2003) 3.31
A database of mass spectrometric assays for the yeast proteome. Nat Methods (2008) 3.19
Redundancy based detection of sequence polymorphisms in expressed sequence tag data using autoSNP. Bioinformatics (2003) 3.11
Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Hum Mol Genet (2007) 3.09
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell (2007) 3.06
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science (2007) 3.05
Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31. Nat Genet (2003) 2.98
Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium. Dis Model Mech (2012) 2.73
EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res (2009) 2.72
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet (2009) 2.68
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest (2011) 2.60
PhosphoPep--a phosphoproteome resource for systems biology research in Drosophila Kc167 cells. Mol Syst Biol (2007) 2.56
VectorBase: improvements to a bioinformatics resource for invertebrate vector genomics. Nucleic Acids Res (2011) 2.45
An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res (2009) 2.37
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal (2010) 2.36
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk. PLoS Genet (2011) 2.34
SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data. Nucleic Acids Res (2005) 2.30
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Curr Biol (2008) 2.27
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. Cell Metab (2006) 2.21
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res (2013) 2.20
Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice. Diabetes (2006) 2.17
Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies. Cancer Epidemiol Biomarkers Prev (2006) 2.15
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12
Mining for single nucleotide polymorphisms and insertions/deletions in maize expressed sequence tag data. Plant Physiol (2003) 2.05
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
A decadal view of biodiversity informatics: challenges and priorities. BMC Ecol (2013) 2.01
B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen. J Exp Med (2002) 2.01
Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A (2011) 2.01
PhosphoPep--a database of protein phosphorylation sites in model organisms. Nat Biotechnol (2008) 1.96
SBEAMS-Microarray: database software supporting genomic expression analyses for systems biology. BMC Bioinformatics (2006) 1.94
The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. BMC Pediatr (2008) 1.91
Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population. Hum Genet (2005) 1.81
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study. Physiol Genomics (2008) 1.76
A gene-driven approach to the identification of ENU mutants in the mouse. Nat Genet (2002) 1.76
Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources. Mamm Genome (2007) 1.75
Genetic analysis of the mouse brain proteome. Nat Genet (2002) 1.73
Refractive index measurement in viable cells using quantitative phase-amplitude microscopy and confocal microscopy. Cytometry A (2005) 1.71
The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder. Eur J Hum Genet (2012) 1.71
The susceptibility of small fruits and cherries to the spotted-wing drosophila, Drosophila suzukii. Pest Manag Sci (2011) 1.71
Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data. BMC Bioinformatics (2009) 1.70
The reference genetic linkage map for the multinational Brassica rapa genome sequencing project. Theor Appl Genet (2007) 1.65
Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans. Mamm Genome (2012) 1.63
ENU mutagenesis, a way forward to understand gene function. Annu Rev Genomics Hum Genet (2008) 1.59
Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea. Genome Biol (2014) 1.56
Simple sequence repeat marker loci discovery using SSR primer. Bioinformatics (2004) 1.54
Use of machine learning theory to predict the need for femoral nerve block following ACL repair. Pain Med (2011) 1.52
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest (2008) 1.50
Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP. EMBO J (2005) 1.49
Corra: Computational framework and tools for LC-MS discovery and targeted mass spectrometry-based proteomics. BMC Bioinformatics (2008) 1.48
Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. Clin Sci (Lond) (2009) 1.47
Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats. BMC Neurol (2004) 1.47
Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2. Development (2011) 1.47
Absolute quantification of microbial proteomes at different states by directed mass spectrometry. Mol Syst Biol (2011) 1.46
An evidence based alcohol screening, brief intervention and referral to treatment (SBIRT) curriculum for emergency department (ED) providers improves skills and utilization. Subst Abus (2007) 1.45
Segmentation of brain MRI in young children. Acad Radiol (2007) 1.45
UniPep--a database for human N-linked glycosites: a resource for biomarker discovery. Genome Biol (2006) 1.43
SSRPrimer and SSR Taxonomy Tree: Biome SSR discovery. Nucleic Acids Res (2006) 1.43
SNPServer: a real-time SNP discovery tool. Nucleic Acids Res (2005) 1.42
Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet (2002) 1.41
Inadvertent placement of a flow-directed pulmonary artery catheter in the coronary sinus, detected by transesophageal echocardiography. Anesth Analg (2006) 1.38
A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment. Nat Protoc (2010) 1.36
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest (2012) 1.35
AutoSNPdb: an annotated single nucleotide polymorphism database for crop plants. Nucleic Acids Res (2008) 1.35
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity (2005) 1.33
Elongation of hair cell stereocilia is defective in the mouse mutant whirler. J Comp Neurol (2002) 1.31
Men's constructions of smoking in the context of women's tobacco reduction during pregnancy and postpartum. Soc Sci Med (2006) 1.31
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet (2013) 1.31
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome (2009) 1.31
Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium. Hum Mol Genet (2004) 1.30
The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet (2010) 1.30
A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse. J Neurosci (2003) 1.29