Engineered gene circuits.

PubWeight™: 6.25‹?› | Rank: Top 1%

🔗 View Article (PMID 12432407)

Published in Nature on November 14, 2002

Authors

Jeff Hasty1, David McMillen, J J Collins

Author Affiliations

1: Department of Bioengineering, University of California San Diego, La Jolla, California 92093, USA. hasty@ucsd.edu

Articles citing this

(truncated to the top 100)

On schemes of combinatorial transcription logic. Proc Natl Acad Sci U S A (2003) 6.02

A synchronized quorum of genetic clocks. Nature (2010) 5.47

Programmable cells: interfacing natural and engineered gene networks. Proc Natl Acad Sci U S A (2004) 4.72

A tunable synthetic mammalian oscillator. Nature (2009) 4.33

Diversity-based, model-guided construction of synthetic gene networks with predicted functions. Nat Biotechnol (2009) 3.86

Nanoparticles that communicate in vivo to amplify tumour targeting. Nat Mater (2011) 3.83

Spatiotemporal control of gene expression with pulse-generating networks. Proc Natl Acad Sci U S A (2004) 3.61

Growth rate-dependent global effects on gene expression in bacteria. Cell (2009) 3.57

A methodology for the structural and functional analysis of signaling and regulatory networks. BMC Bioinformatics (2006) 3.55

Evolvability and hierarchy in rewired bacterial gene networks. Nature (2008) 3.43

Programming gene expression with combinatorial promoters. Mol Syst Biol (2007) 3.29

Plasticity of the cis-regulatory input function of a gene. PLoS Biol (2006) 3.22

Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Proc Natl Acad Sci U S A (2009) 3.01

A gene regulatory network model for cell-fate determination during Arabidopsis thaliana flower development that is robust and recovers experimental gene expression profiles. Plant Cell (2004) 2.94

A synthetic Escherichia coli predator-prey ecosystem. Mol Syst Biol (2008) 2.92

Dispersing biofilms with engineered enzymatic bacteriophage. Proc Natl Acad Sci U S A (2007) 2.87

Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing. Proc Natl Acad Sci U S A (2004) 2.83

Cooperativity in long-range gene regulation by the lambda CI repressor. Genes Dev (2004) 2.65

Synthetic circuits integrating logic and memory in living cells. Nat Biotechnol (2013) 2.62

Microfluidic devices for measuring gene network dynamics in single cells. Nat Rev Genet (2009) 2.52

Combinatorial promoter design for engineering noisy gene expression. Proc Natl Acad Sci U S A (2007) 2.40

A tunable algorithm for collective decision-making. Proc Natl Acad Sci U S A (2006) 2.38

Robustness properties of circadian clock architectures. Proc Natl Acad Sci U S A (2004) 2.31

Adaptive response of a gene network to environmental changes by fitness-induced attractor selection. PLoS One (2006) 2.30

Inferring network mechanisms: the Drosophila melanogaster protein interaction network. Proc Natl Acad Sci U S A (2005) 2.28

A sensing array of radically coupled genetic 'biopixels'. Nature (2011) 2.18

Hysteresis in a synthetic mammalian gene network. Proc Natl Acad Sci U S A (2005) 2.12

Uniform sampling of steady-state flux spaces: means to design experiments and to interpret enzymopathies. Biophys J (2004) 2.12

Frequency domain analysis of noise in autoregulated gene circuits. Proc Natl Acad Sci U S A (2003) 2.10

Optimizing genetic circuits by global sensitivity analysis. Biophys J (2004) 1.87

Monitoring dynamics of single-cell gene expression over multiple cell cycles. Mol Syst Biol (2005) 1.76

Dynamics of single-cell gene expression. Mol Syst Biol (2006) 1.69

A modular network model of aging. Mol Syst Biol (2007) 1.68

A synthetic mammalian gene circuit reveals antituberculosis compounds. Proc Natl Acad Sci U S A (2008) 1.68

Tracking, tuning, and terminating microbial physiology using synthetic riboregulators. Proc Natl Acad Sci U S A (2010) 1.66

Entrainment of a population of synthetic genetic oscillators. Science (2011) 1.66

Network physiology reveals relations between network topology and physiological function. Nat Commun (2012) 1.63

A synthetic time-delay circuit in mammalian cells and mice. Proc Natl Acad Sci U S A (2007) 1.59

Identification of genetic networks. Genetics (2004) 1.53

Engineering gene networks to emulate Drosophila embryonic pattern formation. PLoS Biol (2005) 1.48

Queueing up for enzymatic processing: correlated signaling through coupled degradation. Mol Syst Biol (2011) 1.47

Synthesis of orthogonal transcription-translation networks. Proc Natl Acad Sci U S A (2009) 1.46

Tunable signal processing in synthetic MAP kinase cascades. Cell (2011) 1.45

A review of imaging techniques for systems biology. BMC Syst Biol (2008) 1.42

A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae. Mol Syst Biol (2007) 1.42

Gateway vectors for efficient artificial gene assembly in vitro and expression in yeast Saccharomyces cerevisiae. PLoS One (2013) 1.42

Design of artificial cell-cell communication using gene and metabolic networks. Proc Natl Acad Sci U S A (2004) 1.40

Biology by design: reduction and synthesis of cellular components and behaviour. J R Soc Interface (2007) 1.33

Artificial Molecular Machines. Chem Rev (2015) 1.31

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization. Development (2007) 1.28

OptCircuit: an optimization based method for computational design of genetic circuits. BMC Syst Biol (2008) 1.24

Dynamical principles of two-component genetic oscillators. PLoS Comput Biol (2006) 1.24

Standard biological parts knowledgebase. PLoS One (2011) 1.19

Robust synchronization control scheme of a population of nonlinear stochastic synthetic genetic oscillators under intrinsic and extrinsic molecular noise via quorum sensing. BMC Syst Biol (2012) 1.17

An engineered mammalian band-pass network. Nucleic Acids Res (2010) 1.16

Deterministic characterization of stochastic genetic circuits. Proc Natl Acad Sci U S A (2007) 1.15

Nano-enabled synthetic biology. Mol Syst Biol (2007) 1.15

Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Genes Dev (2008) 1.14

Correlation resonance generated by coupled enzymatic processing. Biophys J (2010) 1.10

Boolean logic functions of a synthetic peptide network. J Am Chem Soc (2004) 1.10

Computational design of a Zn2+ receptor that controls bacterial gene expression. Proc Natl Acad Sci U S A (2003) 1.09

Intelligent medical diagnostics via molecular logic. J Am Chem Soc (2009) 1.09

Building better scientists through cross-disciplinary collaboration in synthetic biology: A report from the Genome Consortium for Active Teaching Workshop 2010. CBE Life Sci Educ (2010) 1.08

Tracking operator state fluctuations in gene expression in single cells. Biophys J (2004) 1.08

Cell-free synthetic biology: a bottom-up approach to discovery by design. Mol Syst Biol (2006) 1.08

Dose response relationship in anti-stress gene regulatory networks. PLoS Comput Biol (2006) 1.07

Localized transfection on arrays of magnetic beads coated with PCR products. Nat Methods (2005) 1.06

Tweaking biological switches through a better understanding of bistability behavior. Curr Opin Biotechnol (2008) 1.06

Synthetic biology: advancing biological frontiers by building synthetic systems. Genome Biol (2012) 1.06

The selective values of alleles in a molecular network model are context dependent. Genetics (2004) 1.05

On the attenuation and amplification of molecular noise in genetic regulatory networks. BMC Bioinformatics (2006) 1.04

Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Appl Environ Microbiol (2011) 1.03

Computational design of Candida boidinii xylose reductase for altered cofactor specificity. Protein Sci (2009) 1.02

Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. PLoS Genet (2011) 1.02

Rules for biological regulation based on error minimization. Proc Natl Acad Sci U S A (2006) 1.01

Meeting report: synthetic biology Jamboree for undergraduates. Cell Biol Educ (2005) 1.01

Bottom-up construction of in vitro switchable memories. Proc Natl Acad Sci U S A (2012) 1.01

A Boolean model of the gene regulatory network underlying Mammalian cortical area development. PLoS Comput Biol (2010) 1.00

Stochastic dynamics of macromolecular-assembly networks. Mol Syst Biol (2006) 1.00

Detection of regulatory circuits by integrating the cellular networks of protein-protein interactions and transcription regulation. Nucleic Acids Res (2003) 0.99

Designing new cellular signaling pathways. Chem Biol (2009) 0.99

Opportunities for microfluidic technologies in synthetic biology. J R Soc Interface (2009) 0.97

Cell cycle-dependent variations in protein concentration. Nucleic Acids Res (2009) 0.97

A synthetic low-frequency mammalian oscillator. Nucleic Acids Res (2010) 0.97

Evolution of genetic switch complexity. Bacteriophage (2013) 0.96

Bimodal and hysteretic expression in mammalian cells from a synthetic gene circuit. PLoS One (2008) 0.96

The pedestrian watchmaker: genetic clocks from engineered oscillators. FEBS Lett (2009) 0.95

Fan-out in gene regulatory networks. J Biol Eng (2010) 0.95

GA-based Design Algorithms for the Robust Synthetic Genetic Oscillators with Prescribed Amplitude, Period and Phase. Gene Regul Syst Bio (2010) 0.95

A systematic design method for robust synthetic biology to satisfy design specifications. BMC Syst Biol (2009) 0.94

Robust synthetic biology design: stochastic game theory approach. Bioinformatics (2009) 0.94

Develop reusable and combinable designs for transcriptional logic gates. Mol Syst Biol (2010) 0.94

Genetic Circuits in Salmonella typhimurium. ACS Synth Biol (2012) 0.93

On the adaptive design rules of biochemical networks in evolution. Evol Bioinform Online (2007) 0.92

Synthetic biology to access and expand nature's chemical diversity. Nat Rev Microbiol (2016) 0.91

Engineered temperature compensation in a synthetic genetic clock. Proc Natl Acad Sci U S A (2014) 0.91

Development and fabrication of nanoporous silicon-based bioreactors within a microfluidic chip. Lab Chip (2010) 0.91

Robust design of biological circuits: evolutionary systems biology approach. J Biomed Biotechnol (2011) 0.91

Engineering prokaryotic gene circuits. FEMS Microbiol Rev (2008) 0.91

Computational design of synthetic regulatory networks from a genetic library to characterize the designability of dynamical behaviors. Nucleic Acids Res (2011) 0.90

Articles by these authors

Construction of a genetic toggle switch in Escherichia coli. Nature (2000) 24.02

Noise in eukaryotic gene expression. Nature (2003) 13.01

Noise-based switches and amplifiers for gene expression. Proc Natl Acad Sci U S A (2000) 5.95

Computational studies of gene regulatory networks: in numero molecular biology. Nat Rev Genet (2001) 5.86

Prediction and measurement of an autoregulatory genetic module. Proc Natl Acad Sci U S A (2003) 5.07

Predictors of atrial fibrillation after coronary artery surgery. Current trends and impact on hospital resources. Circulation (1996) 4.40

A bottom-up approach to gene regulation. Nature (2006) 4.03

Designer gene networks: Towards fundamental cellular control. Chaos (2001) 2.79

Biomechanical gait alterations independent of speed in the healthy elderly: evidence for specific limiting impairments. Arch Phys Med Rehabil (1998) 2.38

Synchronizing genetic relaxation oscillators by intercell signaling. Proc Natl Acad Sci U S A (2002) 2.29

Impact of body mass index and albumin on morbidity and mortality after cardiac surgery. J Thorac Cardiovasc Surg (1999) 1.87

Life-support system benefits from noise. Nature (1998) 1.81

Noise-enhanced human balance control. Phys Rev Lett (2002) 1.80

Reduced hip extension during walking: healthy elderly and fallers versus young adults. Arch Phys Med Rehabil (2001) 1.79

The engineering of gene regulatory networks. Annu Rev Biomed Eng (2003) 1.73

Open-loop and closed-loop postural control mechanisms in Parkinson's disease: increased mediolateral activity during quiet standing. Neurosci Lett (1995) 1.69

Left ventricular ejection fraction as a prognostic guide in surgical treatment of coronary and valvular heart disease. Am J Cardiol (1974) 1.67

Drop size and rate in parenteral infusion. Surgery (1971) 1.58

Noise-enhanced tactile sensation. Nature (1996) 1.57

Axilloaxillary cardiopulmonary bypass: a practical alternative to femorofemoral bypass. Ann Thorac Surg (1997) 1.57

Posttranscriptional control of Klebsiella pneumoniae nif mRNA stability by the nifL product. J Bacteriol (1986) 1.55

Biochemical Network Stochastic Simulator (BioNetS): software for stochastic modeling of biochemical networks. BMC Bioinformatics (2004) 1.54

Symmetry in locomotor central pattern generators and animal gaits. Nature (1999) 1.51

Surgical treatment of adult atrial septal defect: early and long-term results. J Am Coll Cardiol (1992) 1.44

Noise in human muscle spindles. Nature (1996) 1.44

Favorable results of coronary artery bypass grafting in patients older than 75 years. J Thorac Cardiovasc Surg (1990) 1.43

Comparative morbidity of mitral valve repair versus replacement for mitral regurgitation with and without coronary artery disease. 1988. Updated in 1995. Ann Thorac Surg (1995) 1.41

Reproductive effects of theophylline in mice and rats. Fundam Appl Toxicol (1988) 1.39

Comparative in vitro and in vivo susceptibilities of the Lyme disease spirochete Borrelia burgdorferi to cefuroxime and other antimicrobial agents. Antimicrob Agents Chemother (1990) 1.38

Rationale for total pancreatectomy for carcinoma of the pancreatic head. N Engl J Med (1966) 1.37

Role of the spoT gene product and manganese ion in the metabolism of guanosine 5'-diphosphate 3'-diphosphate in Escherichia coli. J Biol Chem (1979) 1.35

Analysis of surface antigens on simian virus 40-transformed cells. II. Exposure of simian virus 40-induced antigens on transformed rabbit kidney and inbred hamster kidney cells by phospholipase C. J Natl Cancer Inst (1973) 1.34

Age-related changes in the initiation of gait: degradation of central mechanisms for momentum generation. Arch Phys Med Rehabil (1998) 1.27

The role of the quadriceps in controlling impulsive forces around heel strike. Proc Inst Mech Eng H (1990) 1.27

Experimental graft arteriosclerosis. I. The Lewis-to-F-344 allograft model. Transplantation (1992) 1.26

Dissection of the thoracic aorta. Medical or surgical therapy? Am J Cardiol (1974) 1.26

Extrapleural pneumonectomy, chemotherapy, and radiotherapy in the treatment of diffuse malignant pleural mesothelioma. J Thorac Cardiovasc Surg (1991) 1.24

Control of Klebsiella pneumoniae nif mRNA synthesis. J Bacteriol (1985) 1.24

Transient growth inhibition of Escherichia coli K-12 by ion chelators: "in vivo" inhibition of ribonucleic acid synthesis. J Bacteriol (1979) 1.22

Atherosclerotic aneurysms of aortocoronary vein grafts. Am J Cardiol (1988) 1.21

The stability and structure of cholesterol-rich codispersions of cholesterol and phosphatidylcholine. J Lipid Res (1982) 1.20

Mouse strains for chemical carcinogenicity studies: overview of a workshop. Fundam Appl Toxicol (1988) 1.19

Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease. Ann Intern Med (1992) 1.18

Ovulation suppression for endometriosis. Cochrane Database Syst Rev (2007) 1.15

Estrogen receptor-alpha and beta- immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord. Cell Tissue Res (2001) 1.15

Determinants of survival following cardiac operations in elderly patients. Chest (1975) 1.15

End-systolic volume as a predictor of postoperative left ventricular performance in volume overload from valvular regurgitation. Am J Med (1980) 1.15

Small vessel replacement with gore-tex (expanded polytetrafluoroethylene). Arch Surg (1976) 1.14

Coronary bypass grafting with totally calcified or acutely dissected ascending aorta. Ann Thorac Surg (1991) 1.14

The criminal justice client in drug abuse treatment. NIDA Res Monogr (1988) 1.14

Hemodynamic determinants of prognosis of aortic valve replacement in critical aortic stenosis and advanced congestive heart failure. Circulation (1980) 1.13

The effects of stochastic galvanic vestibular stimulation on human postural sway. Exp Brain Res (1999) 1.11

Primary myxomatous degeneration of cardiac valves. Clinical, pathological, haemodynamic, and echocardiographic profile. Br Heart J (1980) 1.10

Reevaluation of lung cancer risk in the acrylonitrile cohort study of the National Cancer Institute and the National Institute for Occupational Safety and Health. Scand J Work Environ Health (2001) 1.09

Noise shaping in populations of coupled model neurons. Proc Natl Acad Sci U S A (1999) 1.09

Long-term results of mitral valve reconstruction for regurgitation of the myxomatous mitral valve. J Thorac Cardiovasc Surg (1994) 1.08

Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Occup Environ Med (2003) 1.07

Immunologic control of the ascites form of murine adenocarcinoma 755. V. Antibody-directed macrophages mediate tumor cell destruction. J Immunol (1981) 1.07

Results of reoperation for recurrent angina pectoris. Ann Thorac Surg (1977) 1.06

Role of carbohydrate in determining the immunochemical properties of the major glycoprotein (gp71) of Friend murine leukemia virus. J Virol (1975) 1.06

Reduced mortality and morbidity for ascending aortic aneurysm resection regardless of cause. Ann Thorac Surg (1996) 1.05

Five to eight-year follow-up of patients undergoing porcine heart-valve replacement. N Engl J Med (1981) 1.05

A pathway and genetic factors contributing to elevated gene expression noise in stationary phase. Biophys J (2007) 1.04

Repression of nitrogen fixation in Klebsiella pneumoniae at high temperature. J Bacteriol (1984) 1.03

Improved surgical approach to left atrial appendage aneurysm. J Card Surg (1992) 1.02

Comparison of cefuroxime axetil and doxycycline in treatment of patients with early Lyme disease associated with erythema migrans. Antimicrob Agents Chemother (1995) 1.02

Cancer mortality among workers with benzene exposure. Epidemiology (1997) 1.02

Environmental factors in child mortality in England and Wales. Am J Epidemiol (1971) 1.02

Pathologic findings after cardiac valve replacement with glutaraldehyde-fixed porcine valves. Am J Cardiol (1977) 1.01

Evaluation of mortality and cancer incidence among alachlor manufacturing workers. Environ Health Perspect (1996) 1.01

Local cardiac hypothermia for myocardial protection. Ann Thorac Surg (1974) 1.01

Immunologic control of the ascites form of murine adenocarcinoma 755. IV. Characterization of the protective antibody in hyperimmune serum. J Immunol (1981) 1.01

Guidelines for permanent cardiac pacemaker implantation, May 1984. A report of the Joint American College of Cardiology/American Heart Association Task Force on Assessment of Cardiovascular Procedures (Subcommittee on Pacemaker Implantation). Circulation (1984) 1.01

Efficacy and safety of timolol for prevention of supraventricular tachyarrhythmias after coronary artery bypass surgery. Circulation (1984) 1.01

Hemorrhagic pancreatitis. A fatal complication of renal transplantation. N Engl J Med (1966) 1.00

Use of the augmented ejection fraction to select patients with left ventricular dysfunction for coronary revascularization. J Thorac Cardiovasc Surg (1976) 1.00

Legal coercion and retention in drug abuse treatment. Hosp Community Psychiatry (1983) 1.00

Predicting cerebral blood flow response to orthostatic stress from resting dynamics: effects of healthy aging. Am J Physiol Regul Integr Comp Physiol (2001) 0.99

Robust identification of large genetic networks. Pac Symp Biocomput (2004) 0.99

Coronary artery bypass surgery: assessment of revascularization by determination of blood flow and myocardial mass. Am J Cardiol (1974) 0.99

Coronary artery disease in patients requiring abdominal aortic aneurysm repair. Selective use of a combined operation. Ann Surg (1985) 0.98

The effect of pathophysiology on the surgical treatment of ischemic mitral regurgitation: operative and late risks of repair versus replacement. Eur J Cardiothorac Surg (1995) 0.98

Early and late risk of mitral valve replacement. A 12 year concomitant comparison of the porcine bioprosthetic and prosthetic disc mitral valves. J Thorac Cardiovasc Surg (1985) 0.98

Enhancing human balance control with galvanic vestibular stimulation. Biol Cybern (2001) 0.98

Decrease in operative risk of reoperative valve surgery. Ann Thorac Surg (1993) 0.98

Aorto-coronary bypass for acute coronary occlusion. J Thorac Cardiovasc Surg (1972) 0.97

Mitral valve repair in cardiomyopathy. Circulation (1998) 0.97

The role of thoracotomy in the management of patients with chest metastases from gestational trophoblastic disease. J Thorac Cardiovasc Surg (1972) 0.97

Long-term survival of more than 2,000 patients after coronary artery bypass grafting. Am J Cardiol (1986) 0.96

Long-term failure rate and morphologic correlations in porcine bioprosthetic heart valves. Am J Cardiol (1983) 0.96

PBBH-HP intensive care computer system: current status. J Assoc Adv Med Instrum (1972) 0.96

Isolation of simian virus 40-transformed inbred hamster cell lines heterogeneous for virus induction by chemicals or radiation. Virology (1975) 0.96

Cardiac valve replacement with the stabilized glutaraldehyde porcine aortic valve: indications, operative results, and followup. Chest (1975) 0.95

Molecular epidemiology of cystic fibrosis-linked Burkholderia cepacia complex isolates from three national referral centres in Ireland. J Appl Microbiol (2002) 0.95

Transformation by simian virus 40 of spleen cells from a hyperimmune rabbit: evidence for synthesis of immunoglobulin by the transformed cells. Proc Natl Acad Sci U S A (1974) 0.95

Role of carbohydrate in biological functions of Friend murine leukemia virus gp71. J Virol (1977) 0.94

Time course of resolution of pulmonary hypertension and right ventricular remodeling after orthotopic cardiac transplantation. Circulation (1987) 0.93

Neutralizing noise in gene networks. Nature (2000) 0.93

Kinetic alterations independent of walking speed in elderly fallers. Arch Phys Med Rehabil (2000) 0.92