Published in Protein Sci on December 01, 2002
DNA binding and cleavage by the periplasmic nuclease Vvn: a novel structure with a known active site. EMBO J (2003) 1.49
Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with DNA/Zn2+ or inhibitor/Ni2+. Protein Sci (2006) 1.01
Crystal structure and mechanism of action of the N6-methyladenine-dependent type IIM restriction endonuclease R.DpnI. Nucleic Acids Res (2012) 0.95
Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases. Nucleic Acids Res (2006) 0.93
The role of the N-terminal loop in the function of the colicin E7 nuclease domain. J Biol Inorg Chem (2013) 0.84
HNHDb: a database on pattern based classification of HNH domains reveals functional relevance of sequence patterns and domain associations. Bioinformation (2009) 0.81
Characterization of a novel non-specific nuclease from thermophilic bacteriophage GBSV1. BMC Biotechnol (2008) 0.80
Fine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N-terminal mutations. Protein Sci (2014) 0.78
Substrate binding activates the designed triple mutant of the colicin E7 metallonuclease. J Biol Inorg Chem (2014) 0.77
Design of a colicin E7 based chimeric zinc-finger nuclease. J Comput Aided Mol Des (2014) 0.76
Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes. Protein Sci (2015) 0.75
Crystallization and preliminary crystallographic analysis of an Escherichia coli-selected mutant of the nuclease domain of the metallonuclease colicin E7. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.75
Intrinsic protein disorder could be overlooked in cocrystallization conditions: An SRCD case study. Protein Sci (2016) 0.75
The evolution of reduced microbial killing. Genome Biol Evol (2009) 0.75
The Pfam protein families database. Nucleic Acids Res (2002) 51.34
Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. Science (1991) 15.97
Introns as mobile genetic elements. Annu Rev Biochem (1993) 5.63
Group II self-splicing introns in bacteria. Nature (1993) 3.44
Structural and mechanistic basis of immunity toward endonuclease colicins. Nat Struct Biol (1999) 3.37
Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility. Nucleic Acids Res (2001) 3.04
Analysis of zinc binding sites in protein crystal structures. Protein Sci (1998) 2.80
Colicin E2 is DNA endonuclease. Proc Natl Acad Sci U S A (1976) 2.34
Barriers to intron promiscuity in bacteria. J Bacteriol (2000) 2.29
Recognition and cleavage of DNA by type-II restriction endonucleases. Eur J Biochem (1997) 2.26
Mechanisms of intron mobility. J Biol Chem (1995) 2.21
Amino acid sequence motif of group I intron endonucleases is conserved in open reading frames of group II introns. Trends Biochem Sci (1994) 2.15
Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis. Cell (1999) 2.14
Hypersensitive substrate for ribonucleases. Nucleic Acids Res (1999) 1.96
The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein. Structure (1999) 1.87
Self-splicing group I and group II introns encode homologous (putative) DNA endonucleases of a new family. Protein Sci (1994) 1.85
Type II restriction endonucleases: structural, functional and evolutionary relationships. Curr Opin Chem Biol (1999) 1.79
Treble clef finger--a functionally diverse zinc-binding structural motif. Nucleic Acids Res (2001) 1.71
The phage T4 nrdB intron: a deletion mutant of a version found in the wild. Genes Dev (1991) 1.57
Beyond homing: competition between intron endonucleases confers a selective advantage on flanking genetic markers. Cell (1996) 1.56
X-ray structure of T4 endonuclease VII: a DNA junction resolvase with a novel fold and unusual domain-swapped dimer architecture. EMBO J (1999) 1.55
A self-splicing group I intron in the DNA polymerase gene of Bacillus subtilis bacteriophage SPO1. Cell (1990) 1.49
Lessons from zinc-binding peptides. Annu Rev Biophys Biomol Struct (1997) 1.49
Structural parsimony in endonuclease active sites: should the number of homing endonuclease families be redefined? FEBS Lett (1999) 1.45
Introns and intein coding sequence in the ribonucleotide reductase genes of Bacillus subtilis temperate bacteriophage SPbeta. Proc Natl Acad Sci U S A (1998) 1.43
A novel endonuclease mechanism directly visualized for I-PpoI. Nat Struct Biol (1999) 1.43
Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa. J Bacteriol (1993) 1.40
Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9. J Mol Biol (2001) 1.36
The active site of Serratia endonuclease contains a conserved magnesium-water cluster. J Mol Biol (1999) 1.33
Homing in on the role of transition metals in the HNH motif of colicin endonucleases. J Biol Chem (1999) 1.28
Recognition of single-stranded DNA by nuclease P1: high resolution crystal structures of complexes with substrate analogs. Proteins (1998) 1.28
Widespread distribution of a group I intron and its three deletion derivatives in the lysin gene of Streptococcus thermophilus bacteriophages. J Virol (2000) 1.27
A coral mitochondrial mutS gene. Nature (1995) 1.26
Cloning and characterization of the ColE7 plasmid. J Gen Microbiol (1991) 1.25
Colicin E8, a DNase which indicates an evolutionary relationship between colicins E2 and E3. J Bacteriol (1988) 1.24
The intron of a plastid gene from a green alga contains an open reading frame for a reverse transcriptase-like enzyme. Mol Gen Genet (1989) 1.21
Mutagenic scan of the H-N-H motif of colicin E9: implications for the mechanistic enzymology of colicins, homing enzymes and apoptotic endonucleases. Nucleic Acids Res (2002) 1.18
The DNA polymerase genes of several HMU-bacteriophages have similar group I introns with highly divergent open reading frames. Nucleic Acids Res (1994) 1.17
A novel transposon-like structure carries the genes for pyocin AP41, a Pseudomonas aeruginosa bacteriocin with a DNase domain homology to E2 group colicins. Mol Gen Genet (1993) 1.17
A similar active site for non-specific and specific endonucleases. Nat Struct Biol (1999) 1.15
Cloning and structural characterization of the mcrA locus of Escherichia coli. J Bacteriol (1991) 1.00
The zinc ion in the HNH motif of the endonuclease domain of colicin E7 is not required for DNA binding but is essential for DNA hydrolysis. Nucleic Acids Res (2002) 1.00
Molecular analysis of the protein-protein interaction between the E9 immunity protein and colicin E9. Eur J Biochem (1992) 0.94
The crystal structure of the immunity protein of colicin E7 suggests a possible colicin-interacting surface. Proc Natl Acad Sci U S A (1996) 0.91
Multistep binding of transition metals to the H-N-H endonuclease toxin colicin E9. Biochemistry (2002) 0.88
Three-dimensional structure of Serratia marcescens nuclease at 1.7 A resolution and mechanism of its action. FEBS Lett (1997) 0.84
Self-quenched covalent fluorescent dye-nucleic acid conjugates as polymeric substrates for enzymatic nuclease assays. Anal Biochem (2002) 0.83
Structure of an agonist-bound human A2A adenosine receptor. Science (2011) 6.21
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86
Structure of the human κ-opioid receptor in complex with JDTic. Nature (2012) 5.18
Crystal structure of a lipid G protein-coupled receptor. Science (2012) 3.78
Serial femtosecond crystallography of G protein-coupled receptors. Science (2013) 3.58
Structure of the human histamine H1 receptor complex with doxepin. Nature (2011) 3.48
Structural basis for allosteric regulation of GPCRs by sodium ions. Science (2012) 3.40
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Structure of the human smoothened receptor bound to an antitumour agent. Nature (2013) 3.08
Structure of the human glucagon class B G-protein-coupled receptor. Nature (2013) 2.86
Structural features for functional selectivity at serotonin receptors. Science (2013) 2.60
Structural insights into TDP-43 in nucleic-acid binding and domain interactions. Nucleic Acids Res (2009) 2.37
Structural basis for molecular recognition at serotonin receptors. Science (2013) 1.86
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science (2014) 1.81
A fence-like coat for the nuclear pore membrane. Mol Cell (2008) 1.73
Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTP. Mol Cell Biol (2005) 1.61
Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins (2006) 1.51
DNA binding and cleavage by the periplasmic nuclease Vvn: a novel structure with a known active site. EMBO J (2003) 1.49
An unusual sugar conformation in the structure of an RNA/DNA decamer of the polypurine tract may affect recognition by RNase H. J Mol Biol (2003) 1.41
Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. J Biol Chem (2006) 1.40
The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Structure (2005) 1.33
Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.28
Crystal structure of Escherichia coli PNPase: central channel residues are involved in processive RNA degradation. RNA (2008) 1.25
The crystal structure of the nuclease domain of colicin E7 suggests a mechanism for binding to double-stranded DNA by the H-N-H endonucleases. J Mol Biol (2002) 1.23
Structural basis of murein peptide specificity of a gamma-D-glutamyl-l-diamino acid endopeptidase. Structure (2009) 1.23
DNA binding and degradation by the HNH protein ColE7. Structure (2004) 1.20
Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc Natl Acad Sci U S A (2009) 1.18
Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing. Nucleic Acids Res (2008) 1.17
Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 A resolution. Proteins (2009) 1.14
Structural and functional insight into sugar-nonspecific nucleases in host defense. Curr Opin Struct Biol (2005) 1.12
Crystal structure of soluble MD-1 and its interaction with lipid IVa. Proc Natl Acad Sci U S A (2010) 1.09
Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA. Proteins (2007) 1.09
Identification of an essential cleavage site in ColE7 required for import and killing of cells. J Biol Chem (2005) 1.05
The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates. J Biol Chem (2013) 1.05
Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif. Proteins (2007) 1.04
Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution. Proteins (2006) 1.03
The conserved asparagine in the HNH motif serves an important structural role in metal finger endonucleases. J Mol Biol (2007) 1.03
Crystal structure of a natural circularly permuted jellyroll protein: 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes. J Mol Biol (2003) 1.02
Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme. Protein Sci (2002) 1.02
Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair. J Mol Biol (2010) 1.01
Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with DNA/Zn2+ or inhibitor/Ni2+. Protein Sci (2006) 1.01
Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria. Mol Genet Metab (2005) 1.00
The zinc ion in the HNH motif of the endonuclease domain of colicin E7 is not required for DNA binding but is essential for DNA hydrolysis. Nucleic Acids Res (2002) 1.00
Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold. Proteins (2005) 0.99
Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution. Proteins (2008) 0.99
Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.98
Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.95
The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. Structure (2013) 0.95
The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.94
The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.94
Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases. Nucleic Acids Res (2006) 0.93
Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes. J Biol Chem (2012) 0.91
Crystal structure of CRN-4: implications for domain function in apoptotic DNA degradation. Mol Cell Biol (2008) 0.90
Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.89
Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.89
Structural basis for RNA trimming by RNase T in stable RNA 3'-end maturation. Nat Chem Biol (2011) 0.88
A structural basis for the regulatory inactivation of DnaA. J Mol Biol (2008) 0.87
Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins (2006) 0.87
Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold. Proteins (2005) 0.86
The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids. Nucleic Acids Res (2014) 0.86
Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.86
Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 angstroms resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases. Proteins (2007) 0.85
Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold. Proteins (2005) 0.85
The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.85
Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 A resolution. Proteins (2007) 0.85
Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 A resolution. Proteins (2005) 0.85
Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. Blood (2011) 0.85
Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain. J Mol Biol (2009) 0.85
Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation. Nucleic Acids Res (2011) 0.85
Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.84
Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution. Proteins (2005) 0.84
A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.84
Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold. Proteins (2006) 0.84
How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexes. Nucleic Acids Res (2012) 0.84
Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution. Proteins (2008) 0.83
Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes. J Biol Chem (2009) 0.83
Categorizing host-dependent RNA viruses by principal component analysis of their codon usage preferences. J Comput Biol (2009) 0.83
Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.83
The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin-producing Escherichia coli. J Biol Chem (2006) 0.83
Redesign of high-affinity nonspecific nucleases with altered sequence preference. J Am Chem Soc (2009) 0.83
Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus. J Mol Biol (2009) 0.83
Characterization of the membrane-coating Nup84 complex: paradigm for the nuclear pore complex structure. Nucleus (2010) 0.82
Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution. Proteins (2006) 0.82
Crystal structure of a novel archaeal AAA+ ATPase SSO1545 from Sulfolobus solfataricus. Proteins (2009) 0.81
Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans. J Biol Chem (2012) 0.81
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima. Proteins (2012) 0.80
Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. Proteins (2005) 0.80
Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold. Proteins (2008) 0.80
High-resolution crystal structure of a truncated ColE7 translocation domain: implications for colicin transport across membranes. J Mol Biol (2005) 0.79