Published in Oncogene on November 21, 2002
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nat Med (2010) 4.00
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A (2006) 2.97
Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res (2010) 2.50
IGF2: epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev (2008) 1.73
Gene expression profiling supports the hypothesis that human ovarian surface epithelia are multipotent and capable of serving as ovarian cancer initiating cells. BMC Med Genomics (2009) 1.55
The PMP22 gene and its related diseases. Mol Neurobiol (2012) 1.53
Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation. Br J Cancer (2007) 1.41
Hedgehog-Gli pathway activation during kidney fibrosis. Am J Pathol (2012) 1.34
Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One (2010) 1.21
Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice. Cancer Res (2008) 1.18
The LIM and SH3 domain protein family: structural proteins or signal transducers or both? Mol Cancer (2008) 1.17
Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res (2010) 1.15
Sonic hedgehog-responsive genes in the fetal prostate. J Biol Chem (2008) 1.11
Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids. J Biol Chem (2010) 1.00
Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and the PI3-kinase/AKT pathways in multiple myeloma. J Steroid Biochem Mol Biol (2008) 0.99
Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. Clin Cancer Res (2015) 0.96
Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy. Am J Stem Cells (2012) 0.95
BMP and TGF-β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells. Dev Biol (2013) 0.95
Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models. PLoS One (2012) 0.93
Insulin and IGF receptor signalling in neural-stem-cell homeostasis. Nat Rev Endocrinol (2014) 0.93
Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. Lab Invest (2009) 0.93
Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to Pseudomonas aeruginosa infection. Infect Immun (2003) 0.92
Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion. Am J Physiol Gastrointest Liver Physiol (2008) 0.90
Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. Am J Physiol Gastrointest Liver Physiol (2010) 0.89
Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties. Cell Rep (2015) 0.89
Identification of Hedgehog signaling outcomes in mouse testis development using a hanging drop-culture system. Biol Reprod (2008) 0.88
Enteric neural crest differentiation in ganglioneuromas implicates Hedgehog signaling in peripheral neuroblastic tumor pathogenesis. PLoS One (2009) 0.85
Recent insights into the actions of IGFBP-6. J Cell Commun Signal (2015) 0.85
Smooth muscle differentiation and patterning in the urinary bladder. Differentiation (2010) 0.84
Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. Proc Natl Acad Sci U S A (2015) 0.83
Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol (2012) 0.80
LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia. Oncotarget (2014) 0.80
Molecular conversations and the development of the hair follicle and basal cell carcinoma. Cancer Prev Res (Phila) (2010) 0.80
Yeast-based assay identifies novel Shh/Gli target genes in vertebrate development. BMC Genomics (2012) 0.79
Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source. PLoS One (2013) 0.78
PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis. Cancer Prev Res (Phila) (2014) 0.78
A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells. PLoS One (2014) 0.77
Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis. Cell (2017) 0.75
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma. Oncogene (2017) 0.75
Stem cell transcriptome profiling via massive-scale mRNA sequencing. Nat Methods (2008) 31.04
Signatures of mutational processes in human cancer. Nature (2013) 21.63
International network of cancer genome projects. Nature (2010) 20.35
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Res (2008) 6.43
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
The regulated retrotransposon transcriptome of mammalian cells. Nat Genet (2009) 5.79
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell (2008) 5.06
Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res (2005) 4.86
Tiny RNAs associated with transcription start sites in animals. Nat Genet (2009) 4.19
A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2002) 4.06
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23
A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics (2008) 3.19
A de novo mutation in the β-tubulin gene TUBB4A results in the leukoencephalopathy hypomyelination with atrophy of the basal ganglia and cerebellum. Am J Hum Genet (2013) 2.42
The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition. Genome Biol (2008) 2.29
PINA v2.0: mining interactome modules. Nucleic Acids Res (2011) 2.23
NRED: a database of long noncoding RNA expression. Nucleic Acids Res (2008) 2.21
MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biol (2011) 2.15
Transcriptome content and dynamics at single-nucleotide resolution. Genome Biol (2008) 2.12
A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res (2010) 2.02
The abundance of short proteins in the mammalian proteome. PLoS Genet (2006) 1.96
Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic (2003) 1.88
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol (2009) 1.83
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A (2012) 1.82
RNA-MATE: a recursive mapping strategy for high-throughput RNA-sequencing data. Bioinformatics (2009) 1.81
The uniqueome: a mappability resource for short-tag sequencing. Bioinformatics (2010) 1.79
qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles. PLoS One (2012) 1.77
Genome-wide identification of long noncoding RNAs in CD8+ T cells. J Immunol (2009) 1.73
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proc Natl Acad Sci U S A (2012) 1.72
The phasevarion: a genetic system controlling coordinated, random switching of expression of multiple genes. Proc Natl Acad Sci U S A (2005) 1.63
Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Dev Biol (2007) 1.61
Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prev Res (Phila) (2010) 1.55
Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells (2010) 1.50
Genetic control of the innate immune response. BMC Immunol (2003) 1.50
Phasevarions mediate random switching of gene expression in pathogenic Neisseria. PLoS Pathog (2009) 1.48
Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. Am J Hum Genet (2013) 1.46
Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities. Stem Cell Res (2011) 1.45
Characterization of the OxyR regulon of Neisseria gonorrhoeae. Mol Microbiol (2006) 1.40
Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture. BMC Genomics (2007) 1.34
Probabilistic resolution of multi-mapping reads in massively parallel sequencing data using MuMRescueLite. Bioinformatics (2009) 1.32
Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome. Genome Res (2010) 1.32
Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. J Immunol (2002) 1.28
Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. Development (2012) 1.28
miR-139-5p is a regulator of metastatic pathways in breast cancer. RNA (2013) 1.25
Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer (2014) 1.24
Identifying the molecular phenotype of renal progenitor cells. J Am Soc Nephrol (2004) 1.18
Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies. J Biol Chem (2006) 1.18
Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR. Proc Natl Acad Sci U S A (2007) 1.17
Identification of human embryonic stem cell surface markers by combined membrane-polysome translation state array analysis and immunotranscriptional profiling. Stem Cells (2009) 1.16
Phasevarion mediated epigenetic gene regulation in Helicobacter pylori. PLoS One (2011) 1.13
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Proc Natl Acad Sci U S A (2012) 1.13
Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases. Genome Biol (2006) 1.13
Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development (2012) 1.13
Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One (2011) 1.10
Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs. Genome Biol (2014) 1.08
Alternate transcription of the Toll-like receptor signaling cascade. Genome Biol (2006) 1.08
PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae. Mol Microbiol (2006) 1.07
Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One (2011) 1.07
Subcellular localization of mammalian type II membrane proteins. Traffic (2006) 1.06
MicroRNA-182-5p targets a network of genes involved in DNA repair. RNA (2012) 1.06
Whole genome sequence analysis of the first Australian OXA-48-producing outbreak-associated Klebsiella pneumoniae isolates: the resistome and in vivo evolution. PLoS One (2013) 1.04
Somatic point mutation calling in low cellularity tumors. PLoS One (2013) 1.03
Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation. Development (2009) 1.03
Identification of novel markers of mouse fetal ovary development. PLoS One (2012) 1.03
Subfractionation of differentiating human embryonic stem cell populations allows the isolation of a mesodermal population enriched for intermediate mesoderm and putative renal progenitors. Stem Cells Dev (2010) 1.02
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00
Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis. Dev Biol (2003) 0.98
Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development (2009) 0.97
Transcriptome-wide prediction of miRNA targets in human and mouse using FASTH. PLoS One (2009) 0.95
The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. Blood (2009) 0.95
Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups. Proc Natl Acad Sci U S A (2013) 0.95
A high-throughput platform for lentiviral overexpression screening of the human ORFeome. PLoS One (2011) 0.94
Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clin Chem (2007) 0.94
Proteogenomic analysis of Bradyrhizobium japonicum USDA110 using GenoSuite, an automated multi-algorithmic pipeline. Mol Cell Proteomics (2013) 0.94
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. J Clin Invest (2011) 0.93
Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. Int J Cancer (2013) 0.92
Spatial gene expression in the T-stage mouse metanephros. Gene Expr Patterns (2006) 0.92
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Hum Mol Genet (2002) 0.91
Understanding pancreatic cancer genomes. J Hepatobiliary Pancreat Sci (2013) 0.91
PhosphoregDB: the tissue and sub-cellular distribution of mammalian protein kinases and phosphatases. BMC Bioinformatics (2006) 0.91
Ascorbate promotes epigenetic activation of CD30 in human embryonic stem cells. Stem Cells (2010) 0.90
Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes. Blood (2014) 0.90
Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limb. Dev Dyn (2008) 0.90
Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae. J Proteomics (2009) 0.90
Sequencing transcriptomes in toto. Integr Biol (Camb) (2011) 0.89
Minor class splicing shapes the zebrafish transcriptome during development. Proc Natl Acad Sci U S A (2014) 0.89
MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis. Biol Reprod (2013) 0.89
Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation. Dev Biol (2010) 0.88
Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Rep (2013) 0.86
Clinical and pathologic features of familial pancreatic cancer. Cancer (2014) 0.86
Deep-transcriptome and ribonome sequencing redefines the molecular networks of pluripotency and the extracellular space in human embryonic stem cells. Genome Res (2011) 0.86
Refining transcriptional programs in kidney development by integration of deep RNA-sequencing and array-based spatial profiling. BMC Genomics (2011) 0.85
Patched1 is required in neural crest cells for the prevention of orofacial clefts. Hum Mol Genet (2013) 0.85
In vivo evolution of antimicrobial resistance in a series of Staphylococcus aureus patient isolates: the entire picture or a cautionary tale? J Antimicrob Chemother (2013) 0.84
Nuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations. Dev Dyn (2014) 0.84