Signatures of mutational processes in human cancer.

Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med (2014) 16.83

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science (2015) 11.89

The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet (2013) 11.29

Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12

The causes and consequences of genetic heterogeneity in cancer evolution. Nature (2013) 5.91

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science (2014) 5.63

Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells. Science (2015) 4.29

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science (2014) 4.28

Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature (2014) 4.13

Whole genomes redefine the mutational landscape of pancreatic cancer. Nature (2015) 4.01

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A (2014) 3.39

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science (2016) 3.38

The Molecular Taxonomy of Primary Prostate Cancer. Cell (2015) 3.29

Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science (2015) 3.29

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell (2013) 3.26

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma. Nat Commun (2014) 3.12

Whole-genome characterization of chemoresistant ovarian cancer. Nature (2015) 3.06

Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature (2016) 3.05

Genome-wide analysis of noncoding regulatory mutations in cancer. Nat Genet (2014) 2.86

Racial diversity of actionable mutations in non-small cell lung cancer. J Thorac Oncol (2015) 2.80

Individualized medicine from prewomb to tomb. Cell (2014) 2.76

Integrated genomic characterization of oesophageal carcinoma. Nature (2017) 2.76

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet (2014) 2.72

Transmissible [corrected] dog cancer genome reveals the origin and history of an ancient cell lineage. Science (2014) 2.58

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition. Nat Med (2016) 2.46

Substantial contribution of extrinsic risk factors to cancer development. Nature (2015) 2.46

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma. Nat Med (2014) 2.40

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Nat Med (2016) 2.36

Cell-of-origin chromatin organization shapes the mutational landscape of cancer. Nature (2015) 2.35

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nat Genet (2015) 2.29

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution. Sci Transl Med (2015) 2.29

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance. Nat Genet (2016) 2.28

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet (2015) 2.27

The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell (2014) 2.21

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet (2015) 2.17

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Sci Transl Med (2016) 2.16

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature (2014) 2.11

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat Rev Clin Oncol (2016) 2.09

Mutations driving CLL and their evolution in progression and relapse. Nature (2015) 2.06

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature (2015) 2.04

Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state. Nat Biotechnol (2015) 2.03

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A (2013) 2.00

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discov (2014) 1.99

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med (2015) 1.98

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat Commun (2015) 1.94

Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect. Cell (2015) 1.94

Clock-like mutational processes in human somatic cells. Nat Genet (2015) 1.91

Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma. Nat Genet (2015) 1.89

Realizing the promise of cancer predisposition genes. Nature (2014) 1.84

Repair Pathway Choices and Consequences at the Double-Strand Break. Trends Cell Biol (2015) 1.84

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma. Nat Med (2015) 1.80

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy. Cancer Discov (2015) 1.76

Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy. Proc Natl Acad Sci U S A (2015) 1.72

Cancer genomics: one cell at a time. Genome Biol (2014) 1.70

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer. Nat Genet (2014) 1.68

Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection. Nat Methods (2015) 1.67

Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer (2014) 1.67

The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell (2015) 1.66

Molecular genetics of clear-cell renal cell carcinoma. J Clin Oncol (2014) 1.65

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene (2015) 1.65

Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nat Commun (2013) 1.62

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes. Curr Opin Genet Dev (2013) 1.62

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev (2013) 1.61

Expanding the computational toolbox for mining cancer genomes. Nat Rev Genet (2014) 1.60

Genomic spectra of biliary tract cancer. Nat Genet (2015) 1.58

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell (2014) 1.58

SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep (2014) 1.57

Novel recurrently mutated genes in African American colon cancers. Proc Natl Acad Sci U S A (2015) 1.57

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. Nature (2014) 1.57

Combination cancer immunotherapies tailored to the tumour microenvironment. Nat Rev Clin Oncol (2015) 1.54

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers. Gastroenterology (2016) 1.52

UV signature mutations. Photochem Photobiol (2014) 1.52

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer. Nat Commun (2015) 1.49

Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma. JAMA Oncol (2015) 1.49

Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes. Ann Oncol (2015) 1.48

Genome sequencing of normal cells reveals developmental lineages and mutational processes. Nature (2014) 1.48

The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning. Neuron (2016) 1.48

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun (2015) 1.47

The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing. Hum Mutat (2015) 1.46

High-definition reconstruction of clonal composition in cancer. Cell Rep (2014) 1.45

Cell Fusion Connects Oncogenesis with Tumor Evolution. Am J Pathol (2015) 1.44

Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell (2016) 1.44

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma. Cancer Res (2013) 1.43

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nat Commun (2014) 1.42

Immunotherapy in endometrial cancer - an evolving therapeutic paradigm. Gynecol Oncol Res Pract (2015) 1.42

Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer. PLoS One (2015) 1.41

Frequency of regulatory T cells determines the outcome of the T-cell-engaging antibody blinatumomab in patients with B-precursor ALL. Leukemia (2017) 1.40

Whole-genome landscapes of major melanoma subtypes. Nature (2017) 1.40

Recurrent and functional regulatory mutations in breast cancer. Nature (2017) 1.39

Rekindling cancer vaccines. Nat Biotechnol (2016) 1.39

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife (2014) 1.39

γδ T cells in cancer. Nat Rev Immunol (2015) 1.39

BRCAness revisited. Nat Rev Cancer (2016) 1.38

Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis (2013) 1.38

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. Nat Biotechnol (2015) 1.37

The melanoma revolution: from UV carcinogenesis to a new era in therapeutics. Science (2014) 1.37

Mutational dynamics between primary and relapse neuroblastomas. Nat Genet (2015) 1.36

FunSeq2: a framework for prioritizing noncoding regulatory variants in cancer. Genome Biol (2014) 1.36

CTCF/cohesin-binding sites are frequently mutated in cancer. Nat Genet (2015) 1.36

Timing, rates and spectra of human germline mutation. Nat Genet (2015) 1.35

dbSNP: the NCBI database of genetic variation. Nucleic Acids Res (2001) 76.97

An integrated map of genetic variation from 1,092 human genomes. Nature (2012) 59.82

Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13

Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02

The cancer genome. Nature (2009) 23.13

International network of cancer genome projects. Nature (2010) 20.35

Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature (2013) 20.16

The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33

Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29

The genomic complexity of primary human prostate cancer. Nature (2011) 14.06

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18

A landscape of driver mutations in melanoma. Cell (2012) 12.61

The mutational landscape of lethal castration-resistant prostate cancer. Nature (2012) 11.82

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell (2012) 11.69

The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24

Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (2010) 10.78

The life history of 21 breast cancers. Cell (2012) 10.59

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (2011) 10.26

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet (2012) 9.93

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature (2012) 9.89

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature (2011) 9.71

The origin and evolution of mutations in acute myeloid leukemia. Cell (2012) 9.66

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants. Nature (2012) 8.91

Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77

Microsatellite instability in colorectal cancer. Gastroenterology (2010) 7.39

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene (2002) 7.04

Transcription-coupled DNA repair: two decades of progress and surprises. Nat Rev Mol Cell Biol (2008) 7.00

Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem (2007) 6.92

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res (2006) 6.91

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet (2011) 6.43

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet (2011) 5.68

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28

APOBEC3B is an enzymatic source of mutation in breast cancer. Nature (2013) 5.18

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol Cell (2002) 5.14

Recurrent R-spondin fusions in colon cancer. Nature (2012) 5.10

BAP1 loss defines a new class of renal cell carcinoma. Nat Genet (2012) 4.97

TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol (2010) 4.92

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat Genet (2012) 4.82

The genetic landscape of high-risk neuroblastoma. Nat Genet (2013) 4.71

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet (2012) 4.70

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet (2013) 4.48

Mutations induced by ultraviolet light. Mutat Res (2005) 4.45

The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res (2012) 3.80

Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66

Deciphering signatures of mutational processes operative in human cancer. Cell Rep (2013) 3.61

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A (2011) 3.51

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet (2013) 3.51

The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet (2013) 3.43

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nat Genet (2012) 3.38

The genetic landscape of mutations in Burkitt lymphoma. Nat Genet (2012) 3.03

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. Elife (2013) 2.67

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet (2012) 2.64

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat Genet (2011) 2.36

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. Mutat Res (2012) 2.28

Mutagenesis at methylated CpG sequences. Curr Top Microbiol Immunol (2006) 2.24

Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors. BMC Genomics (2008) 2.11

False positive peaks in ChIP-seq and other sequencing-based functional assays caused by unannotated high copy number regions. Bioinformatics (2011) 1.85

Noncanonical mismatch repair as a source of genomic instability in human cells. Mol Cell (2012) 1.63

Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases. Front Microbiol (2013) 1.33

Environmental exposures and mutational patterns of cancer genomes. Genome Med (2010) 1.29

Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene. Mutat Res (2000) 1.26

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (2004) 61.56

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 39.09

Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41

A census of human cancer genes. Nat Rev Cancer (2004) 36.20

Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A (2003) 34.68

A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03

The landscape of somatic copy-number alteration across human cancers. Nature (2010) 31.88

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78

Stem cell transcriptome profiling via massive-scale mRNA sequencing. Nat Methods (2008) 31.04

Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet (2005) 29.45

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med (2005) 26.35

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature (2005) 26.32

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res (2010) 25.55

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40

A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27

The cancer genome. Nature (2009) 23.13

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature (2012) 20.47

Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays. PLoS Genet (2008) 20.38

International network of cancer genome projects. Nature (2010) 20.35

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A (2007) 18.83

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet (2005) 18.59

A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39