Published in Chem Biol on November 01, 2002
The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest (2007) 1.95
Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions. J Am Chem Soc (2009) 1.72
Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest (2006) 1.20
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol (2005) 1.17
Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. PLoS One (2009) 1.13
Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation. Bioorg Med Chem Lett (2009) 1.11
Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2). J Exp Med (2009) 1.01
Discovery of inhibitors of aberrant gene transcription from Libraries of DNA binding molecules: inhibition of LEF-1-mediated gene transcription and oncogenic transformation. J Am Chem Soc (2009) 0.93
Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions. J Am Chem Soc (2011) 0.93
Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library. Bioorg Med Chem Lett (2012) 0.89
A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation. J Biol Chem (2010) 0.82
Discovery libraries targeting the major enzyme classes: the serine hydrolases. Bioorg Med Chem Lett (2014) 0.76
A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorg Med Chem (2008) 0.76
Cell migration: integrating signals from front to back. Science (2003) 29.13
Talin binding to integrin beta tails: a final common step in integrin activation. Science (2003) 7.56
Structural basis of integrin activation by talin. Cell (2007) 5.37
The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol (2010) 4.72
Networks and crosstalk: integrin signalling spreads. Nat Cell Biol (2002) 4.66
Structural determinants of integrin recognition by talin. Mol Cell (2003) 4.20
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A (2003) 4.03
Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol (2006) 3.81
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67
An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol (2005) 3.44
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nat Biotechnol (2003) 3.17
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther (2004) 2.99
The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem (2002) 2.97
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol (2007) 2.92
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J (2009) 2.76
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell (2011) 2.70
Recreation of the terminal events in physiological integrin activation. J Cell Biol (2010) 2.48
The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J (2009) 2.45
Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. J Am Chem Soc (2009) 2.35
Regulation of integrin activation. Annu Rev Cell Dev Biol (2011) 2.32
RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem (2008) 2.29
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol (2007) 2.27
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med (2010) 2.23
Intramolecular Diels-Alder and tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reactions of 1,3,4-oxadiazoles. J Am Chem Soc (2002) 2.18
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med (2009) 2.12
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Proc Natl Acad Sci U S A (2002) 2.11
Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine. J Am Chem Soc (2008) 2.10
Integrin modulation and signaling in leukocyte adhesion and migration. Immunol Rev (2007) 2.10
Total synthesis of (-)- and ent-(+)-vindoline. Org Lett (2005) 2.09
Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids. J Am Chem Soc (2006) 2.07
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol (2009) 1.99
The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem (2003) 1.97
The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest (2007) 1.95
Mechanisms of in situ activation for DNA-targeting antitumor agents. Chem Rev (2002) 1.94
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol (2008) 1.93
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke (2011) 1.91
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin. Nat Chem Biol (2006) 1.90
CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A (2004) 1.88
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci U S A (2007) 1.85
Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. J Biol Chem (2004) 1.84
Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol (2003) 1.81
Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry (2008) 1.80
Sequence-selective DNA recognition: natural products and nature's lessons. Chem Biol (2004) 1.78
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73
Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood (2008) 1.73
Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions. J Am Chem Soc (2009) 1.72
Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol (2012) 1.68
Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell (2006) 1.67
Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem (2005) 1.65
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues. Org Lett (2012) 1.64
Total synthesis of (-)- and ent-(+)-vindorosine: tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles. Angew Chem Int Ed Engl (2006) 1.63
Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles. J Am Chem Soc (2006) 1.63
A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity. Acc Chem Res (2004) 1.59
Total synthesis and evaluation of a key series of C5-substituted vinblastine derivatives. J Am Chem Soc (2010) 1.58
Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol (2003) 1.58
Total synthesis of anhydrolycorinone utilizing sequential intramolecular Diels-Alder reactions of a 1,3,4-oxadiazole. J Org Chem (2002) 1.58
Asymmetric total synthesis of vindorosine, vindoline, and key vinblastine analogues. J Am Chem Soc (2010) 1.51
UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. Blood (2008) 1.51
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51
Partitioning the loss in vancomycin binding affinity for D-Ala-D-Lac into lost H-bond and repulsive lone pair contributions. J Am Chem Soc (2003) 1.48
Competition for talin results in trans-dominant inhibition of integrin activation. J Biol Chem (2004) 1.46
The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem (2002) 1.46
Alpha4 integrins and the immune response. Immunol Rev (2002) 1.45
Talin forges the links between integrins and actin. Nat Cell Biol (2003) 1.45
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood (2009) 1.41
Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J Biol Chem (2009) 1.40
Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J (2002) 1.40
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet (2010) 1.39
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol (2006) 1.38
Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity. Chem Rev (2005) 1.38
Asymmetric total synthesis of vindoline. J Am Chem Soc (2010) 1.36
Integrin activation. Biochem Soc Trans (2008) 1.36
DNA alkylation properties of yatakemycin. J Am Chem Soc (2003) 1.35
Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35
Fe(III)/NaBH4-mediated free radical hydrofluorination of unactivated alkenes. J Am Chem Soc (2012) 1.33
Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol Biol Cell (2005) 1.33
Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues. Bioorg Med Chem Lett (2010) 1.32
Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell (2008) 1.32
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem (2004) 1.32
Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip (2008) 1.32
Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol (2007) 1.31
Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech (2009) 1.31
Total synthesis of the ristocetin aglycon. J Am Chem Soc (2004) 1.31
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation. J Biol Chem (2003) 1.30
Basic amino-acid side chains regulate transmembrane integrin signalling. Nature (2011) 1.30
Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses. J Biol Chem (2008) 1.29
Total synthesis and evaluation of [Psi[CH2NH]Tpg4]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding. J Am Chem Soc (2006) 1.29
10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids. ACS Med Chem Lett (2011) 1.27
Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer. J Am Chem Soc (2006) 1.26
Yatakemycin: total synthesis, DNA alkylation, and biological properties. Nat Prod Rep (2007) 1.26
Total synthesis of ningalin D. J Am Chem Soc (2005) 1.25
Total synthesis of piericidin A1 and B1 and key analogues. J Am Chem Soc (2006) 1.25
CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci (2012) 1.24
Total synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidine. J Am Chem Soc (2010) 1.22