Published in Immunol Rev on August 01, 2007
Foreign body reaction to biomaterials. Semin Immunol (2007) 8.32
Contribution of platelets to tumour metastasis. Nat Rev Cancer (2011) 4.16
Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell (2011) 2.70
Force probing surfaces of living cells to molecular resolution. Nat Chem Biol (2009) 2.28
Significantly improved precision of cell migration analysis in time-lapse video microscopy through use of a fully automated tracking system. BMC Cell Biol (2010) 2.04
Why integrin as a primary target for imaging and therapy. Theranostics (2011) 1.61
Regulation of integrin activity and signalling. Biochim Biophys Acta (2009) 1.51
Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane. J Cell Biol (2009) 1.41
Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow. Blood (2008) 1.35
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci (2008) 1.32
HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. J Virol (2009) 1.28
Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1. J Immunol (2009) 1.28
Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling. Eur J Immunol (2011) 1.19
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells. Mol Cell Biol (2009) 1.19
Leukocyte integrins and their ligand interactions. Immunol Res (2009) 1.18
Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells. Cancer Res (2010) 1.18
Recent developments and complexities in neutrophil transmigration. Curr Opin Hematol (2010) 1.17
Quantifying cellular adhesion to extracellular matrix components by single-cell force spectroscopy. Nat Protoc (2010) 1.16
Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells. Am J Transplant (2011) 1.15
Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity (2010) 1.10
Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of alpha4beta1 integrins. J Biol Chem (2008) 1.09
Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proc Natl Acad Sci U S A (2011) 1.09
Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch. Nat Cell Biol (2015) 1.08
Tumor-exosomes and leukocyte activation: an ambivalent crosstalk. Cell Commun Signal (2012) 1.08
The dark sides of capillary morphogenesis gene 2. EMBO J (2011) 1.08
Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane. Mol Cell Biol (2009) 1.08
Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations. Dev Biol (2010) 1.06
Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo. PLoS One (2010) 1.06
Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo. PLoS One (2014) 1.05
CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol (2009) 1.00
A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. J Exp Med (2010) 0.97
PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth. PLoS One (2013) 0.96
Functional properties of fibronectin in the trabecular meshwork. Exp Eye Res (2008) 0.96
The EMILIN/Multimerin family. Front Immunol (2012) 0.96
Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses. Transplantation (2012) 0.95
On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda) (2011) 0.95
Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol (2010) 0.94
Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis. Arthritis Rheum (2008) 0.94
T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins. Int J Cancer (2014) 0.93
Mesh biocompatibility: effects of cellular inflammation and tissue remodelling. Langenbecks Arch Surg (2011) 0.93
In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell--endothelial cell interaction. BMC Cancer (2010) 0.92
Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway. Exp Cell Res (2010) 0.91
Regulation of eosinophil trafficking by SWAP-70 and its role in allergic airway inflammation. J Immunol (2011) 0.90
Hematopoietic mobilization: Potential biomarker of response to natalizumab in multiple sclerosis. Neurology (2015) 0.90
Epigallocatechin gallate reduces human monocyte mobility and adhesion in vitro. Br J Pharmacol (2009) 0.89
beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection. J Virol (2010) 0.88
The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes. J Biol Chem (2011) 0.87
Rap1 and its effector RIAM are required for lymphocyte trafficking. Blood (2015) 0.85
CD47-independent effects mediated by the TSP-derived 4N1K peptide. PLoS One (2014) 0.84
Antisense-mediated RNA targeting: versatile and expedient genetic manipulation in the brain. Front Mol Neurosci (2011) 0.84
Integrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway. Cell Signal (2011) 0.83
Disintegrins from snake venoms and their applications in cancer research and therapy. Curr Protein Pept Sci (2015) 0.83
Radil controls neutrophil adhesion and motility through β2-integrin activation. Mol Biol Cell (2012) 0.82
Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool. Nat Commun (2014) 0.82
The Drosophila cell adhesion molecule Neuroglian regulates Lissencephaly-1 localisation in circulating immunosurveillance cells. BMC Immunol (2009) 0.82
Integrins step up the pace of cell migration through polyamines and potassium channels. Proc Natl Acad Sci U S A (2008) 0.82
Neutrophil microdomains: linking heterocellular interactions with vascular injury. Curr Opin Hematol (2010) 0.81
Regulation of serotonin-induced trafficking and migration of eosinophils. PLoS One (2013) 0.80
An integrated stochastic model of "inside-out" integrin activation and selective T-lymphocyte recruitment. Langmuir (2012) 0.79
The role of 9-O-acetylated ganglioside D3 (CD60) and {alpha}4{beta}1 (CD49d) expression in predicting the survival of patients with Sezary syndrome. Haematologica (2010) 0.79
Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion. J Biol Chem (2014) 0.78
Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling. Acta Neuropathol (2015) 0.78
9-cis-retinoic acid promotes cell adhesion through integrin dependent and independent mechanisms across immune lineages. J Nutr Biochem (2012) 0.78
Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration. Nat Commun (2017) 0.77
A clonal model for human CD8+ regulatory T cells: unrestricted contact-dependent killing of activated CD4+ T cells. Eur J Immunol (2011) 0.77
Eosinophil-expressed galectin-3 regulates cell trafficking and migration. Front Pharmacol (2013) 0.77
Laminin-Mediated Interactions in Thymocyte Migration and Development. Front Immunol (2015) 0.75
Phenotyping of Leukocytes and Leukocyte-Derived Extracellular Vesicles. J Immunol Res (2016) 0.75
Immunosuppressive drugs affect high-mannose/hybrid N-glycans on human allostimulated leukocytes. Anal Cell Pathol (Amst) (2015) 0.75
Static adhesion assay for the study of integrin activation in T lymphocytes. J Vis Exp (2014) 0.75
Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells. Toxicol Appl Pharmacol (2016) 0.75
Neutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-α4β1 integrin interaction, cell adhesion and anti-proliferative activity. Sci Rep (2017) 0.75
Endotoxin-induced autocrine ATP signaling inhibits neutrophil chemotaxis through enhancing myosin light chain phosphorylation. Proc Natl Acad Sci U S A (2017) 0.75
Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices. Biophys J (2017) 0.75
Structural and mechanical functions of integrins. Biophys Rev (2013) 0.75
Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance. BMC Genomics (2016) 0.75
Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype. PLoS One (2017) 0.75
PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury. Cell Rep (2017) 0.75
Cell migration: integrating signals from front to back. Science (2003) 29.13
Talin binding to integrin beta tails: a final common step in integrin activation. Science (2003) 7.56
Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol (2005) 7.47
Structural basis of integrin activation by talin. Cell (2007) 5.37
The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol (2010) 4.72
Networks and crosstalk: integrin signalling spreads. Nat Cell Biol (2002) 4.66
Structural determinants of integrin recognition by talin. Mol Cell (2003) 4.20
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A (2003) 4.03
Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol (2006) 3.81
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67
An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol (2005) 3.44
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol (2007) 3.41
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood (2005) 3.26
Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nat Immunol (2005) 3.07
The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem (2002) 2.97
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol (2007) 2.92
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood (2004) 2.84
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J (2009) 2.76
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell (2011) 2.70
Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity (2009) 2.50
Recreation of the terminal events in physiological integrin activation. J Cell Biol (2010) 2.48
The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J (2009) 2.45
Regulation of integrin activation. Annu Rev Cell Dev Biol (2011) 2.32
RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem (2008) 2.29
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol (2007) 2.27
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med (2010) 2.23
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med (2009) 2.12
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol (2009) 1.99
The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem (2003) 1.97
The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest (2007) 1.95
Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots. Nat Immunol (2011) 1.93
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol (2008) 1.93
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke (2011) 1.91
CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A (2004) 1.88
A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J Leukoc Biol (2008) 1.87
Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. J Biol Chem (2004) 1.84
Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol (2003) 1.81
Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry (2008) 1.80
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73
Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood (2008) 1.73
Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol (2012) 1.68
A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets. J Exp Med (2007) 1.67
Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell (2006) 1.67
Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem (2005) 1.65
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol (2003) 1.58
Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration. J Immunol (2004) 1.56
UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. Blood (2008) 1.51
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51
Competition for talin results in trans-dominant inhibition of integrin activation. J Biol Chem (2004) 1.46
The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem (2002) 1.46
Alpha4 integrins and the immune response. Immunol Rev (2002) 1.45
Talin forges the links between integrins and actin. Nat Cell Biol (2003) 1.45
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood (2009) 1.41
Kindlin-3: a new gene involved in the pathogenesis of LAD-III. Blood (2008) 1.40
Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J Biol Chem (2009) 1.40
Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J (2002) 1.40
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet (2010) 1.39
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol (2006) 1.38
Integrin activation. Biochem Soc Trans (2008) 1.36
Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. J Clin Invest (2005) 1.36
Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35
Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol Biol Cell (2005) 1.33
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem (2004) 1.32
Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell (2008) 1.32
Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip (2008) 1.32
Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol (2007) 1.31
Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech (2009) 1.31
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation. J Biol Chem (2003) 1.30
Basic amino-acid side chains regulate transmembrane integrin signalling. Nature (2011) 1.30
Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm. Blood (2006) 1.27
Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes. Thromb Haemost (2006) 1.24
CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci (2012) 1.24
The mechanism of kindlin-mediated activation of integrin αIIbβ3. Curr Biol (2013) 1.22
The talin-tail interaction places integrin activation on FERM ground. Trends Biochem Sci (2004) 1.22
Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions. Blood (2009) 1.21
CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol (2007) 1.21
Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry (2003) 1.21
Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest (2006) 1.20
Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers. J Cell Biol (2003) 1.20
Talin phosphorylation sites mapped by mass spectrometry. J Cell Sci (2005) 1.19
An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip (2009) 1.18
Integrin-associated proteins as potential therapeutic targets. Immunol Rev (2008) 1.17
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol (2005) 1.17
Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow. Cancer Res (2009) 1.17
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts. J Immunol (2004) 1.16
DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration. Blood (2006) 1.15
Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis. J Neuroimmunol (2010) 1.15
CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. J Biol Chem (2007) 1.12
Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration. J Exp Med (2004) 1.10
Two modes of integrin activation form a binary molecular switch in adhesion maturation. Mol Biol Cell (2013) 1.10
Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. J Biol Chem (2003) 1.10
A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell (2011) 1.09
Talin activates integrins by altering the topology of the β transmembrane domain. J Cell Biol (2012) 1.09
Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. PLoS One (2012) 1.08