Published in Annu Rev Cell Dev Biol on June 10, 2011
The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors. Br J Pharmacol (2013) 2.29
Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol (2011) 1.89
Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions. Curr Biol (2014) 1.75
Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome. J Clin Invest (2012) 1.66
Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. J Exp Med (2015) 1.50
Integrin inactivators: balancing cellular functions in vitro and in vivo. Nat Rev Mol Cell Biol (2013) 1.45
A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3. PLoS Pathog (2016) 1.39
Initial activation of STIM1, the regulator of store-operated calcium entry. Nat Struct Mol Biol (2013) 1.24
Two-step engulfment of apoptotic cells. Mol Cell Biol (2011) 1.21
Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction. Curr Opin Cell Biol (2012) 1.21
Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Mol Cell (2013) 1.17
Talin activates integrins by altering the topology of the β transmembrane domain. J Cell Biol (2012) 1.09
Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer. Mol Biol Cell (2012) 1.09
Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. J Cell Biol (2015) 1.07
Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J Immunol (2013) 1.05
Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. Proc Natl Acad Sci U S A (2011) 1.03
Cell-matrix adhesion of podocytes in physiology and disease. Nat Rev Nephrol (2013) 1.02
Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol (2012) 1.01
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One (2012) 1.00
Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells. Mol Cell Proteomics (2012) 0.99
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J Cell Biol (2012) 0.99
SHARPIN is a key regulator of immune and inflammatory responses. J Cell Mol Med (2012) 0.99
αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. Mol Biol Cell (2013) 0.97
Origins of eukaryotic sexual reproduction. Cold Spring Harb Perspect Biol (2014) 0.96
Integrins as receptor targets for neurological disorders. Pharmacol Ther (2011) 0.96
Vinculin controls talin engagement with the actomyosin machinery. Nat Commun (2015) 0.96
Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors. Cancers (Basel) (2013) 0.95
HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host Microbe (2014) 0.93
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Mechanism of regulation of stem cell differentiation by matrix stiffness. Stem Cell Res Ther (2015) 0.93
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Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse. Front Immunol (2016) 0.91
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature (2016) 0.90
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Biophysical analysis of Kindlin-3 reveals an elongated conformation and maps integrin binding to the membrane-distal β-subunit NPXY motif. J Biol Chem (2012) 0.90
Integrins in Wound Healing. Adv Wound Care (New Rochelle) (2014) 0.90
Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2. J Biol Chem (2012) 0.89
Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides. J Drug Target (2012) 0.89
Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins. Front Immunol (2013) 0.89
Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr (2012) 0.88
Crossroads of integrins and cadherins in epithelia and stroma remodeling. Cell Adh Migr (2012) 0.88
Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest (2014) 0.87
Arteriolar vascular smooth muscle cells: mechanotransducers in a complex environment. Int J Biochem Cell Biol (2012) 0.87
Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. Mol Biol Cell (2013) 0.86
The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells. J Biol Chem (2014) 0.86
Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite. Wiley Interdiscip Rev Dev Biol (2013) 0.86
The role of integrins in the trabecular meshwork. J Ocul Pharmacol Ther (2013) 0.85
Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Proc Natl Acad Sci U S A (2013) 0.85
Podocyte-actin dynamics in health and disease. Nat Rev Nephrol (2016) 0.85
The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand. J Biol Chem (2015) 0.84
Integrin β1 is critical for gastrin-releasing peptide receptor-mediated neuroblastoma cell migration and invasion. Surgery (2013) 0.84
SnapShot: talin and the modular nature of the integrin adhesome. Cell (2014) 0.84
Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol Biol Cell (2014) 0.84
Anti-integrin therapy for multiple sclerosis. Autoimmune Dis (2012) 0.84
NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer. Genes Cancer (2012) 0.84
Integrin activation. BMB Rep (2014) 0.84
Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain. Development (2015) 0.84
Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol (2015) 0.83
FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly. Nat Cell Biol (2016) 0.83
Kindlin-1 regulates integrin dynamics and adhesion turnover. PLoS One (2013) 0.82
Extracellular matrix is required for muscle differentiation in primary cell cultures of larval Mytilus trossulus (Mollusca: Bivalvia). Cytotechnology (2013) 0.81
The membrane-proximal KXGFFKR motif of α-integrin mediates chemoresistance. Mol Cell Biol (2013) 0.81
"Ins" and "Outs" of mesenchymal stem cell osteogenesis in regenerative medicine. World J Stem Cells (2014) 0.81
Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem (2014) 0.81
RAP1-GTPase signaling and platelet function. J Mol Med (Berl) (2015) 0.81
Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. Dev Biol (2015) 0.80
Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nat Commun (2016) 0.80
Discovery of platyhelminth-specific α/β-integrin families and evidence for their role in reproduction in Schistosoma mansoni. PLoS One (2012) 0.80
The origins of the molecular era of adhesion research. Nat Rev Mol Cell Biol (2012) 0.79
B-Raf regulation of integrin α4β1-mediated resistance to shear stress through changes in cell spreading and cytoskeletal association in T cells. J Biol Chem (2014) 0.79
The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells. Biochim Biophys Acta (2014) 0.79
Research advances on structure and biological functions of integrins. Springerplus (2016) 0.79
AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol (2017) 0.79
Single cell adhesion assay using computer controlled micropipette. PLoS One (2014) 0.79
The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood (2016) 0.79
GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells. J Biol Chem (2016) 0.78
Activity-dependent adaptations in inhibitory axons. Front Cell Neurosci (2013) 0.78
Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons. J Cell Biol (2015) 0.78
Band 4.1 proteins regulate integrin-dependent cell spreading. Biochem Biophys Res Commun (2012) 0.78
Matrix adhesion polarizes heart progenitor induction in the invertebrate chordate Ciona intestinalis. Development (2013) 0.78
Full length talin stimulates integrin activation and axon regeneration. Mol Cell Neurosci (2015) 0.78
Bacterial genotoxins promote inside-out integrin β1 activation, formation of focal adhesion complexes and cell spreading. PLoS One (2015) 0.77
Astroglial integrins in the development and regulation of neurovascular units. Pain Res Treat (2012) 0.77
The unique disulfide bond-stabilized W1 β4-β1 loop in the α4 β-propeller domain regulates integrin α4β7 affinity and signaling. J Biol Chem (2013) 0.77
Elucidating protein inter- and intramolecular interacting domains using chemical cross-linking and matrix-assisted laser desorption ionization-time of flight/time of flight mass spectrometry. Anal Biochem (2011) 0.77
In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by α4β1 cytoplasmic-binding proteins. Leukemia (2015) 0.77
Antagonizing Integrin β3 Increases Immunosuppression in Cancer. Cancer Res (2016) 0.77
Juxtamembrane contribution to transmembrane signaling. Biopolymers (2015) 0.76
Integrin αIIbβ3 transmembrane domain separation mediates bi-directional signaling across the plasma membrane. PLoS One (2015) 0.76
Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death Differ (2015) 0.76
Molecular cloning, overexpression, and an efficient one-step purification of α5β1 integrin. Protein Expr Purif (2013) 0.76
Matrix control of pancreatic cancer: New insights into fibronectin signaling. Cancer Lett (2015) 0.76
Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy. J Exp Med (2017) 0.76
IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy (2013) 0.76
Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators. Cancers (Basel) (2017) 0.76
CIB1 and CIB2 are HIV-1 helper factors involved in viral entry. Sci Rep (2016) 0.75
Rational design of a protein that binds integrin αvβ3 outside the ligand binding site. Nat Commun (2016) 0.75
Intermolecular transmembrane domain interactions activate integrin αIIbβ3. J Biol Chem (2014) 0.75
CIB1: a small protein with big ambitions. FASEB J (2016) 0.75
Cell migration: integrating signals from front to back. Science (2003) 29.13
Talin binding to integrin beta tails: a final common step in integrin activation. Science (2003) 7.56
Structural basis of integrin activation by talin. Cell (2007) 5.37
The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol (2010) 4.72
Networks and crosstalk: integrin signalling spreads. Nat Cell Biol (2002) 4.66
Structural determinants of integrin recognition by talin. Mol Cell (2003) 4.20
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A (2003) 4.03
Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol (2006) 3.81
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67
An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol (2005) 3.44
MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24
The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem (2002) 2.97
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol (2007) 2.92
Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A (2003) 2.89
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med (2007) 2.85
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J (2009) 2.76
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell (2011) 2.70
Recreation of the terminal events in physiological integrin activation. J Cell Biol (2010) 2.48
The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J (2009) 2.45
RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem (2008) 2.29
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol (2007) 2.27
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med (2010) 2.23
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med (2009) 2.12
Integrin modulation and signaling in leukocyte adhesion and migration. Immunol Rev (2007) 2.10
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol (2009) 1.99
The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem (2003) 1.97
The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest (2007) 1.95
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol (2008) 1.93
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke (2011) 1.91
CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A (2004) 1.88
Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. J Biol Chem (2004) 1.84
Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol (2003) 1.81
Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry (2008) 1.80
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73
Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood (2008) 1.73
Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol (2012) 1.68
Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell (2006) 1.67
Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem (2005) 1.65
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci (2009) 1.60
Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol (2003) 1.58
Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29. J Pathol (2011) 1.57
A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding. Blood (2014) 1.55
miR-375 is down-regulated in squamous cervical cancer and inhibits cell migration and invasion via targeting transcription factor SP1. Am J Pathol (2011) 1.52
UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. Blood (2008) 1.51
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51
miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression. Clin Cancer Res (2013) 1.47
Competition for talin results in trans-dominant inhibition of integrin activation. J Biol Chem (2004) 1.46
The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem (2002) 1.46
Alpha4 integrins and the immune response. Immunol Rev (2002) 1.45
Talin forges the links between integrins and actin. Nat Cell Biol (2003) 1.45
Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time polymerase chain reaction. Anal Biochem (2009) 1.44
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood (2009) 1.41
Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J Biol Chem (2009) 1.40
Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J (2002) 1.40
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet (2010) 1.39
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol (2006) 1.38
Integrin activation. Biochem Soc Trans (2008) 1.36
Structural determinants of integrin binding to the talin rod. J Biol Chem (2009) 1.35
Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol Biol Cell (2005) 1.33
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem (2004) 1.32
Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell (2008) 1.32
Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip (2008) 1.32
Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol (2007) 1.31
Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech (2009) 1.31
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation. J Biol Chem (2003) 1.30
Basic amino-acid side chains regulate transmembrane integrin signalling. Nature (2011) 1.30
Prevalence and risk profile of cervical Human papillomavirus infection in Zhejiang Province, southeast China: a population-based study. Virol J (2010) 1.25
Tomographic subvolume alignment and subvolume classification applied to myosin V and SIV envelope spikes. J Struct Biol (2008) 1.24
CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci (2012) 1.24
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The talin-tail interaction places integrin activation on FERM ground. Trends Biochem Sci (2004) 1.22
CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol (2007) 1.21
Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry (2003) 1.21
Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest (2006) 1.20
Talin phosphorylation sites mapped by mass spectrometry. J Cell Sci (2005) 1.19
Reduced miR-100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein. Eur J Cancer (2011) 1.19
An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip (2009) 1.18
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol (2005) 1.17
Integrin-associated proteins as potential therapeutic targets. Immunol Rev (2008) 1.17
Osteoinduction of hydroxyapatite/beta-tricalcium phosphate bioceramics in mice with a fractured fibula. Acta Biomater (2009) 1.15
Preoperative plasma fibrinogen, platelet count and prognosis in epithelial ovarian cancer. J Obstet Gynaecol Res (2012) 1.14
Hollow and cage-bell structured nanomaterials of noble metals. J Am Chem Soc (2012) 1.14
Interfacing live cells with nanocarbon substrates. Langmuir (2010) 1.13
CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. J Biol Chem (2007) 1.12
Two modes of integrin activation form a binary molecular switch in adhesion maturation. Mol Biol Cell (2013) 1.10
Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. J Biol Chem (2003) 1.10
Identification of miR-23a as a novel microRNA normalizer for relative quantification in human uterine cervical tissues. Exp Mol Med (2011) 1.09
Talin activates integrins by altering the topology of the β transmembrane domain. J Cell Biol (2012) 1.09
A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell (2011) 1.09
Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. PLoS One (2012) 1.08