Published in Bioessays on December 01, 2002
Integrative analysis of cell cycle control in budding yeast. Mol Biol Cell (2004) 4.77
Boolean network model predicts cell cycle sequence of fission yeast. PLoS One (2008) 3.05
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
Analysis of a generic model of eukaryotic cell-cycle regulation. Biophys J (2006) 1.86
Temporal organization of the cell cycle. Curr Biol (2008) 1.63
Current approaches to gene regulatory network modelling. BMC Bioinformatics (2007) 1.60
Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis. Cancer Res (2010) 1.59
Dynamics of the cell cycle: checkpoints, sizers, and timers. Biophys J (2003) 1.47
A model of yeast cell-cycle regulation based on multisite phosphorylation. Mol Syst Biol (2010) 1.33
Mathematical model of the morphogenesis checkpoint in budding yeast. J Cell Biol (2003) 1.33
A quantitative systems view of the spindle assembly checkpoint. EMBO J (2009) 1.26
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst Biol (2012) 1.25
Mapping global sensitivity of cellular network dynamics: sensitivity heat maps and a global summation law. J R Soc Interface (2008) 1.22
Dynamical modeling of syncytial mitotic cycles in Drosophila embryos. Mol Syst Biol (2007) 1.14
Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle. Biophys J (2004) 1.12
Reliability of transcriptional cycles and the yeast cell-cycle oscillator. PLoS Comput Biol (2010) 1.11
A proposal for robust temperature compensation of circadian rhythms. Proc Natl Acad Sci U S A (2007) 1.11
Scalable steady state analysis of Boolean biological regulatory networks. PLoS One (2009) 1.11
Achieving optimal growth through product feedback inhibition in metabolism. PLoS Comput Biol (2010) 1.10
The cell cycle switch computes approximate majority. Sci Rep (2012) 1.09
Global entrainment of transcriptional systems to periodic inputs. PLoS Comput Biol (2010) 1.08
Detecting intrinsic slow variables in stochastic dynamical systems by anisotropic diffusion maps. Proc Natl Acad Sci U S A (2009) 1.08
Bistable responses in bacterial genetic networks: designs and dynamical consequences. Math Biosci (2011) 1.08
Rule-based multi-level modeling of cell biological systems. BMC Syst Biol (2011) 1.06
Systems biology: On the cell cycle and its switches. Nature (2008) 1.02
Start and the restriction point. Curr Opin Cell Biol (2013) 1.01
Inverse bifurcation analysis: application to simple gene systems. Algorithms Mol Biol (2006) 0.97
Conceptual modeling in systems biology fosters empirical findings: the mRNA lifecycle. PLoS One (2007) 0.90
A review of molecular mechanisms of the anti-leukemic effects of phenolic compounds in honey. Int J Mol Sci (2012) 0.90
The stochastic behavior of a molecular switching circuit with feedback. Biol Direct (2007) 0.90
Cell cycle control by a minimal Cdk network. PLoS Comput Biol (2015) 0.90
Modelling in molecular biology: describing transcription regulatory networks at different scales. Philos Trans R Soc Lond B Biol Sci (2006) 0.89
Boolean network model predicts knockout mutant phenotypes of fission yeast. PLoS One (2013) 0.89
A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci (2010) 0.88
The role of modelling in identifying drug targets for diseases of the cell cycle. J R Soc Interface (2006) 0.87
Role of E3 ubiquitin ligases in lung cancer. World J Clin Oncol (2013) 0.86
Simple molecular networks that respond optimally to time-periodic stimulation. BMC Syst Biol (2009) 0.84
Tensor methods for parameter estimation and bifurcation analysis of stochastic reaction networks. J R Soc Interface (2015) 0.83
Strategic cell-cycle regulatory features that provide mammalian cells with tunable G1 length and reversible G1 arrest. PLoS One (2012) 0.83
Hysteresis and cell cycle transitions: how crucial is it? Biophys J (2004) 0.83
Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses. Environ Health Perspect (2014) 0.82
Computational modeling of signaling pathways mediating cell cycle checkpoint control and apoptotic responses to ionizing radiation-induced DNA damage. Dose Response (2011) 0.81
Time scale and dimension analysis of a budding yeast cell cycle model. BMC Bioinformatics (2006) 0.81
Modeling Dose-response at Low Dose: A Systems Biology Approach for Ionization Radiation. Dose Response (2010) 0.81
The molecular genetics of breast cancer and targeted therapy. Biologics (2007) 0.81
Transcriptional regulation is a major controller of cell cycle transition dynamics. PLoS One (2012) 0.81
SRC family kinases and receptors: analysis of three activation mechanisms by dynamic systems modeling. Biophys J (2007) 0.80
Decoding complex biological networks - tracing essential and modulatory parameters in complex and simplified models of the cell cycle. BMC Syst Biol (2011) 0.79
Cell cycle-dependent regulation of the RNA-binding protein Staufen1. Nucleic Acids Res (2014) 0.79
A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects. Gene Regul Syst Bio (2012) 0.79
Hysteresis meets the cell cycle. Proc Natl Acad Sci U S A (2003) 0.78
14-3-3s are potential biomarkers for HIV-related neurodegeneration. J Neurovirol (2012) 0.78
Minimal models for cell-cycle control based on competitive inhibition and multisite phosphorylations of Cdk substrates. Biophys J (2013) 0.78
The role of dynamic stimulation pattern in the analysis of bistable intracellular networks. Biosystems (2008) 0.78
'Signalling' between chromosomes in crane-fly spermatocytes studied using ultraviolet microbeam irradiation. Chromosome Res (2003) 0.77
MicroRNA-mediated regulation in biological systems with oscillatory behavior. Biomed Res Int (2013) 0.77
Method for finding metabolic properties based on the general growth law. Liver examples. A general framework for biological modeling. PLoS One (2014) 0.77
A Dynamic Gene Regulatory Network Model That Recovers the Cyclic Behavior of Arabidopsis thaliana Cell Cycle. PLoS Comput Biol (2015) 0.76
An Extended, Boolean Model of the Septation Initiation Network in S.Pombe Provides Insights into Its Regulation. PLoS One (2015) 0.76
Polyphenols as key players for the antileukaemic effects of propolis. Evid Based Complement Alternat Med (2014) 0.75
Systems Cancer Biology and the Controlling Mechanisms for the J-Shaped Cancer Dose Response: Towards Relaxing the LNT Hypothesis. Dose Response (2012) 0.75
A model of the regulatory network involved in the control of the cell cycle and cell differentiation in the Caenorhabditis elegans vulva. BMC Bioinformatics (2015) 0.75
A self-regulating biomolecular comparator for processing oscillatory signals. J R Soc Interface (2015) 0.75
Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases. Syst Synth Biol (2011) 0.75
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol (2003) 8.91
Integrative analysis of cell cycle control in budding yeast. Mol Biol Cell (2004) 4.77
Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell (2006) 2.29
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint. Curr Biol (2009) 1.76
Irreversible cell-cycle transitions are due to systems-level feedback. Nat Cell Biol (2007) 1.68
Temporal organization of the cell cycle. Curr Biol (2008) 1.63
The influence of catalysis on mad2 activation dynamics. PLoS Biol (2009) 1.40
Morphogenetic checkpoint in fission yeast? Yes! Microbiology (2002) 1.39
A model of yeast cell-cycle regulation based on multisite phosphorylation. Mol Syst Biol (2010) 1.33
Mathematical model of the morphogenesis checkpoint in budding yeast. J Cell Biol (2003) 1.33
Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis. Philos Trans R Soc Lond B Biol Sci (2011) 1.30
The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation. Mol Cell (2013) 1.23
Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1. Plant Cell (2009) 1.19
Dynamical modeling of syncytial mitotic cycles in Drosophila embryos. Mol Syst Biol (2007) 1.14
Antagonism and bistability in protein interaction networks. J Theor Biol (2007) 1.11
Size control in growing yeast and mammalian cells. Theor Biol Med Model (2004) 1.05
Modelling the fission yeast cell cycle. Brief Funct Genomic Proteomic (2004) 1.02
A general G1/S-phase cell-cycle control module in the flowering plant Arabidopsis thaliana. PLoS Genet (2012) 1.01
Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. Cell (2012) 0.93
Molecular mechanisms creating bistable switches at cell cycle transitions. Open Biol (2013) 0.92
Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches. Proc Natl Acad Sci U S A (2012) 0.89
Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity control. Nat Commun (2013) 0.88
Different effects of redundant feedback loops on a bistable switch. Chaos (2010) 0.87
The regulatory network of cell-cycle progression is fundamentally different in plants versus yeast or metazoans. Plant Signal Behav (2010) 0.85
Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles. J R Soc Interface (2011) 0.84
Cell cycle: who turns the crank? Curr Biol (2011) 0.81
The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles. Biophys Chem (2013) 0.80
Interplay of transcriptional and proteolytic regulation in driving robust cell cycle progression. Mol Biosyst (2012) 0.78
CDK-dependent nuclear localization of B-cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast. PLoS One (2013) 0.76
Bistability, oscillations, and traveling waves in frog egg extracts. Bull Math Biol (2014) 0.76