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Rank Title Journal Year PubWeight™‹?›
1 Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 2011 1.95
2 Retracted Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem 2009 1.88
3 High-fat diet induces apoptosis of hypothalamic neurons. PLoS One 2009 1.73
4 Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS One 2012 1.47
5 Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol 2008 1.47
6 Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 2012 1.27
7 RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes. Am J Physiol Heart Circ Physiol 2005 1.25
8 The thymus is a common target in malnutrition and infection. Br J Nutr 2007 1.22
9 Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways. Endocrinology 2003 1.18
10 Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver. J Nutr Biochem 2011 1.15
11 Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion. Endocrinology 2011 1.12
12 Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur J Endocrinol 2002 1.10
13 Retracted Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress. J Biol Chem 2012 1.01
14 Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology 2009 0.98
15 Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Mol Cell Endocrinol 2009 0.97
16 Partial reversibility of hypothalamic dysfunction and changes in brain activity after body mass reduction in obese subjects. Diabetes 2011 0.93
17 Neuroendocrine body weight regulation: integration between fat tissue, gastrointestinal tract, and the brain. Endokrynol Pol 2010 0.92
18 Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes. Eur J Pharmacol 2012 0.92
19 Fructose-induced hypothalamic AMPK activation stimulates hepatic PEPCK and gluconeogenesis due to increased corticosterone levels. Endocrinology 2012 0.91
20 Concern Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. J Physiol 2009 0.91
21 Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters. J Neurochem 2006 0.90
22 Disruption of metabolic pathways--perspectives for the treatment of cancer. Curr Cancer Drug Targets 2006 0.87
23 The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice. Liver Int 2010 0.87
24 Intracerebroventricular injection of citrate inhibits hypothalamic AMPK and modulates feeding behavior and peripheral insulin signaling. J Endocrinol 2008 0.86
25 Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats. Diabetes 2007 0.86
26 Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice. Endocrinology 2012 0.86
27 Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade. Am J Physiol Endocrinol Metab 2002 0.85
28 The phosphatidylinositol/AKT/atypical PKC pathway is involved in the improved insulin sensitivity by DHEA in muscle and liver of rats in vivo. Life Sci 2004 0.85
29 Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology 2006 0.85
30 Defective regulation of the ubiquitin/proteasome system in the hypothalamus of obese male mice. Endocrinology 2014 0.84
31 Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. FEBS Lett 2006 0.84
32 Taurine supplementation modulates glucose homeostasis and islet function. J Nutr Biochem 2008 0.84
33 Ablation of primary afferent neurons by neonatal capsaicin treatment reduces the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury in cirrhotic rats. Eur J Pharmacol 2008 0.80
34 Intermittent fasting induces hypothalamic modifications resulting in low feeding efficiency, low body mass and overeating. Endocrinology 2014 0.80
35 TLR4 expression in bone marrow-derived cells is both necessary and sufficient to produce the insulin resistance phenotype in diet-induced obesity. Endocrinology 2015 0.80
36 Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals. FEBS Lett 2005 0.79
37 Hypothalamic inhibition of acetyl-CoA carboxylase stimulates hepatic counter-regulatory response independent of AMPK activation in rats. PLoS One 2013 0.79
38 Solidago chilensis Meyen hydroalcoholic extract reduces JNK/IκB pathway activation and ameliorates insulin resistance in diet-induced obesity mice. Exp Biol Med (Maywood) 2011 0.79
39 Hypothalamic inflammation and thermogenesis: the brown adipose tissue connection. J Bioenerg Biomembr 2011 0.79
40 [Hypothalamic dysfunction in obesity]. Arq Bras Endocrinol Metabol 2012 0.78
41 Taurine enhances the anorexigenic effects of insulin in the hypothalamus of rats. Amino Acids 2011 0.78
42 Infliximab prevents increased systolic blood pressure and upregulates the AKT/eNOS pathway in the aorta of spontaneously hypertensive rats. Eur J Pharmacol 2012 0.78
43 Distinct subsets of hypothalamic genes are modulated by two different thermogenesis-inducing stimuli. Obesity (Silver Spring) 2008 0.78
44 Hypothalamic action of glutamate leads to body mass reduction through a mechanism partially dependent on JAK2. J Cell Biochem 2012 0.77
45 Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas). Diabetologia 2015 0.77
46 Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats. Life Sci 2008 0.77
47 Long-term disruption of maternal glucose homeostasis induced by prenatal glucocorticoid treatment correlates with miR-29 upregulation. Am J Physiol Endocrinol Metab 2013 0.76
48 Inhibition of 72 kDa inositol polyphosphate 5-phosphatase E improves insulin signal transduction in diet-induced obesity. J Endocrinol 2013 0.76
49 Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats. World J Gastrointest Pathophysiol 2012 0.75
50 Statement of Retraction. Effect of Captopril, Losartan, and Bradykinin on Early Steps of Insulin Action. Diabetes 1997;46:1950-1957. DOI: 10.2337/diab.46.12.1950. Diabetes 2016 0.75
51 Deletion of tumor necrosis factor-α receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem 2016 0.75
52 Chaperone insufficiency links TLR4 signaling to endoplasmic reticulum stress. J Biol Chem 2016 0.75
53 The influence of aging in the insulin-signaling system in rat exocrine glands. Adv Exp Med Biol 2002 0.75
54 Assessing Specimens of Devitalized Tissue in Chronic Sacral Pressure Ulcers: A Pilot Study. Adv Skin Wound Care 2017 0.75
55 Leptin, Neuroinflammation and Obesity. Front Horm Res 2017 0.75