Published in J Biol Chem on November 27, 2002
Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol (2004) 1.66
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway. Blood (2013) 1.61
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Mol Cell Biol (2008) 1.53
Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins. Mol Cell Biol (2008) 1.50
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation. Mol Cell Biol (2006) 1.46
Ras diffusion is sensitive to plasma membrane viscosity. Biophys J (2005) 1.31
Functional specificity of ras isoforms: so similar but so different. Genes Cancer (2011) 1.30
Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol Cell Biol (2004) 1.21
Differential Regulation of RasGAPs in Cancer. Genes Cancer (2011) 1.07
The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells. Leukemia (2011) 1.01
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Oncogene (2004) 0.98
The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. Cancer Res (2011) 0.97
Spatial cycles in G-protein crowd control. EMBO J (2010) 0.96
Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands. Neoplasia (2010) 0.95
Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events. Genes Cancer (2011) 0.93
Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. PLoS One (2012) 0.93
PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length. Mol Cell (2014) 0.92
The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway. Biochem J (2006) 0.91
Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones. Bioorg Med Chem (2006) 0.90
Effect of Ras inhibition in hematopoiesis and BCR/ABL leukemogenesis. J Hematol Oncol (2008) 0.87
Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer. Cancer Gene Ther (2010) 0.86
Transcriptomal profiling of site-specific Ras signals. Cell Signal (2007) 0.84
Transforming growth factor beta receptor 2 (TGFBR2) changes sialylation in the microsatellite unstable (MSI) Colorectal cancer cell line HCT116. PLoS One (2013) 0.84
Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. Mol Biol Cell (2009) 0.82
H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events. Mol Cell Biol (2015) 0.82
Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis. J Biol Chem (2009) 0.82
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1. EMBO Rep (2014) 0.81
Expression of ets-1 is not affected by N-ras or H-ras during oral oncogenesis. J Cancer Res Clin Oncol (2006) 0.78
The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics. Mol Cell Biol (2013) 0.78
Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner. Stem Cells (2015) 0.78
The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding. Curr Opin Struct Biol (2015) 0.78
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells. J Neuropathol Exp Neurol (2015) 0.78
Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains. Oncogenesis (2016) 0.75
Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. PLoS One (2017) 0.75
Genetics of Bladder Malignant Tumors in Childhood. Curr Genomics (2016) 0.75
Contextualizing the Genes Altered in Bladder Neoplasms in Pediatric andTeen Patients Allows Identifying Two Main Classes of Biological ProcessesInvolved and New Potential Therapeutic Targets. Curr Genomics (2016) 0.75
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature (2003) 3.66
Criteria for Guillain-Barré syndrome: additional insights from clinico-pathological studies. Clin Neurophysiol (2012) 2.49
Dynamic association of RNA-editing enzymes with the nucleolus. J Cell Sci (2003) 2.14
Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma. J Natl Cancer Inst (2012) 2.01
Use of Google Insights for Search to track seasonal and geographic kidney stone incidence in the United States. Urology (2011) 1.84
Uroplakins in urothelial biology, function, and disease. Kidney Int (2009) 1.79
Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol (2004) 1.66
Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2. Mol Cell Biol (2002) 1.64
Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells. Mol Cancer Ther (2003) 1.61
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. EMBO J (2006) 1.61
Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins. Mol Cell Biol (2008) 1.50
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation. Mol Cell Biol (2006) 1.46
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol Cell (2011) 1.44
Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes. Mol Cell (2008) 1.42
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. Oncogene (2004) 1.42
Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. J Cell Biol (2008) 1.36
LEF1 in androgen-independent prostate cancer: regulation of androgen receptor expression, prostate cancer growth, and invasion. Cancer Res (2009) 1.34
Systemic tumor targeting and killing by Sindbis viral vectors. Nat Biotechnol (2003) 1.31
Patient decision aids for prostate cancer treatment: a systematic review of the literature. CA Cancer J Clin (2009) 1.26
Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol (2006) 1.25
Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1. EMBO J (2003) 1.24
The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Res (2002) 1.23
Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol Cell Biol (2004) 1.21
Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism. J Cell Sci (2006) 1.21
Vitamin D regulates the phenotype of human breast cancer cells. Differentiation (2006) 1.20
RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol (2011) 1.17
Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth. Cancer Res (2002) 1.16
In vivo aggregation properties of the nuclear poly(A)-binding protein PABPN1. RNA (2005) 1.13
Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion. Clin Cancer Res (2010) 1.11
TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons. J Struct Biol (2009) 1.11
Using sindbis viral vectors for specific detection and suppression of advanced ovarian cancer in animal models. Cancer Res (2004) 1.09
Mice deficient for N-ras: impaired antiviral immune response and T-cell function. Cancer Res (2003) 1.07
ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes. J Cell Biol (2010) 1.05
Blockade of epidermal growth factor receptors chemosensitizes breast cancer cells through up-regulation of Bnip3L. Cancer Res (2005) 1.05
Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus. Hum Mol Genet (2004) 1.03
U.S. national statistics on penile fracture. J Sex Med (2010) 1.03
Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function. Mol Phylogenet Evol (2006) 1.02
Cajal body number and nucleolar size correlate with the cell body mass in human sensory ganglia neurons. J Struct Biol (2006) 1.02
The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies. Bioessays (2010) 1.01
Inhibition of Ras oncogenic activity by Ras protooncogenes. Int J Cancer (2005) 1.01
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. J Cell Biol (2008) 1.01
p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis. Oncogene (2004) 1.01
Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases. Sci Signal (2011) 0.99
Mxi2 promotes stimulus-independent ERK nuclear translocation. EMBO J (2007) 0.97
p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels. Mol Cell Biol (2003) 0.96
Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue. Stem Cells (2013) 0.95
Nucleolar targeting of coilin is regulated by its hypomethylation state. Chromosoma (2010) 0.95
New druggable targets in the Ras pathway? Curr Opin Mol Ther (2010) 0.95
Nucleolar disruption and cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in purkinje cells. Brain Pathol (2010) 0.94
Cajal's contribution to the knowledge of the neuronal cell nucleus. Chromosoma (2009) 0.94
Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events. Genes Cancer (2011) 0.93
ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task. Cell Cycle (2009) 0.93
National incidence and outcomes of postoperative urinary retention in the Surgical Care Improvement Project. Am J Surg (2012) 0.92
Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells. J Biol Chem (2004) 0.92
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway. J Biol Chem (2004) 0.91
Purkinje cell degeneration in pcd mice reveals large scale chromatin reorganization and gene silencing linked to defective DNA repair. J Biol Chem (2011) 0.91
Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior. Cancer Res (2005) 0.90
Hydrocele in the pediatric patient: inguinal or scrotal approach? J Urol (2008) 0.90
The PML-nuclear inclusion of human supraoptic neurons: a new compartment with SUMO-1- and ubiquitin-proteasome-associated domains. Neurobiol Dis (2005) 0.89
Novel snail1 target proteins in human colon cancer identified by proteomic analysis. PLoS One (2010) 0.88
c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation. Mol Cancer Res (2008) 0.88
Evaluation of renal function after major renal injury: correlation with the American Association for the Surgery of Trauma Injury Scale. J Urol (2010) 0.88
Lung-specific expression of dominant-negative mutant p53 in transgenic mice increases spontaneous and benzo(a)pyrene-induced lung cancer. Am J Respir Cell Mol Biol (2002) 0.88
Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons. Neurotox Res (2009) 0.87
Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1. PLoS One (2009) 0.87
Pre-neurodegeneration of mitral cells in the pcd mutant mouse is associated with DNA damage, transcriptional repression, and reorganization of nuclear speckles and Cajal bodies. Mol Cell Neurosci (2006) 0.87
Nuclear speckles are involved in nuclear aggregation of PABPN1 and in the pathophysiology of oculopharyngeal muscular dystrophy. Neurobiol Dis (2012) 0.87
The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons. J Struct Biol (2007) 0.86
Targeting SMN to Cajal bodies and nuclear gems during neuritogenesis. Chromosoma (2004) 0.85
Complex effects of Ras proto-oncogenes in tumorigenesis. Carcinogenesis (2003) 0.85
Lysophosphatidic acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol. J Neurochem (2007) 0.84
NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity. J Cell Physiol (2003) 0.84
Transcriptomal profiling of site-specific Ras signals. Cell Signal (2007) 0.84
rgr oncogene: activation by elimination of translational controls and mislocalization. Cancer Res (2003) 0.84
Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle. Acta Neuropathol (2011) 0.84
Nuclear compartmentalization and dynamics of the poly(A)-binding protein nuclear 1 (PABPN1) inclusions in supraoptic neurons under physiological and osmotic stress conditions. Mol Cell Neurosci (2007) 0.83
Proton beam therapy and treatment for localized prostate cancer: if you build it, they will come. Arch Intern Med (2012) 0.82
Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage. Traffic (2010) 0.82
Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. Mol Biol Cell (2009) 0.82
The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations. J Cell Physiol (2015) 0.82
LPS-induced down-regulation of NO-sensitive guanylyl cyclase in astrocytes occurs by proteasomal degradation in clastosomes. Mol Cell Neurosci (2007) 0.81
Reorganization of Cajal bodies and nucleolar targeting of coilin in motor neurons of type I spinal muscular atrophy. Histochem Cell Biol (2012) 0.81
Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells. Chromosoma (2007) 0.81