Published in Cancer Gene Ther on October 29, 2010
Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation. Oncotarget (2014) 0.95
Regulation of pancreatic cancer growth by superoxide. Mol Carcinog (2012) 0.94
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma. Mol Cancer Res (2014) 0.93
Regulation of Ras proteins by reactive nitrogen species. Free Radic Biol Med (2011) 0.90
NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicity. Int J Mol Sci (2013) 0.89
Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells. Redox Biol (2015) 0.84
Oxidative stress and cytokines in the pathogenesis of pancreatic cancer. J Cancer Prev (2014) 0.82
Singlet oxygen treatment of tumor cells triggers extracellular singlet oxygen generation, catalase inactivation and reactivation of intercellular apoptosis-inducing signaling. Redox Biol (2015) 0.81
Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A. Oncotarget (2016) 0.78
Targeting reactive oxygen species in development and progression of pancreatic cancer. Expert Rev Anticancer Ther (2016) 0.77
RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 6.50
rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem (1989) 3.21
Regulation of NADPH oxidases: the role of Rac proteins. Circ Res (2006) 3.16
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J (1996) 2.31
Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem (2004) 2.28
Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate (2005) 2.19
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain. Circ Res (2004) 1.98
rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation. Mol Cell Biol (1996) 1.86
Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogene (2005) 1.86
Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood (2002) 1.80
Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Res (2007) 1.80
Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci (2002) 1.72
Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene (2001) 1.68
In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. Cancer Res (2005) 1.61
Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Mol Cancer Ther (2003) 1.45
A Rac1 effector site controlling mitogenesis through superoxide production. J Biol Chem (1998) 1.35
Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species. Blood (2004) 1.33
Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization. J Biol Chem (2002) 1.31
Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells. Am J Physiol Cell Physiol (2004) 1.28
Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch. Am J Physiol Cell Physiol (2003) 1.25
Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS. Am J Physiol (1999) 1.20
Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer. Mol Carcinog (2005) 1.18
Modulation of reactive oxygen species in pancreatic cancer. Clin Cancer Res (2007) 1.18
The actin cytoskeleton reorganization induced by Rac1 requires the production of superoxide. Antioxid Redox Signal (1999) 1.13
EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2. Biochem Biophys Res Commun (2008) 1.10
Chronic pancreatitis and pancreatic cancer. Dig Dis (2002) 1.08
Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways. Mol Cell Biol (1996) 1.06
Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinoma. Arch Biochem Biophys (2000) 0.97
Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients. J Gastroenterol (2004) 0.92
NADH oxidase activity (NOX) and enlargement of HeLa cells oscillate with two different temperature-compensated period lengths of 22 and 24 minutes corresponding to different NOX forms. Biochim Biophys Acta (2001) 0.83
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature (2000) 8.37
fw2.2: a quantitative trait locus key to the evolution of tomato fruit size. Science (2000) 7.91
A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell (1999) 6.82
Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature (2001) 6.36
Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science (1999) 6.02
Digital tomosynthesis in breast imaging. Radiology (1997) 5.82
Atomic structure of a thermostable subdomain of HIV-1 gp41. Proc Natl Acad Sci U S A (1997) 5.76
Self-monitoring of blood glucose levels and glycemic control: the Northern California Kaiser Permanente Diabetes registry. Am J Med (2001) 5.68
Separation of caveolae from associated microdomains of GPI-anchored proteins. Science (1995) 5.25
High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod (1993) 5.06
Mesoscale iron enrichment experiments 1993-2005: synthesis and future directions. Science (2007) 4.92
Comparing sequenced segments of the tomato and Arabidopsis genomes: large-scale duplication followed by selective gene loss creates a network of synteny. Proc Natl Acad Sci U S A (2000) 4.90
Autotrophic picoplankton in the tropical ocean. Science (1983) 4.80
Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (2009) 4.41
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am J Pathol (1996) 4.25
Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am J Pathol (2000) 4.19
Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey. Br J Psychiatry Suppl (1996) 3.99
Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature (1985) 3.97
Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci U S A (1996) 3.83
Ultralong single-wall carbon nanotubes. Nat Mater (2004) 3.83
Lung cancer histologic type in the surveillance, epidemiology, and end results registry versus independent review. J Natl Cancer Inst (2004) 3.51
A prognostic score for patients with lower risk myelodysplastic syndrome. Leukemia (2007) 3.45
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet (2001) 3.45
Comparison of human stromelysin and collagenase by cloning and sequence analysis. Biochem J (1986) 3.31
Proton-pump inhibitors and risk of fractures: an update meta-analysis. Osteoporos Int (2016) 3.30
Developing a prediction rule from automated clinical databases to identify high-risk patients in a large population with diabetes. Diabetes Care (2001) 3.27
A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature (1989) 3.27
Genetic analysis of salt tolerance in arabidopsis. Evidence for a critical role of potassium nutrition. Plant Cell (1998) 3.25
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res (2000) 3.24
Attitudes and barriers to incident reporting: a collaborative hospital study. Qual Saf Health Care (2006) 3.23
The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science (1999) 3.23
The major facilitator superfamily. J Mol Microbiol Biotechnol (1999) 3.17
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett (1998) 3.04
Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group. Diabetes Care (1997) 3.03
Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J Biol Chem (1996) 3.01
Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects. Hum Brain Mapp (2000) 2.98
Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol (1999) 2.95
Genetic architecture of a morphological shape difference between two Drosophila species. Genetics (2000) 2.92
New tumor markers: CA125 and beyond. Int J Gynecol Cancer (2005) 2.92
SOS3 function in plant salt tolerance requires N-myristoylation and calcium binding. Plant Cell (2000) 2.91
Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol (1995) 2.88
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet (1998) 2.87
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. Endocr Rev (2001) 2.84
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82
Oceans. Dis-crediting ocean fertilization. Science (2001) 2.76
Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75
Toxicity of ALS-linked SOD1 mutants. Science (2000) 2.69
Survival of recipients of livers from donation after circulatory death who are relisted and undergo retransplant for graft failure. Am J Transplant (2014) 2.67
Sino-MONICA project: a collaborative study on trends and determinants in cardiovascular diseases in China, Part i: morbidity and mortality monitoring. Circulation (2001) 2.56
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes. Biochem J (1987) 2.54
Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol Pharmacol (1993) 2.54
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 2.49
Intracytoplasmic single sperm injection of 1-day-old unfertilized human oocytes. Hum Reprod (1993) 2.46
The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion. Structure (2001) 2.41
Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases. J Biol Chem (1995) 2.41
Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol (1997) 2.41
The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem (1998) 2.39
Exploration of antigenic variation in gp120 from clades A through F of human immunodeficiency virus type 1 by using monoclonal antibodies. J Virol (1994) 2.36
Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis (1993) 2.34
Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34
Inner ear defects induced by null mutation of the isk gene. Neuron (1996) 2.34
Gate-voltage control of chemical potential and weak antilocalization in Bi₂Se₃. Phys Rev Lett (2010) 2.32
A comparative linkage map of oilseed rape and its use for QTL analysis of seed oil and erucic acid content. Theor Appl Genet (2006) 2.21
The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J Biol Chem (1995) 2.20
The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate. J Bacteriol (1992) 2.20
Classification and 3D averaging with missing wedge correction in biological electron tomography. J Struct Biol (2008) 2.19
Formation of a gated channel by a ligand-specific transport protein in the bacterial outer membrane. Science (1992) 2.19
Identification of conserved and variant epitopes of human immunodeficiency virus type 1 (HIV-1) gp120 by human monoclonal antibodies produced by EBV-transformed cell lines. AIDS Res Hum Retroviruses (1990) 2.18
Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China. Infection (2013) 2.18
An introgression analysis of quantitative trait loci that contribute to a morphological difference between Drosophila simulans and D. mauritiana. Genetics (1997) 2.17
Residential radon gas exposure and lung cancer: the Iowa Radon Lung Cancer Study. Am J Epidemiol (2000) 2.13
The DNA replication protein PriA and the recombination protein RecG bind D-loops. J Mol Biol (1997) 2.13
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Cell Death Differ (2007) 2.12
C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis. Mol Biol Cell (2000) 2.11
Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res (1997) 2.05
Continuous positive airways pressure for obstructive sleep apnoea in adults. Cochrane Database Syst Rev (2006) 2.05
Automatic prediction of protein function. Cell Mol Life Sci (2003) 2.03
Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles. Hum Reprod (1993) 2.02
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis. Oncogene (2009) 2.01
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol Biol Cell (2001) 2.00
Neonatal blood: a source of haematopoietic stem cells for transplantation? Lancet (1998) 1.99
The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans. Genes Dev (1999) 1.97
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol (1997) 1.94
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J (1994) 1.94
Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. J Exp Med (1992) 1.93
Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res (2001) 1.92
A diploid epithelial cell line from normal adult rat liver with phenotypic properties of 'oval' cells. Exp Cell Res (1984) 1.91
Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet (1996) 1.89
Present-day crustal deformation in China constrained by global positioning system measurements. Science (2001) 1.87
Monoclonal antibody K1 reacts with epithelial mesothelioma but not with lung adenocarcinoma. Am J Surg Pathol (1992) 1.85
Cortactin potentiates bone metastasis of breast cancer cells. Cancer Res (2001) 1.85
Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med (1999) 1.85
Keratin gene expression in non-epithelial tissues. Detection with polymerase chain reaction. Am J Pathol (1993) 1.84
Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma. Am J Pathol (1998) 1.82
Correlation between testicular histology and outcome after intracytoplasmic sperm injection using testicular spermatozoa. Hum Reprod (1996) 1.82
Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. J Exp Med (1994) 1.82
Neuronal regulation of glutamate transporter subtype expression in astrocytes. J Neurosci (1997) 1.81
Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase. Clin Pharmacol Ther (2015) 1.81