Published in Prog Drug Res on January 01, 2002
A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A (2010) 2.41
Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci U S A (2004) 2.32
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J Virol (2005) 1.91
Triaryl pyrazoline compound inhibits flavivirus RNA replication. Antimicrob Agents Chemother (2006) 1.72
Conventional and unconventional mechanisms for capping viral mRNA. Nat Rev Microbiol (2011) 1.61
c-Src protein kinase inhibitors block assembly and maturation of dengue virus. Proc Natl Acad Sci U S A (2007) 1.42
Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond? Leuk Lymphoma (2010) 1.20
Further evidence that ribavirin interacts with eIF4E. RNA (2005) 1.13
The oncogene eIF4E: using biochemical insights to target cancer. J Interferon Cytokine Res (2013) 1.03
RNA virus population diversity, an optimum for maximal fitness and virulence. J Biol Chem (2014) 1.00
Successful fertility restoration after allogeneic hematopoietic stem cell transplantation. Endocr Pract (2014) 0.86
Characterization of synthetic Chikungunya viruses based on the consensus sequence of recent E1-226V isolates. PLoS One (2013) 0.84
HPLC-MS/MS method for the intracellular determination of ribavirin monophosphate and ribavirin triphosphate in CEM ss cells. J Pharm Biomed Anal (2009) 0.81
Synthesis and Antibacterial Evaluation of New Thione Substituted 1,2,4-Triazole Schiff Bases as Novel Antimicrobial Agents. Iran J Pharm Res (2015) 0.80
The threat of avian influenza A (H5N1). Part III: Antiviral therapy. Med Microbiol Immunol (2007) 0.79
Sultam thiourea inhibition of West Nile virus. Antimicrob Agents Chemother (2007) 0.78
Attenuation of vesicular stomatitis virus infection of brain using antiviral drugs and an adeno-associated virus-interferon vector. Virology (2014) 0.77
A pharmacological profile of ribavirin and monitoring of its plasma concentration in chronic hepatitis C infection. J Clin Exp Hepatol (2012) 0.77
Hepatitis C virus infection--pathobiology and implications for new therapeutic options. Dig Dis Sci (2007) 0.75
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature (2005) 6.78
Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell (2010) 4.47
Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein. J Biol Chem (2005) 2.61
5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science (2007) 2.48
Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J Biol Chem (2005) 2.40
Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nat Struct Mol Biol (2009) 2.13
Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. Biochemistry (2004) 2.10
Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol (2005) 2.00
Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.). J Virol (2006) 1.93
Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol (2008) 1.90
Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry (2004) 1.76
Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition. Structure (2012) 1.71
Isolation of enzymatically active replication complexes from feline calicivirus-infected cells. J Virol (2002) 1.67
Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J Biol Chem (2002) 1.61
Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target. J Biol Chem (2010) 1.58
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proc Natl Acad Sci U S A (2007) 1.55
Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+. Biochemistry (2004) 1.50
The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage. J Mol Biol (2002) 1.48
Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. J Virol (2007) 1.48
Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res (2005) 1.48
Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr Purif (2004) 1.45
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J Hepatol (2010) 1.43
Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. J Gen Virol (2006) 1.39
Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A (2010) 1.34
Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol (2006) 1.30
Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro. J Biol Chem (2005) 1.30
Quasispecies, error catastrophe, and the antiviral activity of ribavirin. Virology (2002) 1.28
Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus. J Biol Chem (2005) 1.28
Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J Biol Chem (2007) 1.23
Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelity. J Mol Biol (2011) 1.22
Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. J Biol Chem (2007) 1.16
Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue. J Virol (2007) 1.16
Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. J Virol (2010) 1.15
The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent. Nucleic Acids Res (2009) 1.14
Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. PLoS Pathog (2012) 1.11
Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry (2002) 1.11
Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro. J Biol Chem (2010) 1.09
An on-chip, multichannel droplet sorter using standing surface acoustic waves. Anal Chem (2013) 1.08
Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues. Antimicrob Agents Chemother (2008) 1.07
Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. Antivir Chem Chemother (2004) 1.07
A Polymerase mechanism-based strategy for viral attenuation and vaccine development. J Biol Chem (2012) 1.06
Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. J Virol (2005) 1.05
NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations. J Biol Chem (2008) 1.04
Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance? Drug Resist Updat (2004) 1.02
Correlation between NS5A dimerization and hepatitis C virus replication. J Biol Chem (2012) 1.01
Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. J Virol (2011) 1.01
Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro. J Biol Chem (2008) 1.00
Therapeutically targeting RNA viruses via lethal mutagenesis. Future Virol (2008) 0.99
Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity. Anal Biochem (2005) 0.98
Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase. Biochemistry (2010) 0.98
Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase. Nucleic Acids Res (2009) 0.96
RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase. Biochemistry (2008) 0.96
Intermolecular interactions within the abundant DEAD-box protein Dhh1 regulate its activity in vivo. J Biol Chem (2011) 0.94
Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants. J Virol (2009) 0.93
Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proc Natl Acad Sci U S A (2012) 0.93
Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases. J Med Chem (2006) 0.93
Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds. Biochemistry (2011) 0.92
Regulation of PKR by HCV IRES RNA: importance of domain II and NS5A. J Mol Biol (2010) 0.92
Manganese-dependent polioviruses caused by mutations within the viral polymerase. J Virol (2003) 0.90
Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. Virol J (2005) 0.90
Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition. Biochim Biophys Acta (2012) 0.90
Picornavirus genome replication: roles of precursor proteins and rate-limiting steps in oriI-dependent VPg uridylylation. J Biol Chem (2008) 0.88
Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase. J Virol (2011) 0.88
Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase. Chembiochem (2007) 0.87
Standing surface acoustic wave based cell coculture. Anal Chem (2014) 0.87
Control of template positioning during de novo initiation of RNA synthesis by the bovine viral diarrhea virus NS5B polymerase. J Biol Chem (2006) 0.86
The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I. PLoS One (2012) 0.86
Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. J Virol (2005) 0.84
One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates. Org Lett (2008) 0.84
Standing surface acoustic wave (SSAW)-based cell washing. Lab Chip (2015) 0.83
Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. PLoS One (2013) 0.83
Poliovirus infection transiently increases COPII vesicle budding. J Virol (2012) 0.83
Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity. J Biol Chem (2013) 0.82
Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses. J Med Chem (2010) 0.82
Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. PLoS One (2013) 0.82
Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine. Biochemistry (2014) 0.80
Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity. J Med Chem (2007) 0.80
Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG. Nucleic Acids Res (2010) 0.79
Exploring the dynamics of four RNA-dependent RNA polymerases by a coarse-grained model. J Phys Chem B (2012) 0.79
Binding by the hepatitis C virus NS3 helicase partially melts duplex DNA. Biochemistry (2012) 0.78
Acoustofluidic Transfer of Inflammatory Cells from Human Sputum Samples. Anal Chem (2016) 0.77
Accurate nanoscale flexibility measurement of DNA and DNA-protein complexes by atomic force microscopy in liquid. Nanoscale (2017) 0.76
Microfluidic opportunities in the field of nutrition. Lab Chip (2013) 0.75
Assay for Primed RNA-Dependent RNA Polymerase Transcription. CSH Protoc (2006) 0.75
Preparation and Fractionation of Drosophila Embryo Extracts for the In Vitro Characterization of RNAi. CSH Protoc (2006) 0.75
26 Sequence-specific DNA looping by mitochondrial transcription factor A (TFAM). J Biomol Struct Dyn (2015) 0.75
Protocol for siRNA-Primed RNA Synthesis. CSH Protoc (2006) 0.75
An Assay for RNA-Dependent RNA Polymerase Activity. CSH Protoc (2006) 0.75
Preparation of siRNAs from Drosophila Embryo Extracts. CSH Protoc (2006) 0.75