Published in J Med Chem on October 22, 2010
Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus. J Virol (2014) 0.95
Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus. Eur J Med Chem (2014) 0.83
Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells. ChemMedChem (2014) 0.77
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med (2000) 5.73
Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub). J Biol Chem (2000) 2.41
An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A (2009) 2.20
Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. Biochemistry (2004) 2.10
Quantitative detection of dengue 2 virus using fluorogenic RT-PCR based on 3'-noncoding sequence. J Virol Methods (2000) 1.97
A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties. Antimicrob Agents Chemother (2004) 1.94
Through the "gatekeeper door": exploiting the active kinase conformation. J Med Chem (2010) 1.92
Adenosine kinase from rabbit liver. II. Substrate and inhibitor specificity. J Biol Chem (1979) 1.35
Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol (2006) 1.30
Pyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirus. Antimicrob Agents Chemother (1987) 1.30
Antiviral agents acting as DNA or RNA chain terminators. Handb Exp Pharmacol (2009) 1.23
Some properties of partially purified mammalian adenosine kinase. J Biol Chem (1967) 1.18
Antiviral properties of deazaadenine nucleoside derivatives. Curr Med Chem (2006) 1.14
Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents. J Med Chem (1993) 1.13
Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. Antivir Chem Chemother (2004) 1.07
Antiviral activity of C-5 substituted tubercidin analogues. J Med Chem (1984) 1.06
John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity. Nucleosides Nucleotides Nucleic Acids (2005) 1.02
Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem (2003) 0.93
Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains. Proc Natl Acad Sci U S A (1995) 0.91
Broad-spectrum antiviral activity of adenosine analogues. Antiviral Res (1984) 0.91
Improved synthesis and antitumor activity of 1-deazaadenosine. J Med Chem (1987) 0.90
Analogs of 6-methyl-9-beta-D-ribofuranosylpurine. J Med Chem (1968) 0.89
Herpes simplex virus-1 DNA primase: a remarkably inaccurate yet selective polymerase. Biochemistry (2009) 0.88
Studies on the uptake of tubeidin (7-deazaadenosine) by blood cells and its distribution in whole animals. Cancer Res (1970) 0.87
One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates. Org Lett (2008) 0.84
Nucleic acid related compounds. 51. Synthesis and biological properties of sugar-modified analogues of the nucleoside antibiotics tubercidin, toyocamycin, sangivamycin, and formycin. J Med Chem (1987) 0.83
Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives. J Med Chem (1992) 0.83
Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2'-C-methyladenosine. Bioorg Med Chem (2007) 0.81
6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents. J Med Chem (2010) 0.81
Synthesis of 3-deaza-3-nitro-2'-deoxyadenosine. Bioorg Med Chem (2005) 0.79
Tubercidin metabolism in mouse L5178y cells in vivo and in vitro. Gan (1978) 0.78
Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives. Nucleic Acids Symp Ser (Oxf) (2008) 0.77
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature (2005) 6.78
Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell (2010) 4.47
Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein. J Biol Chem (2005) 2.61
5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science (2007) 2.48
Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J Biol Chem (2005) 2.40
Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nat Struct Mol Biol (2009) 2.13
Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. Biochemistry (2004) 2.10
Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol (2005) 2.00
Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.). J Virol (2006) 1.93
Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol (2008) 1.90
Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry (2004) 1.76
Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition. Structure (2012) 1.71
Isolation of enzymatically active replication complexes from feline calicivirus-infected cells. J Virol (2002) 1.67
Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J Biol Chem (2002) 1.61
Silver bromide nanoparticle/polymer composites: dual action tunable antimicrobial materials. J Am Chem Soc (2006) 1.61
Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase. J Biol Chem (2008) 1.60
Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target. J Biol Chem (2010) 1.58
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proc Natl Acad Sci U S A (2007) 1.55
Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+. Biochemistry (2004) 1.50
The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage. J Mol Biol (2002) 1.48
Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. J Virol (2007) 1.48
Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res (2005) 1.48
Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr Purif (2004) 1.45
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J Hepatol (2010) 1.43
Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. J Gen Virol (2006) 1.39
Synthetic mimics of small Mammalian cell surface receptors. J Am Chem Soc (2004) 1.34
Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A (2010) 1.34
Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol (2006) 1.30
Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro. J Biol Chem (2005) 1.30
Quasispecies, error catastrophe, and the antiviral activity of ribavirin. Virology (2002) 1.28
Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus. J Biol Chem (2005) 1.28
Antibacterial and hemolytic activities of pyridinium polymers as a function of the spatial relationship between the positive charge and the pendant alkyl tail. Angew Chem Int Ed Engl (2008) 1.27
Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J Biol Chem (2007) 1.23
Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelity. J Mol Biol (2011) 1.22
Pleiotropic mechanisms of ribavirin antiviral activities. Prog Drug Res (2002) 1.22
Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. J Biol Chem (2007) 1.16
Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue. J Virol (2007) 1.16
The Pennsylvania Green Fluorophore: a hybrid of Oregon Green and Tokyo Green for the construction of hydrophobic and pH-insensitive molecular probes. Org Lett (2006) 1.15
Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. J Virol (2010) 1.15
The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent. Nucleic Acids Res (2009) 1.14
Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. PLoS Pathog (2012) 1.11
Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry (2002) 1.11
Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro. J Biol Chem (2010) 1.09
Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases. Bioorg Med Chem (2005) 1.08
An on-chip, multichannel droplet sorter using standing surface acoustic waves. Anal Chem (2013) 1.08
Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues. Antimicrob Agents Chemother (2008) 1.07
Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. Antivir Chem Chemother (2004) 1.07
A Polymerase mechanism-based strategy for viral attenuation and vaccine development. J Biol Chem (2012) 1.06
Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. J Virol (2005) 1.05
NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations. J Biol Chem (2008) 1.04
A synthetic mimic of human Fc receptors: defined chemical modification of cell surfaces enables efficient endocytic uptake of human immunoglobulin-G. J Am Chem Soc (2006) 1.02
Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance? Drug Resist Updat (2004) 1.02
Identification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replication. J Biol Chem (2011) 1.01
Correlation between NS5A dimerization and hepatitis C virus replication. J Biol Chem (2012) 1.01
Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. J Virol (2011) 1.01
Synthetic cell surface receptors for delivery of therapeutics and probes. Adv Drug Deliv Rev (2012) 1.01
A concise synthesis of the Pennsylvania Green fluorophore and labeling of intracellular targets with O6-benzylguanine derivatives. Org Lett (2007) 1.00
Synthesis of a beta-estradiol-biotin chimera that potently heterodimerizes estrogen receptor and streptavidin proteins in a yeast three-hybrid system. J Am Chem Soc (2003) 1.00
Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro. J Biol Chem (2008) 1.00
Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol. Assay Drug Dev Technol (2010) 1.00
Japanese encephalitis virus in culicine mosquitoes (Diptera: Culicidae) collected at Daeseongdong, a village in the demilitarized zone of the Republic of Korea. J Med Entomol (2011) 1.00
Endocytic delivery of vancomycin mediated by a synthetic cell surface receptor: rescue of bacterially infected Mammalian cells and tissue targeting in vivo. J Am Chem Soc (2007) 1.00
Chemico-genetic identification of drebrin as a regulator of calcium responses. Int J Biochem Cell Biol (2009) 0.99
Therapeutically targeting RNA viruses via lethal mutagenesis. Future Virol (2008) 0.99
Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity. Anal Biochem (2005) 0.98
Selective disruption of early/recycling endosomes: release of disulfide-linked cargo mediated by a N-alkyl-3beta-cholesterylamine-capped peptide. J Am Chem Soc (2008) 0.98
Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase. Biochemistry (2010) 0.98
Control of gene expression with small molecules: biotin-mediated acylation of targeted lysine residues in recombinant yeast. Chem Biol (2003) 0.97
The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Free Radic Biol Med (2007) 0.97
Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase. Nucleic Acids Res (2009) 0.96
RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase. Biochemistry (2008) 0.96
A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity. Anal Biochem (2002) 0.96
Dengue virus infection promotes translocation of high mobility group box 1 protein from the nucleus to the cytosol in dendritic cells, upregulates cytokine production and modulates virus replication. J Gen Virol (2009) 0.95
A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression. MBio (2014) 0.95
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry. ACS Chem Biol (2012) 0.95
Intermolecular interactions within the abundant DEAD-box protein Dhh1 regulate its activity in vivo. J Biol Chem (2011) 0.94
Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants. J Virol (2009) 0.93
Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proc Natl Acad Sci U S A (2012) 0.93
Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases. J Med Chem (2006) 0.93
Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds. Biochemistry (2011) 0.92
Regulation of PKR by HCV IRES RNA: importance of domain II and NS5A. J Mol Biol (2010) 0.92
Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation. Arterioscler Thromb Vasc Biol (2011) 0.91
Synthesis of chimeric 7alpha-substituted estradiol derivatives linked to cholesterol and cholesterylamine. Org Lett (2002) 0.91
Synthesis of an artificial cell surface receptor that enables oligohistidine affinity tags to function as metal-dependent cell-penetrating peptides. J Am Chem Soc (2006) 0.91