Published in Arterioscler Thromb Vasc Biol on December 01, 2002
Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther (2006) 1.88
AKT2 confers protection against aortic aneurysms and dissections. Circ Res (2012) 1.65
Oxidized LDL: diversity, patterns of recognition, and pathophysiology. Antioxid Redox Signal (2010) 1.47
Nanotherapeutics for inhibition of atherogenesis and modulation of inflammation in atherosclerotic plaques. Cardiovasc Res (2015) 1.39
Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo. Proc Natl Acad Sci U S A (2015) 1.13
Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology. Cardiovasc Res (2009) 1.12
Interaction of aldehydes derived from lipid peroxidation and membrane proteins. Front Physiol (2013) 0.97
Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation. BMC Cardiovasc Disord (2013) 0.95
Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A-I. J Cell Mol Med (2009) 0.93
Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function. Microvasc Res (2011) 0.88
Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One (2010) 0.87
The ubiquitin ligase Nedd4 mediates oxidized low-density lipoprotein-induced downregulation of insulin-like growth factor-1 receptor. Am J Physiol Heart Circ Physiol (2008) 0.84
Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells. Free Radic Biol Med (2012) 0.83
Statin-Induced Increase in HDL-C and Renal Function in Coronary Heart Disease Patients. Open Cardiovasc Med J (2007) 0.82
Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. Am J Pathol (2005) 0.80
Resveratrol inhibits phenotype modulation by platelet derived growth factor-bb in rat aortic smooth muscle cells. Oxid Med Cell Longev (2014) 0.79
Escherichia coli morphological changes and lipid A removal induced by reduced pressure nitrogen afterglow exposure. PLoS One (2015) 0.78
Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival. J Lipid Res (2009) 0.77
Ceramide signaling in the coronary microcirculation: a double-edged sword? Circ Res (2014) 0.76
Galectin-3-induced oxidized low-density lipoprotein promotes the phenotypic transformation of vascular smooth muscle cells. Mol Med Rep (2015) 0.75
Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL. Redox Biol (2014) 0.75
NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia. J Am Heart Assoc (2016) 0.75
Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate. Int J Mol Sci (2015) 0.75
The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat Genet (2006) 3.17
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem (2006) 2.96
Recommendations on the diagnosis and management of Niemann-Pick disease type C. Mol Genet Metab (2009) 2.78
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem (2008) 2.31
Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation (2004) 1.80
The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J Biol Chem (2008) 1.80
Changes in transcriptional profiles are associated with early fruit tissue specialization in tomato. Plant Physiol (2005) 1.63
Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. Cancer Res (2005) 1.59
Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Circ Res (2008) 1.56
Pathological aspects of lipid peroxidation. Free Radic Res (2010) 1.56
Gene and metabolite regulatory network analysis of early developing fruit tissues highlights new candidate genes for the control of tomato fruit composition and development. Plant Physiol (2009) 1.50
A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse. Nat Genet (2005) 1.50
Oxidized low-density lipoprotein-induced apoptosis. Biochim Biophys Acta (2002) 1.48
Automated SNP detection in expressed sequence tags: statistical considerations and application to maritime pine sequences. Plant Mol Biol (2004) 1.32
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? Autophagy (2007) 1.28
Hyperglycemia and glycation in diabetic complications. Antioxid Redox Signal (2009) 1.28
Sphingomyelin hydrolysis during apoptosis. Biochim Biophys Acta (2002) 1.27
GDP-D-mannose 3,5-epimerase (GME) plays a key role at the intersection of ascorbate and non-cellulosic cell-wall biosynthesis in tomato. Plant J (2009) 1.27
Incidence and natural history of mucopolysaccharidosis type III in France and comparison with United Kingdom and Greece. Am J Med Genet A (2011) 1.26
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J (2007) 1.25
Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis. Proc Natl Acad Sci U S A (2002) 1.23
Silencing of the mitochondrial ascorbate synthesizing enzyme L-galactono-1,4-lactone dehydrogenase affects plant and fruit development in tomato. Plant Physiol (2007) 1.21
Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities. Arterioscler Thromb Vasc Biol (2013) 1.21
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood (2005) 1.20
Combination of copeptin and troponin assays to rapidly rule out non-ST elevation myocardial infarction in the emergency department. Acad Emerg Med (2012) 1.20
Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells. Biochem Cell Biol (2002) 1.15
Structural modifications of HDL and functional consequences. Atherosclerosis (2005) 1.13
Danon's disease (X-linked vacuolar cardiomyopathy and myopathy): a case with a novel Lamp-2 gene mutation. Neuromuscul Disord (2002) 1.13
Two distinct calcium-dependent mitochondrial pathways are involved in oxidized LDL-induced apoptosis. Arterioscler Thromb Vasc Biol (2004) 1.12
Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1. Am J Hum Genet (2012) 1.11
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res (2009) 1.11
Ceramide-induced autophagy: to junk or to protect cells? Autophagy (2009) 1.09
Intestinal cholesterol transport proteins: an update and beyond. Curr Opin Lipidol (2007) 1.09
Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells. Free Radic Biol Med (2006) 1.09
Detection of intracellular reactive oxygen species in cultured cells using fluorescent probes. Methods Enzymol (2002) 1.09
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol (2007) 1.08
Striking phenotypic variability in two familial cases of myosin storage myopathy with a MYH7 Leu1793pro mutation. Neuromuscul Disord (2009) 1.07
Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives. Free Radic Biol Med (2008) 1.05
Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes (2011) 1.05
Transcriptome analysis of bud burst in sessile oak (Quercus petraea). New Phytol (2006) 1.04
Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). Biochim Biophys Acta (2005) 1.04
Glutathione peroxidase-1 protects from CD95-induced apoptosis. J Biol Chem (2002) 1.03
Dual role of oxidized LDL on the NF-kappaB signaling pathway. Free Radic Res (2004) 1.03
Functions of sphingolipid metabolism in mammals--lessons from genetic defects. Biochim Biophys Acta (2008) 1.03
The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator. FASEB J (2004) 1.02
Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells. Atherosclerosis (2008) 1.01
Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity. Atherosclerosis (2007) 1.01
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. PLoS One (2009) 1.01
Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. J Biol Chem (2005) 1.00
Synthesis and antioxidant activity evaluation of a syringic hydrazones family. Eur J Med Chem (2010) 1.00
Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis. FASEB J (2007) 1.00
Sphingolipids as modulators of cancer cell death: potential therapeutic targets. Biochim Biophys Acta (2006) 0.98
N-acetylcysteine prevents the deleterious effect of tumor necrosis factor-(alpha) on calcium transients and contraction in adult rat cardiomyocytes. Circulation (2004) 0.98
High-density lipoproteins prevent the oxidized low-density lipoprotein-induced epidermal [corrected] growth factor receptor activation and subsequent matrix metalloproteinase-2 upregulation. Arterioscler Thromb Vasc Biol (2005) 0.98
Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. Chem Phys Lipids (2006) 0.96
Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion. J Am Soc Nephrol (2004) 0.96
FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response. J Immunol (2009) 0.96
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem (2007) 0.96
Genome-wide analysis of intraspecific DNA polymorphism in 'Micro-Tom', a model cultivar of tomato (Solanum lycopersicum). Plant Cell Physiol (2013) 0.95
Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23. PLoS One (2012) 0.95
Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs. Autophagy (2011) 0.94
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem (2014) 0.94
Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med (2013) 0.94
A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease. J Lipid Res (2010) 0.94
Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A-I. J Cell Mol Med (2009) 0.93
E-cadherin/beta-catenin/T-cell factor pathway is involved in smooth muscle cell proliferation elicited by oxidized low-density lipoprotein. Circ Res (2008) 0.93
Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis. Apoptosis (2007) 0.93
Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage. Hum Mol Genet (2008) 0.93
Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity. Mol Aspects Med (2003) 0.93
The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism. Biochem Pharmacol (2009) 0.93
Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats. J Mol Cell Cardiol (2007) 0.93
Ceramide production associated with retinal apoptosis after retinal detachment. Graefes Arch Clin Exp Ophthalmol (2008) 0.92
A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant. BMC Med Genet (2009) 0.91
Regulation of autophagy by sphingolipids. Anticancer Agents Med Chem (2011) 0.91
Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine. J Biol Chem (2011) 0.91
Desensitization of platelet-derived growth factor receptor-beta by oxidized lipids in vascular cells and atherosclerotic lesions: prevention by aldehyde scavengers. Circ Res (2006) 0.90
Sphingolipids in macroautophagy. Methods Mol Biol (2008) 0.90
IPPRED: server for proteins interactions inference. Bioinformatics (2003) 0.89
Genotype-dependent response to carbon availability in growing tomato fruit. Plant Cell Environ (2010) 0.89
Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice. J Biol Chem (2004) 0.89
A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody. Circulation (2011) 0.89
The French Gaucher's disease registry: clinical characteristics, complications and treatment of 562 patients. Orphanet J Rare Dis (2012) 0.89
Synthesis of cytotoxic aza analogues of jaspine B. J Org Chem (2010) 0.89