Published in J Cell Sci on January 15, 2003
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17
Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet (2004) 6.15
The PD-1 pathway in tolerance and autoimmunity. Immunol Rev (2010) 5.99
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol (2007) 5.60
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27
Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest (2007) 5.19
Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer (2009) 5.02
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature (2007) 4.94
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res (2006) 4.38
Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol (2004) 4.16
The immune system and cardiac repair. Pharmacol Res (2008) 3.42
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol (2007) 2.94
Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol (2004) 2.90
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol (2008) 2.69
Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β. Am J Respir Crit Care Med (2012) 2.68
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med (2012) 2.47
Transforming growth factor-beta and fibrosis. World J Gastroenterol (2007) 2.35
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The bone morphogenetic protein 1/Tolloid-like metalloproteinases. Matrix Biol (2007) 2.27
Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood (2010) 2.21
BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein. J Cell Biol (2006) 2.17
TGF-β: duality of function between tumor prevention and carcinogenesis. J Natl Cancer Inst (2014) 2.08
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci U S A (2010) 2.03
Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes Dev (2005) 2.02
Matricellular proteins in cardiac adaptation and disease. Physiol Rev (2012) 2.01
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98
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T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine. Immunity (2011) 1.85
Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci (2010) 1.82
Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology (2007) 1.80
Transforming growth factor beta as a therapeutic target in systemic sclerosis. Nat Rev Rheumatol (2009) 1.79
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med (2007) 1.79
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet (2008) 1.78
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice. J Cell Sci (2009) 1.75
Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest (2007) 1.73
The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol (2013) 1.73
Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell (2009) 1.72
TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol (2010) 1.70
Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem (2010) 1.69
Transglutaminase 2 and its role in pulmonary fibrosis. Am J Respir Crit Care Med (2011) 1.68
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature (2008) 1.68
Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis. J Exp Med (2007) 1.67
Fibrillin-1 regulates the bioavailability of TGFbeta1. J Cell Biol (2007) 1.67
TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol (2003) 1.66
Cellular and molecular mechanisms of thoracic aortic aneurysms. Nat Rev Cardiol (2009) 1.65
TGF-β activation and function in immunity. Annu Rev Immunol (2013) 1.63
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. J Clin Invest (2010) 1.63
Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol (2011) 1.60
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol (2005) 1.60
Targeting the transforming growth factor-beta signaling pathway in human cancer. Expert Opin Investig Drugs (2010) 1.57
Intestinal dendritic cells specialize to activate transforming growth factor-β and induce Foxp3+ regulatory T cells via integrin αvβ8. Gastroenterology (2011) 1.56
Expression and function of transforming growth factor-β isoforms and cognate receptors in the rat urinary bladder following cyclophosphamide-induced cystitis. Am J Physiol Renal Physiol (2013) 1.53
Kielin/chordin-like protein attenuates both acute and chronic renal injury. J Am Soc Nephrol (2013) 1.51
Pathogenesis of idiopathic pulmonary fibrosis. Annu Rev Pathol (2013) 1.51
TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol (2008) 1.49
Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation. J Cell Biol (2010) 1.49
The harmonies played by TGF-β in stem cell biology. Cell Stem Cell (2012) 1.47
Retracted TGFbeta1 signaling via alphaVbeta6 integrin. Mol Cancer (2003) 1.47
Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure. Dev Biol (2008) 1.47
Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res (2010) 1.47
Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity. J Biol Chem (2008) 1.47
Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts. Am J Pathol (2006) 1.46
The role of the myofibroblast in tumor stroma remodeling. Cell Adh Migr (2012) 1.46
Transforming growth factor-β: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis. PLoS Pathog (2010) 1.44
Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol (2013) 1.43
Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS One (2012) 1.43
Highly sensitive and specific bioassay for measuring bioactive TGF-beta. BMC Cell Biol (2006) 1.42
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. J Vasc Res (2008) 1.42
Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet. Sci Signal (2008) 1.42
Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition. J Bone Miner Res (2012) 1.41
Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer? Breast Cancer Res Treat (2008) 1.41
Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic. Infect Immun (2004) 1.41
Fibroblasts in post-infarction inflammation and cardiac repair. Biochim Biophys Acta (2012) 1.41
Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Proc Natl Acad Sci U S A (2008) 1.40
Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-β. J Leukoc Biol (2012) 1.40
Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. Dev Cell (2009) 1.40
Role of transforming growth factor Beta in corneal function, biology and pathology. Curr Mol Med (2010) 1.39
PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway. PLoS One (2016) 1.39
Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration. Am J Pathol (2008) 1.38
LTBPs, more than just an escort service. J Cell Biochem (2012) 1.37
Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy. Biochim Biophys Acta (2008) 1.36
Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech (2010) 1.35
Review of the activation of TGF-beta in immunity. J Leukoc Biol (2008) 1.35
Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development. Am J Hum Genet (2009) 1.34
Skin wound healing modulation by macrophages. Int J Clin Exp Pathol (2010) 1.34
Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. Am J Pathol (2006) 1.30
GARP regulates the bioavailability and activation of TGFβ. Mol Biol Cell (2012) 1.28
Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia. Am J Pathol (2009) 1.27
Vascular consequences of dietary salt intake. Am J Physiol Renal Physiol (2009) 1.25
Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders. Am J Pathol (2009) 1.25
Predisposition for disrepair in the aged lung. Am J Med Sci (2012) 1.24
Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment. Clin Dev Immunol (2011) 1.24
The many faces of aggressive aortic pathology: Loeys-Dietz syndrome. Neth Heart J (2008) 1.24
TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth. EMBO J (2005) 1.23
Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy. Oncologist (2010) 1.23
The epithelium in idiopathic pulmonary fibrosis: breaking the barrier. Front Pharmacol (2014) 1.23
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (2006) 10.25
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet (2005) 9.62
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol (2007) 5.60
The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol (2002) 4.60
Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem (2002) 3.92
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol (2007) 2.94
Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol (2004) 2.90
Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling. Curr Opin Cell Biol (2009) 1.96
In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. Blood (2008) 1.94
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med (2007) 1.79
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice. J Cell Sci (2009) 1.75
Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites. J Biol Chem (2009) 1.73
The integrin alphaVbeta6 binds and activates latent TGFbeta3. FEBS Lett (2002) 1.64
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J (2005) 1.61
GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58
Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. J Cell Sci (2002) 1.49
Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species. Radiat Res (2006) 1.47
Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology. Physiol Genomics (2004) 1.45
A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol (2007) 1.45
Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Proc Natl Acad Sci U S A (2008) 1.40
Matrix control of transforming growth factor-β function. J Biochem (2012) 1.39
LTBPs, more than just an escort service. J Cell Biochem (2012) 1.37
Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol (2002) 1.37
Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development. Am J Hum Genet (2009) 1.34
p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice. J Biol Chem (2008) 1.32
Cell signaling events: a view from the matrix. Matrix Biol (2003) 1.26
TGFbeta1 and TGFbeta3 are partially redundant effectors in brain vascular morphogenesis. Mech Dev (2008) 1.24
Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development (2007) 1.22
Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin. J Cell Physiol (2012) 1.22
Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity. J Cell Physiol (2009) 1.14
Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation. Cytokine Growth Factor Rev (2013) 1.08
Lung alveolar septation defects in Ltbp-3-null mice. Am J Pathol (2005) 1.08
Hedgehog signaling in neonatal and adult lung. Am J Respir Cell Mol Biol (2013) 1.06
E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest (2010) 1.05
Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. Proc Natl Acad Sci U S A (2013) 1.04
Microfibril structure masks fibrillin-2 in postnatal tissues. J Biol Chem (2010) 1.03
Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. Hum Mol Genet (2010) 1.03
Mechanisms of tendon injury and repair. J Orthop Res (2015) 1.02
Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling. J Cell Sci (2005) 1.02
Sonic hedgehog signaling in the lung. From development to disease. Am J Respir Cell Mol Biol (2015) 1.02
Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta. J Mol Biol (2003) 0.99
Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. J Mol Biol (2005) 0.98
What the lung has taught us about latent TGF-beta activation. Am J Respir Cell Mol Biol (2008) 0.98
An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS One (2012) 0.95
Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin. Am J Pathol (2008) 0.95
Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett (2002) 0.95
Transforming growth factor beta signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition. Cancer Res (2002) 0.93
F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation. FASEB J (2008) 0.93
Methods for measuring TGF-b using antibodies, cells, and mice. Methods Mol Med (2005) 0.93
Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Dev Biol (2004) 0.90
Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev Dyn (2011) 0.88
Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-β1 (TGF-β1). Endocrinology (2012) 0.88
Active and total transforming growth factor-β1 are differentially regulated by dopamine and estradiol in the pituitary. Endocrinology (2011) 0.88
Function of latent TGFβ binding protein 4 and fibulin 5 in elastogenesis and lung development. J Cell Physiol (2015) 0.87
Control of lung development by latent TGF-β binding proteins. J Cell Physiol (2011) 0.87
Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice. J Cell Physiol (2003) 0.86
The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling. Dev Biol (2002) 0.84
Production of gastrointestinal tumors in mice by modulating latent TGF-β1 activation. Cancer Res (2012) 0.83
Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms. Gene (2003) 0.82
A genetic screen to identify latent transforming growth factor beta activators. Anal Biochem (2004) 0.81
Overexpression of the 18 kDa and 22/24 kDa FGF-2 isoforms results in differential drug resistance and amplification potential. J Cell Physiol (2002) 0.79
Sex differences in the pituitary transforming growth factor-β1 system: studies in a model of resistant prolactinomas. Endocrinology (2013) 0.78
Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-β in gastric tissue. Cancer Res (2014) 0.77
Is losartan the drug for all seasons? Curr Opin Pharmacol (2012) 0.76