Published in Radiat Res on December 01, 2006
Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst (2013) 3.07
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med (2007) 1.79
Radiation as an immunological adjuvant: current evidence on dose and fractionation. Front Oncol (2012) 1.76
TGF-beta biology in mammary development and breast cancer. Cold Spring Harb Perspect Biol (2011) 1.75
Cancer and inflammation: promise for biologic therapy. J Immunother (2010) 1.72
Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med (2009) 1.61
Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol (2011) 1.60
Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma. Am J Respir Crit Care Med (2007) 1.44
Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene (2007) 1.40
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β. Cancer Res (2012) 1.34
Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta (2012) 1.31
TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Clin Cancer Res (2011) 1.30
Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment. Clin Dev Immunol (2011) 1.24
Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration. Sci Transl Med (2014) 1.16
Role of T lymphocytes in tumor response to radiotherapy. Front Oncol (2012) 1.12
Therapeutic targets in malignant glioblastoma microenvironment. Semin Radiat Oncol (2009) 1.11
Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation. Cytokine Growth Factor Rev (2013) 1.08
New insights into the role of oxidative stress in scleroderma fibrosis. Open Rheumatol J (2012) 0.99
What the lung has taught us about latent TGF-beta activation. Am J Respir Cell Mol Biol (2008) 0.98
TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity. Cancer Res (2015) 0.98
Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection. Antioxid Redox Signal (2014) 0.94
Comprehensive clinical and molecular analysis of 12 families with type 1 recessive cutis laxa. Hum Mutat (2012) 0.93
Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression. Oxid Med Cell Longev (2015) 0.91
Cancer as an emergent phenomenon in systems radiation biology. Radiat Environ Biophys (2007) 0.91
Portrait of inflammatory response to ionizing radiation treatment. J Inflamm (Lond) (2015) 0.89
Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences. Redox Biol (2015) 0.86
The optimal partnership of radiation and immunotherapy: from preclinical studies to clinical translation. Radiat Res (2014) 0.86
Biophysical Approaches for Oral Wound Healing: Emphasis on Photobiomodulation. Adv Wound Care (New Rochelle) (2015) 0.86
Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic disease. Biomed Res Int (2014) 0.84
The TGF-β/Smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a Smad signaling pathway. PLoS One (2012) 0.84
Inhibiting TGFβ1 has a protective effect on mouse bone marrow suppression following ionizing radiation exposure in vitro. J Radiat Res (2013) 0.84
Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor β1 (TGF-β1) activation. J Biol Chem (2013) 0.84
Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β. Aging (Albany NY) (2016) 0.84
Hyperoxia induces alveolar epithelial-to-mesenchymal cell transition. Am J Physiol Lung Cell Mol Physiol (2013) 0.83
Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice. Mucosal Immunol (2013) 0.83
Inactivation of thrombomodulin by ionizing radiation in a cell-free system: possible implications for radiation responses in vascular endothelium. Radiat Res (2008) 0.83
Reactive oxygen species and fibrosis: further evidence of a significant liaison. Cell Tissue Res (2016) 0.83
Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis. Redox Biol (2015) 0.83
Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas. Semin Radiat Oncol (2013) 0.83
TGF-β: Titan of Lung Fibrogenesis. Curr Enzym Inhib (2010) 0.81
Stem cell niches and other factors that influence the sensitivity of bone marrow to radiation-induced bone cancer and leukaemia in children and adults. Int J Radiat Biol (2011) 0.79
Quercetin liposomes protect against radiation-induced pulmonary injury in a murine model. Oncol Lett (2013) 0.79
Nature and Implications of Oxidative and Nitrosative Stresses in Autoimmune Hepatitis. Dig Dis Sci (2016) 0.78
Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored. Front Immunol (2014) 0.77
Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation. Mol Cancer (2017) 0.76
Environmental particulate (PM2.5) augments stiffness-induced alveolar epithelial cell mechanoactivation of transforming growth factor beta. PLoS One (2014) 0.76
Stromal Modulators of TGF-β in Cancer. J Clin Med (2017) 0.76
Simvastatin attenuates radiation-induced salivary gland dysfunction in mice. Drug Des Devel Ther (2016) 0.75
Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium. Oncotarget (2016) 0.75
Comparison of acute proton, photon, and low-dose priming effects on genes associated with extracellular matrix and adhesion molecules in the lungs. Fibrogenesis Tissue Repair (2013) 0.75
Assessment of the effect of potential antifibrotic compounds on total and αVβ6 integrin-mediated TGF-β activation. Pharmacol Res Perspect (2014) 0.75
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Nat Commun (2017) 0.75
Barriers to Radiation-Induced In Situ Tumor Vaccination. Front Immunol (2017) 0.75
Visible Red Light Emitting Diode Photobiomodulation for Skin Fibrosis: Key Molecular Pathways. Curr Dermatol Rep (2016) 0.75
Immune recognition of irradiated cancer cells. Immunol Rev (2017) 0.75
Crohn's Strictures-Moving Away from the Knife. Front Pediatr (2017) 0.75
Deconstructing the Complexity of TGFβ Signaling in Hematopoietic Stem Cells: Quiescence and Beyond. Curr Stem Cell Rep (2016) 0.75
Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016. Radiat Res (2017) 0.75
Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes. Front Physiol (2017) 0.75
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (2006) 10.25
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet (2005) 9.62
Making sense of latent TGFbeta activation. J Cell Sci (2003) 8.90
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol (2007) 5.81
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol (2007) 5.60
Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem (2002) 3.92
Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst (2002) 3.39
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol (2007) 2.94
Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol (2004) 2.90
Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res (2004) 2.33
Iterative voting for inference of structural saliency and characterization of subcellular events. IEEE Trans Image Process (2007) 2.17
Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling. Curr Opin Cell Biol (2009) 1.96
In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. Blood (2008) 1.94
Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. Am J Pathol (2002) 1.88
Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res (2004) 1.84
A human breast cell model of preinvasive to invasive transition. Cancer Res (2008) 1.79
TGF-beta biology in mammary development and breast cancer. Cold Spring Harb Perspect Biol (2011) 1.75
Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites. J Biol Chem (2009) 1.73
CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc Natl Acad Sci U S A (2005) 1.73
The integrin alphaVbeta6 binds and activates latent TGFbeta3. FEBS Lett (2002) 1.64
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J (2005) 1.61
Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res (2007) 1.60
GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science (2013) 1.58
Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy. J Bone Miner Res (2012) 1.55
A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol (2007) 1.45
Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology. Physiol Genomics (2004) 1.45
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res (2006) 1.42
Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Proc Natl Acad Sci U S A (2008) 1.40
Two Perspectives. Radiat Res (2015) 1.39
Matrix control of transforming growth factor-β function. J Biochem (2012) 1.39
LTBPs, more than just an escort service. J Cell Biochem (2012) 1.37
Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol (2002) 1.37
Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice. Am J Pathol (2005) 1.35
Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development. Am J Hum Genet (2009) 1.34
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β. Cancer Res (2012) 1.34
p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice. J Biol Chem (2008) 1.32
TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Clin Cancer Res (2011) 1.30
Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation. J Am Soc Nephrol (2003) 1.28
Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLoS Comput Biol (2007) 1.26
Cell signaling events: a view from the matrix. Matrix Biol (2003) 1.26
Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type. Cancer Cell (2011) 1.25
Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development (2013) 1.23
Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. Cancer Res (2002) 1.23
Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development (2007) 1.22
Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin. J Cell Physiol (2012) 1.22
The temporal effects of anti-TGF-beta1, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation. J Am Coll Surg (2005) 1.21
Gold nanoparticles cellular toxicity and recovery: effect of size, concentration and exposure time. Nanotoxicology (2010) 1.17
Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts. Radiat Res (2006) 1.16
Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo. Genes Dev (2010) 1.14
Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity. J Cell Physiol (2009) 1.14
Multidimensional profiling of cell surface proteins and nuclear markers. IEEE/ACM Trans Comput Biol Bioinform (2010) 1.13
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol (2011) 1.12
Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation. Cytokine Growth Factor Rev (2013) 1.08
Lung alveolar septation defects in Ltbp-3-null mice. Am J Pathol (2005) 1.08
New rationales for using TGFbeta inhibitors in radiotherapy. Int J Radiat Biol (2007) 1.07
Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors. Stem Cells (2014) 1.05
E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest (2010) 1.05
Polo-like kinase 1 is involved in invasion through extracellular matrix. Cancer Res (2007) 1.05
Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. Proc Natl Acad Sci U S A (2013) 1.04
Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. Hum Mol Genet (2010) 1.03
Microfibril structure masks fibrillin-2 in postnatal tissues. J Biol Chem (2010) 1.03
Mechanisms of tendon injury and repair. J Orthop Res (2015) 1.02
Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling. J Cell Sci (2005) 1.02
Mapping mammary gland architecture using multi-scale in situ analysis. Integr Biol (Camb) (2008) 1.00
Genome-free viral capsids as carriers for positron emission tomography radiolabels. Mol Imaging Biol (2008) 1.00
Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta. J Mol Biol (2003) 0.99
Ionizing radiation induces heritable disruption of epithelial cell interactions. Proc Natl Acad Sci U S A (2003) 0.99
Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. J Mol Biol (2005) 0.98
Targeted and nontargeted effects of ionizing radiation that impact genomic instability. Cancer Res (2008) 0.96
The not-so innocent bystander: the microenvironment as a therapeutic target in cancer. Expert Opin Ther Targets (2003) 0.96
An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS One (2012) 0.95
Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin. Am J Pathol (2008) 0.95
Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett (2002) 0.95
Npt2b deletion attenuates hyperphosphatemia associated with CKD. J Am Soc Nephrol (2012) 0.95
Methods for measuring TGF-b using antibodies, cells, and mice. Methods Mol Med (2005) 0.93
F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation. FASEB J (2008) 0.93
Measuring regional changes in the diastolic deformation of the left ventricle of SHR rats using microPET technology and hyperelastic warping. Ann Biomed Eng (2008) 0.93
Regulation of gamma-secretase activity in Alzheimer's disease. Biochemistry (2007) 0.91
Water transport in AQP0 aquaporin: molecular dynamics studies. J Mol Biol (2006) 0.91
Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Dev Biol (2004) 0.90
Quantitative in vivo microscopy: the return from the 'omics'. Curr Opin Biotechnol (2006) 0.90
TSP50 encodes a testis-specific protease and is negatively regulated by p53. Cancer Res (2007) 0.90
System for combined three-dimensional morphological and molecular analysis of thick tissue specimens. Microsc Res Tech (2002) 0.89
The pivotal role of insulin-like growth factor I in normal mammary development. Endocrinol Metab Clin North Am (2011) 0.88
Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-β1 (TGF-β1). Endocrinology (2012) 0.88
Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies. Breast Cancer Res (2010) 0.88
Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev Dyn (2011) 0.88
Active and total transforming growth factor-β1 are differentially regulated by dopamine and estradiol in the pituitary. Endocrinology (2011) 0.88
Function of latent TGFβ binding protein 4 and fibulin 5 in elastogenesis and lung development. J Cell Physiol (2015) 0.87
Control of lung development by latent TGF-β binding proteins. J Cell Physiol (2011) 0.87
Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells. Cancer Res (2005) 0.87