It's not my fault, blame it on my microenvironment.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 12492489)

Published in Differentiation on December 01, 2002

Authors

Gerald R Cunha, Lynn M Matrisian

Articles by these authors

(truncated to the top 100)

Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 12.29

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell (2004) 7.61

The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res (2009) 6.83

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell (2008) 6.78

Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol (2002) 5.73

Emerging roles of proteases in tumour suppression. Nat Rev Cancer (2007) 3.81

Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat Genet (2004) 2.96

Hormonal, cellular, and molecular control of prostatic development. Dev Biol (2003) 2.67

Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res (2004) 2.67

MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell (2005) 2.65

Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling. FASEB J (2007) 2.40

Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res (2002) 2.29

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest (2002) 2.28

Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. Am J Pathol (2007) 2.23

Matrix metalloproteinases in tumor-host cell communication. Differentiation (2002) 2.16

The other side of MMPs: protective roles in tumor progression. Cancer Metastasis Rev (2007) 2.07

Role of p63 and basal cells in the prostate. Development (2004) 2.00

Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci U S A (2006) 1.97

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res (2008) 1.88

Pancreatic cancer clinical trials and accrual in the United States. J Clin Oncol (2013) 1.81

Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection. Infect Immun (2006) 1.75

Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res (2004) 1.66

Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. Cancer Res (2010) 1.66

Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem J (2004) 1.65

Mouse urogenital development: a practical approach. Differentiation (2003) 1.59

TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res (2010) 1.57

Epithelial-stromal interactions in the mouse and human mammary gland in vivo. Endocr Relat Cancer (2004) 1.57

Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res (2005) 1.56

Differential expression of p63 isoforms in female reproductive organs. Mech Dev (2005) 1.55

Imaging matrix metalloproteinases in cancer. Cancer Metastasis Rev (2008) 1.54

FGF-10 plays an essential role in the growth of the fetal prostate. Dev Biol (2003) 1.53

Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52

Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res (2006) 1.50

Formation of human prostate tissue from embryonic stem cells. Nat Methods (2006) 1.50

Development and characterization of efficient xenograft models for benign and malignant human prostate tissue. Prostate (2005) 1.49

A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblasts. Endocrinology (2002) 1.48

Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction. Circulation (2006) 1.46

Cellular and molecular mechanisms of development of the external genitalia. Differentiation (2003) 1.41

Stem/progenitor and intermediate cell types and the origin of human prostate cancer. Differentiation (2005) 1.40

Matrix metalloproteases in head and neck cancer. Head Neck (2006) 1.35

Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand. Arch Biochem Biophys (2002) 1.35

Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology (2003) 1.34

Matrix metalloproteinase inhibition attenuates aortic calcification. Arterioscler Thromb Vasc Biol (2006) 1.34

A protective role for matrix metalloproteinase-3 in squamous cell carcinoma. Cancer Res (2004) 1.32

Sonic hedgehog regulates prostatic growth and epithelial differentiation. Dev Biol (2003) 1.32

Steroid hormones stimulate human prostate cancer progression and metastasis. Int J Cancer (2006) 1.32

Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens. Environ Res (2004) 1.30

Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis. Differentiation (2006) 1.29

Matrix metalloproteinases in colorectal cancer: is it worth talking about? Cancer Metastasis Rev (2004) 1.26

Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res (2006) 1.26

Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis. Development (2004) 1.26

Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon. Mol Imaging (2009) 1.25

Morphology of mouse external genitalia: implications for a role of estrogen in sexual dimorphism of the mouse genital tubercle. J Urol (2010) 1.23

New insights on the morphology of adult mouse penis. Biol Reprod (2011) 1.22

Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethra. Cell Tissue Res (2001) 1.21

An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Lab Invest (2005) 1.19

Molecular imaging of proteolytic activity in cancer. J Cell Biochem (2003) 1.19

Noninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switch. Mol Imaging (2007) 1.18

The Translational Research Working Group developmental pathways: introduction and overview. Clin Cancer Res (2008) 1.18

Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo. BMC Cancer (2006) 1.16

Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer (2005) 1.14

Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy. Prostate (2007) 1.14

Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. Cancer Res (2007) 1.11

Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor. Cancer Res (2007) 1.10

Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol Cancer Res (2012) 1.10

The Translational Research Working Group developmental pathway for image-based assessment modalities. Clin Cancer Res (2008) 1.09

Molecular, cellular and developmental biology of urothelium as a basis of bladder regeneration. Differentiation (2005) 1.09

Matrilysin-dependent elastolysis by human macrophages. J Exp Med (2003) 1.08

Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone. PLoS One (2011) 1.08

Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. PLoS One (2011) 1.08

Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression. Proc Natl Acad Sci U S A (2002) 1.07

Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis. J Biol Chem (2002) 1.06

Steroid hormones and carcinogenesis of the prostate: the role of estrogens. Differentiation (2007) 1.06

A protective role of mast cells in intestinal tumorigenesis. Carcinogenesis (2008) 1.04

The serum glycoprotein fetuin-A promotes Lewis lung carcinoma tumorigenesis via adhesive-dependent and adhesive-independent mechanisms. Cancer Res (2005) 1.03

The role of smooth muscle in regulating prostatic induction. Development (2002) 1.03

Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis. Carcinogenesis (2012) 1.03

Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse. Int J Exp Pathol (2008) 1.02

Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter. Proc Natl Acad Sci U S A (2001) 1.02

Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Int J Cancer (2007) 0.99

Matrix metalloproteinases and cellular motility in development and disease. Birth Defects Res C Embryo Today (2006) 0.99

Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res (2009) 0.98

A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo. Hybridoma (Larchmt) (2007) 0.97

Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion. FASEB J (2003) 0.97

Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters. Mol Carcinog (2004) 0.96

An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS One (2012) 0.95

Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterus. Endocrinology (2002) 0.95

Mammalian sexual differentiation: lessons from the spotted hyena. Trends Endocrinol Metab (2006) 0.95

Analysis of the effect of estrogen/androgen perturbation on penile development in transgenic and diethylstilbestrol-treated mice. Anat Rec (Hoboken) (2013) 0.95

Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res (2008) 0.94

Molecular mechanisms of external genitalia development. Differentiation (2012) 0.94

The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol Rep (2004) 0.93

Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice. Invest Ophthalmol Vis Sci (2003) 0.93

Annexins expressed on the cell surface serve as receptors for adhesion to immobilized fetuin-A. Biochim Biophys Acta (2004) 0.92

Quantitation of apoptotic activity following castration in human prostatic tissue in vivo. Prostate (2003) 0.92

The application of a murine bone bioreactor as a model of tumor: bone interaction. Clin Exp Metastasis (2006) 0.92

The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen. Differentiation (2005) 0.92

Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo. Cancer Res (2002) 0.91

Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment. Mol Cancer Res (2007) 0.91

Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment. Am J Pathol (2008) 0.91