Imaging matrix metalloproteinases in cancer.

Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. Dis Model Mech (2011) 2.97

Imaging and photodynamic therapy: mechanisms, monitoring, and optimization. Chem Rev (2010) 2.44

Molecular imaging: current status and emerging strategies. Clin Radiol (2010) 1.79

Peptides and peptide hormones for molecular imaging and disease diagnosis. Chem Rev (2010) 1.63

Intravital imaging of stromal cell dynamics in tumors. Curr Opin Genet Dev (2009) 1.16

In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer Res (2010) 1.10

Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe. J Biomed Opt (2011) 1.05

Cancer invasion and metastasis: interacting ecosystems. Virchows Arch (2009) 1.05

Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma. Int J Clin Exp Pathol (2010) 1.04

Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe. Bioconjug Chem (2012) 0.96

Enzyme-directed assembly of a nanoparticle probe in tumor tissue. Adv Mater (2013) 0.95

Enzyme-directed assembly of nanoparticles in tumors monitored by in vivo whole animal imaging and ex vivo super-resolution fluorescence imaging. J Am Chem Soc (2013) 0.93

Fluorogenic Enzyme-Responsive Micellar Nanoparticles. Chem Sci (2012) 0.93

HGF and c-Met interaction promotes migration in human chondrosarcoma cells. PLoS One (2013) 0.92

Aberrant leukocyte infiltration: a direct trigger for breast tumor invasion and metastasis. Int J Biol Sci (2010) 0.92

In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity. Mol Pharm (2011) 0.90

AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma. Cell Commun Signal (2013) 0.89

Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis. Evid Based Complement Alternat Med (2011) 0.87

Nanoparticles for Improving Cancer Diagnosis. Mater Sci Eng R Rep (2013) 0.87

Physiologically relevant oxidative degradation of oligo(proline) cross-linked polymeric scaffolds. Biomacromolecules (2011) 0.87

Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Bioorg Med Chem (2008) 0.86

Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines. Front Neuroanat (2014) 0.85

Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3. Eur J Nucl Med Mol Imaging (2010) 0.81

Molecular Imaging of Proteases in Cancer. Cancer Growth Metastasis (2009) 0.81

Imaging aspects of the tumor stroma with therapeutic implications. Pharmacol Ther (2013) 0.81

A D-amino acid containing peptide as a potent, noncovalent inhibitor of α5β1 integrin in human prostate cancer invasion and lung colonization. Clin Exp Metastasis (2014) 0.80

MR - eyes for cancer: looking within an impenetrable disease. NMR Biomed (2013) 0.79

Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs). J Nanobiotechnology (2011) 0.79

Immobilizing reporters for molecular imaging of the extracellular microenvironment in living animals. ACS Chem Biol (2011) 0.79

Synthesis and in vitro efficacy of MMP9-activated NanoDendrons. Mol Pharm (2013) 0.79

Stromal fibroblasts in the microenvironment of gastric carcinomas promote tumor metastasis via upregulating TAGLN expression. BMC Cell Biol (2013) 0.79

The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts. BMC Cancer (2015) 0.78

Evaluation of a triple-helical peptide with quenched FluorSophores for optical imaging of MMP-2 and MMP-9 proteolytic activity. Molecules (2014) 0.78

New concepts in molecular imaging: non-invasive MRI spotting of proteolysis using an Overhauser effect switch. PLoS One (2009) 0.78

Apoptosis signal-regulating kinase 1 is involved in brain-derived neurotrophic factor (BDNF)-enhanced cell motility and matrix metalloproteinase 1 expression in human chondrosarcoma cells. Int J Mol Sci (2013) 0.77

Assessing the toxicity of ingested Taihu Lake water on mice via hepatic histopathology and matrix metalloproteinase expression. Ecotoxicology (2011) 0.77

Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase-1 and matrix metalloproteinase-10. Exp Ther Med (2014) 0.76

Immunolocalization of MMP9 and MMP2 in osteolytic metastasis originating from MDA-MB-231 human breast cancer cells. Mol Med Rep (2016) 0.76

Molecular and functional imaging of invasion and metastasis: windows into the metastatic cascade. Cancer Biomark (2010) 0.76

New tools for the quantitative assessment of prodrug delivery and neurotoxicity. Neurotoxicology (2015) 0.75

Development of a Novel PET Tracer [18F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging. PLoS One (2015) 0.75

2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm. Microsc Microanal (2016) 0.75

Topical MMP beacon enabled fluorescence-guided resection of oral carcinoma. Biomed Opt Express (2016) 0.75

Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging. Front Oncol (2017) 0.75

Rethinking Brain Cancer Therapy: Tumor Enzyme Activatable Theranostic Nanoparticles. Mol Imaging (2017) 0.75

Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 12.29

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell (2004) 7.61

The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res (2009) 6.83

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell (2008) 6.78

Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol (2002) 5.73

Emerging roles of proteases in tumour suppression. Nat Rev Cancer (2007) 3.81

Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat Genet (2004) 2.96

MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell (2005) 2.65

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest (2002) 2.28

Matrix metalloproteinases in tumor-host cell communication. Differentiation (2002) 2.16

The other side of MMPs: protective roles in tumor progression. Cancer Metastasis Rev (2007) 2.07

Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci U S A (2006) 1.97

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res (2008) 1.88

Pancreatic cancer clinical trials and accrual in the United States. J Clin Oncol (2013) 1.81

Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection. Infect Immun (2006) 1.75

Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. Cancer Res (2010) 1.66

Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem J (2004) 1.65

TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res (2010) 1.57

Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52

Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res (2006) 1.50

Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction. Circulation (2006) 1.46

Matrix metalloproteases in head and neck cancer. Head Neck (2006) 1.35

Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand. Arch Biochem Biophys (2002) 1.35

Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology (2003) 1.34

Matrix metalloproteinase inhibition attenuates aortic calcification. Arterioscler Thromb Vasc Biol (2006) 1.34

A protective role for matrix metalloproteinase-3 in squamous cell carcinoma. Cancer Res (2004) 1.32

Matrix metalloproteinases in colorectal cancer: is it worth talking about? Cancer Metastasis Rev (2004) 1.26

Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res (2006) 1.26

Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon. Mol Imaging (2009) 1.25

Molecular imaging of proteolytic activity in cancer. J Cell Biochem (2003) 1.19

Noninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switch. Mol Imaging (2007) 1.18

The Translational Research Working Group developmental pathways: introduction and overview. Clin Cancer Res (2008) 1.18

Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo. BMC Cancer (2006) 1.16

Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer (2005) 1.14

Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. Cancer Res (2007) 1.11

Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor. Cancer Res (2007) 1.10

Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol Cancer Res (2012) 1.10

The Translational Research Working Group developmental pathway for image-based assessment modalities. Clin Cancer Res (2008) 1.09

Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone. PLoS One (2011) 1.08

Matrilysin-dependent elastolysis by human macrophages. J Exp Med (2003) 1.08

Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. PLoS One (2011) 1.08

Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model. Magn Reson Med (2008) 1.07

A protective role of mast cells in intestinal tumorigenesis. Carcinogenesis (2008) 1.04

The serum glycoprotein fetuin-A promotes Lewis lung carcinoma tumorigenesis via adhesive-dependent and adhesive-independent mechanisms. Cancer Res (2005) 1.03

Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse. Int J Exp Pathol (2008) 1.02

Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Int J Cancer (2007) 0.99

Matrix metalloproteinases and cellular motility in development and disease. Birth Defects Res C Embryo Today (2006) 0.99

Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res (2009) 0.98

A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo. Hybridoma (Larchmt) (2007) 0.97

Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion. FASEB J (2003) 0.97

Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters. Mol Carcinog (2004) 0.96

An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS One (2012) 0.95

Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res (2008) 0.94

The influence of matrix metalloproteinase-7 on early mammary tumorigenesis in the multiple intestinal neoplasia mouse. Oncol Rep (2004) 0.93

IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells. J Allergy Clin Immunol (2010) 0.93

Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice. Invest Ophthalmol Vis Sci (2003) 0.93

Annexins expressed on the cell surface serve as receptors for adhesion to immobilized fetuin-A. Biochim Biophys Acta (2004) 0.92

The application of a murine bone bioreactor as a model of tumor: bone interaction. Clin Exp Metastasis (2006) 0.92

Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo. Cancer Res (2002) 0.91

Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment. Mol Cancer Res (2007) 0.91

An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin Exp Metastasis (2005) 0.91

Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment. Am J Pathol (2008) 0.91

New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging. J Med Chem (2009) 0.91

Optical proteolytic beacons for in vivo detection of matrix metalloproteinase activity. Methods Mol Biol (2009) 0.89

Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA. J Oncol (2010) 0.89

Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment. Mol Cancer Res (2010) 0.88

Matrilysin (matrix metalloproteinase-7) expression in ulcerative colitis-related tumorigenesis. Mol Carcinog (2002) 0.88

Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Clin Exp Metastasis (2008) 0.88

Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med (2008) 0.86

Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors. Int J Oncol (2004) 0.86

Near-infrared optical proteolytic beacons for in vivo imaging of matrix metalloproteinase activity. Methods Mol Biol (2010) 0.85

Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res (2007) 0.84

Salivary proteinase activity: a potential biomarker for preterm premature rupture of the membranes. Am J Obstet Gynecol (2006) 0.83

It's not my fault, blame it on my microenvironment. Differentiation (2002) 0.83

Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy. Clin Cancer Res (2004) 0.82

The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics). Clin Cancer Res (2008) 0.81

Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells. Exp Cell Res (2004) 0.80

Interactions of alpha2-HS-glycoprotein (fetuin) with MMP-3 and murine squamous cell carcinoma cells. Int J Oncol (2002) 0.80

Utility of [18 F]FLT-PET to assess treatment response in trastuzumab-resistant and trastuzumab-sensitive HER2-overexpressing human breast cancer xenografts. Mol Imaging Biol (2015) 0.79

MMP-2 contributes to the development of the mouse ventral prostate by impacting epithelial growth and morphogenesis. Dev Dyn (2010) 0.79

Synthesis and in vitro efficacy of MMP9-activated NanoDendrons. Mol Pharm (2013) 0.79

Alpha 2-HS glycoprotein (fetuin-A) modulates murine skin tumorigenesis. Int J Oncol (2004) 0.77

The Translational Research Working Group developmental pathway for interventive devices. Clin Cancer Res (2008) 0.76

Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer. J Surg Res (2012) 0.76

In the forefront of basic and translational cancer research: Seventh Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association. Cancer Res (2007) 0.76

A novel in vitro assay to assess phosphorylation of 3'-[(18)F]fluoro-3'-deoxythymidine. Mol Imaging Biol (2011) 0.75