PubRank

Rita Bottino

Author PubWeight™ 59.45‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2002 3.96
2 Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev 2009 3.02
3 PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature 2011 2.53
4 A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol 2007 2.23
5 Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience. J Clin Endocrinol Metab 2015 2.14
6 Clinical xenotransplantation: the next medical revolution? Lancet 2011 1.84
7 Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes 2004 1.81
8 Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Dev Cell 2012 1.72
9 HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol 2006 1.58
10 Sirolimus is associated with reduced islet engraftment and impaired beta-cell function. Diabetes 2006 1.49
11 Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes 2005 1.27
12 Clinical islet xenotransplantation: how close are we? Diabetes 2012 1.26
13 Prospective and challenges of islet transplantation for the therapy of autoimmune diabetes. Pancreas 2006 1.25
14 Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies. Xenotransplantation 2007 1.20
15 Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife 2013 1.19
16 Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J Biol Chem 2003 1.12
17 Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis. Diabetes 2007 1.07
18 Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes. Stem Cells 2003 1.07
19 Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein. Biotechniques 2003 1.02
20 Harmful delayed effects of exogenous isolation enzymes on isolated human islets: relevance to clinical transplantation. Am J Transplant 2005 1.01
21 Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation 2007 0.99
22 Redox modulation protects islets from transplant-related injury. Diabetes 2010 0.98
23 Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes 2010 0.97
24 Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses. Pancreas 2006 0.95
25 The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation. J Biomed Res 2013 0.93
26 Safe induction of diabetes by high-dose streptozotocin in pigs. Pancreas 2008 0.93
27 Combined modulation of polycomb and trithorax genes rejuvenates β cell replication. J Clin Invest 2013 0.92
28 Facilitating physiologic self-regeneration: a step beyond islet cell replacement. Pharm Res 2006 0.92
29 Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated? Cell Transplant 2012 0.91
30 Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity. Ann N Y Acad Sci 2007 0.87
31 Cytokine and chemokine production by human pancreatic islets upon enterovirus infection. Diabetes 2012 0.87
32 Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels. Am J Physiol Endocrinol Metab 2007 0.87
33 Insulin secretion and glucose metabolism in alpha 1,3-galactosyltransferase knock-out pigs compared to wild-type pigs. Xenotransplantation 2010 0.86
34 Pig-to-nonhuman primates pancreatic islet xenotransplantation: an overview. Curr Diab Rep 2011 0.86
35 Toward clinical islet xenotransplantation - are revisions to the IXA guidelines warranted? Xenotransplantation 2013 0.86
36 Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation. J Transplant 2011 0.83
37 Flexible management of enzymatic digestion improves human islet isolation outcome from sub-optimal donor pancreata. Am J Transplant 2003 0.83
38 Glucose metabolism in pigs expressing human genes under an insulin promoter. Xenotransplantation 2014 0.82
39 Islet xenotransplantation: what is the optimal age of the islet-source pig? Xenotransplantation 2014 0.82
40 Acute gastric dilatation after porcine islet transplantation in a cynomolgus monkey - case history and review of the literature. Xenotransplantation 2007 0.82
41 Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet β-cells. Cell Immunol 2012 0.81
42 Pancreatic acinar cell nuclear factor κB activation because of bile acid exposure is dependent on calcineurin. J Biol Chem 2013 0.81
43 Technique of endoscopic biopsy of islet allografts transplanted into the gastric submucosal space in pigs. Cell Transplant 2013 0.80
44 Increased yield and improved transplantation outcome of mouse islets with bovine serum albumin. J Transplant 2012 0.80
45 Islet xenotransplantation from genetically engineered pigs. Curr Opin Organ Transplant 2013 0.80
46 Gene therapy for type 1 diabetes: is it ready for the clinic? Immunol Res 2006 0.79
47 The histopathology of PRSS1 hereditary pancreatitis. Am J Surg Pathol 2014 0.79
48 A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs-association with sepsis. Transplantation 2012 0.78
49 Limitations of the pig-to-non-human primate islet transplantation model. Xenotransplantation 2013 0.77
50 Author Response to Letter by Delibasi T., et al. J Clin Endocrinol Metab 2015 0.75
51 Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med 2017 0.75
52 Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med 2017 0.75