Published in Diabetes on September 01, 2006
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes (2012) 2.02
The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. Transplantation (2008) 1.83
Current advances and travails in islet transplantation. Diabetes (2009) 1.63
Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model. Proc Natl Acad Sci U S A (2009) 1.32
Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. Br J Pharmacol (2012) 1.32
mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability. J Biol Chem (2009) 1.24
Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms. Diabetes (2013) 1.17
Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocr Rev (2011) 1.10
Current status of islet cell transplantation. J Hepatobiliary Pancreat Surg (2008) 1.07
Revascularization of transplanted pancreatic islets and role of the transplantation site. Clin Dev Immunol (2013) 1.04
Oxidative stress and redox modulation potential in type 1 diabetes. Clin Dev Immunol (2011) 1.00
Redox modulation protects islets from transplant-related injury. Diabetes (2010) 0.98
mTORC1 signaling and regulation of pancreatic β-cell mass. Cell Cycle (2012) 0.94
Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation. Biomaterials (2014) 0.94
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2). Diabetologia (2012) 0.93
Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia (2012) 0.90
Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation. Clin Exp Immunol (2009) 0.89
Thinking bedside at the bench: the NOD mouse model of T1DM. Nat Rev Endocrinol (2015) 0.88
The use of biomaterials in islet transplantation. Curr Diab Rep (2011) 0.88
Anti-proinflammatory effects of sirolimus on human islet preparations. Transplantation (2008) 0.87
Characterization of pancreatic ductal cells in human islet preparations. Lab Invest (2008) 0.87
Tacrolimus inhibits the revascularization of isolated pancreatic islets. PLoS One (2013) 0.87
Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells. Diabetes (2008) 0.86
TCF7L2 polymorphism associates with new-onset diabetes after transplantation. J Am Soc Nephrol (2009) 0.86
Immune responses against islet allografts during tapering of immunosuppression--a pilot study in 5 subjects. Clin Exp Immunol (2012) 0.86
Long-term survival of allograft murine islets coated via covalently stabilized polymers. Adv Healthc Mater (2014) 0.82
Rapamycin inhibits growth factor-induced cell cycle regulation in pancreatic beta cells. J Investig Med (2008) 0.82
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation. Colomb Med (Cali) (2012) 0.80
Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience. Rev Diabet Stud (2012) 0.79
Engineering a local microenvironment for pancreatic islet replacement. Curr Opin Biotechnol (2013) 0.79
mTOR inhibitors in cancer therapy. F1000Res (2016) 0.79
Long-term graft function of cryostored alginate encapsulated rat islets. Eur J Med Res (2011) 0.79
Reg3α Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant Outcome. Mol Med (2014) 0.76
Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo. Sci Rep (2015) 0.76
Safety and tolerability of the T-cell depletion protocol coupled with anakinra and etanercept for clinical islet cell transplantation. Clin Transplant (2012) 0.76
Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids. J Diabetes Res (2016) 0.75
Post-renal transplant diabetes mellitus in korean subjects: superimposition of transplant-related immunosuppressant factors on genetic and type 2 diabetic risk factors. Diabetes Metab J (2012) 0.75
Autologous and Allogenous Antibodies in Lung and Islet Cell Transplantation. Front Immunol (2016) 0.75
Mesenchymal Stromal Cells as a Therapeutic Strategy to Support Islet Transplantation in Type 1 Diabetes Mellitus. Cell Med (2011) 0.75
Administration of a negative vaccination induces hyporesponsiveness to islet allografts. Cell Transplant (2012) 0.75
The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice. Dis Model Mech (2015) 0.75
Addition of rapamycin to anti-CD3 antibody improves long-term glycaemia control in diabetic NOD mice. PLoS One (2013) 0.75
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol (2006) 5.00
MIF signal transduction initiated by binding to CD74. J Exp Med (2003) 4.79
Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med (2013) 4.75
Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets. Cell (2008) 4.11
Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med (2013) 3.98
Production of alpha 1,3-galactosyltransferase-deficient pigs. Science (2002) 3.96
Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity (2009) 3.32
Asymmetric mating interactions drive widespread invasion and displacement in a whitefly. Science (2007) 3.17
TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors. Am J Transplant (2004) 3.15
Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev (2009) 3.02
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology (2007) 3.02
Epidemiology of schistosomiasis in the People's Republic of China, 2004. Emerg Infect Dis (2007) 3.00
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol (2009) 2.87
Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol (2009) 2.84
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med (2009) 2.73
PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature (2011) 2.53
Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck. Cell Rep (2012) 2.50
Surface contact stimulates the just-in-time deployment of bacterial adhesins. Mol Microbiol (2011) 2.44
Epigenetic mechanisms of regulation of Foxp3 expression. Blood (2009) 2.27
Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology (2009) 2.24
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol (2007) 2.23
Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst (2007) 2.23
A cytoplasmic dynein tail mutation impairs motor processivity. Nat Cell Biol (2010) 2.20
Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes (2004) 2.16
FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest (2008) 2.16
HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis. J Hepatol (2012) 2.15
Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience. J Clin Endocrinol Metab (2015) 2.14
Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med (2011) 2.14
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat Immunol (2007) 2.13
Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes. Am J Transplant (2012) 2.12
Association of high-risk human papillomavirus infection with oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 2.07
MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis. J Cancer Res Clin Oncol (2010) 2.05
Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol (2007) 2.00
Total pancreatectomy and islet autotransplantation for chronic pancreatitis. J Am Coll Surg (2012) 2.00
c-Maf regulates IL-10 expression during Th17 polarization. J Immunol (2009) 1.99
Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci U S A (2009) 1.95
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature (2009) 1.94
Foxo1 mediates insulin action on apoC-III and triglyceride metabolism. J Clin Invest (2004) 1.93
Quality of life improves for pediatric patients after total pancreatectomy and islet autotransplant for chronic pancreatitis. Clin Gastroenterol Hepatol (2011) 1.93
Vector-virus mutualism accelerates population increase of an invasive whitefly. PLoS One (2007) 1.91
The RB-E2F1 pathway regulates autophagy. Cancer Res (2010) 1.90
2-[(Pyrimidin-2-yl-amino)-meth-yl]phenol. Acta Crystallogr Sect E Struct Rep Online (2011) 1.89
G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci U S A (2002) 1.87
Pulmonary artery denervation to treat pulmonary arterial hypertension: the single-center, prospective, first-in-man PADN-1 study (first-in-man pulmonary artery denervation for treatment of pulmonary artery hypertension). J Am Coll Cardiol (2013) 1.84
Clinical xenotransplantation: the next medical revolution? Lancet (2011) 1.84
2-[(Pyridin-3-yl-amino)-meth-yl]phenol. Acta Crystallogr Sect E Struct Rep Online (2011) 1.83
Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes (2004) 1.81
Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol (2006) 1.81
Islet autotransplant outcomes after total pancreatectomy: a contrast to islet allograft outcomes. Transplantation (2008) 1.80
High HIV prevalence detected in 2006 and 2007 among men who have sex with men in China's largest municipality: an alarming epidemic in Chongqing, China. J Acquir Immune Defic Syndr (2009) 1.80
Ureteral stents are associated with reduced risk of ureteral complications after kidney transplantation: a large single center experience. Transplantation (2012) 1.79
VEGF Trap induces antiglioma effect at different stages of disease. Neuro Oncol (2008) 1.77
Stepping, strain gating, and an unexpected force-velocity curve for multiple-motor-based transport. Curr Biol (2008) 1.75
Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Dev Cell (2012) 1.72
Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes. Am J Transplant (2008) 1.68
Transplant glomerulopathy may occur in the absence of donor-specific antibody and C4d staining. Clin J Am Soc Nephrol (2007) 1.64
Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. J Immunol (2005) 1.64
Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. Diabetes Res Clin Pract (2011) 1.62
LRRK2 inhibition attenuates microglial inflammatory responses. J Neurosci (2012) 1.61
Co-receptor requirements for fibroblast growth factor-19 signaling. J Biol Chem (2007) 1.59
HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol (2006) 1.58
Risk of bone fractures associated with glucagon-like peptide-1 receptor agonists' treatment: a meta-analysis of randomized controlled trials. Endocrine (2014) 1.58
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. J Clin Invest (2010) 1.55
Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. Diabetes (2004) 1.54
Comparative reliability of proton spectroscopy techniques designed to improve detection of J-coupled metabolites. Magn Reson Med (2008) 1.53
CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Cell (2013) 1.53
TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer. J Clin Endocrinol Metab (2014) 1.52
Overprescribing in China, driven by financial incentives, results in very high use of antibiotics, injections, and corticosteroids. Health Aff (Millwood) (2012) 1.48
Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol (2007) 1.48
FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS One (2012) 1.47
Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism. Endocrinology (2006) 1.46
Suppressor of cytokine signaling 1 inhibits IL-10-mediated immune responses. J Immunol (2003) 1.45
HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology (2009) 1.45
Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol (2011) 1.45
Hepatitis B virus status and the risk of pancreatic cancer: a meta-analysis. Eur J Cancer Prev (2013) 1.43
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. J Am Soc Nephrol (2009) 1.43
Vascular invasion in hepatitis B virus-related hepatocellular carcinoma with underlying cirrhosis: possible associations with ascites and hepatitis B viral factors? Tumour Biol (2015) 1.43
Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: a meta-analysis. Atherosclerosis (2009) 1.42
Vitrification of mouse embryo-derived ICM cells: a tool for preserving embryonic stem cell potential? J Assist Reprod Genet (2010) 1.42
IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation. J Immunol (2005) 1.42
Community-based study on CKD subjects and the associated risk factors. Nephrol Dial Transplant (2009) 1.42
Schistosomiasis control and the health system in P.R. China. Infect Dis Poverty (2012) 1.41
Pathological classification of intrahepatic cholangiocarcinoma based on a new concept. World J Hepatol (2010) 1.41
p38 MAPK inhibition alleviates experimental acute pancreatitis in mice. Hepatobiliary Pancreat Dis Int (2015) 1.40
The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks. J Virol (2010) 1.40
CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential. Am J Transplant (2004) 1.39
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem (2009) 1.39
Left type I proatlantal artery with bilateral aberrant vertebral arteries and a ruptured aneurysm: a case report and review of the literature. Surg Radiol Anat (2014) 1.39
neo-Clerodane diterpenes from Ajuga ciliata Bunge and their neuroprotective activities. Fitoterapia (2011) 1.38
Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice. FEBS Lett (2009) 1.37
Analysis of SOX9 expression in colorectal cancer. Am J Clin Pathol (2008) 1.35
Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance. Cancer Res (2006) 1.35
Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Crit Care Med (2010) 1.35
TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther (2008) 1.34
Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity. J Virol (2011) 1.34
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys. Endocrinology (2012) 1.30
Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood (2007) 1.29