Gordon C Weir

Author PubWeight™ 86.26‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 New sources of pancreatic beta-cells. Nat Biotechnol 2005 3.11
2 Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 2007 1.99
3 Beta-cell growth and regeneration: replication is only part of the story. Diabetes 2010 1.92
4 Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab 2008 1.91
5 The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A 2005 1.88
6 Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem 2002 1.76
7 A stirred microchamber for oxygen consumption rate measurements with pancreatic islets. Biotechnol Bioeng 2007 1.73
8 The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab 2005 1.72
9 Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab 2007 1.68
10 Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One 2010 1.68
11 Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem 2002 1.67
12 Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem 2005 1.65
13 Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes 2002 1.51
14 Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes 2007 1.50
15 Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes 2002 1.43
16 Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest 2010 1.43
17 Current status of islet cell replacement and regeneration therapy. J Clin Endocrinol Metab 2010 1.43
18 Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem 2002 1.41
19 Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab 2010 1.41
20 GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract 2006 1.37
21 PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes 2003 1.34
22 Prediction of marginal mass required for successful islet transplantation. J Invest Surg 2010 1.23
23 Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA. Diabetes 2013 1.22
24 Retracted Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat Cell Biol 2012 1.20
25 Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A 2012 1.14
26 Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes 2006 1.12
27 Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J Endocrinol 2009 1.10
28 Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocr Rev 2011 1.10
29 Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes 2003 1.10
30 Pig islet xenograft rejection in a mouse model with an established human immune system. Xenotransplantation 2008 1.04
31 Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant 2012 1.03
32 Long-term normoglycemia in rats receiving transplants with encapsulated islets. Transplantation 2005 1.02
33 Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling. Methods Mol Biol 2009 1.00
34 Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes 2007 0.98
35 Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem 2001 0.98
36 Concise review: pancreas regeneration: recent advances and perspectives. Stem Cells Transl Med 2012 0.98
37 Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem 2002 0.95
38 Core-shell hydrogel microcapsules for improved islets encapsulation. Adv Healthc Mater 2012 0.95
39 Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug. Biomaterials 2013 0.94
40 Survival of microencapsulated adult pig islets in mice in spite of an antibody response. Am J Transplant 2004 0.92
41 Birth and death of human β-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice. Cell Transplant 2013 0.92
42 Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation. Diabetes 2007 0.91
43 Islet transplantation: progress and challenge. Arch Med Res 2005 0.91
44 Protective unfolded protein response in human pancreatic beta cells transplanted into mice. PLoS One 2010 0.90
45 β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab 2014 0.90
46 Quantitative assessment of islets of Langerhans encapsulated in alginate. Tissue Eng Part C Methods 2011 0.89
47 Establishment of a diabetic mouse model with progressive diabetic nephropathy. Am J Pathol 2005 0.89
48 Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration. Endocrinology 2013 0.88
49 Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion. Endocrinology 2012 0.88
50 A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse. J Cell Physiol 2008 0.87
51 PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation. Diabetes 2013 0.87
52 Exercise induces hypoglycemia in rats with islet transplantation. Diabetes 2004 0.87
53 The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS One 2013 0.87
54 NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab Res Rev 2007 0.86
55 Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transpl Immunol 2004 0.86
56 Islet transplantation under the kidney capsule corrects the defects in glycogen metabolism in both liver and muscle of streptozocin-diabetic rats. Cell Transplant 2002 0.85
57 Importance of hyperglycemia on the primary function of allogeneic islet transplants. Transplantation 2003 0.85
58 Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation 2003 0.85
59 Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells. Biochem Biophys Res Commun 2005 0.84
60 Islet neogenesis: a possible pathway for beta-cell replenishment. Rev Diabet Stud 2012 0.83
61 Beta-cell precursors--a work in progress. Nat Biotechnol 2004 0.83
62 Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement. Transplantation 2016 0.82
63 A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells. Biomaterials 2010 0.82
64 Repurposing cAMP-modulating medications to promote β-cell replication. Mol Endocrinol 2014 0.82
65 Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells. Endocrinology 2015 0.81
66 Enumeration of islets by nuclei counting and light microscopic analysis. Lab Invest 2010 0.81
67 Making β cells from adult cells within the pancreas. Curr Diab Rep 2013 0.81
68 Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med 2016 0.81
69 Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice. Diabetes Metab Res Rev 2008 0.79
70 Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement. Transplantation 2016 0.79
71 Direct lineage conversion of pancreatic exocrine to endocrine Beta cells in vivo with defined factors. Methods Mol Biol 2014 0.78
72 Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture. Dev Growth Differ 2003 0.78
73 Lack of evidence for recipient precursor cells replenishing β-cells in transplanted islets. Cell Transplant 2010 0.78
74 Induction of Mad expression leads to augmentation of insulin gene transcription. Biochem Biophys Res Commun 2003 0.76
75 Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. PLoS One 2013 0.76
76 An appreciation of Robert Turner. Diabetes 2008 0.75
77 Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int 2008 0.75
78 Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol 2016 0.75