1
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New sources of pancreatic beta-cells.
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Nat Biotechnol
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2005
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3.11
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2
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Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.
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Diabetes
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2007
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1.99
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3
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Beta-cell growth and regeneration: replication is only part of the story.
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Diabetes
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2010
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1.92
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4
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Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.
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J Clin Endocrinol Metab
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2008
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1.91
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5
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The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
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Proc Natl Acad Sci U S A
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2005
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1.88
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6
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Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression.
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J Biol Chem
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2002
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1.76
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7
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A stirred microchamber for oxygen consumption rate measurements with pancreatic islets.
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Biotechnol Bioeng
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2007
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1.73
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8
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The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.
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Cell Metab
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2005
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1.72
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9
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Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.
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J Clin Endocrinol Metab
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2007
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1.68
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10
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Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.
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PLoS One
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2010
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1.68
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11
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Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.
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J Biol Chem
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2002
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1.67
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12
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Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
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J Biol Chem
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2005
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1.65
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13
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Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.
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Diabetes
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2002
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1.51
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14
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Differentiation of affinity-purified human pancreatic duct cells to beta-cells.
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Diabetes
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2007
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1.50
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15
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Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.
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Diabetes
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2002
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1.43
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16
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Quantitative analysis of cell composition and purity of human pancreatic islet preparations.
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Lab Invest
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2010
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1.43
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17
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Current status of islet cell replacement and regeneration therapy.
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J Clin Endocrinol Metab
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2010
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1.43
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18
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Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.
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J Biol Chem
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2002
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1.41
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19
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Ductal origin hypothesis of pancreatic regeneration under attack.
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Cell Metab
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2010
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1.41
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20
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GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts.
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Diabetes Res Clin Pract
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2006
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1.37
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21
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PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.
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Diabetes
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2003
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1.34
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22
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Prediction of marginal mass required for successful islet transplantation.
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J Invest Surg
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2010
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1.23
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23
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Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA.
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Diabetes
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2013
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1.22
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24
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Retracted
Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.
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Nat Cell Biol
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2012
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1.20
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25
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Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist.
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Proc Natl Acad Sci U S A
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2012
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1.14
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26
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Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.
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Diabetes
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2006
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1.12
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27
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Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells.
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J Endocrinol
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2009
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1.10
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28
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Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain.
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Endocr Rev
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2011
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1.10
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29
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Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice.
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Diabetes
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2003
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1.10
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30
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Pig islet xenograft rejection in a mouse model with an established human immune system.
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Xenotransplantation
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2008
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1.04
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31
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Enhanced oxygen supply improves islet viability in a new bioartificial pancreas.
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Cell Transplant
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2012
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1.03
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32
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Long-term normoglycemia in rats receiving transplants with encapsulated islets.
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Transplantation
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2005
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1.02
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33
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Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.
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Methods Mol Biol
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2009
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1.00
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34
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Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.
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Diabetes
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2007
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0.98
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35
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Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.
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J Biol Chem
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2001
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0.98
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36
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Concise review: pancreas regeneration: recent advances and perspectives.
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Stem Cells Transl Med
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2012
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0.98
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37
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Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation.
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J Biol Chem
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2002
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0.95
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38
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Core-shell hydrogel microcapsules for improved islets encapsulation.
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Adv Healthc Mater
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2012
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0.95
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39
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Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug.
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Biomaterials
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2013
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0.94
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40
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Survival of microencapsulated adult pig islets in mice in spite of an antibody response.
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Am J Transplant
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2004
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0.92
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41
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Birth and death of human β-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice.
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Cell Transplant
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2013
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0.92
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42
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Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation.
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Diabetes
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2007
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0.91
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43
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Islet transplantation: progress and challenge.
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Arch Med Res
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2005
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0.91
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44
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Protective unfolded protein response in human pancreatic beta cells transplanted into mice.
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PLoS One
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2010
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0.90
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45
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β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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J Clin Endocrinol Metab
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2014
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0.90
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46
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Quantitative assessment of islets of Langerhans encapsulated in alginate.
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Tissue Eng Part C Methods
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2011
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0.89
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47
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Establishment of a diabetic mouse model with progressive diabetic nephropathy.
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Am J Pathol
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2005
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0.89
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48
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Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration.
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Endocrinology
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2013
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0.88
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49
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Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion.
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Endocrinology
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2012
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0.88
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50
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A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse.
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J Cell Physiol
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2008
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0.87
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51
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PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation.
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Diabetes
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2013
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0.87
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52
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Exercise induces hypoglycemia in rats with islet transplantation.
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Diabetes
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2004
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0.87
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53
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The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs.
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PLoS One
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2013
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0.87
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54
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NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes.
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Diabetes Metab Res Rev
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2007
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0.86
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55
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Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors.
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Transpl Immunol
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2004
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0.86
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56
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Islet transplantation under the kidney capsule corrects the defects in glycogen metabolism in both liver and muscle of streptozocin-diabetic rats.
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Cell Transplant
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2002
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0.85
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57
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Importance of hyperglycemia on the primary function of allogeneic islet transplants.
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Transplantation
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2003
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0.85
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58
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Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats.
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Xenotransplantation
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2003
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0.85
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59
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Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells.
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Biochem Biophys Res Commun
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2005
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0.84
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60
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Islet neogenesis: a possible pathway for beta-cell replenishment.
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Rev Diabet Stud
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2012
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0.83
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61
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Beta-cell precursors--a work in progress.
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Nat Biotechnol
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2004
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62
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Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement.
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Transplantation
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2016
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63
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A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells.
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Biomaterials
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2010
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0.82
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64
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Repurposing cAMP-modulating medications to promote β-cell replication.
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Mol Endocrinol
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2014
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0.82
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65
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Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing β-Like Cells.
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Endocrinology
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2015
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0.81
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66
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Enumeration of islets by nuclei counting and light microscopic analysis.
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Lab Invest
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2010
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0.81
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67
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Making β cells from adult cells within the pancreas.
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Curr Diab Rep
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2013
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0.81
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68
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Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
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Nat Med
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2016
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0.81
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69
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Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice.
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Diabetes Metab Res Rev
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2008
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0.79
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70
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Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement.
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Transplantation
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2016
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0.79
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71
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Direct lineage conversion of pancreatic exocrine to endocrine Beta cells in vivo with defined factors.
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Methods Mol Biol
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2014
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0.78
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72
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Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture.
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Dev Growth Differ
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2003
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0.78
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73
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Lack of evidence for recipient precursor cells replenishing β-cells in transplanted islets.
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Cell Transplant
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2010
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0.78
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74
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Induction of Mad expression leads to augmentation of insulin gene transcription.
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Biochem Biophys Res Commun
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2003
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0.76
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75
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Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes.
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PLoS One
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2013
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0.76
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76
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An appreciation of Robert Turner.
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Diabetes
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2008
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0.75
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77
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Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
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Kidney Int
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2008
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0.75
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78
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Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
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Nat Biotechnol
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2016
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0.75
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