Published in Semin Cancer Biol on February 01, 2003
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer (2008) 6.10
p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev (2004) 3.16
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol (2009) 2.91
Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem Biol (2012) 2.34
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat Rev Cancer (2011) 2.06
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy. Genes Cancer (2010) 1.80
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. Cell Cycle (2010) 1.74
F-box protein Skp2: a novel transcriptional target of E2F. Oncogene (2006) 1.74
Hdm2- and proteasome-dependent turnover limits p21 accumulation during S phase. Cell Cycle (2011) 1.49
E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia (2006) 1.49
A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci U S A (2004) 1.47
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol (2008) 1.44
IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. EMBO J (2006) 1.43
CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms. Blood (2007) 1.42
beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Mol Cell Biol (2009) 1.37
Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1. J Mol Biol (2007) 1.32
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol Cell Biol (2006) 1.31
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Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases. J Biol Chem (2009) 1.27
Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. Am J Pathol (2004) 1.17
Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. Int J Cancer (2008) 1.15
Targeting the ubiquitin-proteasome system for cancer therapy. Expert Opin Ther Targets (2013) 1.14
Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem (2010) 1.14
Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma. Clin Cancer Res (2009) 1.13
HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1. Biochem J (2007) 1.05
Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulation. Mol Cell Biol (2009) 1.04
Role of T198 modification in the regulation of p27(Kip1) protein stability and function. PLoS One (2011) 1.04
Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma. Cancer Res (2008) 1.01
Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7. Mol Biol Cell (2008) 0.99
Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes. BMC Biochem (2007) 0.99
Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer. Oncogene (2009) 0.99
The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal. Blood (2011) 0.98
Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation. PLoS One (2010) 0.98
Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21. Br J Cancer (2006) 0.96
Novel roles of Skp2 E3 ligase in cellular senescence, cancer progression, and metastasis. Chin J Cancer (2011) 0.95
Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life. Front Physiol (2012) 0.94
Multiple Interactions between Peroxisome Proliferators-Activated Receptors and the Ubiquitin-Proteasome System and Implications for Cancer Pathogenesis. PPAR Res (2008) 0.93
Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression. Cancer Res (2007) 0.92
Cap-independent translation through the p27 5'-UTR. Nucleic Acids Res (2007) 0.91
Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a. Mol Cell Biol (2003) 0.90
Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer. Endocrinology (2013) 0.90
A strategy based on protein-protein interface motifs may help in identifying drug off-targets. J Chem Inf Model (2012) 0.90
Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer. PLoS One (2012) 0.89
Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. J Biol Chem (2009) 0.89
Low-molecular-weight cyclin E: the missing link between biology and clinical outcome. Breast Cancer Res (2004) 0.88
Robustness and backbone motif of a cancer network regulated by miR-17-92 cluster during the G1/S transition. PLoS One (2013) 0.88
P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori. Gut (2004) 0.88
Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer. Cell Cycle (2012) 0.86
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Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors. Leukemia (2010) 0.85
The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation. Oncogene (2012) 0.85
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. Biochem J (2015) 0.85
Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras. Cancer Discov (2013) 0.85
Mutant AKT1-E17K is oncogenic in lung epithelial cells. Oncotarget (2015) 0.85
The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1. FEBS Open Bio (2012) 0.84
Optimization of immunolocalization of cell cycle proteins in human corneal endothelial cells. Mol Vis (2011) 0.84
Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset. Mol Biol Cell (2013) 0.84
CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27(Kip1) via Skp2 and FOXO3a regulation. Oncogene (2014) 0.83
Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J Biomol Screen (2012) 0.83
Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex. Oncogene (2012) 0.82
CKS1B nuclear expression is inversely correlated with p27Kip1 expression and is predictive of an adverse survival in patients with multiple myeloma. Haematologica (2010) 0.82
Iron depletion results in Src kinase inhibition with associated cell cycle arrest in neuroblastoma cells. Physiol Rep (2015) 0.81
ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). Cell Death Differ (2013) 0.81
The Relevance of Women's Diseases, Jun Activation-domain Binding Protein 1 (JAB1) and p27(kip1). J Menopausal Med (2016) 0.81
High Skp2/Low p57(Kip2) Expression is Associated with Poor Prognosis in Human Breast Carcinoma. Breast Cancer (Auckl) (2015) 0.80
Ubiquitylation of nuclear receptors: new linkages and therapeutic implications. J Mol Endocrinol (2015) 0.79
Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies. PLoS One (2012) 0.77
Antiproliferative effects and molecular mechanisms of troglitazone in human cervical cancer in vitro. Onco Targets Ther (2015) 0.77
Loss of heterozygosity at 12p13 and loss of p27KIP1 protein expression contribute to melanoma progression. Virchows Arch (2004) 0.76
Possible implication of Mdm2 as a prognostic marker in invasive laryngeal carcinoma. Eur Arch Otorhinolaryngol (2012) 0.76
Gastrointestinal stromal tumors (GIST): facing cell death between autophagy and apoptosis. Autophagy (2017) 0.75
AMPKα2 Regulates Bladder Cancer Growth through SKP2-Mediated Degradation of p27. Mol Cancer Res (2016) 0.75
The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine. Sultan Qaboos Univ Med J (2011) 0.75
Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene (2016) 0.75
Transforming growth factor β1 increases p27 levels via synthesis and degradation mechanisms in the hyperproliferative gastric epithelium in rats. PLoS One (2014) 0.75
Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma. Mol Oncol (2011) 0.75
p27 modulates tropism of mesenchymal stem cells toward brain tumors. Exp Ther Med (2010) 0.75
Effect of p27mt gene on apoptosis of the colorectal cancer cell line Lovo. World J Gastroenterol (2009) 0.75
Dual effects of Ral-activated pathways on p27 localization and TGF-β signaling. Mol Biol Cell (2013) 0.75
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol (2004) 8.21
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer (2008) 6.10
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science (2006) 5.94
Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev (2004) 4.68
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell (2008) 4.04
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature (2004) 3.73
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem (2003) 3.68
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev Cell (2003) 3.62
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science (2007) 3.59
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature (2003) 3.54
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev (2008) 3.49
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest (2002) 3.36
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Nature (2006) 3.31
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science (2007) 3.05
American Idol and NIH Grant Review. Cell (2006) 3.01
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell (2006) 2.75
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75
Mechanisms and function of substrate recruitment by F-box proteins. Nat Rev Mol Cell Biol (2013) 2.56
Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation. Cell (2003) 2.54
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature (2008) 2.46
APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell (2007) 2.35
Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem Biol (2012) 2.34
The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol (2008) 2.32
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature (2007) 2.20
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature (2010) 2.15
Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. J Cell Biol (2008) 2.08
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. Proc Natl Acad Sci U S A (2004) 2.05
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell (2012) 1.98
Dual mode of degradation of Cdc25 A phosphatase. EMBO J (2002) 1.95
APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. Cell Cycle (2009) 1.94
USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature (2013) 1.94
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle (2008) 1.90
SnapShot: F Box Proteins II. Cell (2009) 1.88
Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol (2003) 1.85
FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature (2012) 1.79
mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR. Mol Cell (2011) 1.78
Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Am J Pathol (2007) 1.77
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell (2009) 1.77
Control of cell growth by the SCF and APC/C ubiquitin ligases. Curr Opin Cell Biol (2009) 1.55
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell (2004) 1.55
Oncogenic aberrations of cullin-dependent ubiquitin ligases. Oncogene (2004) 1.51
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol (2012) 1.47
Stabilizers and destabilizers controlling cell cycle oscillators. Mol Cell (2006) 1.42
SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature (2013) 1.41
The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer. Biochim Biophys Acta (2013) 1.34
Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis. Mol Cell Biol (2004) 1.33
Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. Cell Cycle (2005) 1.32
INTS3 controls the hSSB1-mediated DNA damage response. J Cell Biol (2009) 1.31
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. J Cell Biol (2013) 1.28
SnapShot: F box proteins I. Cell (2009) 1.27
Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med (2004) 1.24
Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. Sci Signal (2012) 1.23
DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age. Dev Cell (2007) 1.22
Cell cycle, proteolysis and cancer. Curr Opin Cell Biol (2004) 1.22
Experimental tests to definitively determine ubiquitylation of a substrate. Methods Enzymol (2005) 1.21
SCF ubiquitin ligases in the maintenance of genome stability. Trends Biochem Sci (2011) 1.21
Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J Biol Chem (2002) 1.20
Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients. Clin Cancer Res (2003) 1.19
S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase. Am J Pathol (2002) 1.17
Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. Am J Pathol (2004) 1.17
Cdh1: a master G0/G1 regulator. Nat Cell Biol (2008) 1.16
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation. Mol Cell Biol (2002) 1.13
Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. J Biol Chem (2006) 1.12
Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle (2010) 1.10
Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222. Cancer Res (2009) 1.09
Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer. PLoS One (2007) 1.07
Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma. Cancer (2004) 1.07
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. J Cell Biol (2011) 1.06
Cdk1: the dominant sibling of Cdk2. Nat Cell Biol (2005) 1.06
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nat Cell Biol (2013) 1.04
Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer. Am J Pathol (2010) 1.02
Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes. BMC Biochem (2007) 0.99
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nat Cell Biol (2013) 0.98
Multisite phosphorylation of nuclear interaction partner of ALK (NIPA) at G2/M involves cyclin B1/Cdk1. J Biol Chem (2007) 0.94
The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain. Cell Cycle (2005) 0.93
Don't skip the G1 phase: how APC/CCdh1 keeps SCFSKP2 in check. Cell Cycle (2004) 0.93
Role of the ubiquitin proteasome system in the heart. Circ Res (2013) 0.93
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To be or not to be ubiquitinated? Cell Cycle (2004) 0.92
A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis. Trends Cell Biol (2012) 0.92
Clinical relevance of SKP2 alterations in metastatic melanoma. Pigment Cell Melanoma Res (2010) 0.92
A peptidomimetic siRNA transfection reagent for highly effective gene silencing. Mol Biosyst (2006) 0.91
The atrial natriuretic peptide genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a Mediterranean population. Diabetes Care (2013) 0.91
Fenton's pre-treatment of mature landfill leachate. Chemosphere (2004) 0.90
Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis. Adv Cancer Res (2003) 0.89
MCL1 meets its end during mitotic arrest. EMBO Rep (2011) 0.89
Skp2, the FoxO1 hunter. Cancer Cell (2005) 0.88
Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion. Genes Dev (2010) 0.87
FBH1 protects melanocytes from transformation and is deregulated in melanomas. Cell Cycle (2013) 0.86
Wnt signaling in mitosis. Dev Cell (2009) 0.86
BubR1 is modified by sumoylation during mitotic progression. J Biol Chem (2011) 0.84
Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase. J Biol Chem (2007) 0.84
The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy. Urol Oncol (2009) 0.84
APC/C (Cdh1) controls the proteasome-mediated degradation of E2F3 during cell cycle exit. Cell Cycle (2012) 0.83
The metabolic syndrome predicts cardiovascular events in subjects with normal fasting glucose: results of a 15 years follow-up in a Mediterranean population. Atherosclerosis (2007) 0.83
Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis. Nat Commun (2013) 0.81
Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A (2014) 0.81
Nutritional characteristics of a rural Southern Italy population: the Ventimiglia di Sicilia Project. J Am Coll Nutr (2002) 0.80
Prediction of incident type 2 diabetes mellitus based on a twenty-year follow-up of the Ventimiglia heart study. Acta Diabetol (2011) 0.80