Published in Brain Res Mol Brain Res on December 30, 2002
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest (2006) 2.74
Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proc Natl Acad Sci U S A (2007) 2.47
Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J (2008) 2.31
TRPC3 channels are required for synaptic transmission and motor coordination. Neuron (2008) 2.30
A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. Circ Res (2006) 2.12
TRPC channel activation by extracellular thioredoxin. Nature (2008) 1.97
Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol (2005) 1.72
A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci U S A (2009) 1.66
Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains. BMC Genomics (2006) 1.65
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proc Natl Acad Sci U S A (2004) 1.51
Direct evidence of intracrine angiotensin II signaling in neurons. Am J Physiol Cell Physiol (2014) 1.51
Progressive degeneration of dopaminergic neurons through TRP channel-induced cell death. J Neurosci (2014) 1.43
Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS One (2007) 1.41
Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. J Physiol (2006) 1.38
Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. Am J Pathol (2007) 1.29
Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Neuron (2014) 1.25
Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment. Chem Biol (2011) 1.25
Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. J Clin Invest (2012) 1.21
Arts syndrome is caused by loss-of-function mutations in PRPS1. Am J Hum Genet (2007) 1.20
Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis--a review. Eur J Pediatr (2009) 1.19
Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol (2008) 1.10
Receptor-operated cation channels formed by TRPC4 and TRPC5. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.10
Ligation of complement receptor 1 increases erythrocyte membrane deformability. Blood (2010) 1.09
Axial stretch-dependent cation entry in dystrophic cardiomyopathy: Involvement of several TRPs channels. Cell Calcium (2016) 1.07
TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP(+). Cell Calcium (2009) 1.07
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1. Pflugers Arch (2009) 1.04
TRPC channels in smooth muscle cells. Front Biosci (Landmark Ed) (2010) 1.00
TRPC channels and their implication in neurological diseases. CNS Neurol Disord Drug Targets (2010) 0.97
The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. J Biol Chem (2010) 0.94
Neurobiology of TRPC2: from gene to behavior. Pflugers Arch (2005) 0.93
Differential regulation of calcium homeostasis in adenocarcinoma cell line A549 and its Taxol-resistant subclone. Br J Pharmacol (2004) 0.93
Heteromerization of TRP channel subunits: extending functional diversity. Protein Cell (2010) 0.90
Transient receptor potential-like channels mediate metabotropic glutamate receptor EPSCs in rat dopamine neurones. J Physiol (2004) 0.90
Molecular candidates for cardiac stretch-activated ion channels. Glob Cardiol Sci Pract (2014) 0.90
Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons. J Neurophysiol (2011) 0.90
Understanding the mechanisms of proteinuria: therapeutic implications. Int J Nephrol (2012) 0.90
Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. Proc Natl Acad Sci U S A (2012) 0.89
Compartmentalization of calcium entry pathways in mouse rods. Eur J Neurosci (2005) 0.88
Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer. PLoS One (2013) 0.87
Mechanism and functional significance of TRPC channel multimerization. Semin Cell Dev Biol (2006) 0.87
Emerging roles of canonical TRP channels in neuronal function. Adv Exp Med Biol (2011) 0.87
The TRPC2 ion channel and pheromone sensing in the accessory olfactory system. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.87
Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci (2014) 0.85
Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene. J Neurosci (2011) 0.84
Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. Proc Natl Acad Sci U S A (2005) 0.84
Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons. J Neuroinflammation (2015) 0.83
Cardiac Mechano-Gated Ion Channels and Arrhythmias. Circ Res (2016) 0.82
Hyperforin attenuates brain damage induced by transient middle cerebral artery occlusion (MCAO) in rats via inhibition of TRPC6 channels degradation. J Cereb Blood Flow Metab (2012) 0.82
Riluzole activates TRPC5 channels independently of PLC activity. Br J Pharmacol (2014) 0.81
G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels. Pflugers Arch (2013) 0.81
Physiological Function and Characterization of TRPCs in Neurons. Cells (2014) 0.80
Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes. Neurotoxicology (2012) 0.80
Mechanochemical regulation of growth cone motility. Front Cell Neurosci (2015) 0.80
The role of canonical transient receptor potential channels in seizure and excitotoxicity. Cells (2014) 0.80
A rat knockout model implicates TRPC4 in visceral pain sensation. Neuroscience (2014) 0.80
TRPC1 expression and distribution in rat hearts. Eur J Histochem (2009) 0.79
Increasing the expression of calcium-permeable TRPC3 and TRPC7 channels enhances constitutive secretion. Biochem J (2008) 0.79
Differential regulation of TRPC4 in the vasopressin magnocellular system by water deprivation and hepatic cirrhosis in the rat. Am J Physiol Regul Integr Comp Physiol (2013) 0.78
Cytoskeletal regulation of TRPC channels in the cardiorenal system. Curr Hypertens Rep (2012) 0.77
Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing. Hum Genet (2009) 0.77
Mammal cells double their total RNAs against diabetes, ischemia reperfusion and malaria-induced oxidative stress. Mol Med (2010) 0.77
Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel. Handb Exp Pharmacol (2014) 0.76
TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling. J Cell Physiol (2010) 0.76
Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca(2+) Entry and Ca(2+)-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation. Front Neurosci (2017) 0.75
TRPC6 May Protect Renal Ischemia-Reperfusion Injury Through Inhibiting Necroptosis of Renal Tubular Epithelial Cells. Med Sci Monit (2016) 0.75
Chronic Treatment with Anti-bipolar Drugs Down-Regulates Gene Expression of TRPC1 in Neurones. Front Cell Neurosci (2017) 0.75
Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes. PLoS One (2014) 0.75
Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5. Stem Cells Dev (2014) 0.75
Transient Receptor Potential Canonical 1 (TRPC1) Channels as Regulators of Sphingolipid and VEGF Receptor Expression: IMPLICATIONS FOR THYROID CANCER CELL MIGRATION AND PROLIFERATION. J Biol Chem (2015) 0.75
Movement deficits and neuronal loss in basal ganglia in TRPC1 deficient mice. Oncotarget (2016) 0.75
The Outwardly Rectifying Current of Layer 5 Neocortical Neurons that was Originally Identified as "Non-Specific Cationic" Is Essentially a Potassium Current. PLoS One (2015) 0.75
The regulation of transient receptor potential canonical 4 (TRPC4) channel by phosphodiesterase 5 inhibitor via the cyclic guanosine 3'5'-monophosphate. Pflugers Arch (2017) 0.75
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 3.61
Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem (2002) 3.14
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem (2002) 2.87
Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci (2010) 2.78
The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci (2002) 2.45
Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron (2007) 2.38
Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci (2008) 2.29
Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. J Neurosci (2005) 2.05
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci (2008) 1.92
The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. J Neurosci (2008) 1.83
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol Pharmacol (2010) 1.81
The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol Cell Neurosci (2007) 1.66
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol (2004) 1.62
Tissue distribution profiles of the human TRPM cation channel family. J Recept Signal Transduct Res (2006) 1.62
Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci U S A (2005) 1.56
[3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution. Brain Res (2004) 1.54
Sensing of lysophospholipids by TRPC5 calcium channel. J Biol Chem (2005) 1.54
BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes. Mol Cell Neurosci (2003) 1.52
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol (2007) 1.51
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther (2009) 1.51
Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites. J Neurosci (2007) 1.49
Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability. J Biol Chem (2004) 1.40
Treatment strategies targeting amyloid β-protein. Cold Spring Harb Perspect Med (2012) 1.37
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther (2007) 1.30
A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner. Mol Cell Neurosci (2008) 1.30
Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke. J Cereb Blood Flow Metab (2007) 1.26
Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations. BMC Urol (2006) 1.26
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A (2007) 1.23
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem (2008) 1.22
Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons. J Physiol (2009) 1.20
Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. J Biol Chem (2002) 1.19
Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors. Proc Natl Acad Sci U S A (2010) 1.14
Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis. Neurobiol Dis (2006) 1.12
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A (2008) 1.12
Marlin-1, a novel RNA-binding protein associates with GABA receptors. J Biol Chem (2004) 1.12
The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons. J Biol Chem (2008) 1.12
Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology (2005) 1.11
The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J Biol Chem (2006) 1.11
An in vitro model of traumatic brain injury utilising two-dimensional stretch of organotypic hippocampal slice cultures. J Neurosci Methods (2005) 1.10
Unravelling the unusual signalling properties of the GABA(B) receptor. Biochem Pharmacol (2004) 1.09
Stretch-induced injury in organotypic hippocampal slice cultures reproduces in vivo post-traumatic neurodegeneration: role of glutamate receptors and voltage-dependent calcium channels. J Neurochem (2007) 1.08
Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596. Front Pharmacol (2011) 1.02
Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease. Neurobiol Aging (2011) 1.02
Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment. Eur J Neurosci (2007) 1.01
Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Neuron (2012) 1.01
Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts. Mol Pharmacol (2009) 0.99
Multiple motifs regulate the trafficking of GABA(B) receptors at distinct checkpoints within the secretory pathway. Mol Cell Neurosci (2005) 0.99
Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem (2008) 0.98
Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett (2006) 0.98
GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses. J Neurosci (2009) 0.97
Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain. Pain (2007) 0.96
The development of stroke therapeutics: promising mechanisms and translational challenges. Neuropharmacology (2008) 0.96
GABA(A) receptor membrane trafficking regulates spine maturity. Proc Natl Acad Sci U S A (2009) 0.96
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem (2012) 0.94
Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J Biol Chem (2009) 0.94
Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's disease. J Neurochem (2009) 0.94
TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res (2006) 0.94
A unified model of CA1/3 pyramidal cells: an investigation into excitability. Prog Biophys Mol Biol (2010) 0.91
Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the rat. Eur J Neurosci (2009) 0.91
Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein. Mol Brain (2010) 0.90
Regional differential effects of the novel histamine H3 receptor antagonist 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on histamine release in the central nervous system of freely moving rats. J Pharmacol Exp Ther (2009) 0.90
Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy. J Neurosci Methods (2006) 0.90
Functional modulation of GABAB receptors by protein kinases and receptor trafficking. Adv Pharmacol (2010) 0.90
Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci (2013) 0.90
Gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence. Neuropharmacology (2004) 0.90
Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory. J Neurosci (2014) 0.90
Dissociation and trafficking of rat GABAB receptor heterodimer upon chronic capsaicin stimulation. Eur J Neurosci (2007) 0.89
Lactate and glucose as energy substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices. J Neurochem (2003) 0.89
Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders. Curr Mol Pharmacol (2009) 0.88
Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP. Brain Res (2005) 0.88
A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. J Neurosci Methods (2007) 0.88
Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease. Free Radic Biol Med (2010) 0.88
11C-GSK189254: a selective radioligand for in vivo central nervous system imaging of histamine H3 receptors by PET. J Nucl Med (2009) 0.87
TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Eur J Pharmacol (2006) 0.87
Prodrugs of perzinfotel with improved oral bioavailability. J Med Chem (2009) 0.87
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J Med Chem (2010) 0.87
Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist. J Pharmacol Exp Ther (2011) 0.86
Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice. Hippocampus (2005) 0.86
Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia. J Pharmacol Exp Ther (2009) 0.86
Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice. Exp Neurol (2009) 0.86