Published in Circ Res on January 22, 2016
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease. Nat Rev Drug Discov (2016) 0.82
The Effects of Stretch Activation on Ionic Selectivity of the TREK-2 K2P K(+) Channel. Channels (Austin) (2017) 0.76
Comparing maximum rate and sustainability of pacing by mechanical vs. electrical stimulation in the Langendorff-perfused rabbit heart. Europace (2016) 0.75
Mechanically Induced Ectopy via Stretch-Activated Cation-Nonselective Channels Is Caused by Local Tissue Deformation and Results in Ventricular Fibrillation if Triggered on the Repolarization Wave Edge (Commotio Cordis). Circ Arrhythm Electrophysiol (2017) 0.75
Asymmetric mechanosensitivity in a eukaryotic ion channel. Proc Natl Acad Sci U S A (2017) 0.75
The influence of venous filling upon the rate of the heart. J Physiol (1915) 14.80
ATP-regulated K+ channels in cardiac muscle. Nature (1983) 10.05
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science (1995) 9.16
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat Rev Genet (2012) 8.55
Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. Science (1998) 7.51
Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science (1995) 6.91
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (2010) 6.29
Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. Science (2002) 5.82
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest (2004) 5.68
Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol (1984) 5.57
A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. Nature (1994) 5.46
An experimental model of sudden death due to low-energy chest-wall impact (commotio cordis) N Engl J Med (1998) 4.92
Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res (2005) 4.79
TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol (2005) 3.92
Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci (1999) 3.73
A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J (1998) 3.58
Piezo proteins are pore-forming subunits of mechanically activated channels. Nature (2012) 3.54
Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circulation (2006) 3.44
Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature (1987) 3.37
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature (2004) 3.12
Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli. Biophys J (1997) 2.98
Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol (2004) 2.94
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science (2012) 2.94
Characteristics of a membrane reservoir buffering membrane tension. Biophys J (1999) 2.93
Cell control by membrane-cytoskeleton adhesion. Nat Rev Mol Cell Biol (2001) 2.91
Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res (2004) 2.90
Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation. Biophys J (1991) 2.80
Cell surface area regulation and membrane tension. J Membr Biol (2001) 2.75
The pharmacology of mechanogated membrane ion channels. Pharmacol Rev (1996) 2.73
Properties and modulation of mammalian 2P domain K+ channels. Trends Neurosci (2001) 2.68
SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell (2014) 2.47
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat Med (2002) 2.45
Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science (2014) 2.42
MscS-like proteins control plastid size and shape in Arabidopsis thaliana. Curr Biol (2006) 2.41
Tarantula peptide inhibits atrial fibrillation. Nature (2001) 2.38
ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif. EMBO J (2005) 2.37
Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. Circ Res (2009) 2.35
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A (2006) 2.30
Eukaryotic mechanosensitive channels. Annu Rev Biophys (2010) 2.23
Cytoprotective role of Ca2+- activated K+ channels in the cardiac inner mitochondrial membrane. Science (2002) 2.23
Membrane tension in swelling and shrinking molluscan neurons. J Neurosci (1998) 2.18
Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol (2006) 2.17
Biophysics and structure of the patch and the gigaseal. Biophys J (2009) 2.15
The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle. Cardiovasc Res (2005) 2.14
Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol (2000) 2.09
TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res (2003) 2.08
Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proc Natl Acad Sci U S A (2008) 2.07
Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res (2004) 2.06
Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00
mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res (2002) 1.98
Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nat Commun (2012) 1.96
Compression-induced changes in the shape and volume of the chondrocyte nucleus. J Biomech (1995) 1.96
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry (2011) 1.93
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res (2001) 1.90
Stretch-activated ion channels: what are they? Physiology (Bethesda) (2010) 1.85
Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch (2007) 1.81
In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome. Cardiovasc Res (2007) 1.80
Part 5: Adult basic life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation (2010) 1.80
Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. J Electrocardiol (2005) 1.75
A hitchhiker's guide to mechanobiology. Dev Cell (2011) 1.72
Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation. Circ Res (2014) 1.70
TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res (2009) 1.64
Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch. Am J Physiol (1998) 1.63
Using gadolinium to identify stretch-activated channels: technical considerations. Am J Physiol (1998) 1.62
Mechanosensitive ion channels in nonspecialized cells. Rev Physiol Biochem Pharmacol (1998) 1.61
Ineffectiveness of precordial thump for cardioversion of malignant ventricular tachyarrhythmias. Pacing Clin Electrophysiol (2007) 1.59
Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol (2010) 1.58
Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models. Prog Biophys Mol Biol (1999) 1.57
Transduction of membrane tension by the ion channel alamethicin. Biophys J (1994) 1.57
Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction. Cardiovasc Res (2004) 1.57
Mechanosensitive gating of atrial ATP-sensitive potassium channels. Circ Res (1993) 1.54
Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. BMC Physiol (2005) 1.53
Mechanics and thermodynamics of biomembranes: part 1. CRC Crit Rev Bioeng (1979) 1.52
Myocardial ischemia lowers precordial thump efficacy: an inquiry into mechanisms using three-dimensional simulations. Heart Rhythm (2006) 1.51
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49
A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J (2008) 1.49
Volatile anesthetic-induced preconditioning. Perfusion (2013) 1.47
Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images. Biophys J (2008) 1.47
Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction. Circ Res (2012) 1.47
Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias. Circulation (1992) 1.46
Mechanosensitive channels: what can they do and how do they do it? Structure (2011) 1.45
Nav channel mechanosensitivity: activation and inactivation accelerate reversibly with stretch. Biophys J (2007) 1.44
Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording. Channels (Austin) (2012) 1.43
Precordial thump efficacy in termination of induced ventricular arrhythmias. Resuscitation (2008) 1.42
Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci U S A (2007) 1.41
Mechanical properties of the cell nucleus and the effect of emerin deficiency. Biophys J (2006) 1.40
Increased intraventricular pressures are as harmful as the electrophysiological substrate of heart failure in favoring sustained reentry in the swine heart. Heart Rhythm (2015) 1.40
Respiratory sinus arrhythmia in the denervated human heart. J Appl Physiol (1985) (1989) 1.39
Electrical remodeling due to atrial fibrillation in chronically instrumented conscious goats: roles of neurohumoral changes, ischemia, atrial stretch, and high rate of electrical activation. Circulation (1997) 1.37
Mechanisms of mechanically induced spontaneous arrhythmias in acute regional ischemia. Circ Res (2009) 1.36
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. J Mol Cell Cardiol (2011) 1.34
A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor-regulated channel. J Cell Biol (2003) 1.34
Translation of Otto Frank's paper "Die Grundform des Arteriellen Pulses" Zeitschrift für Biologie 37: 483-526 (1899). J Mol Cell Cardiol (1990) 1.34
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. Proc Natl Acad Sci U S A (2014) 1.34
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue. Proc Natl Acad Sci U S A (2009) 1.31
Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J Cell Sci (2010) 1.30
Effect of changes in action potential spike configuration, junctional sarcoplasmic reticulum micro-architecture and altered t-tubule structure in human heart failure. J Muscle Res Cell Motil (2006) 1.29
A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Dev Cell (2012) 1.29
ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage. Circ Res (1991) 1.29
Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways. Anesthesiology (2002) 1.28