Published in J Cell Sci on February 15, 2003
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest (2005) 3.15
Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell (2003) 2.76
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell (2005) 2.46
Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Mol Biol Cell (2005) 2.31
Microbial translocation across the GI tract. Annu Rev Immunol (2012) 2.30
Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell (2005) 2.29
Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex. Mol Biol Cell (2004) 2.05
TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration. Cell Host Microbe (2009) 1.87
LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology (2007) 1.70
Synapses: sites of cell recognition, adhesion, and functional specification. Annu Rev Biochem (2007) 1.65
A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem (2004) 1.64
Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol Biol Cell (2005) 1.57
Disruption of tight junctions and induction of proinflammatory cytokine responses in colonic epithelial cells by Campylobacter jejuni. Infect Immun (2006) 1.54
Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions. Mol Biol Cell (2007) 1.50
High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer. PLoS One (2013) 1.50
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. Mol Biol Cell (2007) 1.49
Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J Biol Chem (2009) 1.42
Organization of multiprotein complexes at cell-cell junctions. Histochem Cell Biol (2008) 1.33
Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium. Mol Biol Cell (2007) 1.27
Regulation and roles for claudin-family tight junction proteins. IUBMB Life (2009) 1.26
RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity. EMBO J (2004) 1.22
JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. Mol Biol Cell (2006) 1.20
Stimulus-induced reorganization of tight junction structure: the role of membrane traffic. Biochim Biophys Acta (2007) 1.18
Breaking into the epithelial apical-junctional complex--news from pathogen hackers. Curr Opin Cell Biol (2004) 1.15
Functional analysis of VopF activity required for colonization in Vibrio cholerae. MBio (2010) 1.14
Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. J Cell Biol (2012) 1.12
A key claudin extracellular loop domain is critical for epithelial barrier integrity. Am J Pathol (2008) 1.09
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Mol Biol Cell (2011) 1.09
Regulation of tight junction assembly and epithelial polarity by a resident protein of apical endosomes. Traffic (2010) 1.02
CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells. Mol Biol Cell (2006) 0.98
Afadin controls p120-catenin-ZO-1 interactions leading to endothelial barrier enhancement by oxidized phospholipids. J Cell Physiol (2012) 0.97
Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology. Biosci Rep (2014) 0.96
RhoGTPases, actomyosin signaling and regulation of the epithelial Apical Junctional Complex. Semin Cell Dev Biol (2014) 0.95
IBD candidate genes and intestinal barrier regulation. Inflamm Bowel Dis (2014) 0.92
The interdependence of the Rho GTPases and apicobasal cell polarity. Small GTPases (2014) 0.91
Diet, microbiome, and the intestinal epithelium: an essential triumvirate? Biomed Res Int (2013) 0.91
Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin. J Biol Chem (2012) 0.90
Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms. Tissue Barriers (2013) 0.90
Signaling to the apical membrane and to the paracellular pathway: changes in the cytosolic proteome of Aedes Malpighian tubules. J Exp Biol (2009) 0.90
Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. Am J Physiol Gastrointest Liver Physiol (2010) 0.89
Cytotoxic Necrotizing Factors (CNFs)-A Growing Toxin Family. Toxins (Basel) (2011) 0.89
The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases. PLoS Pathog (2013) 0.89
Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis. Inflamm Bowel Dis (2013) 0.87
Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration. Oxid Med Cell Longev (2013) 0.87
Endocytosis and recycling of tight junction proteins in inflammation. J Biomed Biotechnol (2010) 0.86
RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes. J Biol Chem (2008) 0.86
Cross-talk between tight and anchoring junctions-lesson from the testis. Adv Exp Med Biol (2008) 0.83
Microtubules are required for efficient epithelial tight junction homeostasis and restoration. Am J Physiol Cell Physiol (2014) 0.82
Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration. Cell Microbiol (2014) 0.82
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation. J Clin Invest (2016) 0.80
Effect of salvianolate on intestinal epithelium tight junction protein zonula occludens protein 1 in cirrhotic rats. World J Gastroenterol (2012) 0.80
Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host. Small GTPases (2014) 0.80
Interaction between the type III effector VopO and GEF-H1 activates the RhoA-ROCK pathway. PLoS Pathog (2015) 0.80
Escherichia coli cytotoxic necrotizing factor 1 inhibits intestinal epithelial wound healing in vitro after mechanical injury. Infect Immun (2004) 0.79
Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology (2016) 0.79
The role of Sonic Hedgehog as a regulator of gastric function and differentiation. Vitam Horm (2012) 0.77
Activation of RhoA in alcohol-induced intestinal barrier dysfunction. Inflammation (2013) 0.76
Alterations of the apical junctional complex and actin cytoskeleton and their role in colorectal cancer progression. Tissue Barriers (2015) 0.76
Prostate cancer cells specifically reorganize epithelial cell-fibroblast communication through proteoglycan and junction pathways. Cell Adh Migr (2016) 0.75
Research Advance in Intestinal Mucosal Barrier and Pathogenesis of Crohn's Disease. Gastroenterol Res Pract (2016) 0.75
Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. Exp Cell Res (2017) 0.75
Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk. World J Biol Chem (2016) 0.75
Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway. Exp Cell Res (2017) 0.75
Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol (2003) 4.00
Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A (2006) 3.98
CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell (2002) 2.77
Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell (2003) 2.76
JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med (2007) 2.63
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell (2005) 2.46
Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity (2010) 2.39
Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Mol Biol Cell (2005) 2.31
Invasive Escherichia coli are a feature of Crohn's disease. Lab Invest (2007) 2.27
Self-assembling cages from coiled-coil peptide modules. Science (2013) 2.24
Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J (2005) 2.17
Cytokine regulation of tight junctions. Biochim Biophys Acta (2008) 2.16
Phase coexistence and connectivity in the apical membrane of polarized epithelial cells. Proc Natl Acad Sci U S A (2006) 2.09
FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells. Proc Natl Acad Sci U S A (2006) 2.08
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice. J Clin Invest (2011) 2.08
Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex. Mol Biol Cell (2004) 2.05
Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J Biol Chem (2005) 2.03
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell (2009) 1.99
Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development. J Cell Sci (2008) 1.89
Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on beta1 integrins and Rap1 activity. J Biol Chem (2005) 1.89
Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med (2004) 1.85
Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. Nat Cell Biol (2004) 1.79
Cytoskeletal regulation of epithelial barrier function during inflammation. Am J Pathol (2010) 1.73
Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol (2008) 1.72
A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions. PLoS One (2007) 1.72
RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am J Physiol Cell Physiol (2004) 1.65
Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. Mol Biol Cell (2009) 1.61
Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci (2006) 1.59
Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol Biol Cell (2005) 1.57
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest (2012) 1.57
Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER. J Cell Sci (2009) 1.56
Nanoparticles can cause DNA damage across a cellular barrier. Nat Nanotechnol (2009) 1.56
Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem (2006) 1.55
Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers. Bioessays (2005) 1.52
Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions. Mol Biol Cell (2007) 1.50
SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting. Semin Cell Dev Biol (2009) 1.49
Regulation of the intestinal epithelial barrier by the apical junctional complex. Curr Opin Gastroenterol (2006) 1.48
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. Free Radic Biol Med (2009) 1.41
PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest (2009) 1.41
FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. J Cell Biol (2005) 1.40
Helicobacter pylori counteracts the apoptotic action of its VacA toxin by injecting the CagA protein into gastric epithelial cells. PLoS Pathog (2009) 1.40
The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair. Gastroenterology (2011) 1.39
Leukocyte transendothelial migration: a junctional affair. Semin Immunol (2002) 1.39
Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol (2011) 1.38
Regulation of epithelial apical junctional complex by Rho family GTPases. Front Biosci (Landmark Ed) (2009) 1.34
Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42. J Immunol (2007) 1.33
Microtubules regulate disassembly of epithelial apical junctions. BMC Cell Biol (2006) 1.31
Helicobacter pylori VacA cytotoxin: a probe for a clathrin-independent and Cdc42-dependent pinocytic pathway routed to late endosomes. Mol Biol Cell (2005) 1.30
JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. Mol Biol Cell (2004) 1.29
Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases. Proc Natl Acad Sci U S A (2011) 1.28
SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation. Traffic (2011) 1.27
Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium. Mol Biol Cell (2007) 1.27
Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration. J Immunol (2008) 1.26
Recent advances in high-pressure freezing: equipment- and specimen-loading methods. Methods Mol Biol (2007) 1.25
The role of endothelial cell lateral junctions during leukocyte trafficking. Immunol Rev (2002) 1.22
Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis. Immunity (2012) 1.21
Caveolin-1 is required for fatty acid translocase (FAT/CD36) localization and function at the plasma membrane of mouse embryonic fibroblasts. Biochim Biophys Acta (2006) 1.19
Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol (2008) 1.18
Early endosomes associated with dynamic F-actin structures are required for late trafficking of H. pylori VacA toxin. J Cell Biol (2007) 1.17
Cis-dimerization mediates function of junctional adhesion molecule A. Mol Biol Cell (2008) 1.17
Myosin II regulates the shape of three-dimensional intestinal epithelial cysts. J Cell Sci (2008) 1.16
Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics. Am J Surg Pathol (2002) 1.15
Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signaling. Am J Pathol (2007) 1.15
Long-chain fatty acid uptake into adipocytes depends on lipid raft function. Biochemistry (2004) 1.14
ICAM-1: targeted docking for exogenous as well as endogenous ligands. Adv Drug Deliv Rev (2004) 1.14
Dynamic regulation of epithelial cell fate and barrier function by intercellular junctions. Ann N Y Acad Sci (2009) 1.14
Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3. J Biol Chem (2011) 1.13
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest (2015) 1.13
Citrobacter rodentium lifA/efa1 is essential for colonic colonization and crypt cell hyperplasia in vivo. Infect Immun (2005) 1.11
Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility. BMC Cell Biol (2009) 1.11
Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology (2011) 1.10
The second loop of occludin is required for suppression of Raf1-induced tumor growth. Oncogene (2005) 1.10
Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils. J Biol Chem (2004) 1.09
Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion. Am J Pathol (2009) 1.09
A key claudin extracellular loop domain is critical for epithelial barrier integrity. Am J Pathol (2008) 1.09
Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling. Cell Host Microbe (2012) 1.08
Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett (2003) 1.08
Commensal-epithelial signaling mediated via formyl peptide receptors. Am J Pathol (2010) 1.08
Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. Mol Biol Cell (2009) 1.08
Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling. Mol Biol Cell (2011) 1.07
Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium. Am J Pathol (2009) 1.07
JAM-A regulates epithelial proliferation through Akt/β-catenin signalling. EMBO Rep (2011) 1.07
RAS testing of colorectal carcinoma—a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group. J Clin Pathol (2014) 1.07
Expression of cnf1 by Escherichia coli J96 involves a large upstream DNA region including the hlyCABD operon, and is regulated by the RfaH protein. Mol Microbiol (2003) 1.06
Tight junctions and cell-cell interactions. Methods Mol Biol (2006) 1.04
Organized migration of epithelial cells requires control of adhesion and protrusion through Rho kinase effectors. Am J Physiol Gastrointest Liver Physiol (2006) 1.03
Neutrophil migration across intestinal epithelium: evidence for a role of CD44 in regulating detachment of migrating cells from the luminal surface. J Immunol (2010) 1.03
Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. J Biol Chem (2003) 1.03
The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruption. Novartis Found Symp (2004) 1.03
NAD binding induces conformational changes in Rho ADP-ribosylating clostridium botulinum C3 exoenzyme. J Biol Chem (2002) 1.03
Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating occludin, claudin-1 and E-cadherin expression. Biochem Biophys Res Commun (2010) 1.01
Lipid rafts mediate internalization of beta1-integrin in migrating intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2008) 1.01
Intracellular membrane traffic at high resolution. Methods Cell Biol (2010) 1.00
Mice lacking the nuclear pore complex protein ALADIN show female infertility but fail to develop a phenotype resembling human triple A syndrome. Mol Cell Biol (2006) 0.99
Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation. Am J Pathol (2009) 0.99
A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes. J Cell Sci (2013) 0.99
The life and death of epithelia during inflammation: lessons learned from the gut. Annu Rev Pathol (2011) 0.99
Introduction to correlative light and electron microscopy. Methods Cell Biol (2012) 0.99
CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells. Mol Biol Cell (2006) 0.98
Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda. Inflamm Bowel Dis (2013) 0.97