Published in World J Biol Chem on February 26, 2016
Rho GTPases and the actin cytoskeleton. Science (1998) 28.19
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell (1995) 24.99
Cell migration: a physically integrated molecular process. Cell (1996) 23.49
ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer (2005) 16.73
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science (1997) 14.41
Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell (1993) 13.21
CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol (2003) 9.13
Origins of cell polarity. Cell (1996) 7.99
GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol (1993) 5.86
Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science (2003) 5.23
Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol Biol Cell (1998) 5.00
Paxillin: a new vinculin-binding protein present in focal adhesions. J Cell Biol (1990) 4.75
Tight junctions and cell polarity. Annu Rev Cell Dev Biol (2006) 4.39
Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol (2007) 4.28
Regulation of development and differentiation by the extracellular matrix. Development (1993) 4.13
Helicobacter exploits integrin for type IV secretion and kinase activation. Nature (2007) 4.02
Junction adhesion molecule is a receptor for reovirus. Cell (2001) 4.00
Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol (2010) 3.97
Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro. Breast Cancer Res Treat (2007) 3.83
Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene (2008) 3.63
Structural basis for vinculin activation at sites of cell adhesion. Nature (2004) 3.62
Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev (2009) 3.57
New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol Rev (1999) 3.51
Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol (2011) 3.36
Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. Cell Host Microbe (2007) 3.34
Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways. Trends Cell Biol (2006) 3.07
Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev (2013) 3.07
Crosstalk of tight junction components with signaling pathways. Biochim Biophys Acta (2007) 3.04
Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J Cell Biol (2002) 2.99
Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol (2008) 2.93
CD44 cell adhesion molecules. Mol Pathol (1999) 2.89
Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection. Cancer Res (2007) 2.84
Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol (2011) 2.82
Desmosomes: new perspectives on a classic. J Invest Dermatol (2007) 2.78
Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling. J Cell Biol (2011) 2.67
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nat Cell Biol (2001) 2.57
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol (2002) 2.50
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer (2002) 2.38
Vinculin is part of the cadherin-catenin junctional complex: complex formation between alpha-catenin and vinculin. J Cell Biol (1998) 2.33
Desmosome structure, composition and function. Biochim Biophys Acta (2007) 2.31
Extracellular matrix and integrin signalling: the shape of things to come. Biochem J (1999) 2.28
Are desmosomes more than tethers for intermediate filaments? Nat Rev Mol Cell Biol (2000) 2.20
Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain. Proc Natl Acad Sci U S A (2004) 2.19
Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J (2005) 2.17
The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res (2001) 2.14
Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res (2000) 2.14
Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal (2006) 2.09
Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. Am J Pathol (2006) 2.07
Transmembrane proteins of tight junctions. Biochim Biophys Acta (2007) 2.02
Mechanisms of integrin activation and trafficking. Curr Opin Cell Biol (2011) 2.00
Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev (2012) 1.96
Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry. Biochim Biophys Acta (2004) 1.85
Rho family GTPases. Biochem Soc Trans (2012) 1.85
Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol (2005) 1.85
Integrins and cadherins join forces to form adhesive networks. J Cell Sci (2011) 1.82
Molecular bases of cell-cell junctions stability and dynamics. Cold Spring Harb Perspect Biol (2009) 1.78
Molecular components of the adherens junction. Biochim Biophys Acta (2008) 1.78
Role of epidermal growth factor receptor in breast cancer. Breast Cancer Res Treat (2012) 1.77
Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin. Gastroenterology (2001) 1.75
Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function. J Cell Sci (2003) 1.70
MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide. Biochem J (2006) 1.66
Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4. Am J Pathol (2004) 1.66
Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. Mol Biol Cell (2009) 1.61
Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res (2006) 1.61
Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci (2010) 1.60
MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell (2005) 1.59
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res (2004) 1.58
Targeting Src in breast cancer. Ann Oncol (2008) 1.57
Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling. Nat Rev Mol Cell Biol (2014) 1.53
Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells. Cancer Res (1999) 1.48
New insights into vinculin function and regulation. Int Rev Cell Mol Biol (2011) 1.47
Tight junctions at a glance. J Cell Sci (2008) 1.46
Vinculin, an adapter protein in control of cell adhesion signalling. Eur J Cell Biol (2010) 1.44
Beta1 integrin mediates internalization of mammalian reovirus. J Virol (2006) 1.43
Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Mol Biol Cell (2004) 1.39
Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review). Mol Membr Biol (2008) 1.39
Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases. Breast Cancer Res (2000) 1.37
Cell-cell connectivity: desmosomes and disease. J Pathol (2011) 1.36
The presence of human coxsackievirus and adenovirus receptor is associated with efficient adenovirus-mediated transgene expression in human melanoma cell cultures. Hum Gene Ther (1998) 1.36
Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines. Cancer Res (2001) 1.36
E-cadherin adhesion activates c-Src signaling at cell-cell contacts. Mol Biol Cell (2007) 1.33
Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells. Mol Biol Cell (2002) 1.32
Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin. Cancer Res (2005) 1.28
Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling. J Biol Chem (2013) 1.27
Structure of reovirus sigma1 in complex with its receptor junctional adhesion molecule-A. PLoS Pathog (2008) 1.25
SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther (2008) 1.23
Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase. Eur J Cancer (2000) 1.23
Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion. Mol Cell Biol (2007) 1.22
Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods Enzymol (2006) 1.22
Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. J Cell Biol (2012) 1.20
The nonreceptor tyrosine kinase fer mediates cross-talk between N-cadherin and beta1-integrins. J Cell Biol (2000) 1.19
Unmasking of intestinal epithelial lateral membrane beta1 integrin consequent to transepithelial neutrophil migration in vitro facilitates inv-mediated invasion by Yersinia pseudotuberculosis. Infect Immun (1997) 1.18
A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One (2013) 1.17
The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells. J Cell Sci (2004) 1.17
Syndecans as cell surface receptors: Unique structure equates with functional diversity. Matrix Biol (2010) 1.16
Insulin-like growth factor-I receptor, E-cadherin and alpha v integrin form a dynamic complex under the control of alpha-catenin. Int J Cancer (2008) 1.15
Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase. Breast Cancer Res (2011) 1.15
Hijacking of Rho GTPases during bacterial infection. Exp Cell Res (2013) 1.15