Published in J Biol Chem on January 24, 2003
Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. PLoS One (2012) 1.48
Inhibition of intracellular clusterin attenuates cell death in nephropathic cystinosis. J Am Soc Nephrol (2014) 1.46
Radioadaptive response revisited. Radiat Environ Biophys (2006) 1.41
Targeting the cytoprotective chaperone, clusterin, for treatment of advanced cancer. Clin Cancer Res (2010) 1.22
Advances and challenges in basic and translational research on clusterin. Cancer Res (2009) 1.20
Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. J Natl Cancer Inst (2009) 1.19
Genetics of clusterin isoform expression and Alzheimer's disease risk. PLoS One (2012) 1.18
Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res (2009) 1.16
Application of proteomics in the discovery of candidate protein biomarkers in a diabetes autoantibody standardization program sample subset. J Proteome Res (2007) 1.16
Clusterin: a key player in cancer chemoresistance and its inhibition. Onco Targets Ther (2014) 1.07
Increased clusterin expression in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci (2008) 1.04
Effects of clusterin over-expression on metastatic progression and therapy in breast cancer. BMC Cancer (2010) 1.01
Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control. J Mol Histol (2006) 1.00
Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease. Pediatr Cardiol (2010) 0.99
New insights into the mechanisms of green tea catechins in the chemoprevention of prostate cancer. Nutr Cancer (2011) 0.98
Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation. Am J Pathol (2012) 0.95
Alzheimer's risk variants in the clusterin gene are associated with alternative splicing. Transl Psychiatry (2011) 0.94
Clusterin in human gut-associated lymphoid tissue, tonsils, and adenoids: localization to M cells and follicular dendritic cells. Histochem Cell Biol (2007) 0.94
Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling. J Mol Signal (2007) 0.92
Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro. Int J Nanomedicine (2006) 0.91
Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway. J Biol Chem (2013) 0.91
Clusterin attenuates the development of renal fibrosis. J Am Soc Nephrol (2011) 0.90
Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. J Biol Chem (2011) 0.90
Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression. World J Gastroenterol (2005) 0.88
Identification of clusterin domain involved in NF-kappaB pathway regulation. J Biol Chem (2009) 0.88
The role of stress proteins in prostate cancer. Curr Genomics (2007) 0.88
Clusterin confers gemcitabine resistance in pancreatic cancer. World J Surg Oncol (2011) 0.88
Clusterin overexpression in both malignant and nonmalignant prostate epithelial cells induces cell cycle arrest and apoptosis. Br J Cancer (2004) 0.87
Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation. Mol Cell Biol (2008) 0.87
Trichinella spiralis: nurse cell formation with emphasis on analogy to muscle cell repair. Parasit Vectors (2008) 0.86
Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Res (2014) 0.85
Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. FEBS J (2009) 0.84
Alterations in expression, proteolysis and intracellular localizations of clusterin in esophageal squamous cell carcinoma. World J Gastroenterol (2004) 0.84
Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin. Biochem J (2004) 0.84
Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression. Cell Cycle (2009) 0.84
The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. J Mol Histol (2008) 0.83
Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer. Biochim Biophys Acta (2007) 0.82
Functional proteomic analysis of seminal plasma proteins in men with various semen parameters. Reprod Biol Endocrinol (2013) 0.82
Gene expression profiling of mouse teratocarcinomas uncovers epigenetic changes associated with the transformation of mouse embryonic stem cells. Neoplasia (2004) 0.82
Proapoptotic role of nuclear clusterin in brain. Anat Cell Biol (2011) 0.82
Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-κB signaling pathway. PLoS One (2013) 0.81
CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem (2011) 0.81
Mass spectrometry quantification of clusterin in the human brain. Mol Neurodegener (2012) 0.81
Exon-skipping strategy by ratio modulation between cytoprotective versus pro-apoptotic clusterin forms increased sensitivity of LNCaP to cell death. PLoS One (2013) 0.80
Role of Chemotherapy and Mechanisms of Resistance to Chemotherapy in Metastatic Castration-Resistant Prostate Cancer. Clin Med Insights Oncol (2016) 0.80
Research in castration-resistant prostate cancer: what does the future hold? Curr Oncol (2010) 0.79
Plasma Clusterin and Lipid Profile: A Link with Aging and Cardiovascular Diseases in a Population with a Consistent Number of Centenarians. PLoS One (2015) 0.79
Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker. Proteome Sci (2009) 0.79
eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells. Oncotarget (2016) 0.79
pVHL mediates K63-linked ubiquitination of nCLU. PLoS One (2012) 0.78
mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer. J Cell Physiol (2012) 0.78
miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin. Sci Rep (2016) 0.77
Expression of the protein chaperone, clusterin, in spinal cord cells constitutively and following cellular stress, and upregulation by treatment with Hsp90 inhibitor. Cell Stress Chaperones (2013) 0.77
CLU blocks HDACI-mediated killing of neuroblastoma. Tumour Biol (2010) 0.77
Hypoxia inducible factor-1α directly regulates nuclear clusterin transcription by interacting with hypoxia response elements in the clusterin promoter. Mol Cells (2014) 0.76
Nucleofection of rat pheochromocytoma PC-12 cells with human mutated beta-amyloid precursor protein gene (APP-sw) leads to reduced viability, autophagy-like process, and increased expression and secretion of beta amyloid. Biomed Res Int (2015) 0.76
Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations. Mol Neurodegener (2015) 0.76
Differential age-associated regulation of clusterin expression in prostate lobes of brown Norway rats. Prostate (2009) 0.76
Presence, localization, and origin of clusterin in normal human spermatozoa. J Assist Reprod Genet (2012) 0.76
Effects of female sex hormones on clusterin expression and paclitaxel resistance in endometrial cancer cell lines. Int J Med Sci (2011) 0.76
Se-methylselenocysteine inhibits apoptosis induced by clusterin knockdown in neuroblastoma N2a and SH-SY5Y cell lines. Int J Mol Sci (2014) 0.75
Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases. Neuropathol Appl Neurobiol (2015) 0.75
Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression. Sci Rep (2017) 0.75
Green tea and the risk of prostate cancer: A systematic review and meta-analysis. Medicine (Baltimore) (2017) 0.75
Clusterin: Review of research progress and looking ahead to direction in hepatocellular carcinoma. World J Gastroenterol (2015) 0.75
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. Neurobiol Aging (2015) 0.75
Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response. PLoS One (2014) 0.75
Proteomics analysis of pleomorphic adenoma of the human parotid gland. Eur Arch Otorhinolaryngol (2017) 0.75
Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways. Proc Natl Acad Sci U S A (2017) 0.75
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Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med (2011) 6.35
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Global diversity in the human salivary microbiome. Genome Res (2009) 5.16
Metabolite identification via the Madison Metabolomics Consortium Database. Nat Biotechnol (2008) 5.12
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest (2008) 4.12
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol (2011) 4.09
Modification of kidney barrier function by the urokinase receptor. Nat Med (2007) 4.01
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett (2006) 3.94
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The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med (2011) 3.19
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
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Circulating suPAR in two cohorts of primary FSGS. J Am Soc Nephrol (2012) 2.83
Retracted Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat Cell Biol (2003) 2.83
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Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients. J Infect Dis (2012) 2.53
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A (2003) 2.50
Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem (2011) 2.46
N-Benzyl-2-(2,6-dichloro-phen-oxy)-acetamide. Acta Crystallogr Sect E Struct Rep Online (2008) 2.36
Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol (2006) 2.32
Control of the pattern-recognition receptor EFR by an ER protein complex in plant immunity. EMBO J (2009) 2.28
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Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci U S A (2007) 2.20
Project management system for structural and functional proteomics: Sesame. J Struct Funct Genomics (2003) 2.19
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Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Am J Physiol Lung Cell Mol Physiol (2002) 2.19
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A (2010) 2.16
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A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. Circ Res (2006) 2.12
A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma. Ann Surg Oncol (2006) 2.10
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The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res (2009) 2.08
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Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease. Environ Health Perspect (2012) 2.05
Learning brain connectivity of Alzheimer's disease by sparse inverse covariance estimation. Neuroimage (2010) 2.04
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TRPC channel activation by extracellular thioredoxin. Nature (2008) 1.97
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An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. Proc Natl Acad Sci U S A (2007) 1.92
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DNA mismatch repair initiates 6-thioguanine--induced autophagy through p53 activation in human tumor cells. Clin Cancer Res (2007) 1.85
Phase I study of ON 01910.Na, a novel modulator of the Polo-like kinase 1 pathway, in adult patients with solid tumors. J Clin Oncol (2008) 1.84
A conserved Tyr residue is required for sugar selectivity in a Pol alpha DNA polymerase. Biochemistry (2002) 1.81
Using spatial principles to optimize distributed computing for enabling the physical science discoveries. Proc Natl Acad Sci U S A (2011) 1.81
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Beta-AMYLASE4, a noncatalytic protein required for starch breakdown, acts upstream of three active beta-amylases in Arabidopsis chloroplasts. Plant Cell (2008) 1.72
Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions. Biochem Biophys Res Commun (2006) 1.72
The WRKY family of transcription factors in rice and Arabidopsis and their origins. DNA Res (2005) 1.70
Overexpression of the R2 subunit of ribonucleotide reductase in human nasopharyngeal cancer cells reduces radiosensitivity. Cancer J (2003) 1.69
Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. Nat Neurosci (2011) 1.66
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Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. Cancer Res (2009) 1.64
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Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation. Mol Cell (2005) 1.58
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Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol (2009) 1.56
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