Published in Drug Discov Today on February 15, 2003
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med (2006) 2.13
Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nat Chem Biol (2006) 2.08
PANDORA: keyword-based analysis of protein sets by integration of annotation sources. Nucleic Acids Res (2003) 1.31
Development of an ischemic tolerance model in a PC12 cell line. J Cereb Blood Flow Metab (2005) 1.25
Surfection: a new platform for transfected cell arrays. Nucleic Acids Res (2004) 0.97
Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. Annu Rev Pharmacol Toxicol (2015) 0.89
High-content phenotypic screenings to identify inhibitors of Candida albicans biofilm formation and filamentation. Pathog Dis (2014) 0.82
Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells. Cancer Cell Int (2010) 0.81
Integrative analysis of intraerythrocytic differentially expressed transcripts yields novel insights into the biology of Plasmodium falciparum. Malar J (2003) 0.80
Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan. Tetrahedron (2013) 0.79
The Use of Omic Technologies Applied to Traditional Chinese Medicine Research. Evid Based Complement Alternat Med (2017) 0.75
DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing. BMC Bioinformatics (2016) 0.75
Design and synthesis of biologically active peptides: a 'tail' of amino acids can modulate activity of synthetic cyclic peptides. Peptides (2011) 0.75
INTEGRATING COMPUTATIONAL PROTEIN FUNCTION PREDICTION INTO DRUG DISCOVERY INITIATIVES. Drug Dev Res (2011) 0.75
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell (2008) 8.41
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A (2006) 2.51
Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A (2003) 2.45
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. J Biol Chem (2009) 1.91
Human Cep192 is required for mitotic centrosome and spindle assembly. Curr Biol (2007) 1.81
Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res (2009) 1.79
Identification of p53 regulators by genome-wide functional analysis. Proc Natl Acad Sci U S A (2004) 1.48
Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells. Genome Biol (2008) 1.46
Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening. Virology (2007) 1.04
Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus. Mol Cell Biol (2003) 1.02
Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J Clin Endocrinol Metab (2003) 0.99
Identification and characterization of a small molecule antagonist of human VPAC(2) receptor. Mol Pharmacol (2009) 0.94
A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. Anal Biochem (2009) 0.92
Parsimonious discovery of synergistic drug combinations. ACS Chem Biol (2011) 0.89
Learning from the data: mining of large high-throughput screening databases. J Chem Inf Model (2006) 0.89
HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1. Curr Chem Genomics (2010) 0.85
Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening. PLoS One (2009) 0.83
PDX1, a cellular homeoprotein, binds to and regulates the activity of human cytomegalovirus immediate early promoter. J Biol Chem (2004) 0.82
Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes. Virology (2007) 0.80
An intracellular conformational sensor assay for Abl T315I. Anal Biochem (2008) 0.78
Cellular Ser/Thr-kinase assays using generic peptide substrates. Curr Chem Genomics (2008) 0.77
An interview with Jeremy S. Caldwell. Assay Drug Dev Technol (2008) 0.75
Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4. Anal Biochem (2009) 0.75