Published in Science on February 14, 2003
Crystal structures of Fe2+ dioxygenase superoxo, alkylperoxo, and bound product intermediates. Science (2007) 3.03
The 2-His-1-carboxylate facial triad: a versatile platform for dioxygen activation by mononuclear non-heme iron(II) enzymes. J Biol Inorg Chem (2005) 2.82
Finding intermediates in the O2 activation pathways of non-heme iron oxygenases. Acc Chem Res (2007) 2.64
Versatility of biological non-heme Fe(II) centers in oxygen activation reactions. Nat Chem Biol (2008) 2.64
A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase. Biochemistry (2008) 2.09
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase. Proc Natl Acad Sci U S A (2006) 1.91
Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of Mycobacterium tuberculosis. J Biol Chem (2009) 1.64
Synthetic analogues of cysteinate-ligated non-heme iron and non-corrinoid cobalt enzymes. Chem Rev (2004) 1.54
Mechanism of extradiol aromatic ring-cleaving dioxygenases. Curr Opin Struct Biol (2008) 1.43
Structure and reactivity of a mononuclear non-haem iron(III)-peroxo complex. Nature (2011) 1.40
Gene-targeted-metagenomics reveals extensive diversity of aromatic dioxygenase genes in the environment. ISME J (2009) 1.31
Peroxo and oxo intermediates in mononuclear nonheme iron enzymes and related active sites. Curr Opin Chem Biol (2009) 1.26
Crystal structure of the terminal oxygenase component of cumene dioxygenase from Pseudomonas fluorescens IP01. J Bacteriol (2005) 1.23
Mechanism of action of a flavin-containing monooxygenase. Proc Natl Acad Sci U S A (2006) 1.20
Radical intermediates in monooxygenase reactions of rieske dioxygenases. J Am Chem Soc (2007) 1.20
Hydrogen peroxide dependent cis-dihydroxylation of benzoate by fully oxidized benzoate 1,2-dioxygenase. Biochemistry (2007) 1.16
Mononuclear metal-O2 complexes bearing macrocyclic N-tetramethylated cyclam ligands. Acc Chem Res (2012) 1.15
Characterization of biphenyl dioxygenase of Pandoraea pnomenusa B-356 as a potent polychlorinated biphenyl-degrading enzyme. J Bacteriol (2007) 1.14
Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proc Natl Acad Sci U S A (2014) 1.13
Oxy intermediates of homoprotocatechuate 2,3-dioxygenase: facile electron transfer between substrates. Biochemistry (2011) 1.07
Pinpointing biphenyl dioxygenase residues that are crucial for substrate interaction. J Bacteriol (2003) 1.04
Reduction of dioxygen by enzymes containing copper. J Biol Inorg Chem (2006) 1.04
Observation of Fe(V)=O using variable-temperature mass spectrometry and its enzyme-like C-H and C=C oxidation reactions. Nat Chem (2011) 1.04
Crystallographic, spectroscopic, and computational analysis of a flavin C4a-oxygen adduct in choline oxidase. Biochemistry (2009) 1.04
Structural investigations of the ferredoxin and terminal oxygenase components of the biphenyl 2,3-dioxygenase from Sphingobium yanoikuyae B1. BMC Struct Biol (2007) 1.02
Biochemistry. How iron activates O2. Science (2003) 1.02
A theoretical study of the cis-dihydroxylation mechanism in naphthalene 1,2-dioxygenase. J Biol Inorg Chem (2004) 0.99
Metal-dioxygen and metal-dinitrogen complexes: where are the electrons? Dalton Trans (2010) 0.97
Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase. Proc Natl Acad Sci U S A (2016) 0.97
Near-IR MCD of the nonheme ferrous active site in naphthalene 1,2-dioxygenase: correlation to crystallography and structural insight into the mechanism of Rieske dioxygenases. J Am Chem Soc (2008) 0.96
Structural insight into the substrate- and dioxygen-binding manner in the catalytic cycle of rieske nonheme iron oxygenase system, carbazole 1,9a-dioxygenase. BMC Struct Biol (2012) 0.96
A Mononuclear Nonheme Iron(III)-Peroxo Complex Binding Redox-Inactive Metal Ions. Chem Sci (2013) 0.96
O(2)-evolving chlorite dismutase as a tool for studying O(2)-utilizing enzymes. Biochemistry (2012) 0.95
Purification, characterization, and crystallization of the components of the nitrobenzene and 2-nitrotoluene dioxygenase enzyme systems. Appl Environ Microbiol (2005) 0.93
Comparison of high-spin and low-spin nonheme Fe(III)-OOH complexes in O-O bond homolysis and H-atom abstraction reactivities. J Am Chem Soc (2013) 0.92
Spectroscopic studies of the mononuclear non-heme Fe(II) enzyme FIH: second-sphere contributions to reactivity. J Am Chem Soc (2013) 0.92
The "bridging" aspartate 178 in phthalate dioxygenase facilitates interactions between the Rieske center and the iron(II)--mononuclear center. Biochemistry (2006) 0.91
Structural basis for regioselectivity and stereoselectivity of product formation by naphthalene 1,2-dioxygenase. J Bacteriol (2006) 0.90
Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system. Acta Crystallogr D Biol Crystallogr (2008) 0.90
Oxygen activation at mononuclear nonheme iron centers: a superoxo perspective. Inorg Chem (2010) 0.90
Subtle difference between benzene and toluene dioxygenases of Pseudomonas putida. Appl Environ Microbiol (2005) 0.88
The oxo/peroxo debate: a nonheme iron perspective. J Biol Inorg Chem (2004) 0.88
Crystal structure of dicamba monooxygenase: a Rieske nonheme oxygenase that catalyzes oxidative demethylation. J Mol Biol (2009) 0.88
Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase. Proc Natl Acad Sci U S A (2014) 0.87
Structure and increased thermostability of Rhodococcus sp. naphthalene 1,2-dioxygenase. J Bacteriol (2005) 0.87
Structural insight into the expanded PCB-degrading abilities of a biphenyl dioxygenase obtained by directed evolution. J Mol Biol (2010) 0.86
Retuning Rieske-type oxygenases to expand substrate range. J Biol Chem (2011) 0.85
NO binding to naphthalene dioxygenase. J Biol Inorg Chem (2005) 0.85
Structural characterization of Pandoraea pnomenusa B-356 biphenyl dioxygenase reveals features of potent polychlorinated biphenyl-degrading enzymes. PLoS One (2013) 0.85
Phylogenetic analysis reveals the surprising diversity of an oxygenase class. J Biol Inorg Chem (2011) 0.84
Saturation mutagenesis of Burkholderia cepacia R34 2,4-dinitrotoluene dioxygenase at DntAc valine 350 for synthesizing nitrohydroquinone, methylhydroquinone, and methoxyhydroquinone. Appl Environ Microbiol (2004) 0.84
Probing the substrate specificity of aminopyrrolnitrin oxygenase (PrnD) by mutational analysis. J Bacteriol (2006) 0.84
Kinetic analysis of the conversion of nonheme (alkylperoxo)iron(III) species to iron(IV) complexes. Inorg Chem (2007) 0.83
Mono- and binuclear non-heme iron chemistry from a theoretical perspective. J Biol Inorg Chem (2016) 0.82
X-ray absorption spectroscopy and reactivity of thiolate-ligated Fe(III)-OOR complexes. Inorg Chem (2010) 0.82
Crystallographic snapshots of the reaction of aromatic C-H with O(2) catalysed by a protein-bound iron complex. Nat Chem (2010) 0.82
Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases. ACS Catal (2013) 0.80
Crystallization and preliminary X-ray diffraction studies of the reduced form of the terminal oxygenase component of the Rieske nonhaem iron oxygenase system carbazole 1,9a-dioxygenase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.80
Pleiotropic and epistatic behavior of a ring-hydroxylating oxygenase system in the polycyclic aromatic hydrocarbon metabolic network from Mycobacterium vanbaalenii PYR-1. J Bacteriol (2014) 0.80
Rate-Determining Attack on Substrate Precedes Rieske Cluster Oxidation during Cis-Dihydroxylation by Benzoate Dioxygenase. Biochemistry (2015) 0.80
3-Ketosteroid 9α-hydroxylase enzymes: Rieske non-heme monooxygenases essential for bacterial steroid degradation. Antonie Van Leeuwenhoek (2014) 0.80
Epoxide formation on the aromatic B ring of flavanone by biphenyl dioxygenase of Pseudomonas pseudoalcaligenes KF707. Appl Environ Microbiol (2005) 0.79
Crystallographic and spectroscopic characterization and reactivities of a mononuclear non-haem iron(III)-superoxo complex. Nat Commun (2014) 0.78
Activation of Dioxygen by Iron and Manganese Complexes: A Heme and Nonheme Perspective. J Am Chem Soc (2016) 0.78
First- and second-sphere contributions to Fe(II) site activation by cosubstrate binding in non-heme Fe enzymes. Dalton Trans (2014) 0.77
Re-evaluation of dioxygenase gene phylogeny for the development and validation of a quantitative assay for environmental aromatic hydrocarbon degraders. FEMS Microbiol Ecol (2015) 0.77
Crystallographic evidence for dioxygen interactions with iron proteins. J Biol Inorg Chem (2007) 0.77
Dioxygen activation by nonheme iron enzymes with the 2-His-1-carboxylate facial triad that generate high-valent oxoiron oxidants. J Biol Inorg Chem (2017) 0.77
A DFT study of the cis-dihydroxylation of nitroaromatic compounds catalyzed by nitrobenzene dioxygenase. J Phys Chem B (2014) 0.76
Structural basis of the divergent oxygenation reactions catalyzed by the rieske nonheme iron oxygenase carbazole 1,9a-dioxygenase. Appl Environ Microbiol (2014) 0.76
Molecular Dynamics Simulation of Nitrobenzene Dioxygenase Using AMBER Force Field. J Chem Theory Comput (2014) 0.76
Substrate specificities and conformational flexibility of 3-ketosteroid 9α-hydroxylases. J Biol Chem (2014) 0.76
Oxygen activation by mononuclear nonheme iron dioxygenases involved in the degradation of aromatics. J Biol Inorg Chem (2017) 0.75
The Catalytic Function of Nonheme Iron (III) Complex for Hydrocarbon Oxidation. Bioinorg Chem Appl (2010) 0.75
O2 Activation by Non-Heme Iron Enzymes. Biochemistry (2016) 0.75
Distal end of 105-125 loop--a putative reductase binding domain of phthalate dioxygenase. Arch Biochem Biophys (2009) 0.75
Structural Basis of the Enhanced Pollutant-Degrading Capabilities of an Engineered Biphenyl Dioxygenase. J Bacteriol (2016) 0.75
Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology. Curr Opin Chem Biol (2016) 0.75
Theoretical approach to the innovative mutation of naphthalene 1,2-dioxygenase: a molecular dynamics and docking study. J Mol Model (2014) 0.75
The iron-sulfur core in Rieske proteins is not symmetric. J Biol Inorg Chem (2014) 0.75
Reply to Kiser: Dioxygen binding in NOV1 crystal structures. Proc Natl Acad Sci U S A (2017) 0.75
One enzyme, many reactions: structural basis for the various reactions catalyzed by naphthalene 1,2-dioxygenase. IUCrJ (2017) 0.75
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex. Science (1998) 6.53
Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol (2000) 5.22
Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid. Science (1998) 3.81
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol (2000) 3.42
Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase. Structure (1998) 3.10
Negligible genetic diversity of mycobacterium tuberculosis host immune system protein targets: evidence of limited selective pressure. Genetics (2000) 2.63
Structure of a cephalosporin synthase. Nature (1998) 2.59
Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations. Proc Natl Acad Sci U S A (2004) 2.43
Selection of antibiotic-resistant bacterial mutants: allelic diversity among fluoroquinolone-resistant mutations. J Infect Dis (2000) 2.35
Rieske business: structure-function of Rieske non-heme oxygenases. Biochem Biophys Res Commun (2005) 2.24
Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru. Tuber Lung Dis (1998) 2.09
Complex transmission dynamics of clonally related virulent Mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men. J Infect Dis (1999) 2.06
Molecular classification of multiple tumor types. Bioinformatics (2001) 2.02
Nitroaromatic compounds, from synthesis to biodegradation. Microbiol Mol Biol Rev (2010) 1.98
Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure (1997) 1.96
Structural basis for myosin V discrimination between distinct cargoes. EMBO J (2006) 1.95
Quality of protein crystal structures. Acta Crystallogr D Biol Crystallogr (2007) 1.79
Phenotypic and genotypic characterization of Mycobacterium africanum isolates from West Africa. J Clin Microbiol (1999) 1.74
Substrate binding site of naphthalene 1,2-dioxygenase: functional implications of indole binding. J Mol Biol (2000) 1.62
Non-heme iron-dependent dioxygenases: unravelling catalytic mechanisms for complex enzymatic oxidations. Curr Opin Chem Biol (2008) 1.60
Reconstructing the evolutionary history of nitrotoluene detection in the transcriptional regulator NtdR. Mol Microbiol (2009) 1.60
Structures of thymidine kinase 1 of human and mycoplasmic origin. Proc Natl Acad Sci U S A (2004) 1.56
WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol Cell (2010) 1.50
PLUNC is a novel airway surfactant protein with anti-biofilm activity. PLoS One (2010) 1.44
A transcript map of the chromosome 19q-arm glioma tumor suppressor region. Genomics (2000) 1.39
Structure of betaine aldehyde dehydrogenase at 2.1 A resolution. Protein Sci (1998) 1.36
EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. Genomics (2000) 1.31
Complete genome of the cellulolytic thermophile Acidothermus cellulolyticus 11B provides insights into its ecophysiological and evolutionary adaptations. Genome Res (2009) 1.29
Molecular characterization and substrate specificity of nitrobenzene dioxygenase from Comamonas sp. strain JS765. Appl Environ Microbiol (2002) 1.29
Structural insight into the dioxygenation of nitroarene compounds: the crystal structure of nitrobenzene dioxygenase. J Mol Biol (2005) 1.24
Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat Struct Mol Biol (2010) 1.21
Crystal structure of E.coli alcohol dehydrogenase YqhD: evidence of a covalently modified NADP coenzyme. J Mol Biol (2004) 1.20
Crystal structure of plant pectin methylesterase. FEBS Lett (2002) 1.20
The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2. J Mol Biol (1996) 1.17
Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases. J Mol Biol (2002) 1.15
Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur cluster. Science (2000) 1.11
Active membrane fluctuations studied by micropipet aspiration. Phys Rev E Stat Nonlin Soft Matter Phys (2001) 1.11
Crystal structure of the Nod1 caspase activation and recruitment domain. Biochem Biophys Res Commun (2006) 1.10
Structural snapshots along the reaction pathway of ferredoxin-thioredoxin reductase. Nature (2007) 1.09
Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit. EMBO J (2009) 1.09
Alpha-adrenergic receptor blocking effect of Cleistanthus collinus (Roxb.) Benth. and Hook f. leaf extract on guinea pig isolated smooth muscle preparations. Indian J Exp Biol (2011) 1.09
Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 A resolution. J Mol Biol (1996) 1.08
Characterization of the N-acetyl-5-neuraminic acid-binding site of the extracytoplasmic solute receptor (SiaP) of nontypeable Haemophilus influenzae strain 2019. J Biol Chem (2007) 1.08
Crystal structure of NAD(P)H:flavin oxidoreductase from Escherichia coli. Biochemistry (1999) 1.07
Evidence that down regulation of hypothalamic KiSS-1 expression is involved in the negative feedback action of testosterone to regulate luteinising hormone secretion in the adult male rhesus monkey (Macaca mulatta). J Neuroendocrinol (2007) 1.07
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases. Nat Struct Biol (2001) 1.07
Expression of the nitroarene dioxygenase genes in Comamonas sp. strain JS765 and Acidovorax sp. strain JS42 is induced by multiple aromatic compounds. J Bacteriol (2003) 1.07
Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates. Proc Natl Acad Sci U S A (2000) 1.06
Structure of a mutant form of proliferating cell nuclear antigen that blocks translesion DNA synthesis. Biochemistry (2008) 1.05
Identification of a chemoreceptor for tricarboxylic acid cycle intermediates: differential chemotactic response towards receptor ligands. J Biol Chem (2010) 1.03
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia (2012) 1.03
Structural investigations of the ferredoxin and terminal oxygenase components of the biphenyl 2,3-dioxygenase from Sphingobium yanoikuyae B1. BMC Struct Biol (2007) 1.02
Tetrameric NAD-dependent alcohol dehydrogenase. Chem Biol Interact (2003) 1.02
Rat liver imidase. J Biol Chem (1993) 1.02
Regulated exopolysaccharide production in Myxococcus xanthus. J Bacteriol (1999) 1.02
Structural and evolutionary aspects of thioredoxin reductases in photosynthetic organisms. Trends Plant Sci (2009) 1.01
Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J Mol Biol (2003) 1.01
On the lifespan of virgin T lymphocytes. J Immunol (1999) 1.01
Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib. Oncogene (2011) 1.01
Effects of orchidectomy on levels of the mRNAs encoding gonadotropin-releasing hormone and other hypothalamic peptides in the adult male rhesus monkey (Macaca mulatta). J Neuroendocrinol (2000) 1.01
Angiogenic role for glycodelin in tumorigenesis. Proc Natl Acad Sci U S A (2001) 0.99
The actin cortex as an active wetting layer. Eur Phys J E Soft Matter (2013) 0.99
Structural basis for light activation of a chloroplast enzyme: the structure of sorghum NADP-malate dehydrogenase in its oxidized form. Biochemistry (1999) 0.99
Contributions of valine-292 in the nicotinamide binding site of liver alcohol dehydrogenase and dynamics to catalysis. Biochemistry (2001) 0.98
X-ray crystal structure of benzoate 1,2-dioxygenase reductase from Acinetobacter sp. strain ADP1. J Mol Biol (2002) 0.98
A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines. EMBO J (2002) 0.98
Pheromones in red pine cone beetle,Conophthorus resinosae hopkins, and its synonym,C. banksianae McPherson (Coleoptera: Scolytidae). J Chem Ecol (1995) 0.97
Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme. FEBS J (2005) 0.96
Purification and crystallization of the oxygenase component of naphthalene dioxygenase in native and selenomethionine-derivatized forms. Biochem Biophys Res Commun (1997) 0.95
Analgesic effect of O-(beta-hydroxy ethyl)rutoside in mice. Indian J Exp Biol (1985) 0.94
Flexibility of liver alcohol dehydrogenase in stereoselective binding of 3-butylthiolane 1-oxides. Biochemistry (1997) 0.94
The crystal structure of Synechocystis hemoglobin with a covalent heme linkage. J Biol Chem (2004) 0.94
Purification, characterization, and crystallization of the components of the nitrobenzene and 2-nitrotoluene dioxygenase enzyme systems. Appl Environ Microbiol (2005) 0.93
Medium- and short-chain dehydrogenase/reductase gene and protein families : Three-dimensional structures of MDR alcohol dehydrogenases. Cell Mol Life Sci (2008) 0.93
Chemotaxis to pyrimidines and identification of a cytosine chemoreceptor in Pseudomonas putida. J Bacteriol (2009) 0.93
The reduction of the Rieske iron-sulfur cluster in naphthalene dioxygenase by X-rays. J Inorg Biochem (2000) 0.93
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J Mol Biol (2010) 0.93
Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: studies of the Drosophila deoxyribonucleoside kinase. Biochemistry (2003) 0.92
Active site residues controlling substrate specificity in 2-nitrotoluene dioxygenase from Acidovorax sp. strain JS42. J Ind Microbiol Biotechnol (2005) 0.92
Application of nitroarene dioxygenases in the design of novel strains that degrade chloronitrobenzenes. Microb Biotechnol (2009) 0.92
Metabolism-dependent taxis towards (methyl)phenols is coupled through the most abundant of three polar localized Aer-like proteins of Pseudomonas putida. Environ Microbiol (2008) 0.92
Structural basis for regioselectivity and stereoselectivity of product formation by naphthalene 1,2-dioxygenase. J Bacteriol (2006) 0.90
Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system. Acta Crystallogr D Biol Crystallogr (2008) 0.90
Definition of a novel binding site on CD8 cells for a conserved region of the MHC class Ib molecule Qa-1 that regulates IFN-gamma expression. Eur J Immunol (2001) 0.89