PubRank

Maarten van Lohuizen

Author PubWeight™ 136.71‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006 11.48
2 Stem cells and cancer; the polycomb connection. Cell 2004 7.43
3 Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol Cell 2010 6.71
4 Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 2005 3.89
5 Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet 2006 3.83
6 Polycomb complexes and silencing mechanisms. Curr Opin Cell Biol 2004 3.25
7 Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 2004 3.25
8 Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell 2008 3.25
9 Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. PLoS Biol 2009 3.24
10 Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J 2006 3.21
11 Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell 2007 3.14
12 Polycomb repression: from cellular memory to cellular proliferation and cancer. Biochim Biophys Acta 2002 2.96
13 Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell 2008 2.96
14 Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. Proc Natl Acad Sci U S A 2005 2.81
15 Stem cell regulation by polycomb repressors: postponing commitment. Curr Opin Cell Biol 2008 2.81
16 Epigenetics and cancer. Genes Dev 2004 2.72
17 Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci U S A 2003 2.67
18 Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet 2002 2.53
19 PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 2008 2.37
20 Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1. Mol Cell Biol 2005 2.27
21 Chromatin position effects assayed by thousands of reporters integrated in parallel. Cell 2013 2.16
22 Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest 2012 2.03
23 Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev 2002 1.95
24 A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat Protoc 2009 1.95
25 Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 2006 1.94
26 In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell 2013 1.89
27 Interactions among Polycomb domains are guided by chromosome architecture. PLoS Genet 2011 1.76
28 Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells. PLoS One 2008 1.72
29 PRC1 coordinates timing of sexual differentiation of female primordial germ cells. Nature 2013 1.65
30 BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol 2011 1.52
31 Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation. J Neurosci 2005 1.48
32 TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J Biol Chem 2001 1.46
33 Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium. Curr Biol 2008 1.45
34 BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A. Breast Cancer Res 2009 1.44
35 EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer. Breast Cancer Res 2008 1.42
36 The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. J Biol Chem 2002 1.42
37 Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol Cell Biol 2003 1.41
38 RUNX: a trilogy of cancer genes. Cancer Cell 2002 1.34
39 The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev 2009 1.24
40 Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1. Mol Cell 2003 1.20
41 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. Hum Mol Genet 2012 1.18
42 The emerging role of Polycomb repressors in the response to DNA damage. J Cell Sci 2012 1.14
43 Polycomb function during oogenesis is required for mouse embryonic development. Genes Dev 2012 1.09
44 Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression. Immunity 2008 1.05
45 Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion. Neoplasia 2008 1.04
46 Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res 2010 1.03
47 Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes. Cancer Res 2010 1.02
48 Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J Immunol 2006 1.01
49 The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. Proc Natl Acad Sci U S A 2011 1.00
50 Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 2006 0.99
51 Developmental biology: two paths to silence merge. Nature 2006 0.95
52 Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J 2011 0.94
53 The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation. EMBO J 2013 0.94
54 Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies. Clin Cancer Res 2010 0.93
55 Computational identification of insertional mutagenesis targets for cancer gene discovery. Nucleic Acids Res 2011 0.92
56 A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation. J Exp Med 2011 0.89
57 Analysis of tumor heterogeneity and cancer gene networks using deep sequencing of MMTV-induced mouse mammary tumors. PLoS One 2013 0.88
58 Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool. Stem Cells 2013 0.87
59 Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix. Biochim Biophys Acta 2009 0.83
60 SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes. PLoS One 2009 0.83
61 Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci U S A 2013 0.82
62 Controlling stem cell proliferation: CKIs at work. Cell Cycle 2006 0.81
63 The Polycomb protein and E3 ubiquitin ligase Ring1B harbors an IRES in its highly conserved 5' UTR. PLoS One 2008 0.79
64 The Polycomb group protein Ring1b is essential for pectoral fin development. Development 2012 0.79
65 BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice. Adv Exp Med Biol 2006 0.79
66 GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors. PLoS One 2012 0.79
67 Differentiation and gene regulation. Genomic programs and differentiation: editorial overview. Curr Opin Genet Dev 2006 0.76
68 Chromosome conformation capture on chip in single Drosophila melanogaster tissues. Methods 2012 0.76
69 Corrigendum: using TRIP for genome-wide position effect analysis in cultured cells. Nat Protoc 2015 0.75