PubRank

Mary Chebib

Author PubWeight™ 50.79‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors. Bioorg Med Chem 2005 3.38
2 Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochem Pharmacol 2009 1.11
3 Flavonoid modulation of GABA(A) receptors. Br J Pharmacol 2011 1.09
4 Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. Br J Pharmacol 2011 1.07
5 Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorg Med Chem 2009 1.07
6 GABA(C) receptors as drug targets. Curr Drug Targets CNS Neurol Disord 2003 1.05
7 The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor. J Neurochem 2007 1.03
8 Modulation of ionotropic GABA receptors by natural products of plant origin. Adv Pharmacol 2006 1.00
9 α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci U S A 2012 0.99
10 The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. Biochem Pharmacol 2004 0.97
11 Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors. Eur J Pharmacol 2003 0.96
12 A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chem Biol Drug Des 2008 0.95
13 (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. J Med Chem 2011 0.91
14 Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. J Biol Chem 2004 0.91
15 Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology 2008 0.90
16 Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. J Med Chem 2008 0.88
17 Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review. Amino Acids 2013 0.87
18 Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. Eur J Pharmacol 2004 0.87
19 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes. Biochem Pharmacol 2011 0.86
20 Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. Biochem Pharmacol 2012 0.86
21 Double-Mannich annulation of cyclic ketones using N,N-Bis(ethoxymethyl)alkylamine reagents. Org Lett 2006 0.85
22 Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue. J Med Chem 2009 0.84
23 Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorg Med Chem Lett 2007 0.83
24 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. Eur J Pharmacol 2005 0.83
25 Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses. Neuropharmacology 2004 0.83
26 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol 2012 0.82
27 Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors. Br J Pharmacol 2012 0.82
28 Medicinal chemistry of ρ GABAC receptors. Future Med Chem 2011 0.82
29 Aza-THIP and related analogues of THIP as GABA C antagonists. Bioorg Med Chem 2003 0.82
30 Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity. Eur J Pharmacol 2007 0.82
31 The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochem Res 2009 0.81
32 Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett 2003 0.81
33 Stabilization of zwitterions in solution: GABA analogues. J Phys Chem A 2005 0.81
34 Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors. ACS Chem Neurosci 2012 0.81
35 Neurochemicals for the investigation of GABA(C) receptors. Neurochem Res 2010 0.80
36 Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. J Biol Chem 2013 0.80
37 Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABA(C) receptor antagonists. Neurochem Int 2003 0.80
38 Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci 2015 0.79
39 Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Org Biomol Chem 2006 0.79
40 Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol 2004 0.79
41 Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chem Commun (Camb) 2012 0.79
42 ρ1 GABAC receptors are expressed in fibrous and cartilaginous layers of chick sclera and located on sclera fibroblasts and chondrocytes. J Neurochem 2011 0.79
43 2-Aminoethyl methylphosphonate, a potent and rapidly acting antagonist of GABA(A)-ρ1 receptors. Mol Pharmacol 2011 0.79
44 trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors. Br J Pharmacol 2002 0.78
45 Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors. ACS Chem Neurosci 2010 0.78
46 The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA(C) receptor. Chem Commun (Camb) 2011 0.78
47 Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chem Commun (Camb) 2011 0.78
48 Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor. ACS Chem Neurosci 2012 0.78
49 Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). Org Biomol Chem 2010 0.77
50 Identification of GABA receptors in chick cornea. Mol Vis 2012 0.76
51 Identification of benzopyran-4-one derivatives (isoflavones) as positive modulators of GABA(A) receptors. ChemMedChem 2011 0.76
52 Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorg Med Chem 2005 0.76
53 Dengue virus PrM/M proteins fail to show pH-dependent ion channel activity in Xenopus oocytes. Virology 2011 0.76
54 Γ-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates. J Med Chem 2013 0.76
55 Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone. Neurochem Res 2013 0.75
56 Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors. Neuropharmacology 2012 0.75
57 Stabilization of zwitterions in solution: phosphinic and phosphonic acid GABA analogues. J Phys Chem A 2005 0.75
58 Efficiency considerations in the construction of interpolated potential energy surfaces for the calculation of quantum observables by diffusion Monte Carlo. J Chem Phys 2004 0.75
59 Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg Med Chem Lett 2012 0.75
60 Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents. Pharmacol Biochem Behav 2011 0.75