Published in J Biol Chem on February 20, 2003
Viral control of mitochondrial apoptosis. PLoS Pathog (2008) 2.21
Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J Virol (2009) 1.76
Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly. J Biol Chem (2008) 1.71
Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly. PLoS Pathog (2010) 1.67
Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondrion-mediated, caspase 3-dependent pathway. J Virol (2008) 1.60
Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer. Oncogene (2011) 1.56
Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J Virol (2010) 1.43
Hepatitis C virus infection and apoptosis. World J Gastroenterol (2007) 1.36
Modulation of tumor necrosis factor by microbial pathogens. PLoS Pathog (2006) 1.34
Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome. J Virol (2005) 1.32
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Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges. Cancer Lett (2010) 1.22
Determinants of the hepatitis C virus nonstructural protein 2 protease domain required for production of infectious virus. J Virol (2009) 1.21
Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice. J Biol Chem (2009) 1.10
Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression. Virol J (2006) 1.08
Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR. J Biol Chem (2010) 1.07
Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. PLoS Pathog (2013) 0.92
New animal models for hepatitis C viral infection and pathogenesis studies. World J Gastroenterol (2007) 0.92
Cell death-inducing DFFA-like effector b is required for hepatitis C virus entry into hepatocytes. J Virol (2014) 0.91
The modulation of apoptosis by oncogenic viruses. Virol J (2013) 0.89
The Rubella virus capsid is an anti-apoptotic protein that attenuates the pore-forming ability of Bax. PLoS Pathog (2011) 0.87
The Hepatitis C Virus Nonstructural Protein 2 (NS2): An Up-and-Coming Antiviral Drug Target. Viruses (2010) 0.86
Cleavage of the Junin virus nucleoprotein serves a decoy function to inhibit the induction of apoptosis during infection. J Virol (2012) 0.85
Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene. Biochem J (2006) 0.85
Hepatitis C virus-induced mitochondrial dysfunctions. Viruses (2013) 0.84
A basic cluster in the N terminus of yellow fever virus NS2A contributes to infectious particle production. J Virol (2015) 0.82
Post-translational modifications of hepatitis C viral proteins and their biological significance. World J Gastroenterol (2013) 0.78
Host restriction factors for hepatitis C virus. World J Gastroenterol (2016) 0.78
Mean protein evolutionary distance: a method for comparative protein evolution and its application. PLoS One (2013) 0.77
Hepatitis C Virus-Induced Degradation of Cell Death-Inducing DFFA-Like Effector B Leads to Hepatic Lipid Dysregulation. J Virol (2016) 0.76
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants. World J Gastroenterol (2012) 0.75
Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Sci Rep (2016) 0.75
Decreased Expression of Inhibitor of Caspase-Activated DNase (ICAD) in Renal Cell Carcinoma - Tissue Microarray of Human Samples. J Kidney Cancer VHL (2016) 0.75
External Qi of Yan Xin Qigong induces cell death and gene expression alterations promoting apoptosis and inhibiting proliferation, migration and glucose metabolism in small-cell lung cancer cells. Mol Cell Biochem (2011) 0.75
Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A (2002) 4.52
Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors. J Hepatol (2012) 2.51
A single cycle of rituximab for the treatment of severe pemphigus. N Engl J Med (2007) 2.41
C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem (2002) 2.16
Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100. J Virol (2007) 1.95
Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening. FASEB J (2009) 1.90
Drug-induced hypersensitivity syndrome: clinical and biologic disease patterns in 24 patients. Medicine (Baltimore) (2009) 1.76
Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans. Hepatology (2007) 1.71
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos (2005) 1.70
Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein. J Virol (2005) 1.68
The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact (2006) 1.54
Hepatitis C virus NS2 protein is phosphorylated by the protein kinase CK2 and targeted for degradation to the proteasome. J Virol (2005) 1.32
Characterization of a hepatitis B and hepatitis delta virus receptor binding site. Hepatology (2006) 1.26
Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug Metab Dispos (2009) 1.25
Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor. Hepatology (2007) 1.23
Inhibition of duck hepatitis B virus infection by a myristoylated pre-S peptide of the large viral surface protein. J Virol (2002) 1.21
Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent. J Hepatol (2012) 1.17
Long-term remissions of severe pemphigus after rituximab therapy are associated with prolonged failure of desmoglein B cell response. Sci Transl Med (2013) 1.15
Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene. J Biol Chem (2006) 1.13
A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation. Cell Microbiol (2008) 1.10
Variability of sorafenib toxicity and exposure over time: a pharmacokinetic/pharmacodynamic analysis. Oncologist (2012) 1.10
PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. Hepatology (2002) 1.09
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway. PLoS Biol (2011) 1.08
Aurora A contributes to p150(glued) phosphorylation and function during mitosis. J Cell Biol (2010) 1.08
Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation. Toxicol Lett (2008) 1.05
Impaired clearance of virus-infected hepatocytes in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology (2004) 1.04
ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages. FEBS Lett (2005) 1.04
Evolving concepts in liver tissue modeling and implications for in vitro toxicology. Expert Opin Drug Metab Toxicol (2008) 1.03
Epidermodysplasia verruciformis in human immunodeficiency virus-infected patients: a marker of human papillomavirus-related disorders not affected by antiretroviral therapy. Arch Dermatol (2011) 1.02
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. Hepatology (2013) 1.02
Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis. Hepatology (2008) 1.00
A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes. Carcinogenesis (2005) 0.99
Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression. Biochim Biophys Acta (2011) 0.97
Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation. J Biol Chem (2002) 0.97
'Liver let die': oxidative DNA damage and hepatotropic viruses. J Gen Virol (2014) 0.97
The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. Gastroenterology (2011) 0.95
Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation. J Biol Chem (2009) 0.95
Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies. Drug Metab Dispos (2008) 0.95
Hepatitis C virus (HCV) occult infection or occult HCV RNA detection? J Infect Dis (2003) 0.95
Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line. Eur J Pharm Sci (2006) 0.94
Downregulation of Gadd45beta expression by hepatitis C virus leads to defective cell cycle arrest. Cancer Res (2010) 0.94
Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth. Am J Physiol Gastrointest Liver Physiol (2003) 0.93
Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes. J Hepatol (2003) 0.93
TNFalpha-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes. Hepatology (2005) 0.93
Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. Hepatology (2009) 0.92
The application of 3D micropatterning of agarose substrate for cell culture and in situ comet assays. Biomaterials (2010) 0.92
Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes. Toxicol Lett (2005) 0.91
Preventive evolutionary medicine of cancers. Evol Appl (2012) 0.91
Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells. Eur J Cancer (2010) 0.90
Optimization of the HepaRG cell model for drug metabolism and toxicity studies. Toxicol In Vitro (2012) 0.90
Overexpression of active Aurora-C kinase results in cell transformation and tumour formation. PLoS One (2011) 0.90
The first transmembrane domain of the hepatitis B virus large envelope protein is crucial for infectivity. J Virol (2009) 0.90
Effects of deferasirox and deferiprone on cellular iron load in the human hepatoma cell line HepaRG. Biometals (2009) 0.90
A new subfamily of structurally related human F-box proteins. Gene (2002) 0.90
Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. Drug Metab Dispos (2007) 0.89
AhR- and c-maf-dependent induction of beta7-integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons. Biochem Biophys Res Commun (2007) 0.89
Transforming growth factor beta controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin. Mol Biol Cell (2007) 0.89
What makes cells move: requirements and obstacles for spontaneous cell motility. Mol Biosyst (2010) 0.89
Improved dendritic cell-based immunization against hepatitis C virus using peptide inhibitors of interleukin 10. Hepatology (2010) 0.89
Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. Mol Pharmacol (2007) 0.88
Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes. J Biol Chem (2002) 0.87
Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1alpha involvement in CYP3A4 repression. Eur J Cancer (2009) 0.86
Three-dimensional polarization sensitizes hepatocytes to Fas/CD95 apoptotic signalling. J Cell Sci (2005) 0.86
Three-dimensional HepaRG model as an attractive tool for toxicity testing. Toxicol Sci (2012) 0.86
Regulation of hepatitis C virus replication by nuclear translocation of nonstructural 5A protein and transcriptional activation of host genes. J Virol (2013) 0.85
Spiny follicular hyperkeratosis eruption: a new cutaneous adverse effect of sorafenib. J Clin Oncol (2010) 0.85
Heterogeneity of skin manifestations in patients with Carney complex. J Am Acad Dermatol (2008) 0.85
Applying ecological and evolutionary theory to cancer: a long and winding road. Evol Appl (2012) 0.84
AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells. Cell Commun Signal (2014) 0.84
Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway. Hepatology (2009) 0.83
Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis. PLoS Pathog (2013) 0.83
Cyclin-dependent kinase 1 plays a critical role in DNA replication control during rat liver regeneration. Hepatology (2009) 0.82
Synthesis and biological properties of Quilamines II, new iron chelators with antiproliferative activities. Bioconjug Chem (2014) 0.82
Human endothelial progenitors constitute targets for environmental atherogenic polycyclic aromatic hydrocarbons. Biochem Biophys Res Commun (2006) 0.82
Hepatic environment elicits monocyte differentiation into a dendritic cell subset directing Th2 response. J Hepatol (2005) 0.82
The first reported case and management of multicentric Castleman's disease associated with Kaposi's sarcoma in an HIV-2-infected patient. AIDS (2007) 0.82
Cutaneous Waldenstrom's macroglobulinemia with "deck-chair" sign treated with cyclophosphamide. J Am Acad Dermatol (2005) 0.81
CYP4F3B expression is associated with differentiation of HepaRG human hepatocytes and unaffected by fatty acid overload. Drug Metab Dispos (2011) 0.81
Sarcoidosis in Patients Treated with Vemurafenib for Metastatic Melanoma: A Paradoxical Autoimmune Activation. Dermatology (2015) 0.81
Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. Biochem Biophys Res Commun (2004) 0.81
Reperfusion stress induced during intermittent selective clamping accelerates rat liver regeneration through JNK pathway. J Hepatol (2010) 0.81
The translocation motif of hepatitis B virus envelope proteins is dispensable for infectivity. J Virol (2007) 0.81
Cell shape and TGF-beta signaling define the choice of lineage during in vitro differentiation of mouse primary hepatic precursors. J Cell Physiol (2010) 0.80
Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). Drug Metab Dispos (2008) 0.80