Published in Cancer Lett on December 18, 2010
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome Res (2012) 2.19
Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice. Sci Signal (2012) 1.50
Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis. World J Gastroenterol (2014) 1.17
Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis. PLoS Pathog (2013) 1.00
Modulation of apoptotic signaling by the hepatitis B virus X protein. Viruses (2012) 0.93
From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms. Genome Med (2012) 0.93
Chronic inflammation and immunologic-based constraints in malignant disease. Immunotherapy (2011) 0.91
Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells. Evid Based Complement Alternat Med (2013) 0.90
Multimodal treatment of hepatocellular carcinoma on cirrhosis: an update. World J Gastroenterol (2013) 0.89
The hepatitis B virus (HBV) HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival. J Virol (2014) 0.88
A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis. PLoS One (2012) 0.88
The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population. PLoS One (2013) 0.87
MicroRNAs, hepatitis C virus, and HCV/HIV-1 co-infection: new insights in pathogenesis and therapy. Viruses (2012) 0.84
Mitochondrial dynamics and viral infections: A close nexus. Biochim Biophys Acta (2015) 0.84
Hepatitis C virus and other risk factors in hepatocellular carcinoma. Acta Virol (2012) 0.84
Apolipoprotein E, but Not Apolipoprotein B, Is Essential for Efficient Cell-to-Cell Transmission of Hepatitis C Virus. J Virol (2015) 0.82
Meta-analysis of associations of interleukin-28B polymorphisms rs8099917 and rs12979860 with development of hepatitis virus-related hepatocellular carcinoma. Onco Targets Ther (2016) 0.82
Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Carcinogenesis (2015) 0.81
Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases. World J Gastroenterol (2015) 0.81
Genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis. J Gastroenterol (2016) 0.78
Potential mechanisms of hepatitis B virus induced liver injury. World J Gastroenterol (2014) 0.78
Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-induced Hepatocellular Carcinoma. Korean J Physiol Pharmacol (2013) 0.78
Inflammatory models drastically alter tumor growth and the immune microenvironment in hepatocellular carcinoma. Sci Bull (Beijing) (2015) 0.78
Occult and Overt HBV Co-Infections Independently Predict Postoperative Prognosis in HCV-Associated Hepatocellular Carcinoma. PLoS One (2013) 0.78
A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines. Cancer Lett (2015) 0.78
Promoter hypermethylation of Wnt pathway inhibitors in hepatitis C virus - induced multistep hepatocarcinogenesis. Virol J (2014) 0.77
Hepatitis B virus infection and intrahepatic cholangiocarcinoma. World J Gastroenterol (2014) 0.77
Current evidence for the hepatoprotective activities of the medicinal mushroom Antrodia cinnamomea. Chin Med (2013) 0.76
Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells. Oncotarget (2016) 0.76
MiR-146a and miR-196a-2 polymorphisms are associated with hepatitis virus-related hepatocellular cancer risk: a meta-analysis. Aging (Albany NY) (2017) 0.75
HBV X gene point mutations are associated with the risk of hepatocellular carcinoma: A systematic review and meta-analysis. Mol Clin Oncol (2016) 0.75
Genetic susceptibility of eight nonsynonymous polymorphisms in HLA-DRB1 gene to hepatocellular carcinoma in Han Chinese. Oncotarget (2016) 0.75
Increased Mitochondrial Genetic Diversity in Persons Infected With Hepatitis C Virus. Cell Mol Gastroenterol Hepatol (2016) 0.75
Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma. Sci Rep (2016) 0.75
Interaction of cyclophilin A with a novel binding protein, SR-25, and characterization of their expression pattern in Chinese hepatocellular carcinoma patients. Oncol Lett (2016) 0.75
Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells. PLoS One (2016) 0.75
Hepatitis B virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes. PLoS One (2017) 0.75
Hepatitis B virus molecular biology and pathogenesis. Hepatoma Res (2016) 0.75
Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma. Gastroenterol Res Pract (2017) 0.75
Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89
Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology (2007) 26.78
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science (2005) 16.84
Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet (1981) 13.54
Mechanisms of hepatic fibrogenesis. Gastroenterology (2008) 11.98
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science (2009) 10.30
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity (1996) 8.27
Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science (2003) 7.91
Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol (2005) 7.54
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 6.96
Viral clearance without destruction of infected cells during acute HBV infection. Science (1999) 6.78
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene (2006) 6.61
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature (2008) 6.25
Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science (1999) 6.21
Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell (2006) 5.97
High-level hepatitis B virus replication in transgenic mice. J Virol (1995) 5.81
Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol (2001) 5.81
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J (1996) 5.47
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res (2007) 5.40
HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (1991) 5.34
Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J Viral Hepat (2006) 5.10
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med (1998) 4.48
Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology (2002) 4.34
microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J (2008) 4.24
Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology (2004) 4.16
Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem (2006) 4.15
Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol (2006) 3.84
RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell (2001) 3.80
Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res (2008) 3.67
Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol (1994) 3.34
Hepatitis C virus entry depends on clathrin-mediated endocytosis. J Virol (2006) 3.33
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci U S A (2001) 3.06
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology (2002) 3.02
MicroRNAs and immunity: tiny players in a big field. Immunity (2007) 3.01
MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology (2008) 3.00
Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol (1997) 2.98
The enigmatic X gene of hepatitis B virus. J Virol (2004) 2.98
Hepatocellular carcinoma: epidemiology, risk factors, and screening. Semin Liver Dis (2005) 2.98
Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science (2001) 2.98
MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology (2008) 2.88
Formation of native hepatitis C virus glycoprotein complexes. J Virol (1997) 2.87
The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J Virol (1993) 2.84
Unscrambling hepatitis C virus-host interactions. Nature (2005) 2.83
Epidemiology of hepatitis C in the West. Semin Liver Dis (1995) 2.77
Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology (2003) 2.66
Flying under the radar: the immunobiology of hepatitis C. Annu Rev Immunol (2007) 2.65
Alcohol and hepatocellular carcinoma. Gastroenterology (2004) 2.61
Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours. Nature (1990) 2.61
Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 2.59
A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science (1985) 2.47
Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol (2004) 2.47
Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J Hepatol (1999) 2.46
Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Hepatology (2009) 2.43
Inflammation and liver cancer: new molecular links . Ann N Y Acad Sci (2009) 2.29
Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data. Gastroenterology (2006) 2.26
Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis (2005) 2.18
MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res (2009) 2.16
Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo. J Immunol (1994) 2.05
Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology (2004) 2.02
Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology (2008) 1.97
Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential. J Virol (2000) 1.93
Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of woodchucks. Cell (1982) 1.91
The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunity. J Virol (2003) 1.90
Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion. J Hepatol (2008) 1.85
The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis. Hepatology (1992) 1.85
Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology (2010) 1.81
The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice. Oncogene (1997) 1.81
Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc Natl Acad Sci U S A (1997) 1.79
Enhancement of hepatitis B virus replication by its X protein in transgenic mice. J Virol (2002) 1.78
The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J Gastroenterol (2007) 1.77
Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice. J Virol (1994) 1.77
Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology (2004) 1.73
Viral hepatocarcinogenesis. Oncogene (2010) 1.73
The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature (1990) 1.69
Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma. AIDS (2008) 1.66
Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett (2006) 1.66
Hepadnaviral X Protein:Review of Recent Progress. J Biomed Sci (1996) 1.66
Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers. Oncogene (2003) 1.63
Hepatitis B virus X protein interferes with cellular DNA repair. J Virol (1998) 1.62
Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci U S A (1997) 1.60
Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death. J Virol (2005) 1.56
Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog (1996) 1.56
Trans-complementation of an NS2 defect in a late step in hepatitis C virus (HCV) particle assembly and maturation. PLoS Pathog (2009) 1.52
Involvement of host cellular multivesicular body functions in hepatitis B virus budding. Proc Natl Acad Sci U S A (2007) 1.49
Src kinases involved in hepatitis B virus replication. EMBO J (1999) 1.47
Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. J Hepatol (2010) 1.45
Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK. J Virol (2003) 1.45
Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions. J Virol (2001) 1.42
Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. J Biol Chem (2000) 1.40
Hepatitis C virus entry into host cells. Cell Mol Life Sci (2008) 1.40
HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS Pathog (2009) 1.40
Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma. Cancer (2000) 1.39
Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc Natl Acad Sci U S A (2004) 1.39
The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma. J Hepatol (2005) 1.38
Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death. Oncogene (1999) 1.37
Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis. J Viral Hepat (2004) 1.36
Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev (2005) 3.18
Expression and purification of SARS coronavirus proteins using SUMO-fusions. Protein Expr Purif (2005) 1.03
Toll-like receptor 3 in viral pathogenesis: friend or foe? Immunology (2013) 0.94
MicroRNAs, hepatitis C virus, and HCV/HIV-1 co-infection: new insights in pathogenesis and therapy. Viruses (2012) 0.84
RNA viruses and microRNAs: challenging discoveries for the 21st century. Physiol Genomics (2013) 0.84
Protective role of Toll-like Receptor 3-induced type I interferon in murine coronavirus infection of macrophages. Viruses (2012) 0.81