Published in Angew Chem Int Ed Engl on February 17, 2003
Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A (2009) 3.85
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev (2012) 3.34
Millisecond kinetics on a microfluidic chip using nanoliters of reagents. J Am Chem Soc (2003) 3.17
Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc Natl Acad Sci U S A (2006) 2.66
High-throughput quantitative polymerase chain reaction in picoliter droplets. Anal Chem (2008) 2.48
A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip X-ray diffraction. Angew Chem Int Ed Engl (2004) 2.26
Controlling nonspecific protein adsorption in a plug-based microfluidic system by controlling interfacial chemistry using fluorous-phase surfactants. Anal Chem (2005) 2.15
Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab Chip (2008) 2.11
Microfluidic confinement of single cells of bacteria in small volumes initiates high-density behavior of quorum sensing and growth and reveals its variability. Angew Chem Int Ed Engl (2009) 1.99
The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc Natl Acad Sci U S A (2008) 1.90
SlipChip. Lab Chip (2009) 1.84
Microgram-scale testing of reaction conditions in solution using nanoliter plugs in microfluidics with detection by MALDI-MS. J Am Chem Soc (2006) 1.81
Microfluidic systems for chemical kinetics that rely on chaotic mixing in droplets. Philos Trans A Math Phys Eng Sci (2004) 1.62
Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization. Curr Opin Struct Biol (2005) 1.61
Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels. Appl Phys Lett (2003) 1.57
Digital PCR on a SlipChip. Lab Chip (2010) 1.57
Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays. Anal Chem (2004) 1.54
The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS). Acta Crystallogr D Biol Crystallogr (2008) 1.52
A review of microdialysis coupled to microchip electrophoresis for monitoring biological events. J Chromatogr A (2015) 1.49
Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl (2006) 1.45
In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr (2005) 1.42
On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system. Anal Chem (2006) 1.42
Development of a digital microfluidic platform for point of care testing. Lab Chip (2008) 1.40
Improved temporal resolution for in vivo microdialysis by using segmented flow. Anal Chem (2008) 1.39
Digital isothermal quantification of nucleic acids via simultaneous chemical initiation of recombinase polymerase amplification reactions on SlipChip. Anal Chem (2011) 1.36
Heterogeneous immunoassays using magnetic beads on a digital microfluidic platform. Lab Chip (2008) 1.35
Using microfluidics to observe the effect of mixing on nucleation of protein crystals. J Am Chem Soc (2005) 1.31
Nanoliter multiplex PCR arrays on a SlipChip. Anal Chem (2010) 1.30
Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices. Lab Chip (2006) 1.30
Formation of Arrayed Droplets by Soft Lithography and Two-Phase Fluid Flow, and Application in Protein Crystallization. Adv Mater (2004) 1.30
Microfluidic cartridges preloaded with nanoliter plugs of reagents: an alternative to 96-well plates for screening. Curr Opin Chem Biol (2006) 1.28
Reliable microfluidic on-chip incubation of droplets in delay-lines. Lab Chip (2008) 1.23
Using a multijunction microfluidic device to inject substrate into an array of preformed plugs without cross-contamination: comparing theory and experiments. Anal Chem (2007) 1.20
Going local: technologies for exploring bacterial microenvironments. Nat Rev Microbiol (2013) 1.19
SlipChip for immunoassays in nanoliter volumes. Anal Chem (2010) 1.13
Using three-phase flow of immiscible liquids to prevent coalescence of droplets in microfluidic channels: criteria to identify the third liquid and validation with protein crystallization. Langmuir (2007) 1.08
Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen. J Am Chem Soc (2010) 1.07
Analysis of samples stored as individual plugs in a capillary by electrospray ionization mass spectrometry. Anal Chem (2009) 1.06
User-loaded SlipChip for equipment-free multiplexed nanoliter-scale experiments. J Am Chem Soc (2010) 1.04
Polymer nanofibre junctions of attolitre volume serve as zeptomole-scale chemical reactors. Nat Chem (2009) 1.03
Push-pull perfusion sampling with segmented flow for high temporal and spatial resolution in vivo chemical monitoring. Anal Chem (2011) 1.02
Laterally mobile, functionalized self-assembled monolayers at the fluorous-aqueous interface in a plug-based microfluidic system: characterization and testing with membrane protein crystallization. J Am Chem Soc (2009) 1.02
Using a microfluidic device for 1 microl DNA microarray hybridization in 500 s. Nucleic Acids Res (2005) 1.01
Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun (2014) 1.01
Continuous parallel ESI-MS analysis of reactions carried out in a bespoke 3D printed device. Beilstein J Nanotechnol (2013) 1.00
A programmable microenvironment for cellular studies via microfluidics-generated double emulsions. Biomaterials (2013) 0.99
Geometrical optimization of helical flow in grooved micromixers. Lab Chip (2007) 0.98
Opportunities for microfluidic technologies in synthetic biology. J R Soc Interface (2009) 0.97
The potential impact of droplet microfluidics in biology. Anal Chem (2013) 0.94
Microfluidic compartmentalized directed evolution. Chem Biol (2010) 0.94
A Plug-Based Microfluidic System for Dispensing Lipidic Cubic Phase (LCP) Material Validated by Crystallizing Membrane Proteins in Lipidic Mesophases. Microfluid Nanofluidics (2010) 0.93
Mesenchymal-mode migration assay and antimetastatic drug screening with high-throughput microfluidic channel networks. Angew Chem Int Ed Engl (2014) 0.92
A study of EWOD-driven droplets by PIV investigation. Lab Chip (2008) 0.90
Reaction-diffusion processes at the nano- and microscales. Nat Nanotechnol (2016) 0.90
Droplets formation and merging in two-phase flow microfluidics. Int J Mol Sci (2011) 0.89
Electrowetting --a versatile tool for controlling microdrop generation. Eur Phys J E Soft Matter (2008) 0.89
Focusing-enhanced mixing in microfluidic channels. Biomicrofluidics (2008) 0.88
ABO, D blood typing and subtyping using plug-based microfluidics. Anal Chem (2008) 0.87
Crystallization of the large membrane protein complex photosystem I in a microfluidic channel. ACS Nano (2013) 0.87
Cross-talk-free dual-color fluorescence cross-correlation spectroscopy for the study of enzyme activity. Anal Chem (2010) 0.84
Oil-isolated hydrogel microstructures for sensitive bioassays on-chip. Anal Chem (2013) 0.84
A valve-less microfluidic peristaltic pumping method. Biomicrofluidics (2015) 0.82
A new microfluidics-based droplet dispenser for ICPMS. Anal Chem (2014) 0.81
Controlled dispensing and mixing of pico- to nanoliter volumes using on-demand droplet-based microfluidics. Microfluid Nanofluidics (2013) 0.81
Self-digitization of samples into a high-density microfluidic bottom-well array. Anal Chem (2013) 0.81
Chemistry with spatial control using particles and streams(). RSC Adv (2012) 0.79
Microfluidic automation using elastomeric valves and droplets: reducing reliance on external controllers. Small (2012) 0.79
Open-atmosphere sustenance of highly volatile attoliter-size droplets on surfaces. Proc Natl Acad Sci U S A (2013) 0.79
3D-printed Microfluidic Devices: Fabrication, Advantages and Limitations-a Mini Review. Anal Methods (2016) 0.79
An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional Screening. ACS Comb Sci (2017) 0.78
Fluid displacement during droplet formation at microfluidic flow-focusing junctions. Lab Chip (2015) 0.77
Three-dimensional digital microfluidic manipulation of droplets in oil medium. Sci Rep (2015) 0.77
Microfluidic Genipin Deposition Technique for Extended Culture of Micropatterned Vascular Muscular Thin Films. J Vis Exp (2015) 0.77
Microfluidic approaches for isolation, detection, and characterization of extracellular vesicles: Current status and future directions. Biosens Bioelectron (2016) 0.76
Droplet-based microfluidic platform for measurement of rapid erythrocyte water transport. Lab Chip (2015) 0.76
Microfluidic cell isolation technology for drug testing of single tumor cells and their clusters. Sci Rep (2017) 0.75
Pulse-density modulation control of chemical oscillation far from equilibrium in a droplet open-reactor system. Nat Commun (2016) 0.75
Processing of nanolitre liquid plugs for microfluidic cell-based assays. Sci Technol Adv Mater (2012) 0.75
Nanoliter segmented-flow sampling mass spectrometry with online compartmentalization. Anal Chem (2014) 0.75
Computational investigations of the mixing performance inside liquid slugs generated by a microfluidic T-junction. Biomicrofluidics (2014) 0.75
Single Drop Electroanalysis and Interfacial Interactions: Sensitivity versus Limit of Detection(†). Electroanalysis (2016) 0.75
Mapping of Enzyme Kinetics on a Microfluidic Device. PLoS One (2016) 0.75
Formation and Fluorimetric Characterization of Micelles in a Micro-flow Through System with Static Micro Mixer. Sensors (Basel) (2007) 0.75
Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture. Lab Chip (2017) 0.75
Reactions in droplets in microfluidic channels. Angew Chem Int Ed Engl (2006) 5.07
Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets. J Am Chem Soc (2003) 3.97
Millisecond kinetics on a microfluidic chip using nanoliters of reagents. J Am Chem Soc (2003) 3.17
Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature (2005) 3.01
Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc Natl Acad Sci U S A (2006) 2.66
Defined spatial structure stabilizes a synthetic multispecies bacterial community. Proc Natl Acad Sci U S A (2008) 2.42
A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip X-ray diffraction. Angew Chem Int Ed Engl (2004) 2.26
Controlling nonspecific protein adsorption in a plug-based microfluidic system by controlling interfacial chemistry using fluorous-phase surfactants. Anal Chem (2005) 2.15
Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab Chip (2008) 2.11
Microfluidic confinement of single cells of bacteria in small volumes initiates high-density behavior of quorum sensing and growth and reveals its variability. Angew Chem Int Ed Engl (2009) 1.99
The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc Natl Acad Sci U S A (2008) 1.90
Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system. Lab Chip (2004) 1.87
SlipChip. Lab Chip (2009) 1.84
Microgram-scale testing of reaction conditions in solution using nanoliter plugs in microfluidics with detection by MALDI-MS. J Am Chem Soc (2006) 1.81
A microfluidic approach for screening submicroliter volumes against multiple reagents by using preformed arrays of nanoliter plugs in a three-phase liquid/liquid/gas flow. Angew Chem Int Ed Engl (2005) 1.74
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'. Nat Chem Biol (2008) 1.74
Microfluidic systems for chemical kinetics that rely on chaotic mixing in droplets. Philos Trans A Math Phys Eng Sci (2004) 1.62
Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization. Curr Opin Struct Biol (2005) 1.61
Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels. Appl Phys Lett (2003) 1.57
Digital PCR on a SlipChip. Lab Chip (2010) 1.57
Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays. Anal Chem (2004) 1.54
Multiplexed quantification of nucleic acids with large dynamic range using multivolume digital RT-PCR on a rotational SlipChip tested with HIV and hepatitis C viral load. J Am Chem Soc (2011) 1.51
Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl (2006) 1.45
In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr (2005) 1.42
On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system. Anal Chem (2006) 1.42
Digital isothermal quantification of nucleic acids via simultaneous chemical initiation of recombinase polymerase amplification reactions on SlipChip. Anal Chem (2011) 1.36
Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis. Proc Natl Acad Sci U S A (2006) 1.36
Threshold response of initiation of blood coagulation by tissue factor in patterned microfluidic capillaries is controlled by shear rate. Arterioscler Thromb Vasc Biol (2008) 1.33
Theoretical design and analysis of multivolume digital assays with wide dynamic range validated experimentally with microfluidic digital PCR. Anal Chem (2011) 1.32
Using microfluidics to observe the effect of mixing on nucleation of protein crystals. J Am Chem Soc (2005) 1.31
Nanoliter multiplex PCR arrays on a SlipChip. Anal Chem (2010) 1.30
Formation of Arrayed Droplets by Soft Lithography and Two-Phase Fluid Flow, and Application in Protein Crystallization. Adv Mater (2004) 1.30
Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices. Lab Chip (2006) 1.30
Microfluidic cartridges preloaded with nanoliter plugs of reagents: an alternative to 96-well plates for screening. Curr Opin Chem Biol (2006) 1.28
Protein crystallization using microfluidic technologies based on valves, droplets, and SlipChip. Annu Rev Biophys (2010) 1.28
Using a multijunction microfluidic device to inject substrate into an array of preformed plugs without cross-contamination: comparing theory and experiments. Anal Chem (2007) 1.20
Effects of shear rate on propagation of blood clotting determined using microfluidics and numerical simulations. J Am Chem Soc (2008) 1.19
A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm. PLoS One (2008) 1.15
Characterization of the threshold response of initiation of blood clotting to stimulus patch size. Biophys J (2007) 1.15
Minimal functional model of hemostasis in a biomimetic microfluidic system. Angew Chem Int Ed Engl (2004) 1.13
SlipChip for immunoassays in nanoliter volumes. Anal Chem (2010) 1.13
Characterization of the local temperature in space and time around a developing Drosophila embryo in a microfluidic device. Lab Chip (2006) 1.11
Rate of mixing controls rate and outcome of autocatalytic processes: theory and microfluidic experiments with chemical reactions and blood coagulation. Biophys J (2008) 1.11
Microfluidic stochastic confinement enhances analysis of rare cells by isolating cells and creating high density environments for control of diffusible signals. Chem Soc Rev (2010) 1.10
Multiparameter screening on SlipChip used for nanoliter protein crystallization combining free interface diffusion and microbatch methods. J Am Chem Soc (2010) 1.10
Using three-phase flow of immiscible liquids to prevent coalescence of droplets in microfluidic channels: criteria to identify the third liquid and validation with protein crystallization. Langmuir (2007) 1.08
Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen. J Am Chem Soc (2010) 1.07
A synthetic reaction network: chemical amplification using nonequilibrium autocatalytic reactions coupled in time. J Am Chem Soc (2004) 1.07
Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip. Lab Chip (2010) 1.04
Microfluidics using spatially defined arrays of droplets in one, two, and three dimensions. Annu Rev Anal Chem (Palo Alto Calif) (2011) 1.03
Microfluidic Generation of Lipidic Mesophases for Membrane Protein Crystallization. Cryst Growth Des (2009) 1.02
Laterally mobile, functionalized self-assembled monolayers at the fluorous-aqueous interface in a plug-based microfluidic system: characterization and testing with membrane protein crystallization. J Am Chem Soc (2009) 1.02
Combining microfluidic networks and peptide arrays for multi-enzyme assays. J Am Chem Soc (2005) 1.00
Mechanistic evaluation of the pros and cons of digital RT-LAMP for HIV-1 viral load quantification on a microfluidic device and improved efficiency via a two-step digital protocol. Anal Chem (2013) 0.99
Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides. Angew Chem Int Ed Engl (2009) 0.97
Propagation of blood clotting in the complex biochemical network of hemostasis is described by a simple mechanism. J Am Chem Soc (2007) 0.95
Increased robustness of single-molecule counting with microfluidics, digital isothermal amplification, and a mobile phone versus real-time kinetic measurements. Anal Chem (2013) 0.94
Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biol (2010) 0.94
Dynamics of coalescence of plugs with a hydrophilic wetting layer induced by flow in a microfluidic chemistrode. Langmuir (2009) 0.94
A Plug-Based Microfluidic System for Dispensing Lipidic Cubic Phase (LCP) Material Validated by Crystallizing Membrane Proteins in Lipidic Mesophases. Microfluid Nanofluidics (2010) 0.93
Dead-end filling of SlipChip evaluated theoretically and experimentally as a function of the surface chemistry and the gap size between the plates for lubricated and dry SlipChips. Langmuir (2010) 0.91
Simple host-guest chemistry to modulate the process of concentration and crystallization of membrane proteins by detergent capture in a microfluidic device. J Am Chem Soc (2008) 0.90
The pumping lid: investigating multi-material 3D printing for equipment-free, programmable generation of positive and negative pressures for microfluidic applications. Lab Chip (2014) 0.90
Complex function by design using spatially pre-structured synthetic microbial communities: degradation of pentachlorophenol in the presence of Hg(ii). Integr Biol (Camb) (2010) 0.90
A genetically encoded and gate for cell-targeted metabolic labeling of proteins. J Am Chem Soc (2013) 0.88
ABO, D blood typing and subtyping using plug-based microfluidics. Anal Chem (2008) 0.87
Digital biology and chemistry. Lab Chip (2014) 0.87
Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks. Acc Chem Res (2008) 0.85
The endo-siRNA pathway is essential for robust development of the Drosophila embryo. PLoS One (2009) 0.85
Individually addressable arrays of replica microbial cultures enabled by splitting SlipChips. Integr Biol (Camb) (2014) 0.85
Response to shape emerges in a complex biochemical network and its simple chemical analogue. Angew Chem Int Ed Engl (2007) 0.84
A microfluidic device for dry sample preservation in remote settings. Lab Chip (2013) 0.82
Using microfluidics to understand the effect of spatial distribution of tissue factor on blood coagulation. Thromb Res (2008) 0.82
Confinement regulates complex biochemical networks: initiation of blood clotting by "diffusion acting". Biophys J (2009) 0.81
Digital, ultrasensitive, end-point protein measurements with large dynamic range via Brownian trapping with drift. J Am Chem Soc (2014) 0.79
Three-dimensional nanocrystal superlattices grown in nanoliter microfluidic plugs. J Am Chem Soc (2011) 0.79
Using TIRF microscopy to quantify and confirm efficient mass transfer at the substrate surface of the chemistrode. New J Phys (2009) 0.78
Toward mechanistic understanding of nuclear reprocessing chemistries by quantifying lanthanide solvent extraction kinetics via microfluidics with constant interfacial area and rapid mixing. J Am Chem Soc (2011) 0.78
Evaluating 3D printing to solve the sample-to-device interface for LRS and POC diagnostics: example of an interlock meter-mix device for metering and lysing clinical urine samples. Lab Chip (2016) 0.78
Control of initiation, rate, and routing of spontaneous capillary-driven flow of liquid droplets through microfluidic channels on SlipChip. Langmuir (2012) 0.78
Chemical analog-to-digital signal conversion based on robust threshold chemistry and its evaluation in the context of microfluidics-based quantitative assays. J Am Chem Soc (2013) 0.77
Structural and spectropotentiometric analysis of Blastochloris viridis heterodimer mutant reaction center. Biochim Biophys Acta (2009) 0.76
Corrigendum: Digital Quantification of DNA Replication and Chromosome Segregation Enables Determination of Antimicrobial Susceptibility after only 15 Minutes of Antibiotic Exposure. Angew Chem Int Ed Engl (2017) 0.75
Design considerations for electrostatic microvalves with applications in poly(dimethylsiloxane)-based microfluidics. Lab Chip (2012) 0.75