Published in Angew Chem Int Ed Engl on January 01, 2009
Growing unculturable bacteria. J Bacteriol (2012) 2.18
Density-dependent fitness benefits in quorum-sensing bacterial populations. Proc Natl Acad Sci U S A (2012) 1.83
Real-time monitoring of quorum sensing in 3D-printed bacterial aggregates using scanning electrochemical microscopy. Proc Natl Acad Sci U S A (2014) 1.56
Microbial metabolic exchange--the chemotype-to-phenotype link. Nat Chem Biol (2011) 1.55
Probing prokaryotic social behaviors with bacterial "lobster traps". MBio (2010) 1.39
Stochastic Assembly of Bacteria in Microwell Arrays Reveals the Importance of Confinement in Community Development. PLoS One (2016) 1.39
Nanoliter multiplex PCR arrays on a SlipChip. Anal Chem (2010) 1.30
Going local: technologies for exploring bacterial microenvironments. Nat Rev Microbiol (2013) 1.19
3D printing of microscopic bacterial communities. Proc Natl Acad Sci U S A (2013) 1.18
Microfluidics expanding the frontiers of microbial ecology. Annu Rev Biophys (2014) 1.12
Microfluidic stochastic confinement enhances analysis of rare cells by isolating cells and creating high density environments for control of diffusible signals. Chem Soc Rev (2010) 1.10
Physicochemical regulation of biofilm formation. MRS Bull (2011) 1.08
What's in a name? The semantics of quorum sensing. Trends Microbiol (2010) 1.08
Microdroplet-enabled highly parallel co-cultivation of microbial communities. PLoS One (2011) 1.07
Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip. Lab Chip (2010) 1.04
Oxygen limitation within a bacterial aggregate. MBio (2014) 1.03
Quorum sensing between Pseudomonas aeruginosa biofilms accelerates cell growth. J Am Chem Soc (2011) 1.01
Quorum quenching agents: resources for antivirulence therapy. Mar Drugs (2014) 1.01
Detection of acyl-homoserine lactones by Escherichia and Salmonella. Curr Opin Microbiol (2011) 1.00
Bacterial growth and adaptation in microdroplet chemostats. Angew Chem Int Ed Engl (2013) 1.00
A programmable microenvironment for cellular studies via microfluidics-generated double emulsions. Biomaterials (2013) 0.99
Interplay of physical mechanisms and biofilm processes: review of microfluidic methods. Lab Chip (2015) 0.96
Advances in high-throughput single-cell microtechnologies. Curr Opin Biotechnol (2013) 0.95
Thiolactone modulators of quorum sensing revealed through library design and screening. Bioorg Med Chem (2011) 0.95
Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria. Indian J Microbiol (2015) 0.95
Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts. ACS Chem Biol (2011) 0.94
Core principles of bacterial autoinducer systems. Microbiol Mol Biol Rev (2015) 0.94
Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing. Bioorg Med Chem (2011) 0.93
Asynchronous magnetic bead rotation microviscometer for rapid, sensitive, and label-free studies of bacterial growth and drug sensitivity. Anal Chem (2012) 0.92
Dynamics of the quorum sensing switch: stochastic and non-stationary effects. BMC Syst Biol (2013) 0.92
Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nat Chem (2013) 0.91
Quorum sensing in bacterial species that use degenerate autoinducers can be tuned by using structurally identical non-native ligands. Chembiochem (2011) 0.91
Sociomicrobiology in engineered landscapes. Nat Chem Biol (2011) 0.90
Signal diffusion and the mitigation of social exploitation in pneumococcal competence signalling. Proc Biol Sci (2010) 0.89
Single-cell assays. Biomicrofluidics (2011) 0.87
Isolated microbial single cells and resulting micropopulations grow faster in controlled environments. Appl Environ Microbiol (2012) 0.87
Chip in a lab: Microfluidics for next generation life science research. Biomicrofluidics (2013) 0.87
New and unexpected insights into the modulation of LuxR-type quorum sensing by cyclic dipeptides. ACS Chem Biol (2009) 0.87
Biofilm responses to smooth flow fields and chemical gradients in novel microfluidic flow cells. Biotechnol Bioeng (2013) 0.85
Quorum sensing triggers the stochastic escape of individual cells from Pseudomonas putida biofilms. Nat Commun (2015) 0.85
Design of a large-scale femtoliter droplet array for single-cell analysis of drug-tolerant and drug-resistant bacteria. Front Microbiol (2013) 0.84
Microfluidic technologies for synthetic biology. Int J Mol Sci (2011) 0.82
Single cell kinase signaling assay using pinched flow coupled droplet microfluidics. Biomicrofluidics (2014) 0.82
Confinement regulates complex biochemical networks: initiation of blood clotting by "diffusion acting". Biophys J (2009) 0.81
Quorum Sensing Desynchronization Leads to Bimodality and Patterned Behaviors. PLoS Comput Biol (2016) 0.80
Enabling systems biology approaches through microfabricated systems. Anal Chem (2013) 0.80
Confinement-Induced Drug-Tolerance in Mycobacteria Mediated by an Efflux Mechanism. PLoS One (2015) 0.79
Chemistry with spatial control using particles and streams(). RSC Adv (2012) 0.79
Noise regulation by quorum sensing in low mRNA copy number systems. BMC Syst Biol (2011) 0.79
Quorum sensing protects bacterial co-operation from exploitation by cheats. ISME J (2016) 0.78
A millifluidic study of cell-to-cell heterogeneity in growth-rate and cell-division capability in populations of isogenic cells of Chlamydomonas reinhardtii. PLoS One (2015) 0.78
Single cell time-resolved quorum responses reveal dependence on cell density and configuration. J Biol Chem (2011) 0.78
Intra-species bacterial quorum sensing studied at single cell level in a double droplet trapping system. Int J Mol Sci (2013) 0.78
Microbial metabolomics in open microscale platforms. Nat Commun (2016) 0.78
Simultaneous spatiotemporal mapping of in situ pH and bacterial activity within an intact 3D microcolony structure. Sci Rep (2016) 0.77
Density-Dependent Differentiation of Bacteria in Spatially Structured Open Systems. Biophys J (2016) 0.76
Lineage Tracking for Probing Heritable Phenotypes at Single-Cell Resolution. PLoS One (2016) 0.76
Microbial Nanoculture as an Artificial Microniche. Sci Rep (2016) 0.76
Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR. Org Biomol Chem (2015) 0.76
Microfluidic Studies of Biofilm Formation in Dynamic Environments. J Bacteriol (2016) 0.76
Synchronizing stochastic circadian oscillators in single cells of Neurospora crassa. Sci Rep (2016) 0.76
A microfluidic-based bubble generation platform enables analysis of physical property change in phospholipid surfactant layers by interfacial ozone reaction. Lab Chip (2012) 0.75
A crucial role for spatial distribution in bacterial quorum sensing. Sci Rep (2016) 0.75
A design principle of group-level decision making in cell populations. PLoS Comput Biol (2013) 0.75
One-to-one encapsulation based on alternating droplet generation. Sci Rep (2015) 0.75
Cultivation strategies for growth of uncultivated bacteria. J Oral Biosci (2016) 0.75
Two-dimensional arrays of cell-laden polymer hydrogel modules. Biomicrofluidics (2016) 0.75
When being alone is enough: noncanonical functions of canonical bacterial quorum-sensing systems. Future Microbiol (2016) 0.75
Monitoring microbial metabolites using an inductively coupled resonance circuit. Sci Rep (2015) 0.75
New Technologies for Studying Biofilms. Microbiol Spectr (2015) 0.75
Microbe observation and cultivation array (MOCA) for cultivating and analyzing environmental microbiota. Microbiome (2013) 0.75
Microscale microbial culture. Future Microbiol (2015) 0.75
Multimodal microfluidic platform for controlled culture and analysis of unicellular organisms. Biomicrofluidics (2017) 0.75
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol (1994) 17.55
Quorum sensing in bacteria. Annu Rev Microbiol (2001) 14.41
Reactions in droplets in microfluidic channels. Angew Chem Int Ed Engl (2006) 5.07
A microfluidic system for controlling reaction networks in time. Angew Chem Int Ed Engl (2003) 3.96
Microfabrication meets microbiology. Nat Rev Microbiol (2007) 3.45
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology (2002) 3.37
Is quorum sensing a side effect of diffusion sensing? Trends Microbiol (2002) 3.18
Millisecond kinetics on a microfluidic chip using nanoliters of reagents. J Am Chem Soc (2003) 3.17
Does efficiency sensing unify diffusion and quorum sensing? Nat Rev Microbiol (2007) 2.92
Drop-based microfluidic devices for encapsulation of single cells. Lab Chip (2008) 2.90
Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem (2005) 2.58
Responses to nutrient starvation in Pseudomonas putida KT2442: analysis of general cross-protection, cell shape, and macromolecular content. J Bacteriol (1994) 2.46
Defined spatial structure stabilizes a synthetic multispecies bacterial community. Proc Natl Acad Sci U S A (2008) 2.42
Dynamic single-cell analysis for quantitative biology. Anal Chem (2006) 2.36
Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials (2003) 2.27
Bacterial metapopulations in nanofabricated landscapes. Proc Natl Acad Sci U S A (2006) 2.26
A microfluidic processor for gene expression profiling of single human embryonic stem cells. Lab Chip (2007) 2.17
Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab Chip (2008) 2.11
agr expression precedes escape of internalized Staphylococcus aureus from the host endosome. Infect Immun (2001) 2.11
Motion to form a quorum. Science (2003) 1.95
Quorum-sensing-negative (lasR) mutants of Pseudomonas aeruginosa avoid cell lysis and death. J Bacteriol (2005) 1.92
The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc Natl Acad Sci U S A (2008) 1.90
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'. Nat Chem Biol (2008) 1.74
Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel. Lab Chip (2008) 1.71
Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target. J Clin Invest (2003) 1.58
The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities. Anal Bioanal Chem (2006) 1.49
A New Approach for Measuring Single-Cell Oxygen Consumption Rates. IEEE Trans Autom Sci Eng (2008) 1.31
Biphasic intracellular expression of Staphylococcus aureus virulence factors and evidence for Agr-mediated diffusion sensing. Mol Microbiol (2003) 1.22
The expression of alpha-haemolysin is required for Staphylococcus aureus phagosomal escape after internalization in CFT-1 cells. Cell Microbiol (2008) 1.22
Quorum size of Pseudomonas syringae is small and dictated by water availability on the leaf surface. Proc Natl Acad Sci U S A (2008) 1.21
Digital concentration readout of single enzyme molecules using femtoliter arrays and Poisson statistics. Nano Lett (2006) 1.18
Influence of the hydrodynamic environment on quorum sensing in Pseudomonas aeruginosa biofilms. J Bacteriol (2007) 1.11
Pumpless, selective docking of yeast cells inside a microfluidic channel induced by receding meniscus. Lab Chip (2006) 1.05
Detection of Salmonella spp. using microsphere-based, fiber-optic DNA microarrays. Anal Chem (2005) 1.02
Chip devices for miniaturized biotechnology. Appl Microbiol Biotechnol (2005) 0.92
MEMS and the microbe. Lab Chip (2008) 0.86
Localized quorum sensing in Vibrio fischeri. Colloids Surf B Biointerfaces (2007) 0.84
Reactions in droplets in microfluidic channels. Angew Chem Int Ed Engl (2006) 5.07
Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets. J Am Chem Soc (2003) 3.97
A microfluidic system for controlling reaction networks in time. Angew Chem Int Ed Engl (2003) 3.96
Millisecond kinetics on a microfluidic chip using nanoliters of reagents. J Am Chem Soc (2003) 3.17
Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature (2005) 3.01
Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc Natl Acad Sci U S A (2006) 2.66
Defined spatial structure stabilizes a synthetic multispecies bacterial community. Proc Natl Acad Sci U S A (2008) 2.42
A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip X-ray diffraction. Angew Chem Int Ed Engl (2004) 2.26
Controlling nonspecific protein adsorption in a plug-based microfluidic system by controlling interfacial chemistry using fluorous-phase surfactants. Anal Chem (2005) 2.15
Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab Chip (2008) 2.11
The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc Natl Acad Sci U S A (2008) 1.90
Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system. Lab Chip (2004) 1.87
SlipChip. Lab Chip (2009) 1.84
Microgram-scale testing of reaction conditions in solution using nanoliter plugs in microfluidics with detection by MALDI-MS. J Am Chem Soc (2006) 1.81
A microfluidic approach for screening submicroliter volumes against multiple reagents by using preformed arrays of nanoliter plugs in a three-phase liquid/liquid/gas flow. Angew Chem Int Ed Engl (2005) 1.74
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'. Nat Chem Biol (2008) 1.74
Microfluidic systems for chemical kinetics that rely on chaotic mixing in droplets. Philos Trans A Math Phys Eng Sci (2004) 1.62
Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization. Curr Opin Struct Biol (2005) 1.61
Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels. Appl Phys Lett (2003) 1.57
Digital PCR on a SlipChip. Lab Chip (2010) 1.57
Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays. Anal Chem (2004) 1.54
Multiplexed quantification of nucleic acids with large dynamic range using multivolume digital RT-PCR on a rotational SlipChip tested with HIV and hepatitis C viral load. J Am Chem Soc (2011) 1.51
Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl (2006) 1.45
In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr (2005) 1.42
On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system. Anal Chem (2006) 1.42
Digital isothermal quantification of nucleic acids via simultaneous chemical initiation of recombinase polymerase amplification reactions on SlipChip. Anal Chem (2011) 1.36
Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis. Proc Natl Acad Sci U S A (2006) 1.36
Threshold response of initiation of blood coagulation by tissue factor in patterned microfluidic capillaries is controlled by shear rate. Arterioscler Thromb Vasc Biol (2008) 1.33
Theoretical design and analysis of multivolume digital assays with wide dynamic range validated experimentally with microfluidic digital PCR. Anal Chem (2011) 1.32
Using microfluidics to observe the effect of mixing on nucleation of protein crystals. J Am Chem Soc (2005) 1.31
Nanoliter multiplex PCR arrays on a SlipChip. Anal Chem (2010) 1.30
Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices. Lab Chip (2006) 1.30
Formation of Arrayed Droplets by Soft Lithography and Two-Phase Fluid Flow, and Application in Protein Crystallization. Adv Mater (2004) 1.30
Protein crystallization using microfluidic technologies based on valves, droplets, and SlipChip. Annu Rev Biophys (2010) 1.28
Microfluidic cartridges preloaded with nanoliter plugs of reagents: an alternative to 96-well plates for screening. Curr Opin Chem Biol (2006) 1.28
Using a multijunction microfluidic device to inject substrate into an array of preformed plugs without cross-contamination: comparing theory and experiments. Anal Chem (2007) 1.20
Effects of shear rate on propagation of blood clotting determined using microfluidics and numerical simulations. J Am Chem Soc (2008) 1.19
A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm. PLoS One (2008) 1.15
Characterization of the threshold response of initiation of blood clotting to stimulus patch size. Biophys J (2007) 1.15
SlipChip for immunoassays in nanoliter volumes. Anal Chem (2010) 1.13
Minimal functional model of hemostasis in a biomimetic microfluidic system. Angew Chem Int Ed Engl (2004) 1.13
Characterization of the local temperature in space and time around a developing Drosophila embryo in a microfluidic device. Lab Chip (2006) 1.11
Rate of mixing controls rate and outcome of autocatalytic processes: theory and microfluidic experiments with chemical reactions and blood coagulation. Biophys J (2008) 1.11
Multiparameter screening on SlipChip used for nanoliter protein crystallization combining free interface diffusion and microbatch methods. J Am Chem Soc (2010) 1.10
Microfluidic stochastic confinement enhances analysis of rare cells by isolating cells and creating high density environments for control of diffusible signals. Chem Soc Rev (2010) 1.10
Using three-phase flow of immiscible liquids to prevent coalescence of droplets in microfluidic channels: criteria to identify the third liquid and validation with protein crystallization. Langmuir (2007) 1.08
Evolution of catalysts directed by genetic algorithms in a plug-based microfluidic device tested with oxidation of methane by oxygen. J Am Chem Soc (2010) 1.07
A synthetic reaction network: chemical amplification using nonequilibrium autocatalytic reactions coupled in time. J Am Chem Soc (2004) 1.07
Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip. Lab Chip (2010) 1.04
Microfluidics using spatially defined arrays of droplets in one, two, and three dimensions. Annu Rev Anal Chem (Palo Alto Calif) (2011) 1.03
Laterally mobile, functionalized self-assembled monolayers at the fluorous-aqueous interface in a plug-based microfluidic system: characterization and testing with membrane protein crystallization. J Am Chem Soc (2009) 1.02
Combining microfluidic networks and peptide arrays for multi-enzyme assays. J Am Chem Soc (2005) 1.00
Mechanistic evaluation of the pros and cons of digital RT-LAMP for HIV-1 viral load quantification on a microfluidic device and improved efficiency via a two-step digital protocol. Anal Chem (2013) 0.99
Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides. Angew Chem Int Ed Engl (2009) 0.97
Propagation of blood clotting in the complex biochemical network of hemostasis is described by a simple mechanism. J Am Chem Soc (2007) 0.95
Increased robustness of single-molecule counting with microfluidics, digital isothermal amplification, and a mobile phone versus real-time kinetic measurements. Anal Chem (2013) 0.94
Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biol (2010) 0.94
Dynamics of coalescence of plugs with a hydrophilic wetting layer induced by flow in a microfluidic chemistrode. Langmuir (2009) 0.94
A Plug-Based Microfluidic System for Dispensing Lipidic Cubic Phase (LCP) Material Validated by Crystallizing Membrane Proteins in Lipidic Mesophases. Microfluid Nanofluidics (2010) 0.93
Dead-end filling of SlipChip evaluated theoretically and experimentally as a function of the surface chemistry and the gap size between the plates for lubricated and dry SlipChips. Langmuir (2010) 0.91
Complex function by design using spatially pre-structured synthetic microbial communities: degradation of pentachlorophenol in the presence of Hg(ii). Integr Biol (Camb) (2010) 0.90
The pumping lid: investigating multi-material 3D printing for equipment-free, programmable generation of positive and negative pressures for microfluidic applications. Lab Chip (2014) 0.90
Simple host-guest chemistry to modulate the process of concentration and crystallization of membrane proteins by detergent capture in a microfluidic device. J Am Chem Soc (2008) 0.90
A genetically encoded and gate for cell-targeted metabolic labeling of proteins. J Am Chem Soc (2013) 0.88
ABO, D blood typing and subtyping using plug-based microfluidics. Anal Chem (2008) 0.87
Digital biology and chemistry. Lab Chip (2014) 0.87
Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks. Acc Chem Res (2008) 0.85
The endo-siRNA pathway is essential for robust development of the Drosophila embryo. PLoS One (2009) 0.85
Individually addressable arrays of replica microbial cultures enabled by splitting SlipChips. Integr Biol (Camb) (2014) 0.85
Response to shape emerges in a complex biochemical network and its simple chemical analogue. Angew Chem Int Ed Engl (2007) 0.84
Using microfluidics to understand the effect of spatial distribution of tissue factor on blood coagulation. Thromb Res (2008) 0.82
A microfluidic device for dry sample preservation in remote settings. Lab Chip (2013) 0.82
Confinement regulates complex biochemical networks: initiation of blood clotting by "diffusion acting". Biophys J (2009) 0.81
Three-dimensional nanocrystal superlattices grown in nanoliter microfluidic plugs. J Am Chem Soc (2011) 0.79
Digital, ultrasensitive, end-point protein measurements with large dynamic range via Brownian trapping with drift. J Am Chem Soc (2014) 0.79
Evaluating 3D printing to solve the sample-to-device interface for LRS and POC diagnostics: example of an interlock meter-mix device for metering and lysing clinical urine samples. Lab Chip (2016) 0.78
Control of initiation, rate, and routing of spontaneous capillary-driven flow of liquid droplets through microfluidic channels on SlipChip. Langmuir (2012) 0.78
Using TIRF microscopy to quantify and confirm efficient mass transfer at the substrate surface of the chemistrode. New J Phys (2009) 0.78
Toward mechanistic understanding of nuclear reprocessing chemistries by quantifying lanthanide solvent extraction kinetics via microfluidics with constant interfacial area and rapid mixing. J Am Chem Soc (2011) 0.78
Chemical analog-to-digital signal conversion based on robust threshold chemistry and its evaluation in the context of microfluidics-based quantitative assays. J Am Chem Soc (2013) 0.77
Structural and spectropotentiometric analysis of Blastochloris viridis heterodimer mutant reaction center. Biochim Biophys Acta (2009) 0.76
Corrigendum: Digital Quantification of DNA Replication and Chromosome Segregation Enables Determination of Antimicrobial Susceptibility after only 15 Minutes of Antibiotic Exposure. Angew Chem Int Ed Engl (2017) 0.75