Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning.

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Published in Br J Pharmacol on February 01, 2003

Authors

Péter Ferdinandy1, Richard Schulz

Author Affiliations

1: Cardiovascular Research Group, Department of Biochemistry, University of Szeged, Dóm tér 9, Szeged, H-6720 Hungary. PETER@BIOCH.SZOTE.U-SZEGED.HU

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Inhibition of endogenous nitric oxide synthase potentiates ischemia-reperfusion-induced myocardial apoptosis via a caspase-3 dependent pathway. Cardiovasc Res (2000) 0.90

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Preparing family caregivers for death and bereavement. Insights from caregivers of terminally ill patients. J Pain Symptom Manage (2008) 1.42

The prognostic significance of inspiratory capacity in pulmonary arterial hypertension. Respiration (2014) 1.41

An evidence-based medicine elective course to improve student performance in advanced pharmacy practice experiences. Am J Pharm Educ (2011) 1.41

Postresuscitation administration of doxycycline preserves cardiac contractile function in hypoxia-reoxygenation injury of newborn piglets*. Crit Care Med (2014) 1.40

Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix. Cardiovasc Res (2009) 1.39

Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the health aging and body composition study. J Am Geriatr Soc (2003) 1.38

Preparing caregivers for the death of a loved one: a theoretical framework and suggestions for future research. J Palliat Med (2006) 1.35

Positive and negative religious coping and well-being in women with breast cancer. J Palliat Med (2009) 1.34

Development of the risk appraisal measure: a brief screen to identify risk areas and guide interventions for dementia caregivers. J Am Geriatr Soc (2009) 1.33

Antioxidant vitamin C improves endothelial function in obstructive sleep apnea. Am J Respir Crit Care Med (2006) 1.33

A methodology for describing and decomposing complex psychosocial and behavioral interventions. Psychol Aging (2003) 1.32

Older spouses' perceptions of partners' chronic arthritis pain: implications for spousal responses, support provision, and caregiving experiences. Psychol Aging (2006) 1.32

Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2. Cardiovasc Res (2002) 1.30

Positive aspects of caregiving and adaptation to bereavement. Psychol Aging (2004) 1.28

Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione. Biochem Pharmacol (2008) 1.28

Health stresses and depressive symptomatology in the elderly: the importance of health engagement control strategies. Health Psychol (2002) 1.27

Hospital costs in patients receiving prolonged mechanical ventilation: does age have an impact? Crit Care Med (2003) 1.26

Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation. Circ Res (2002) 1.23

Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats. Am J Physiol Heart Circ Physiol (2002) 1.23

Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation. FASEB J (2007) 1.23

Association of enjoyable leisure activities with psychological and physical well-being. Psychosom Med (2009) 1.22

Interventions to enhance physical and psychological functioning among younger women who are ending nonhormonal adjuvant treatment for early-stage breast cancer. J Clin Oncol (2005) 1.18

Guiding research in family care: a new approach to oncology caregiving. Psychooncology (2008) 1.16

Depressive symptoms in older African-American and white adults with functional difficulties: the role of control strategies. J Am Geriatr Soc (2007) 1.14

Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. Circulation (2009) 1.13

Making sense of mild cognitive impairment: a qualitative exploration of the patient's experience. Gerontologist (2006) 1.12

Socioeconomic position and incident mobility impairment in the Cardiovascular Health Study. BMC Geriatr (2007) 1.10

Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury. J Mol Cell Cardiol (2007) 1.09

Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction. Cardiovasc Res (2003) 1.08

Obstructive sleep apnea, oxidative stress and cardiovascular disease: lessons from animal studies. Oxid Med Cell Longev (2013) 1.07

Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression. Psychosom Med (2010) 1.07

Data and safety monitoring in social behavioral intervention trials: the REACH II experience. Clin Trials (2006) 1.07

Hyperlipidemia attenuates the infarct size-limiting effect of ischemic preconditioning: role of matrix metalloproteinase-2 inhibition. J Pharmacol Exp Ther (2005) 1.07

Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection. J Infect Dis (2008) 1.07

Religious beliefs and practices are associated with better mental health in family caregivers of patients with dementia: findings from the REACH study. Am J Geriatr Psychiatry (2006) 1.07

Verbal communication among Alzheimer's disease patients, their caregivers, and primary care physicians during primary care office visits. Patient Educ Couns (2009) 1.05

Ischaemia-reperfusion injury activates matrix metalloproteinases in the human heart. Eur Heart J (2004) 1.05

Spouses' cardiovascular reactivity to their partners' suffering. J Gerontol B Psychol Sci Soc Sci (2010) 1.05

Inhibiting matrix metalloproteinase-2 reduces protein release into coronary effluent from isolated rat hearts during ischemia-reperfusion. Basic Res Cardiol (2008) 1.04

Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinases during acute myocardial [correction of myoctardial] ischemia-reperfusion injury. Circulation (2003) 1.04

Generalized anxiety disorder in late life: lifetime course and comorbidity with major depressive disorder. Am J Geriatr Psychiatry (2005) 1.03

Physical health problems, depressive mood, and cortisol secretion in old age: buffer effects of health engagement control strategies. Health Psychol (2007) 1.02

Finding the best ways to help: opportunities and challenges of intervention research on aging. Gerontologist (2003) 1.02

Peroxynitrite in myocardial ischemia-reperfusion injury. Heart Fail Rev (2002) 1.01

Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. Am J Respir Crit Care Med (2009) 1.01

Improving well-being in caregivers of terminally ill patients. Making the case for patient suffering as a focus for intervention research. J Pain Symptom Manage (2007) 1.00

Matrix metalloproteinase inhibitor properties of tetracyclines: therapeutic potential in cardiovascular diseases. Pharmacol Res (2011) 1.00

What questions do family caregivers want to discuss with health care providers in order to prepare for the death of a loved one? An ethnographic study of caregivers of patients at end of life. J Palliat Med (2008) 1.00

Lower quality of life among women with chronic pelvic pain after pelvic inflammatory disease. Obstet Gynecol (2003) 1.00

Concurrent and long-term predictors of older adults' use of community-based long-term care services: the Caregiver Health Effects Study. J Aging Health (2004) 1.00

Does who you marry matter for your health? Influence of patients' and spouses' personality on their partners' psychological well-being following coronary artery bypass surgery. J Pers Soc Psychol (2006) 1.00

Role of social support in predicting caregiver burden. Arch Phys Med Rehabil (2012) 0.98

Racial differences in self-rated health at similar levels of physical functioning: an examination of health pessimism in the health, aging, and body composition study. J Gerontol B Psychol Sci Soc Sci (2009) 0.98

Matrix metalloproteinase inhibitors attenuate endotoxemia induced cardiac dysfunction: a potential role for MMP-9. Mol Cell Biochem (2003) 0.97

Group-based trajectory modeling of caregiver psychological distress over time. Ann Behav Med (2012) 0.97

Executive functions and cognitive subprocesses in patients with obstructive sleep apnoea. J Sleep Res (2008) 0.97

Concordance of race or ethnicity of interventionists and caregivers of dementia patients: relationship to attrition and treatment outcomes in the REACH study. Gerontologist (2006) 0.96

Concordance of four methods of disability assessment using performance in the home as the criterion method. Arthritis Rheum (2003) 0.96

MMP-2 and MMP-9 and their tissue inhibitors in the plasma of preterm and term neonates. Pediatr Res (2004) 0.96

E-care: a telecommunications technology intervention for family caregivers of dementia patients. Am J Geriatr Psychiatry (2007) 0.95