Published in Am J Clin Nutr on March 01, 2003
Nutrition and depression: implications for improving mental health among childbearing-aged women. Biol Psychiatry (2005) 1.46
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res A Clin Mol Teratol (2009) 1.29
Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene. J Med Genet (2005) 1.13
Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev (2008) 1.08
Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenesis (2008) 1.06
Predictors of vitamin B6 and folate concentrations in older persons: the InCHIANTI study. Clin Chem (2006) 0.98
MTHFR polymorphisms in gastric cancer and in first-degree relatives of patients with gastric cancer. Tumour Biol (2009) 0.89
Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. Cancer (2012) 0.88
The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures. J Bone Miner Metab (2008) 0.85
Nutrient intake values for folate during pregnancy and lactation vary widely around the world. Nutrients (2013) 0.85
Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake. J Epidemiol (2008) 0.83
The biomarker-based validity of a food frequency questionnaire to assess the intake status of folate, pyridoxine and cobalamin among Iranian primary breast cancer patients. Eur J Clin Nutr (2013) 0.83
Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients. J Bone Miner Metab (2009) 0.83
[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol (2009) 0.82
A population model of folate-mediated one-carbon metabolism. Nutrients (2013) 0.81
MTHFR C677T genotype and cardiovascular risk in a general population without mandatory folic acid fortification. Eur J Nutr (2014) 0.80
Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate reductase genotype, lipids and folate: a seroepidemiological study. Nutr Metab (Lond) (2009) 0.78
Response of serum and red blood cell folate concentrations to folic acid supplementation depends on methylenetetrahydrofolate reductase C677T genotype: results from a crossover trial. Mol Nutr Food Res (2013) 0.78
Predictive index for the onset of medication overuse headache in migraine patients. Neurol Sci (2013) 0.78
Distinct effects of folate pathway genes MTHFR and MTHFD1L on ruminative response style: a potential risk mechanism for depression. Transl Psychiatry (2016) 0.78
MTHFR 677T is a strong determinant of the degree of hearing loss among Polish males with postlingual sensorineural hearing impairment. DNA Cell Biol (2012) 0.77
Lack of association between the MTHFR C677T variant and migraine with aura in an older population: could selective survival play a role? Cephalalgia (2012) 0.77
Association of blood lead levels with methylenetetrahydrofolate reductase polymorphisms among Chinese pregnant women in Wuhan city. PLoS One (2015) 0.75
The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia. Am J Clin Nutr (2013) 0.75
Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery. Eur J Obstet Gynecol Reprod Biol (2015) 0.75
The TT genotype of methylenetetrahydrofolate reductase 677C>T polymorphism increases the susceptibility to pediatric ischemic stroke: meta-analysis of the 822 cases and 1,552 controls. Mol Biol Rep (2012) 0.75
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA (2002) 5.29
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts. Clin Chem (2007) 2.82
Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol (2006) 2.31
Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem (2003) 2.15
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis. J Rheumatol (2012) 2.14
Sleep duration and sleep quality in relation to 12-year cardiovascular disease incidence: the MORGEN study. Sleep (2011) 2.07
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr (2006) 1.91
Strict cysteamine dose regimen is required to prevent nocturnal cystine accumulation in cystinosis. Pediatr Nephrol (2005) 1.85
Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation. Eur Heart J (2006) 1.84
Coffee intake and incidence of hypertension. Am J Clin Nutr (2007) 1.80
Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. Eur J Hum Genet (2006) 1.74
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Cohort profile: the EPIC-NL study. Int J Epidemiol (2009) 1.63
Customary use of plant sterol and plant stanol enriched margarine is associated with changes in serum plant sterol and stanol concentrations in humans. J Nutr (2007) 1.62
EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries. Eur J Epidemiol (2007) 1.59
Colors of fruit and vegetables and 10-year incidence of stroke. Stroke (2011) 1.55
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study. Am J Clin Nutr (2013) 1.53
Homocysteine level is associated with aortic stiffness in elderly: cross-sectional results from the B-PROOF study. J Hypertens (2013) 1.52
DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients. Mol Genet Metab (2007) 1.50
Validity of coronary heart diseases and heart failure based on hospital discharge and mortality data in the Netherlands using the cardiovascular registry Maastricht cohort study. Eur J Epidemiol (2009) 1.45
Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev (2002) 1.45
Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia. Cardiovasc Res (2003) 1.42
Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition. Am J Epidemiol (2007) 1.34
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum Mol Genet (2008) 1.33
Body mass index and waist circumference predict both 10-year nonfatal and fatal cardiovascular disease risk: study conducted in 20,000 Dutch men and women aged 20-65 years. Eur J Cardiovasc Prev Rehabil (2009) 1.31
Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology. Clin Chem (2006) 1.29
Type 2 diabetes and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. Diabetes Care (2010) 1.25
Challenging homeostasis to define biomarkers for nutrition related health. Mol Nutr Food Res (2009) 1.25
Raw and processed fruit and vegetable consumption and 10-year coronary heart disease incidence in a population-based cohort study in the Netherlands. PLoS One (2010) 1.24
Genetic variation in genes of folate metabolism and neural-tube defect risk. Proc Nutr Soc (2006) 1.23
The homocysteine controversy. J Inherit Metab Dis (2010) 1.23
Age, period and cohort effects on body weight and body mass index in adults: The Doetinchem Cohort Study. Public Health Nutr (2008) 1.23
Cytosine DNA methylation is found in Drosophila melanogaster but absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other yeast species. Anal Chem (2014) 1.23
Effects of retirement on lifestyle in relation to changes in weight and waist circumference in Dutch men: a prospective study. Public Health Nutr (2005) 1.19
Choline and risk of neural tube defects in a folate-fortified population. Epidemiology (2009) 1.18
Smoking and cognitive decline among middle-aged men and women: the Doetinchem Cohort Study. Am J Public Health (2008) 1.18
A high-density association screen of 155 ion transport genes for involvement with common migraine. Hum Mol Genet (2008) 1.17
Mediterranean style diet and 12-year incidence of cardiovascular diseases: the EPIC-NL cohort study. PLoS One (2012) 1.16
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. Eur Heart J (2016) 1.14
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. Am J Hum Genet (2011) 1.14
Tea and coffee consumption and cardiovascular morbidity and mortality. Arterioscler Thromb Vasc Biol (2010) 1.11
Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. Clin Chem (2005) 1.11
Population trends and inequalities in incidence and short-term outcome of acute myocardial infarction between 1998 and 2007. Int J Cardiol (2012) 1.11
Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC. J Mol Med (Berl) (2005) 1.10
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. J Lipid Res (2008) 1.09
Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study. Atherosclerosis (2010) 1.09
[Extensive neonatal heel injection screening for metabolic diseases in the Netherlands]. Ned Tijdschr Geneeskd (2009) 1.08
MTRR 66A>G polymorphism in relation to congenital heart defects. Clin Chem Lab Med (2006) 1.08
Genetic determinants of plasma total homocysteine. Semin Vasc Med (2005) 1.06
Cardiovascular surveys: manual of operations. Eur J Cardiovasc Prev Rehabil (2007) 1.05
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). Birth Defects Res A Clin Mol Teratol (2009) 1.05
Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects. Eur J Hum Genet (2002) 1.04
Sedoheptulokinase deficiency due to a 57-kb deletion in cystinosis patients causes urinary accumulation of sedoheptulose: elucidation of the CARKL gene. Hum Mutat (2008) 1.04
Evaluation of cardiovascular risk predicted by different SCORE equations: the Netherlands as an example. Eur J Cardiovasc Prev Rehabil (2010) 1.03
Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands. Eur Heart J (2009) 1.03
Beta-carotene affects oxidative stress-related DNA damage in lung epithelial cells and in ferret lung. Carcinogenesis (2009) 1.03
Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects. Clin Chem Lab Med (2008) 1.02
Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts. Am J Obstet Gynecol (2003) 1.01
Do positive or negative experiences of social support relate to current and future health? Results from the Doetinchem Cohort Study. BMC Public Health (2012) 1.01
Maternal homocysteine and small-for-gestational-age offspring: systematic review and meta-analysis. Am J Clin Nutr (2011) 1.01
Population-level changes to promote cardiovascular health. Eur J Prev Cardiol (2012) 1.00
The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida. J Mol Med (Berl) (2006) 1.00
Lifestyle factors of a five-year community-intervention program: the Hartslag Limburg intervention. Am J Prev Med (2009) 1.00
Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis. Thromb Haemost (2002) 0.99
Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients. Clin Chem (2002) 0.99
The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders. Front Neurosci (2013) 0.99
Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. PLoS One (2011) 0.98
Genetics of hyperhomocysteinaemia in cardiovascular disease. Ann Clin Biochem (2003) 0.98
Combined effect of alcohol consumption and lifestyle behaviors on risk of type 2 diabetes. Am J Clin Nutr (2010) 0.98
Suboptimal choices and dosing of statins at start of therapy. Br J Clin Pharmacol (2005) 0.96
The impact of long-term body mass index patterns on health-related quality of life: the Doetinchem Cohort Study. Am J Epidemiol (2013) 0.95
Neural tube defects, folic acid and methylation. Int J Environ Res Public Health (2013) 0.95
Society already achieves economic benefits from generic substitution but fails to do the same for therapeutic substitution. Br J Clin Pharmacol (2007) 0.95
Cystine dimethylester model of cystinosis: still reliable? Pediatr Res (2007) 0.95
Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease. Nephrol Dial Transplant (2008) 0.95
Time trends in lipid lowering drug use in The Netherlands. Has the backlog of candidates for treatment been eliminated? Br J Clin Pharmacol (2002) 0.95
Improved cardiovascular risk profile and renal function in renal transplant patients after randomized conversion from cyclosporine to tacrolimus. J Am Soc Nephrol (2003) 0.95
Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida. Mol Genet Metab (2007) 0.95
Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells. Biochem Biophys Res Commun (2005) 0.95
Metabolic syndrome model definitions predicting type 2 diabetes and cardiovascular disease. Diabetes Care (2012) 0.94
Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism. Bone (2009) 0.94
Cytochrome c oxidase biogenesis in a patient with a mutation in COX10 gene. Ann Neurol (2004) 0.94