Published in J Inherit Metab Dis on June 22, 2010
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Methionine Adenosyltransferase I/III Deficiency in Portugal: High Frequency of a Dominantly Inherited Form in a Small Area of Douro High Lands. JIMD Rep (2012) 0.91
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A personal journey from the joint to the heart. Arthritis Res Ther (2010) 0.75
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No association between elevated homocysteine levels and carotid atherosclerosis in a rural population in China. Stroke Vasc Neurol (2016) 0.75
10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med (2008) 35.49
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Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med (2005) 27.77
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA (2002) 8.11
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA (2002) 5.29
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Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med (2009) 2.33
Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study. Arthritis Res Ther (2006) 2.28
Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr (2006) 2.25
Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT). J Thromb Haemost (2009) 2.08
A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood (2008) 1.49
Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler Thromb Vasc Biol (2008) 1.33
Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J Pathol (2009) 1.27
Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status. J Nutr Biochem (2007) 0.95
Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future Oncol (2009) 0.95
Studies on the polyglutamate specificity of methylenetetrahydrofolate dehydrogenase from pig liver. Biochemistry (1984) 0.91
Increased uptake of folate conjugates by activated macrophages in experimental hyperlipemia. Cell Tissue Res (2005) 0.89
Folic acid supplementation delays atherosclerotic lesion development in apoE-deficient mice. Life Sci (2006) 0.81
Serum folate and risk for coronary heart disease: results from a cohort of US adults. Ann Epidemiol (1998) 0.80
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA (2002) 5.29
Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol (2006) 2.31
Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem (2003) 2.15
Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr (2006) 1.91
Strict cysteamine dose regimen is required to prevent nocturnal cystine accumulation in cystinosis. Pediatr Nephrol (2005) 1.85
Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation. Eur Heart J (2006) 1.84
Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels. Eur J Hum Genet (2006) 1.74
Homocysteine level is associated with aortic stiffness in elderly: cross-sectional results from the B-PROOF study. J Hypertens (2013) 1.52
DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients. Mol Genet Metab (2007) 1.50
Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev (2002) 1.45
Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia. Cardiovasc Res (2003) 1.42
Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function. Hum Mol Genet (2008) 1.33
Genetic variation in genes of folate metabolism and neural-tube defect risk. Proc Nutr Soc (2006) 1.23
Cytosine DNA methylation is found in Drosophila melanogaster but absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other yeast species. Anal Chem (2014) 1.23
Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr (2003) 1.18
Choline and risk of neural tube defects in a folate-fortified population. Epidemiology (2009) 1.18
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. Am J Hum Genet (2011) 1.14
Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. Clin Chem (2005) 1.11
Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC. J Mol Med (Berl) (2005) 1.10
[Extensive neonatal heel injection screening for metabolic diseases in the Netherlands]. Ned Tijdschr Geneeskd (2009) 1.08
MTRR 66A>G polymorphism in relation to congenital heart defects. Clin Chem Lab Med (2006) 1.08
Genetic determinants of plasma total homocysteine. Semin Vasc Med (2005) 1.06
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). Birth Defects Res A Clin Mol Teratol (2009) 1.05
Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects. Eur J Hum Genet (2002) 1.04
Sedoheptulokinase deficiency due to a 57-kb deletion in cystinosis patients causes urinary accumulation of sedoheptulose: elucidation of the CARKL gene. Hum Mutat (2008) 1.04
Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands. Eur Heart J (2009) 1.03
Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects. Clin Chem Lab Med (2008) 1.02
Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts. Am J Obstet Gynecol (2003) 1.01
Maternal homocysteine and small-for-gestational-age offspring: systematic review and meta-analysis. Am J Clin Nutr (2011) 1.01
The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida. J Mol Med (Berl) (2006) 1.00
Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis. Thromb Haemost (2002) 0.99
Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients. Clin Chem (2002) 0.99
Genetics of hyperhomocysteinaemia in cardiovascular disease. Ann Clin Biochem (2003) 0.98
Neural tube defects, folic acid and methylation. Int J Environ Res Public Health (2013) 0.95
Improved cardiovascular risk profile and renal function in renal transplant patients after randomized conversion from cyclosporine to tacrolimus. J Am Soc Nephrol (2003) 0.95
Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells. Biochem Biophys Res Commun (2005) 0.95
Cystine dimethylester model of cystinosis: still reliable? Pediatr Res (2007) 0.95
Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease. Nephrol Dial Transplant (2008) 0.95
Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida. Mol Genet Metab (2007) 0.95
Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism. Bone (2009) 0.94
Prospective study of homocysteine and MTHFR 677TT genotype and risk for venous thrombosis in a general population--results from the HUNT 2 study. Br J Haematol (2008) 0.93
Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study. J Vasc Surg (2007) 0.93
Decreased intracellular ATP content and intact mitochondrial energy generating capacity in human cystinotic fibroblasts. Pediatr Res (2006) 0.92
Inhibition of transmethylation disturbs neurulation in chick embryos. Brain Res Dev Brain Res (2005) 0.92
Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif Tissue Int (2009) 0.91
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. Thromb Res (2003) 0.91
Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia. Circulation (2004) 0.90
Ovarian cyst fluid of serous ovarian tumors contains large quantities of the brain amino acid N-acetylaspartate. PLoS One (2010) 0.90
Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency. Am J Hum Genet (2011) 0.89
Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study. Am J Med Genet B Neuropsychiatr Genet (2005) 0.88
Treatment of inherited homocystinurias. Neuropediatrics (2012) 0.87
Quantification of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent 1,N(6)-etheno derivatives: an adaptation of previously described methodology. J Pharm Biomed Anal (2002) 0.87
Coronary endothelial function in hyperhomocysteinemia: improvement after treatment with folic acid and cobalamin in patients with coronary artery disease. J Am Coll Cardiol (2002) 0.87
Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine. FEBS Lett (2012) 0.87
Coronary heart disease mortality, plasma homocysteine, and B-vitamins: a prospective study. Atherosclerosis (2003) 0.87
Maternal homocysteine and related B vitamins as risk factors for low birthweight. Am J Obstet Gynecol (2010) 0.87
Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia. Biochim Biophys Acta (2013) 0.87
Betaine and folate status as cooperative determinants of plasma homocysteine in humans. Arterioscler Thromb Vasc Biol (2004) 0.86
Gene-gene interaction between the cystathionine beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate reductase 677C > T polymorphism on homocysteine levels and risk for neural tube defects. Mol Genet Metab (2003) 0.86
Plasma choline and betaine correlate with serum folate, plasma S-adenosyl-methionine and S-adenosyl-homocysteine in healthy volunteers. Clin Chem Lab Med (2013) 0.85
Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk. Atherosclerosis (2002) 0.85
Pharmacokinetic study on the utilisation of 5-methyltetrahydrofolate and folic acid in patients with coronary artery disease. Br J Pharmacol (2004) 0.85
Total homocysteine and its predictors in Dutch children. Am J Clin Nutr (2005) 0.84
N-acetyl resonances in in vivo and in vitro NMR spectroscopy of cystic ovarian tumors. NMR Biomed (2009) 0.84
High-resolution 1H NMR spectroscopic investigation of a chick embryo model of neural tube development. Magn Reson Chem (2009) 0.84
The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people. Br J Nutr (2007) 0.84
Enhanced cellular adenosine uptake limits adenosine receptor stimulation in patients with hyperhomocysteinemia. Arterioscler Thromb Vasc Biol (2004) 0.84
Effect of supplementation with cobalamin carried either by a milk product or a capsule in mildly cobalamin-deficient elderly Dutch persons. Am J Clin Nutr (2005) 0.83
MTHFR C677T genotype as a risk factor for epilepsy including post-traumatic epilepsy in a representative military cohort. J Neurotrauma (2011) 0.82
Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity. Cell Biochem Biophys (2013) 0.82
Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis. Eur J Hum Genet (2004) 0.82
Simultaneous determination of asymmetric and symmetric dimethylarginine, L-monomethylarginine, L-arginine, and L-homoarginine in biological samples using stable isotope dilution liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2012) 0.82
Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia. Eur Neuropsychopharmacol (2007) 0.82
Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methods. Clin Chem Lab Med (2010) 0.82
Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells. PLoS One (2013) 0.81
Improved insulin sensitivity and metabolic control in type 2 diabetes does not influence plasma homocysteine. Diabetes Care (2003) 0.81
Homocysteine and familial longevity: the Leiden Longevity Study. PLoS One (2011) 0.81
Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients. J Inherit Metab Dis (2013) 0.81
Aberrant folate status in schizophrenic patients: what is the evidence? Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.81
Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants. J Pediatr (2002) 0.81
The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers. Clin Chem Lab Med (2007) 0.81
Molecular beacons: colorful analysis of nucleic acids. Expert Rev Mol Diagn (2002) 0.81
Marfanoid features in a child with combined methylmalonic aciduria and homocystinuria (CblC type). J Inherit Metab Dis (2007) 0.80
Folic acid supplementation does not reduce intracellular homocysteine, and may disturb intracellular one-carbon metabolism. Clin Chem Lab Med (2013) 0.80
Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk. Clin Chem Lab Med (2007) 0.80
Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring Study. Eur J Hum Genet (2006) 0.80
S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice. Neurol Sci (2009) 0.80
Inhibition of methylation and changes in gene expression in relation to neural tube defects. Birth Defects Res A Clin Mol Teratol (2008) 0.80
Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia. J Am Coll Nutr (2011) 0.80
Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency. Atherosclerosis (2012) 0.80
S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine. Atherosclerosis (2011) 0.80
Methylation metabolites in amniotic fluid depend on gestational age. Prenat Diagn (2013) 0.79
The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans. J Nutr (2003) 0.79
Diversity of cystathionine beta-synthase haplotypes bearing the most common homocystinuria mutation c.833T>C: a possible role for gene conversion. Hum Mutat (2007) 0.79
Insights into the regulatory domain of cystathionine Beta-synthase: characterization of six variant proteins. Hum Mutat (2014) 0.79
No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study. Thromb Haemost (2007) 0.79
Determinants of the essential one-carbon metabolism metabolites, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in cerebrospinal fluid. Clin Chem Lab Med (2012) 0.79
Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial. J Hypertens (2015) 0.78
Homocysteine levels and treatment effect in the PROspective Study of Pravastatin in the Elderly at Risk. J Am Geriatr Soc (2014) 0.78