PubRank

Stephen P Jackson

Author PubWeight™ 283.70‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005 26.32
2 A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003 12.55
3 Human CtIP promotes DNA end resection. Nature 2007 10.63
4 Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 2004 9.70
5 MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 2005 8.39
6 ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 2005 8.27
7 Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 2007 7.61
8 Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005 7.45
9 The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol 2002 6.44
10 XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 2006 5.62
11 Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 2011 5.60
12 Interfaces between the detection, signaling, and repair of DNA damage. Science 2002 5.33
13 A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell 2004 5.29
14 DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev 2008 5.07
15 MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 2003 4.56
16 gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) 2006 4.36
17 Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature 2009 4.30
18 Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol Cell 2004 4.17
19 Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science 2007 4.07
20 CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 2008 3.96
21 Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science 2009 3.68
22 Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol 2010 3.27
23 Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J Biol Chem 2009 3.24
24 Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J 2004 3.20
25 hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell 2005 3.18
26 A means to a DNA end: the many roles of Ku. Nat Rev Mol Cell Biol 2004 3.07
27 The FHA domain. FEBS Lett 2002 3.03
28 Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J 2009 2.98
29 Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell 2007 2.88
30 Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 2010 2.74
31 The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation. Science 2002 2.69
32 Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat Cell Biol 2005 2.63
33 Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Mol Cell 2012 2.51
34 Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol 2012 2.41
35 MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell 2009 2.36
36 Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep 2008 2.35
37 A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus. Mol Cell 2003 2.34
38 DNA damage signaling in response to double-strand breaks during mitosis. J Cell Biol 2010 2.30
39 Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol Cell 2003 2.30
40 Functional links between telomeres and proteins of the DNA-damage response. Genes Dev 2004 2.29
41 Identification of a DNA nonhomologous end-joining complex in bacteria. Science 2002 2.27
42 Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J 2010 2.25
43 Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell 2002 2.22
44 Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol 2011 2.18
45 Chromothripsis and cancer: causes and consequences of chromosome shattering. Nat Rev Cancer 2012 2.17
46 KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 2013 2.17
47 RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev 2012 2.16
48 Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr Biol 2005 2.13
49 A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell 2009 2.07
50 Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell 2002 1.99
51 Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair. Proc Natl Acad Sci U S A 2004 1.79
52 Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Rep 2007 1.66
53 Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ. EMBO J 2007 1.66
54 Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe. J Biol Chem 2007 1.65
55 MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes. DNA Repair (Amst) 2004 1.56
56 BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair. J Cell Sci 2012 1.55
57 Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol Cell 2012 1.50
58 Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos. J Biol Chem 2006 1.50
59 The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair. Mol Biol Cell 2009 1.44
60 Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres. EMBO J 2007 1.38
61 Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation. PLoS One 2011 1.34
62 Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med 2007 1.32
63 A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J Cell Biol 2013 1.29
64 Structural basis for the NAD-dependent deacetylase mechanism of Sir2. J Biol Chem 2002 1.26
65 CtIP Mutations Cause Seckel and Jawad Syndromes. PLoS Genet 2011 1.26
66 Suppression of retroviral infection by the RAD52 DNA repair protein. EMBO J 2004 1.25
67 Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability. Curr Biol 2005 1.24
68 A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1. Genome Biol 2011 1.21
69 Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing. J Biol Chem 2003 1.21
70 EDD mediates DNA damage-induced activation of CHK2. J Biol Chem 2006 1.21
71 Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. DNA Repair (Amst) 2006 1.18
72 Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling events. Cell Cycle 2011 1.16
73 Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat Struct Mol Biol 2012 1.14
74 Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 2014 1.13
75 ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage. Cell Cycle 2013 1.10
76 Histone marks: repairing DNA breaks within the context of chromatin. Biochem Soc Trans 2012 1.10
77 The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku. EMBO Rep 2003 1.07
78 CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination. EMBO Rep 2012 1.07
79 Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. PLoS Genet 2012 1.06
80 The non-homologous end-joining protein Nej1p is a target of the DNA damage checkpoint. DNA Repair (Amst) 2006 1.04
81 Deubiquitylating enzymes and DNA damage response pathways. Cell Biochem Biophys 2013 1.03
82 p53 prevents the accumulation of double-strand DNA breaks at stalled-replication forks induced by UV in human cells. Cell Cycle 2004 1.00
83 A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells. Cytometry A 2012 1.00
84 Systematic identification of functional residues in mammalian histone H2AX. Mol Cell Biol 2012 1.00
85 Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage. Cell Cycle 2005 0.98
86 Tudor domains track down DNA breaks. Nat Cell Biol 2004 0.98
87 Molecular cross-talk among chromosome fragility syndromes. Genes Dev 2004 0.96
88 Activation of the DNA damage response by telomere attrition: a passage to cellular senescence. Cell Cycle 2004 0.94
89 USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism. Mol Cell Biol 2014 0.94
90 Regulation of Rad51 function by phosphorylation. EMBO Rep 2011 0.91
91 Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins. Cell Cycle 2013 0.87
92 Rolled-up functionalized nanomembranes as three-dimensional cavities for single cell studies. Nano Lett 2014 0.87
93 Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination. Nucleic Acids Res 2012 0.86
94 ATM and ATR. Curr Biol 2003 0.86
95 Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation. FEMS Yeast Res 2006 0.85
96 Saccharomyces cerevisiae histone H2A Ser122 facilitates DNA repair. Genetics 2005 0.83
97 On your mark, get SET(D2), go! H3K36me3 primes DNA mismatch repair. Cell 2013 0.80
98 Cancer: protective packaging for DNA. Nature 2003 0.80
99 Confinement and deformation of single cells and their nuclei inside size-adapted microtubes. Adv Healthc Mater 2014 0.79
100 Screening the yeast genome for new DNA-repair genes. Genome Biol 2002 0.76
101 DAY NEUTRAL FLOWERING does not act through GIGANTEA and FKF1 to regulate CONSTANS expression and flowering time. Plant Signal Behav 2010 0.76
102 Increased genome instability in aging yeast. Cell 2003 0.76
103 RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures. Cell Cycle 2013 0.75
104 Corrigendum: Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks. Nat Commun 2017 0.75
105 Erratum: PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat Genet 2017 0.75