Published in Nature on February 27, 2003
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature (2008) 5.11
H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell (2003) 4.94
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol (2009) 3.79
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J Cell Biol (2005) 3.69
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20
Activation of the cellular DNA damage response in the absence of DNA lesions. Science (2008) 3.17
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. EMBO J (2008) 2.95
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell (2009) 2.90
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature (2008) 2.86
Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J (2009) 2.68
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell (2006) 2.61
The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev (2009) 2.56
Control of sister chromatid recombination by histone H2AX. Mol Cell (2004) 2.43
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep (2008) 2.35
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J (2012) 2.34
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol (2008) 2.21
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol Cell Biol (2004) 2.20
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin. J Cell Biol (2008) 2.18
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat Cell Biol (2011) 2.15
The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks. Proc Natl Acad Sci U S A (2009) 2.15
RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev (2011) 2.00
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep (2003) 1.97
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell (2010) 1.94
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev (2012) 1.90
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion. Mol Biol Cell (2004) 1.88
ATM activation and signaling under hypoxic conditions. Mol Cell Biol (2008) 1.84
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev (2006) 1.81
Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol (2004) 1.79
MRE11/RAD50/NBS1: complex activities. Chromosoma (2004) 1.79
Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol (2007) 1.74
H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy. J Nucleic Acids (2010) 1.69
Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol (2005) 1.69
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair (Amst) (2009) 1.66
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage. Nat Cell Biol (2008) 1.63
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A (2008) 1.63
Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev (2005) 1.61
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation. Mol Cell (2015) 1.60
Functional interaction between FOXO3a and ATM regulates DNA damage response. Nat Cell Biol (2008) 1.58
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes. Genes Dev (2009) 1.56
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem (2007) 1.55
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol (2009) 1.55
Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab (2015) 1.54
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev (2011) 1.52
RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. Cancer Lett (2008) 1.50
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci (2009) 1.49
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair. J Cell Biol (2011) 1.47
Tying the loose ends together in DNA double strand break repair with 53BP1. Cell Div (2006) 1.47
Sumoylation of MDC1 is important for proper DNA damage response. EMBO J (2012) 1.44
Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling. Mol Cell Biol (2003) 1.42
A Newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese. PLoS One (2014) 1.42
Choreography of recombination proteins during the DNA damage response. DNA Repair (Amst) (2009) 1.40
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell (2005) 1.39
Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres. EMBO J (2007) 1.38
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol (2008) 1.38
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell (2009) 1.33
Double strand break repair functions of histone H2AX. Mutat Res (2013) 1.31
Cdc7-Dbf4 and the human S checkpoint response to UVC. J Biol Chem (2007) 1.27
An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication. Mol Cell Biol (2006) 1.27
Active role for nibrin in the kinetics of atm activation. Mol Cell Biol (2006) 1.27
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet (2011) 1.23
Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev (2008) 1.23
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. PLoS One (2009) 1.21
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Mol Biol (2010) 1.19
Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network. Chromosoma (2008) 1.18
Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response. PLoS One (2009) 1.18
MDC1: The art of keeping things in focus. Chromosoma (2010) 1.15
Differential regulation of centrosome integrity by DNA damage response proteins. Cell Cycle (2008) 1.14
The cellular response to DNA damage: a focus on MDC1 and its interacting proteins. Nucleus (2009) 1.13
Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks. Mol Biol Cell (2005) 1.10
The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response. Genes Dev (2013) 1.09
Non-homologous end joining in class switch recombination: the beginning of the end. Philos Trans R Soc Lond B Biol Sci (2009) 1.08
Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways. Cell Mol Life Sci (2012) 1.06
The human intra-S checkpoint response to UVC-induced DNA damage. Carcinogenesis (2009) 1.05
A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint. Proc Natl Acad Sci U S A (2009) 1.04
PTIP regulates 53BP1 and SMC1 at the DNA damage sites. J Biol Chem (2009) 1.04
MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes. EMBO Rep (2004) 1.03
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. Mol Biol Cell (2008) 1.02
Modular evolution of phosphorylation-based signalling systems. Philos Trans R Soc Lond B Biol Sci (2012) 1.02
p53: the attractive tumor suppressor in the cancer research field. J Biomed Biotechnol (2010) 1.02
DNA double-strand break signaling and human disorders. Genome Integr (2010) 1.00
The anaphase-promoting complex is a dual integrator that regulates both MicroRNA-mediated transcriptional regulation of cyclin B1 and degradation of Cyclin B1 during Arabidopsis male gametophyte development. Plant Cell (2011) 0.99
Interplay between the DNA damage proteins MDC1 and ATM in the regulation of the spindle assembly checkpoint. J Biol Chem (2014) 0.99
NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway. Cell Cycle (2008) 0.99
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination. Carcinogenesis (2007) 0.98
Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. J Virol (2008) 0.98
DNA damage checkpoints and cancer. J Mol Histol (2006) 0.97
CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res (2009) 0.97
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nat Cell Biol (2014) 0.97
Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathway. PLoS One (2012) 0.97
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. Cell Mol Life Sci (2014) 0.95
Role of p53 in Cell Death and Human Cancers. Cancers (Basel) (2011) 0.95
Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity. PLoS One (2012) 0.95
RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response. Int J Genomics (2013) 0.95
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature (2005) 26.32
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
The DNA-damage response in human biology and disease. Nature (2009) 17.86
Cell-cycle checkpoints and cancer. Nature (2004) 13.19
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76
An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60
Human CtIP promotes DNA end resection. Nature (2007) 10.63
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res (2004) 9.70
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 9.25
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature (2005) 7.45
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell (2009) 6.89
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol (2006) 6.52
The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol (2002) 6.44
The causes and consequences of genetic heterogeneity in cancer evolution. Nature (2013) 5.91
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol (2006) 5.34
Interfaces between the detection, signaling, and repair of DNA damage. Science (2002) 5.33
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev (2008) 5.07
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol (2003) 4.77
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol (2002) 4.45
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) (2006) 4.36
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature (2009) 4.30
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat Cell Biol (2011) 4.23
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol Cell (2004) 4.17
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science (2007) 4.07
CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature (2008) 3.96
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J Cell Biol (2005) 3.69
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell (2003) 3.58
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol (2010) 3.27
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J Biol Chem (2009) 3.24
Regulation of replication fork progression through histone supply and demand. Science (2007) 3.21
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell (2005) 3.18
A means to a DNA end: the many roles of Ku. Nat Rev Mol Cell Biol (2004) 3.07
Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat Rev Cancer (2004) 3.06
The FHA domain. FEBS Lett (2002) 3.03
A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer. Am J Hum Genet (2002) 3.00
ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell (2013) 2.99
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J (2009) 2.98
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet (2002) 2.97
Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol (2004) 2.97
Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J Biol Chem (2002) 2.89
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex. Cell Cycle (2011) 2.85
Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science (2010) 2.74
The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation. Science (2002) 2.69
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol (2004) 2.63
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat Cell Biol (2005) 2.63
The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev (2009) 2.56
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem (2003) 2.54
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes. Cell (2012) 2.53
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Mol Cell (2012) 2.51
Human Asf1 regulates the flow of S phase histones during replicational stress. Mol Cell (2005) 2.51
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell (2006) 2.45
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol (2012) 2.41
Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair (Amst) (2004) 2.39
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J (2002) 2.39
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol (2009) 2.37
MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell (2009) 2.36
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep (2008) 2.35
A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus. Mol Cell (2003) 2.34
p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell (2006) 2.34
8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease. Proteomics (2007) 2.33
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle (2011) 2.31
DNA damage signaling in response to double-strand breaks during mitosis. J Cell Biol (2010) 2.30
Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol Cell (2003) 2.30
Functional links between telomeres and proteins of the DNA-damage response. Genes Dev (2004) 2.29
Identification of a DNA nonhomologous end-joining complex in bacteria. Science (2002) 2.27
ATM activation in normal human tissues and testicular cancer. Cell Cycle (2005) 2.25
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J (2010) 2.25
Measuring elevated intracranial pressure through noninvasive methods: a review of the literature. J Neurosurg Anesthesiol (2013) 2.23
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell (2002) 2.22
The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation. J Cell Biol (2003) 2.22
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. J Exp Med (2012) 2.21
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol (2008) 2.21
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet (2008) 2.18
Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol (2011) 2.18