Published in Science on September 06, 2002
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol Mol Biol Rev (2004) 7.93
RecBCD enzyme and the repair of double-stranded DNA breaks. Microbiol Mol Biol Rev (2008) 3.23
Comparative and evolutionary analysis of the bacterial homologous recombination systems. PLoS Genet (2005) 2.28
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes Dev (2008) 1.90
The origins of vertebrate adaptive immunity. Nat Rev Immunol (2010) 1.81
Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032. PLoS One (2007) 1.71
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Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proc Natl Acad Sci U S A (2006) 1.48
Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola. PLoS Genet (2009) 1.48
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks. J Bacteriol (2007) 1.42
Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3'-OH monoribonucleotide. J Biol Chem (2008) 1.36
Non-homologous end joining as an important mutagenic process in cell cycle-arrested cells. EMBO J (2003) 1.33
Role of DNA repair by nonhomologous-end joining in Bacillus subtilis spore resistance to extreme dryness, mono- and polychromatic UV, and ionizing radiation. J Bacteriol (2007) 1.33
Bacterial genome instability. Microbiol Mol Biol Rev (2014) 1.31
Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. PLoS Genet (2006) 1.31
Characterization of Agrobacterium tumefaciens DNA ligases C and D. Nucleic Acids Res (2007) 1.29
Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86. Mol Cell Biol (2004) 1.20
Comparison of responses to double-strand breaks between Escherichia coli and Bacillus subtilis reveals different requirements for SOS induction. J Bacteriol (2008) 1.17
An end-joining repair mechanism in Escherichia coli. Proc Natl Acad Sci U S A (2010) 1.13
Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain. Genetics (2008) 1.12
Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination. DNA Repair (Amst) (2012) 1.10
Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repair. BMC Mol Biol (2006) 1.07
The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku. EMBO Rep (2003) 1.07
Bacillus subtilis polynucleotide phosphorylase 3'-to-5' DNase activity is involved in DNA repair. Nucleic Acids Res (2009) 1.06
Gap filling activities of Pseudomonas DNA ligase D (LigD) polymerase and functional interactions of LigD with the DNA end-binding Ku protein. J Biol Chem (2009) 1.05
Chromatin organization and radio resistance in the bacterium Gemmata obscuriglobus. J Bacteriol (2008) 1.05
Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase. Biochemistry (2008) 1.04
DNA toroids: framework for DNA repair in Deinococcus radiodurans and in germinating bacterial spores. J Bacteriol (2004) 1.04
DNA repair and genome maintenance in Bacillus subtilis. Microbiol Mol Biol Rev (2012) 1.03
Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining. Genes Dev (2008) 1.03
Evidence for different pathways during horizontal gene transfer in competent Bacillus subtilis cells. PLoS Genet (2009) 1.01
Structure of the DNA-SspC complex: implications for DNA packaging, protection, and repair in bacterial spores. J Bacteriol (2004) 0.99
Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology. DNA Repair (Amst) (2007) 0.98
Evaluation of NAD(+) -dependent DNA ligase of mycobacteria as a potential target for antibiotics. Antimicrob Agents Chemother (2007) 0.98
Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Nucleic Acids Res (2008) 0.95
Enzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radiodurans. BMC Mol Biol (2007) 0.94
The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery. Crit Rev Biochem Mol Biol (2012) 0.94
Dynamic structures of Bacillus subtilis RecN-DNA complexes. Nucleic Acids Res (2007) 0.94
Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates. Proc Natl Acad Sci U S A (2013) 0.93
Recombinational DNA repair in a cellular context: a search for the homology search. Nat Rev Microbiol (2009) 0.93
Survival in nuclear waste, extreme resistance, and potential applications gleaned from the genome sequence of Kineococcus radiotolerans SRS30216. PLoS One (2008) 0.91
Molecular characterization of Brucella abortus chromosome II recombination. J Bacteriol (2003) 0.88
Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining. Mutagenesis (2010) 0.86
Multiple Ku orthologues mediate DNA non-homologous end-joining in the free-living form and during chronic infection of Sinorhizobium meliloti. Mol Microbiol (2007) 0.86
Bacillus subtilis RecA and its accessory factors, RecF, RecO, RecR and RecX, are required for spore resistance to DNA double-strand break. Nucleic Acids Res (2013) 0.86
Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes. Nucleic Acids Res (2015) 0.85
SbcCD regulation and localization in Escherichia coli. J Bacteriol (2007) 0.85
Archaeal replicative primases can perform translesion DNA synthesis. Proc Natl Acad Sci U S A (2015) 0.85
Small variable segments constitute a major type of diversity of bacterial genomes at the species level. Genome Biol (2010) 0.85
A recA null mutation may be generated in Streptomyces coelicolor. J Bacteriol (2006) 0.85
Molecular basis for DNA double-strand break annealing and primer extension by an NHEJ DNA polymerase. Cell Rep (2013) 0.84
Genomic and proteomic evidences unravel the UV-resistome of the poly-extremophile Acinetobacter sp. Ver3. Front Microbiol (2015) 0.82
C-terminal low-complexity sequence repeats of Mycobacterium smegmatis Ku modulate DNA binding. Biosci Rep (2013) 0.82
Multigene disruption in undomesticated Bacillus subtilis ATCC 6051a using the CRISPR/Cas9 system. Sci Rep (2016) 0.81
The minimal Bacillus subtilis nonhomologous end joining repair machinery. PLoS One (2013) 0.81
MutS2 promotes homologous recombination in Bacillus subtilis. J Bacteriol (2016) 0.80
Isolation and characterization of a novel lysine racemase from a soil metagenomic library. Appl Environ Microbiol (2009) 0.80
Towards a processual microbial ontology. Biol Philos (2012) 0.80
Deletion of ku homologs increases gene targeting frequency in Streptomyces avermitilis. J Ind Microbiol Biotechnol (2012) 0.80
Efficient processing of abasic sites by bacterial nonhomologous end-joining Ku proteins. Nucleic Acids Res (2014) 0.80
A Sir2-like protein participates in mycobacterial NHEJ. PLoS One (2011) 0.79
Detection of ligation products of DNA linkers with 5'-OH ends by denaturing PAGE silver stain. PLoS One (2012) 0.78
M. tuberculosis sliding β-clamp does not interact directly with the NAD+-dependent DNA ligase. PLoS One (2012) 0.78
Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences. J Mol Biol (2010) 0.78
Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate. Mutagenesis (2011) 0.77
Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface. Acta Crystallogr D Biol Crystallogr (2014) 0.77
Ring-like nucleoids and DNA repair through error-free nonhomologous end joining in Deinococcus radiodurans. J Bacteriol (2006) 0.77
Identification of a conserved 5'-dRP lyase activity in bacterial DNA repair ligase D and its potential role in base excision repair. Nucleic Acids Res (2016) 0.76
Evaluation of DNA primase DnaG as a potential target for antibiotics. Antimicrob Agents Chemother (2013) 0.76
C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair. Nucleic Acids Res (2016) 0.76
NOVEL ANTIBIOTIC RESISTANCE DETERMINANTS FROM AGRICULTURAL SOIL EXPOSED TO ANTIBIOTICS WIDELY USED IN HUMAN MEDICINE AND ANIMAL FARMING. Appl Environ Microbiol (2017) 0.76
Multiple and Variable NHEJ-Like Genes Are Involved in Resistance to DNA Damage in Streptomyces ambofaciens. Front Microbiol (2016) 0.75
Rad51 and RecA juxtapose dsDNA ends ready for DNA ligase-catalyzed end-joining under recombinase-suppressive conditions. Nucleic Acids Res (2016) 0.75
A moonlighting function of Mycobacterium smegmatis Ku in zinc homeostasis? Protein Sci (2014) 0.75
Evidence for double-strand break mediated mitochondrial DNA replication in Saccharomyces cerevisiae. Nucleic Acids Res (2017) 0.75
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature (2005) 26.32
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature (2006) 11.18
Human CtIP promotes DNA end resection. Nature (2007) 10.63
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res (2004) 9.70
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27
Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell (2008) 7.65
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 7.61
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature (2005) 7.45
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell (2008) 6.60
The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol (2002) 6.44
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet (2003) 6.03
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
Interfaces between the detection, signaling, and repair of DNA damage. Science (2002) 5.33
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev (2008) 5.07
MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature (2003) 4.56
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Science (2012) 4.41
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) (2006) 4.36
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature (2009) 4.30
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol Cell (2004) 4.17
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science (2007) 4.07
CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature (2008) 3.96
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle (2010) 3.56
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer (2007) 3.54
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol (2010) 3.27
The role of double-strand break repair - insights from human genetics. Nat Rev Genet (2006) 3.25
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J Biol Chem (2009) 3.24
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell (2005) 3.18
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet (2007) 3.08
A means to a DNA end: the many roles of Ku. Nat Rev Mol Cell Biol (2004) 3.07
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J (2006) 3.05
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol (2012) 3.03
The FHA domain. FEBS Lett (2002) 3.03
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J (2009) 2.98
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J (2009) 2.94
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase. EMBO J (2006) 2.89
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell (2007) 2.88
Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science (2010) 2.74
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol (2011) 2.69
The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation. Science (2002) 2.69
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat Cell Biol (2005) 2.63
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Nat Genet (2007) 2.58
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res (2004) 2.55
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Mol Cell (2012) 2.51
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol (2012) 2.41
Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science (2012) 2.38
MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell (2009) 2.36
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep (2008) 2.35
A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus. Mol Cell (2003) 2.34
DNA damage signaling in response to double-strand breaks during mitosis. J Cell Biol (2010) 2.30
Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol Cell (2003) 2.30
Functional links between telomeres and proteins of the DNA-damage response. Genes Dev (2004) 2.29
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J (2010) 2.25
Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell (2002) 2.22
Site-specific DICER and DROSHA RNA products control the DNA-damage response. Nature (2012) 2.20
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol (2006) 2.20
Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol (2011) 2.18
Chromothripsis and cancer: causes and consequences of chromosome shattering. Nat Rev Cancer (2012) 2.17
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature (2013) 2.17
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev (2012) 2.16
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr Biol (2005) 2.13
Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A (2009) 2.12
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell (2009) 2.07
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science (2004) 2.04
A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway. Mol Microbiol (2008) 2.03
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell (2002) 1.99
Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum Mol Genet (2004) 1.95
Nbs1 is required for ATR-dependent phosphorylation events. EMBO J (2004) 1.95
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor. EMBO J (2002) 1.92
From one amino acid to another: tRNA-dependent amino acid biosynthesis. Nucleic Acids Res (2008) 1.88
Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem (2003) 1.83
Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair. Proc Natl Acad Sci U S A (2004) 1.79
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nat Genet (2011) 1.76
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J (2012) 1.71
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Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ. EMBO J (2007) 1.66
Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast. EMBO Rep (2007) 1.66
The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis. Mol Microbiol (2007) 1.65
The impact of heterochromatin on DSB repair. Biochem Soc Trans (2009) 1.65
Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe. J Biol Chem (2007) 1.65
Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells. Mol Cell (2004) 1.64
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem (2004) 1.61
Structure of a NHEJ polymerase-mediated DNA synaptic complex. Science (2007) 1.60
Structure and function of a mycobacterial NHEJ DNA repair polymerase. J Mol Biol (2006) 1.58
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes. DNA Repair (Amst) (2004) 1.56