Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat.

PubWeight™: 1.85‹?› | Rank: Top 3%

🔗 View Article (PMID 12615622)

Published in Am J Respir Crit Care Med on February 25, 2003

Authors

Barry W Row1, Rugao Liu, Wei Xu, Leila Kheirandish, David Gozal

Author Affiliations

1: Kosair Children's Hospital Research Institute, University of Louisville, Baxter Biomedical Research Building, Suite 321, 570 South Preston Street, Louisville, KY 40202, USA.

Articles citing this

Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more. Am J Respir Crit Care Med (2007) 2.62

Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radic Biol Med (2006) 1.97

NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. Am J Respir Crit Care Med (2005) 1.91

Inducible nitric oxide synthase in long-term intermittent hypoxia: hypersomnolence and brain injury. Am J Respir Crit Care Med (2005) 1.80

C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children. Am J Respir Crit Care Med (2007) 1.68

Pediatric obstructive sleep apnea: complications, management, and long-term outcomes. Proc Am Thorac Soc (2008) 1.52

Dynamic arterial blood gas analysis in conscious, unrestrained C57BL/6J mice during exposure to intermittent hypoxia. J Appl Physiol (1985) (2008) 1.43

Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitation. Exp Neurol (2009) 1.39

Transcriptional responses to intermittent hypoxia. Respir Physiol Neurobiol (2008) 1.36

Reactive oxygen species contribute to sleep apnea-induced hypertension in rats. Am J Physiol Heart Circ Physiol (2007) 1.35

Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice. J Physiol (2007) 1.32

Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea. PLoS One (2011) 1.30

Sleep disordered breathing and hypertension: does self-reported sleepiness modify the association? Sleep (2008) 1.29

Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage. Neurobiol Dis (2007) 1.27

Intermittent hypoxia induces functional recovery following cervical spinal injury. Respir Physiol Neurobiol (2009) 1.19

Erectile dysfunction in a murine model of sleep apnea. Am J Respir Crit Care Med (2008) 1.14

Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. Am J Physiol Cell Physiol (2010) 1.13

Tissue oxygenation in brain, muscle, and fat in a rat model of sleep apnea: differential effect of obstructive apneas and intermittent hypoxia. Sleep (2011) 1.12

Reactive oxygen species and the brain in sleep apnea. Respir Physiol Neurobiol (2010) 1.10

Leukotriene B4 receptor-1 mediates intermittent hypoxia-induced atherogenesis. Am J Respir Crit Care Med (2011) 1.06

The polymorphic and contradictory aspects of intermittent hypoxia. Am J Physiol Lung Cell Mol Physiol (2014) 1.04

Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia. Am J Respir Crit Care Med (2008) 1.03

Reduced cerebral blood flow during wakefulness in obstructive sleep apnea-hypopnea syndrome. Sleep (2007) 1.02

Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep. Behav Brain Res (2007) 1.01

Spatial learning and memory deficits following exposure to 24 h of sleep fragmentation or intermittent hypoxia in a rat model of obstructive sleep apnea. Brain Res (2009) 0.98

Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stress. Am J Respir Crit Care Med (2010) 0.97

Oxidative damage to RNA in neurodegenerative diseases. J Biomed Biotechnol (2006) 0.96

Obstructive sleep apnea in children: implications for the developing central nervous system. Semin Pediatr Neurol (2008) 0.96

Mechanisms of intermittent hypoxia induced hypertension. J Cell Mol Med (2009) 0.95

Rodent models of sleep apnea. Respir Physiol Neurobiol (2013) 0.95

Hypoxia. 4. Hypoxia and ion channel function. Am J Physiol Cell Physiol (2010) 0.93

Intermittent hypoxia mobilizes bone marrow-derived very small embryonic-like stem cells and activates developmental transcriptional programs in mice. Sleep (2010) 0.93

Localized cortical thinning in patients with obstructive sleep apnea syndrome. Sleep (2013) 0.93

Association Between Sleep Disordered Breathing and Behavior in School-Aged Children: The Tucson Children's Assessment of Sleep Apnea Study. Open Epidemiol J (2008) 0.92

Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats. Neuroscience (2011) 0.92

Diaphragm long-term facilitation following acute intermittent hypoxia during wakefulness and sleep. J Appl Physiol (1985) (2011) 0.92

White matter damage and systemic inflammation in obstructive sleep apnea. Sleep (2015) 0.91

Chronic intermittent hypoxia exerts CNS region-specific effects on rat microglial inflammatory and TLR4 gene expression. PLoS One (2013) 0.91

Systemic inflammation impairs respiratory chemoreflexes and plasticity. Respir Physiol Neurobiol (2011) 0.91

Changes in oxygen partial pressure of brain tissue in an animal model of obstructive apnea. Respir Res (2010) 0.90

Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus. Am J Respir Crit Care Med (2010) 0.90

Neurocognitive performance and behavior before and after treatment for sleep-disordered breathing in children. Nat Sci Sleep (2010) 0.89

Intermittent hypoxia regulates RNA polymerase II in hippocampus and prefrontal cortex. Neuroscience (2008) 0.88

Sleep-disordered breathing: effects on brain structure and function. Respir Physiol Neurobiol (2013) 0.88

Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats. Am J Physiol Regul Integr Comp Physiol (2008) 0.87

Associations between sleep-disordered breathing, nocturnal hypoxemia, and subsequent cognitive decline in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc (2015) 0.86

Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factor. Acta Pharmacol Sin (2012) 0.86

The proinflammatory RAGE/NF-κB pathway is involved in neuronal damage and reactive gliosis in a model of sleep apnea by intermittent hypoxia. PLoS One (2014) 0.86

Mapping gray matter reductions in obstructive sleep apnea: an activation likelihood estimation meta-analysis. Sleep (2014) 0.86

Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. Surg Neurol Int (2012) 0.86

Growth hormone releasing hormone (GHRH) signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse. J Neurochem (2013) 0.85

Xanthine oxidase inhibition attenuates endothelial dysfunction caused by chronic intermittent hypoxia in rats. Respiration (2011) 0.85

Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea. BMC Neurosci (2012) 0.84

Brain tissue hypoxia and oxidative stress induced by obstructive apneas is different in young and aged rats. Sleep (2014) 0.84

Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging. Mol Brain (2017) 0.84

Sublethal RNA oxidation as a mechanism for neurodegenerative disease. Int J Mol Sci (2008) 0.83

Is brain injury in obstructive sleep apnea reversible? Sleep (2012) 0.82

Tumor necrosis factor-α potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia. J Neurosci Res (2015) 0.81

Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats. J Appl Physiol (1985) (2008) 0.81

Diaphragm muscle remodeling in a rat model of chronic intermittent hypoxia. J Histochem Cytochem (2013) 0.80

Role of high-fat diet in stress response of Drosophila. PLoS One (2012) 0.79

Assessment and treatment of common pediatric sleep disorders. Psychiatry (Edgmont) (2010) 0.78

Affective brain areas and sleep-disordered breathing. Prog Brain Res (2014) 0.78

Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea. PLoS One (2015) 0.77

Eszopiclone prevents excitotoxicity and neurodegeneration in the hippocampus induced by experimental apnea. Sleep (2009) 0.77

Adverse cognitive effects of high-fat diet in a murine model of sleep apnea are mediated by NADPH oxidase activity. Neuroscience (2012) 0.77

Repetitive acute intermittent hypoxia does not promote generalized inflammatory gene expression in the rat CNS. Respir Physiol Neurobiol (2015) 0.77

Regulation of oxidative stress and cardioprotection in diabetes mellitus. Curr Cardiol Rev (2008) 0.77

Obstructive sleep apnoea/hypopnoea syndrome and hypertension. Sultan Qaboos Univ Med J (2008) 0.77

Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia. J Physiol (2016) 0.77

The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS. Brain Sci (2016) 0.76

G proteins in rat prefrontal cortex (PFC) are differentially activated as a function of oxygen status and PFC region. J Chem Neuroanat (2008) 0.76

Water-soluble vitamin homeostasis in fasting northern elephant seals (Mirounga angustirostris) measured by metabolomics analysis and standard methods. Comp Biochem Physiol A Mol Integr Physiol (2011) 0.76

Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea. Neuropsychiatr Dis Treat (2016) 0.76

Chronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach. Hypoxia (Auckl) (2016) 0.75

Overview of proteomics studies in obstructive sleep apnea. Sleep Med (2015) 0.75

Intermittent hypoxia reduces microglia proliferation and induces DNA damage in vitro. Iran J Basic Med Sci (2016) 0.75

Role of Oxidative Stress in the Neurocognitive Dysfunction of Obstructive Sleep Apnea Syndrome. Oxid Med Cell Longev (2016) 0.75

Protective effects of choline against hypoxia-induced injuries of vessels and endothelial cells. Exp Ther Med (2017) 0.75

Articles by these authors

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78

Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55

Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med (2012) 8.68

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med (2013) 5.99

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med (2004) 5.01

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell (2002) 4.37

Clinical guidelines for the manual titration of positive airway pressure in patients with obstructive sleep apnea. J Clin Sleep Med (2008) 4.05

Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol (2013) 3.76

Adenotonsillectomy outcomes in treatment of obstructive sleep apnea in children: a multicenter retrospective study. Am J Respir Crit Care Med (2010) 3.69

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65

Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science (2006) 3.37

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35

Polysomnographic characteristics in normal preschool and early school-aged children. Pediatrics (2006) 3.27

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14

The scoring of respiratory events in sleep: reliability and validity. J Clin Sleep Med (2007) 3.07

Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics (2012) 3.01

Leukotriene modifier therapy for mild sleep-disordered breathing in children. Am J Respir Crit Care Med (2005) 2.91

Neurobehavioral implications of habitual snoring in children. Pediatrics (2004) 2.83

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature (2002) 2.78

Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics (2012) 2.75

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70

Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder. Pediatrics (2003) 2.69

Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomy. J Pediatr (2006) 2.57

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc Natl Acad Sci U S A (2004) 2.55

Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52

Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51

Differential expression of cysteinyl leukotriene receptors 1 and 2 in tonsils of children with obstructive sleep apnea syndrome or recurrent infection. Chest (2004) 2.42

Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J Sleep Res (2002) 2.33

Respiratory care of the patient with Duchenne muscular dystrophy: ATS consensus statement. Am J Respir Crit Care Med (2004) 2.26

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut (2011) 2.26

Differential control over postganglionic neurons in rat cardiac ganglia by NA and DmnX neurons: anatomical evidence. Am J Physiol Regul Integr Comp Physiol (2003) 2.20

mRNA transcript quantification in archival samples using multiplexed, color-coded probes. BMC Biotechnol (2011) 2.20

An official American Thoracic Society statement: continuous positive airway pressure adherence tracking systems. The optimal monitoring strategies and outcome measures in adults. Am J Respir Crit Care Med (2013) 2.19

Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study. Blood (2012) 2.16

MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res (2011) 2.15

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3. J Clin Invest (2013) 2.11

Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res (2009) 2.08

The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell (2012) 2.07

Association of high-risk human papillomavirus infection with oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 2.07

Expression of midkine and endoglin in breast carcinomas with different immunohistochemical profiles. APMIS (2010) 2.00

Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc Natl Acad Sci U S A (2003) 1.99

Familial dysautonomia: deep sedation and management in endoscopic procedures. Am J Gastroenterol (2002) 1.97

Periodic limb movements in sleep and iron status in children. Sleep (2003) 1.96

DNA methylation in inflammatory genes among children with obstructive sleep apnea. Am J Respir Crit Care Med (2011) 1.92

Snoring and sleep-disordered breathing in young children: subjective and objective correlates. Sleep (2004) 1.90

Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases. J Biol Chem (2003) 1.89

RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron (2011) 1.89

Plasma C-reactive protein levels among children with sleep-disordered breathing. Pediatrics (2004) 1.88

Reverse and conventional chemical ecology approaches for the development of oviposition attractants for Culex mosquitoes. PLoS One (2008) 1.87

The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence. Pediatrics (2004) 1.85

Intranasal budesonide treatment for children with mild obstructive sleep apnea syndrome. Pediatrics (2008) 1.84

Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol (2011) 1.83

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. J Clin Invest (2014) 1.81

TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell (2010) 1.80

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev (2012) 1.79

Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia. J Clin Oncol (2010) 1.77

Elevated serum aminotransferase levels in children at risk for obstructive sleep apnea. Chest (2008) 1.76

Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits. Sleep (2005) 1.74

Sleep pressure score: a new index of sleep disruption in snoring children. Sleep (2004) 1.74

The visual scoring of sleep and arousal in infants and children. J Clin Sleep Med (2007) 1.73

Neurobehavioral correlates of sleep-disordered breathing in children. J Sleep Res (2004) 1.73

Obstructive sleep apnea in poorly controlled asthmatic children: effect of adenotonsillectomy. Pediatr Pulmonol (2011) 1.72

SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71

Preoperative biological therapy and short-term outcomes of abdominal surgery in patients with inflammatory bowel disease. Gut (2012) 1.70

Characteristics and outcomes of acute myelogenous leukemia patients with very late relapse (>5 years). Leuk Lymphoma (2007) 1.70

The prognostic evaluation of CLLU1 expression levels in 50 Chinese patients with chronic lymphocytic leukemia. Leuk Lymphoma (2007) 1.65

Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells. J Immunol (2004) 1.64

Ethnic difference in periodic limb movements in children. Sleep Med (2007) 1.63

Crystal structure of group II chaperonin in the open state. Structure (2010) 1.62

NREM sleep instability is reduced in children with attention-deficit/hyperactivity disorder. Sleep (2006) 1.62

Autoantibody induction by DNA-containing immune complexes requires HMGB1 with the TLR2/microRNA-155 pathway. J Immunol (2013) 1.61

Sleep duration, sleep regularity, body weight, and metabolic homeostasis in school-aged children. Pediatrics (2011) 1.60

Improved results of induction chemoradiation before surgical intervention for selected patients with stage IIIA-N2 non-small cell lung cancer. J Thorac Cardiovasc Surg (2007) 1.58

Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorg Med Chem Lett (2006) 1.55

Cultural influences on the bedtime behaviors of young children. Sleep Med (2005) 1.55

The effect of stimulants on sleep characteristics in children with attention deficit/hyperactivity disorder. Sleep Med (2003) 1.54

Antimicrobial antibodies are associated with a Crohn's disease-like phenotype after ileal pouch-anal anastomosis. Clin Gastroenterol Hepatol (2011) 1.54

Nonhematological autoimmunity (glomerulosclerosis, paraneoplastic pemphigus and paraneoplastic neurological syndrome) in a patient with chronic lymphocytic leukemia: Diagnosis, prognosis and management. Leuk Res (2008) 1.53

Pediatric obstructive sleep apnea: complications, management, and long-term outcomes. Proc Am Thorac Soc (2008) 1.52

Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. Cancer Discov (2013) 1.52

The NOD2insC polymorphism is associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis. Gut (2012) 1.51

Oxygen therapy for bronchiolitis. Pediatrics (2007) 1.51

Fcγ receptor polymorphisms and clinical efficacy of rituximab in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk (2010) 1.49

Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells. PLoS One (2010) 1.49

Diagnosis and management of restless legs syndrome in children. Sleep Med Rev (2009) 1.49

Adult precursor T-lymphoblastic leukemia/lymphoma with myeloid-associated antigen expression is associated with a lower complete remission rate following induction chemotherapy. Acta Haematol (2008) 1.49

Best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (NPPV) in stable chronic alveolar hypoventilation syndromes. J Clin Sleep Med (2010) 1.48

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A (2008) 1.46

Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese. J Neurol Sci (2010) 1.46

Expression levels of Lyn, Syk, PLCγ2 and ERK in patients with chronic lymphocytic leukemia, and higher levels of Lyn are associated with a shorter treatment-free survival. Leuk Lymphoma (2012) 1.46

The Childhood Adenotonsillectomy Trial (CHAT): rationale, design, and challenges of a randomized controlled trial evaluating a standard surgical procedure in a pediatric population. Sleep (2011) 1.46

miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes. Carcinogenesis (2012) 1.45

Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. Leuk Lymphoma (2012) 1.45

Ischemia-modified albumin in patients with hyperthyroidism and hypothyroidism. Eur J Intern Med (2012) 1.45

Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injury. J Cereb Blood Flow Metab (2006) 1.45

Polymorphisms and haplotypes in multidrug resistance 1 gene are not associated with chronic lymphocytic leukemia susceptibility and prognostic parameters of chronic lymphocytic leukemia in Chinese population. Leuk Lymphoma (2011) 1.44

Cytogenetic characterisation in Chinese patients with chronic lymphocytic leukemia: a prospective, multicenter study on 143 cases analysed with interphase fluorescence in situ hybridisation. Leuk Lymphoma (2008) 1.44

Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma. Cell Rep (2013) 1.43