Published in Nature on January 31, 2002
GlobPlot: Exploring protein sequences for globularity and disorder. Nucleic Acids Res (2003) 5.90
Linking folding and binding. Curr Opin Struct Biol (2009) 5.19
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A (2002) 3.28
Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci U S A (2002) 2.97
Intrinsically disordered proteins in cellular signalling and regulation. Nat Rev Mol Cell Biol (2015) 2.69
Prediction of protein binding regions in disordered proteins. PLoS Comput Biol (2009) 2.69
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
FlgM gains structure in living cells. Proc Natl Acad Sci U S A (2002) 2.46
Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A (2005) 2.40
The origin of allosteric functional modulation: multiple pre-existing pathways. Structure (2009) 2.33
Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol (2006) 1.94
Transcription in four dimensions: nuclear receptor-directed initiation of gene expression. EMBO Rep (2006) 1.94
Malleable machines take shape in eukaryotic transcriptional regulation. Nat Chem Biol (2008) 1.76
Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes. Thyroid (2009) 1.71
A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription. EMBO J (2003) 1.65
Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex. J Biol Chem (2005) 1.64
Expanding the proteome: disordered and alternatively folded proteins. Q Rev Biophys (2011) 1.60
Random coil chemical shift for intrinsically disordered proteins: effects of temperature and pH. J Biomol NMR (2011) 1.51
Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits. Biochemistry (2008) 1.50
Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A (2009) 1.48
Sequence correction of random coil chemical shifts: correlation between neighbor correction factors and changes in the Ramachandran distribution. J Biomol NMR (2011) 1.38
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
Pre-folding IkappaBalpha alters control of NF-kappaB signaling. J Mol Biol (2008) 1.35
Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell (2008) 1.29
Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem (2009) 1.28
Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9. Proc Natl Acad Sci U S A (2006) 1.24
Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains. EMBO J (2009) 1.23
Steroid receptor coactivators 1, 2, and 3: critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy. Mol Cell Endocrinol (2011) 1.22
Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein. Biochemistry (2010) 1.21
Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. Protein Sci (2004) 1.20
Structural investigation of disordered stress proteins. Comparison of full-length dehydrins with isolated peptides of their conserved segments. Plant Physiol (2006) 1.19
Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding. Structure (2012) 1.18
A preformed binding interface in the unbound ensemble of an intrinsically disordered protein: evidence from molecular simulations. PLoS Comput Biol (2012) 1.15
Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP. Proc Natl Acad Sci U S A (2010) 1.13
Mechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domains. Mol Cell Biol (2010) 1.12
Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation. Endocr Rev (2012) 1.11
Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid-receptor-interacting protein), and their importance for the function of GRIP1. Biochem J (2004) 1.11
The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2. Biochem J (2004) 1.10
Residual structures, conformational fluctuations, and electrostatic interactions in the synergistic folding of two intrinsically disordered proteins. PLoS Comput Biol (2012) 1.08
Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes. Protein Expr Purif (2007) 1.04
The transition state structure for coupled binding and folding of disordered protein domains. Sci Rep (2013) 1.04
Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol (2013) 1.02
Fast association and slow transitions in the interaction between two intrinsically disordered protein domains. J Biol Chem (2012) 1.02
Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II? Protein Sci (2010) 1.02
Visualization of coupled protein folding and binding in bacteria and purification of the heterodimeric complex. Proc Natl Acad Sci U S A (2003) 1.00
Structure of a biologically active estrogen receptor-coactivator complex on DNA. Mol Cell (2015) 0.99
Thyroid hormone receptor actions on transcription in amphibia: The roles of histone modification and chromatin disruption. Cell Biosci (2012) 0.98
BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300. Cancer Res (2012) 0.97
Microtubule-dependent subcellular redistribution of the transcriptional coactivator p/CIP. Mol Cell Biol (2002) 0.97
Intrinsically disordered proteins in a physics-based world. Int J Mol Sci (2010) 0.97
Electrostatically accelerated encounter and folding for facile recognition of intrinsically disordered proteins. PLoS Comput Biol (2013) 0.95
Thyroid hormone-induced cell-cell interactions are required for the development of adult intestinal stem cells. Cell Biosci (2013) 0.95
Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges. Mol Endocrinol (2013) 0.94
Prediction of the rotational tumbling time for proteins with disordered segments. J Am Chem Soc (2009) 0.94
Epigenetic regulation of thyroid hormone-induced adult intestinal stem cell development during anuran metamorphosis. Cell Biosci (2014) 0.93
Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300. J Biol Chem (2016) 0.93
MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol (2005) 0.92
Structural instability tuning as a regulatory mechanism in protein-protein interactions. Mol Cell (2011) 0.92
Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms. PLoS One (2011) 0.91
Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives. Curr Pharm Des (2013) 0.91
Intrinsically disordered proteins aggregate at fungal cell-to-cell channels and regulate intercellular connectivity. Proc Natl Acad Sci U S A (2012) 0.90
Resilience of death: intrinsic disorder in proteins involved in the programmed cell death. Cell Death Differ (2013) 0.90
Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications. J Biol Chem (2016) 0.89
Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies? Immunol Rev (2015) 0.88
NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. Proc Natl Acad Sci U S A (2003) 0.87
Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum. J Biol Chem (2016) 0.87
P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain. Nucleic Acids Res (2008) 0.87
Unliganded thyroid hormone receptor regulates metamorphic timing via the recruitment of histone deacetylase complexes. Curr Top Dev Biol (2013) 0.86
Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins. Biochim Biophys Acta (2012) 0.86
Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling. Chin J Cancer Res (2012) 0.86
Coupled folding-binding in a hydrophobic/polar protein model: impact of synergistic folding and disordered flanks. Biophys J (2012) 0.86
Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response. PLoS One (2011) 0.85
Functional diversity and structural disorder in the human ubiquitination pathway. PLoS One (2013) 0.83
Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling. Chem Rev (2016) 0.82
A frustrated binding interface for intrinsically disordered proteins. J Biol Chem (2014) 0.82
Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement. Breast Cancer Res Treat (2015) 0.82
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators. Front Mol Biosci (2014) 0.82
Comprehensive repertoire of foldable regions within whole genomes. PLoS Comput Biol (2013) 0.82
Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain. Biochemistry (2014) 0.81
Molecular and genetic studies suggest that thyroid hormone receptor is both necessary and sufficient to mediate the developmental effects of thyroid hormone. Gen Comp Endocrinol (2010) 0.81
The adenoviral E1A protein displaces corepressors and relieves gene repression by unliganded thyroid hormone receptors in vivo. Cell Res (2009) 0.81
Is a malleable protein necessarily highly dynamic? The hydrophobic core of the nuclear coactivator binding domain is well ordered. Biophys J (2012) 0.80
H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription. Oncotarget (2015) 0.80
Subunit Interactions within the Carbon-Phosphorus Lyase Complex from Escherichia coli. Biochemistry (2015) 0.80
Caught in action: selecting peptide aptamers against intrinsically disordered proteins in live cells. Sci Rep (2015) 0.79
Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model. J Chem Phys (2014) 0.79
Global conformational selection and local induced fit for the recognition between intrinsic disordered p53 and CBP. PLoS One (2013) 0.77
The SCHOOL of nature: II. Protein order, disorder and oligomericity in transmembrane signaling. Self Nonself (2010) 0.77
The interplay between transient α-helix formation and side chain rotamer distributions in disordered proteins probed by methyl chemical shifts. Protein Sci (2011) 0.77
Dynamic footprint of sequestration in the molecular fluctuations of osteopontin. J R Soc Interface (2015) 0.76
Understanding the mechanism of prosegment-catalyzed folding by solution NMR spectroscopy. J Biol Chem (2013) 0.76
Unusual biophysics of immune signaling-related intrinsically disordered proteins. Self Nonself (2010) 0.76
Homo-dimerization and ligand binding by the leucine-rich repeat domain at RHG1/RFS2 underlying resistance to two soybean pathogens. BMC Plant Biol (2013) 0.76
Folding propensity of intrinsically disordered proteins by osmotic stress. Mol Biosyst (2016) 0.75
Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH. Biophys J (2016) 0.75
When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches. Biochem J (2016) 0.75
Binding Mechanisms of Intrinsically Disordered Proteins: Theory, Simulation, and Experiment. Front Mol Biosci (2016) 0.75
Expression of the MOZ-TIF2 oncoprotein in mice represses senescence. Exp Hematol (2016) 0.75
Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol (2005) 17.63
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
The dynamic energy landscape of dihydrofolate reductase catalysis. Science (2006) 7.55
The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol (2009) 7.36
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A (2003) 6.82
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell (2003) 6.53
Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol (2002) 6.53
AMPK and PPARdelta agonists are exercise mimetics. Cell (2008) 6.39
Mechanism of coupled folding and binding of an intrinsically disordered protein. Nature (2007) 6.26
Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol (2004) 5.66
Nuclear receptor expression links the circadian clock to metabolism. Cell (2006) 5.43
Linking folding and binding. Curr Opin Struct Biol (2009) 5.19
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med (2004) 5.01
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell (2006) 4.64
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med (2004) 4.64
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell (2002) 4.37
PRAK is essential for ras-induced senescence and tumor suppression. Cell (2007) 4.30
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
A role for adult TLX-positive neural stem cells in learning and behaviour. Nature (2008) 4.14
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature (2008) 3.98
Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science (2003) 3.97
Muscle-specific Pparg deletion causes insulin resistance. Nat Med (2003) 3.93
Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology (2003) 3.83
Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol (2013) 3.76
PPARγ signaling and metabolism: the good, the bad and the future. Nat Med (2013) 3.71
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65
Vitamin D receptor as an intestinal bile acid sensor. Science (2002) 3.64
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64
PPAR-gamma regulates osteoclastogenesis in mice. Nat Med (2007) 3.59
Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A (2001) 3.58
Structure, dynamics, and catalytic function of dihydrofolate reductase. Annu Rev Biophys Biomol Struct (2004) 3.42
Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nat Struct Mol Biol (2004) 3.39
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science (2006) 3.37
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature (2013) 3.33
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33
PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A (2006) 3.29
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science (2006) 3.26
Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature (2004) 3.25
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (2011) 3.19
PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest (2006) 3.17
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med (2013) 3.15
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature (2016) 3.13
An NMR perspective on enzyme dynamics. Chem Rev (2006) 3.11
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab (2007) 3.00
Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci U S A (2002) 2.97
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell (2003) 2.85
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell (2011) 2.75
Unfolded proteins and protein folding studied by NMR. Chem Rev (2004) 2.71
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69
Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med (2004) 2.61
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell (2013) 2.58
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc Natl Acad Sci U S A (2004) 2.55
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A (2003) 2.46
PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A (2009) 2.38
The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Genes Dev (2007) 2.36
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature (2011) 2.34
Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. Genes Dev (2010) 2.31
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res (2011) 2.30
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol (2005) 2.28
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut (2011) 2.26
International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev (2006) 2.22
Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis. Proc Natl Acad Sci U S A (2005) 2.21
The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A (2002) 2.20
A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem (2006) 2.20
mRNA transcript quantification in archival samples using multiplexed, color-coded probes. BMC Biotechnol (2011) 2.20
PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci U S A (2007) 2.19
MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res (2011) 2.15
ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab (2007) 2.14
A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol (2005) 2.13
Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3. J Clin Invest (2013) 2.11
PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A (2003) 2.10
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res (2009) 2.08
The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell (2012) 2.07
Association of high-risk human papillomavirus infection with oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 2.07
A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol (2005) 2.06
Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A (2007) 2.05
International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev (2006) 2.04
Expression of midkine and endoglin in breast carcinomas with different immunohistochemical profiles. APMIS (2010) 2.00
Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc Natl Acad Sci U S A (2003) 1.99