Published in Neuron on June 05, 2013
iPS cells: a game changer for future medicine. EMBO J (2014) 2.15
Highly efficient Cas9-mediated transcriptional programming. Nat Methods (2015) 1.81
Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Cell Stem Cell (2016) 1.74
Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell (2015) 1.63
Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports (2014) 1.45
A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients. Elife (2016) 1.42
Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation. J Exp Med (2016) 1.41
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Proc Natl Acad Sci U S A (2015) 1.12
Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts. Neuron (2014) 1.11
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Proc Natl Acad Sci U S A (2013) 1.09
Revitalizing psychiatric therapeutics. Neuropsychopharmacology (2014) 1.05
Rapid neurogenesis through transcriptional activation in human stem cells. Mol Syst Biol (2014) 1.05
Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. Neuron (2013) 1.05
Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells. Biol Psychiatry (2013) 1.05
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry (2014) 1.01
Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells. NPJ Schizophr (2015) 0.99
Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Stem Cells (2014) 0.96
Analysis of conditional heterozygous STXBP1 mutations in human neurons. J Clin Invest (2015) 0.95
Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification. Proc Natl Acad Sci U S A (2014) 0.94
Moving stem cells to the clinic: potential and limitations for brain repair. Neuron (2015) 0.94
Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science (2016) 0.93
Concise review: Generation of neurons from somatic cells of healthy individuals and neurological patients through induced pluripotency or direct conversion. Stem Cells (2014) 0.91
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nat Rev Neurosci (2016) 0.90
Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD. Front Cell Neurosci (2014) 0.89
Modeling physiological and pathological human neurogenesis in the dish. Front Neurosci (2014) 0.86
Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain. Sci Rep (2014) 0.86
Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species. Front Aging Neurosci (2014) 0.86
Regenerative medicine in Alzheimer's disease. Transl Res (2013) 0.85
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics. Hum Mol Genet (2016) 0.85
Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery. Expert Rev Mol Diagn (2014) 0.85
Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency. Cell Stem Cell (2015) 0.85
Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells. Methods (2015) 0.85
Human stem cell models of dementia. Hum Mol Genet (2014) 0.84
Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Front Pharmacol (2014) 0.83
Forward engineering neuronal diversity using direct reprogramming. EMBO J (2015) 0.82
Proneural transcription factor Atoh1 drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons. Stem Cells Transl Med (2014) 0.82
Toward stem cell-based phenotypic screens for neurodegenerative diseases. Nat Rev Neurol (2015) 0.81
Applications of Engineered DNA-Binding Molecules Such as TAL Proteins and the CRISPR/Cas System in Biology Research. Int J Mol Sci (2015) 0.81
Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds. Nat Commun (2016) 0.81
Biomedical and clinical promises of human pluripotent stem cells for neurological disorders. Biomed Res Int (2013) 0.80
Fast and efficient neural conversion of human hematopoietic cells. Stem Cell Reports (2014) 0.80
Direct somatic lineage conversion. Philos Trans R Soc Lond B Biol Sci (2015) 0.80
Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2. BMC Biochem (2014) 0.80
Model systems for studying cellular mechanisms of SCN1A-related epilepsy. J Neurophysiol (2016) 0.79
Three-Dimensional Neural Spheroid Culture: An In Vitro Model for Cortical Studies. Tissue Eng Part C Methods (2015) 0.79
Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy. Curr Mol Med (2015) 0.79
Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Cell Rep (2016) 0.79
Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation. Stem Cells Int (2015) 0.79
Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol (2017) 0.78
Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. Mol Psychiatry (2016) 0.78
Induced pluripotent stem cells as a discovery tool for Alzheimer׳s disease. Brain Res (2015) 0.78
Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities. Curr Opin Neurobiol (2015) 0.78
AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation. Cell Discov (2015) 0.78
Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism. Br J Pharmacol (2015) 0.78
Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons. World J Stem Cells (2015) 0.78
Overcoming the hurdles for a reproducible generation of human functionally mature reprogrammed neurons. Exp Biol Med (Maywood) (2015) 0.78
GATA2(-/-) human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment. Cell Regen (Lond) (2015) 0.78
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion. Cell (2017) 0.77
Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells. Mol Cell Neurosci (2016) 0.77
iPSC-based drug screening for Huntington׳s disease. Brain Res (2015) 0.77
In Vivo Reprogramming for Brain and Spinal Cord Repair(1,2,3). eNeuro (2015) 0.77
Connectivity and circuitry in a dish versus in a brain. Alzheimers Res Ther (2015) 0.77
TRIM72 modulates caveolar endocytosis in repair of lung cells. Am J Physiol Lung Cell Mol Physiol (2015) 0.77
Cell-Penetrating Peptide as a Means of Directing the Differentiation of Induced-Pluripotent Stem Cells. Int J Mol Sci (2015) 0.77
Back and forth in time: Directing age in iPSC-derived lineages. Brain Res (2015) 0.77
Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients. Mol Brain (2015) 0.77
Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation. Biotechnol Bioeng (2016) 0.77
Functional maintenance of differentiated embryoid bodies in microfluidic systems: a platform for personalized medicine. Stem Cells Transl Med (2015) 0.76
Advances in reprogramming-based study of neurologic disorders. Stem Cells Dev (2015) 0.76
Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding. J Am Chem Soc (2015) 0.76
PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells. PLoS One (2016) 0.76
Epigenetic changes in the developing brain: Effects on behavior. Proc Natl Acad Sci U S A (2015) 0.76
bHLH proteins involved in Drosophila neurogenesis are mutually regulated at the level of stability. Nucleic Acids Res (2015) 0.76
The conditional KO approach: Cre/Lox technology in human neurons. Rare Dis (2016) 0.76
A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies. Stem Cell Reports (2015) 0.76
From "directed differentiation" to "neuronal induction": modeling neuropsychiatric disease. Biomark Insights (2015) 0.76
Electrophysiological profiles of induced neurons converted directly from adult human fibroblasts indicate incomplete neuronal conversion. Cell Reprogram (2014) 0.76
Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System. Stem Cells Dev (2015) 0.76
Path from schizophrenia genomics to biology: gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing. Neurosci Bull (2015) 0.76
Neural Subtype Specification from Human Pluripotent Stem Cells. Cell Stem Cell (2016) 0.76
Engineering human cells and tissues through pluripotent stem cells. Curr Opin Biotechnol (2016) 0.76
Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease. Cell Rep (2017) 0.75
Transcriptomics analysis of iPSC-derived neurons and modeling of neuropsychiatric disorders. Mol Cell Neurosci (2015) 0.75
Generation of Functional Cardiomyocytes from Efficiently Generated Human iPSCs and a Novel Method of Measuring Contractility. PLoS One (2015) 0.75
Mash1 efficiently reprograms rat astrocytes into neurons. Neural Regen Res (2014) 0.75
Induced pluripotent stem cells and their use in cardiac and neural regenerative medicine. Int J Mol Sci (2015) 0.75
Identifying gene expression modules that define human cell fates. Stem Cell Res (2016) 0.75
Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls. Microbes Infect (2015) 0.75
Heterozygous STXBP1 Mutations Associated With Ohtahara Syndrome: Two Littles Make a Lot. Epilepsy Curr (2016) 0.75
Sex Differences in Mouse Hippocampal Astrocytes after In-Vitro Ischemia. J Vis Exp (2016) 0.75
Prospects for engineering neurons from local neocortical cell populations as cell-mediated therapy for neurological disorders. J Comp Neurol (2014) 0.75
Distinct and Shared Determinants of Cardiomyocyte Contractility in Multi-Lineage Competent Ethnically Diverse Human iPSCs. Sci Rep (2016) 0.75
Dual gene expression in embryoid bodies derived from human induced pluripotent stem cells using episomal vectors. Tissue Eng Part A (2014) 0.75
Coupled electrophysiological recording and single cell transcriptome analyses revealed molecular mechanisms underlying neuronal maturation. Protein Cell (2016) 0.75
A transposon-mediated system for flexible control of transgene expression in stem and progenitor-derived lineages. Stem Cell Reports (2015) 0.75
Lost highway(s): barriers to postnatal cortical neurogenesis and implications for brain repair. Front Cell Neurosci (2015) 0.75
Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules. Stem Cell Reports (2017) 0.75
Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming. Sci Rep (2016) 0.75
Induced Pluripotent Stem Cell Therapies for Cervical Spinal Cord Injury. Int J Mol Sci (2016) 0.75
Non-Viral Nucleic Acid Delivery Strategies to the Central Nervous System. Front Mol Neurosci (2016) 0.75
High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol (1987) 43.61
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol (2009) 13.16
In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol (2001) 9.04
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell (2011) 8.21
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature (2011) 7.90
Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A (2010) 7.31
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature (2011) 6.21
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci (2012) 6.09
Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A (2000) 5.99
SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69
MicroRNA-mediated conversion of human fibroblasts to neurons. Nature (2011) 5.59
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature (2012) 5.47
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev (2008) 5.34
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
Retracted Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons. Cell (2011) 5.09
Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A (2011) 4.81
Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell (2011) 4.65
Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell (2011) 3.62
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell (2012) 3.30
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci U S A (2009) 3.30
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat Neurosci (2012) 3.28
Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture. J Neurosci (2007) 3.25
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A (2010) 3.01
Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron (2013) 2.81
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell (2013) 2.74
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell (2013) 2.74
Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells (2010) 2.62
Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell (2012) 2.62
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60
Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell (2012) 2.42
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35
Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat Biotechnol (2012) 2.09
Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci (2011) 2.09
Efficient derivation of functional floor plate tissue from human embryonic stem cells. Cell Stem Cell (2010) 2.02
Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.97
Induced neuronal cells: how to make and define a neuron. Cell Stem Cell (2011) 1.77
Constructing and deconstructing stem cell models of neurological disease. Neuron (2011) 1.57
Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II. J Neurosci (2010) 1.42
Medicine. iPSC disease modeling. Science (2012) 1.36
Ohtahara syndrome with emphasis on recent genetic discovery. Brain Dev (2011) 1.17
Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry (2012) 1.14
Efficient induction of functional neurons from adult human fibroblasts. Cell Cycle (2011) 1.12
Stem cells assessed. Nat Rev Mol Cell Biol (2012) 1.05
Modeling brain disease in a dish: really? Cell Stem Cell (2012) 1.03
Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells. Proc Natl Acad Sci U S A (2008) 0.95
Cellular reprogramming: recent advances in modeling neurological diseases. J Neurosci (2011) 0.92
Introduction of the MASH1 gene into mouse embryonic stem cells leads to differentiation of motoneuron precursors lacking Nogo receptor expression that can be applicable for transplantation to spinal cord injury. Neurobiol Dis (2006) 0.91
CNS glia are targets for GDNF and neurturin. Histochem Cell Biol (1998) 0.90
Effect of NeuroD2 expression on neuronal differentiation in mouse embryonic stem cells. Cell Biol Int (2008) 0.87
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Membrane fusion. Cell (2003) 7.68
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64
Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell (2005) 6.31
The importance of the normality assumption in large public health data sets. Annu Rev Public Health (2001) 5.71
Neuroligins determine synapse maturation and function. Neuron (2006) 5.70
SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest (2004) 5.59
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (2010) 5.42
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature (2003) 5.19
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med (2004) 5.01
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci U S A (2002) 4.77
An index of substitution saturation and its application. Mol Phylogenet Evol (2003) 4.71
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A (2009) 4.46
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell (2002) 4.37
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet (2007) 4.08
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron (2005) 3.93
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature (2007) 3.91
Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol (2013) 3.76
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet (2009) 3.65
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science (2006) 3.37
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron (2007) 3.18
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol (2003) 3.14
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron (2005) 3.09
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem (2005) 3.06
Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group. J Clin Oncol (2011) 3.05
Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res (2003) 3.04
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet (2007) 2.96
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells (2005) 2.88
Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter. Proc Natl Acad Sci U S A (2005) 2.83
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods (2006) 2.80
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst (2012) 2.79
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature (2002) 2.78
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
Direct lineage conversions: unnatural but useful? Nat Biotechnol (2011) 2.69
Generation of oligodendroglial cells by direct lineage conversion. Nat Biotechnol (2013) 2.64
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62
Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics (2002) 2.58
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci (2010) 2.57
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc Natl Acad Sci U S A (2004) 2.55
In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells (2011) 2.52
Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell (2011) 2.52
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res (2005) 2.50
Long-term results of CCG 5942: a randomized comparison of chemotherapy with and without radiotherapy for children with Hodgkin's lymphoma--a report from the Children's Oncology Group. J Clin Oncol (2012) 2.49
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron (2007) 2.43
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron (2004) 2.43
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci (2006) 2.42
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Solution structure and dynamics of the outer membrane enzyme PagP by NMR. Proc Natl Acad Sci U S A (2002) 2.39
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35