Published in J Biol Chem on March 17, 2003
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev (2013) 2.42
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Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J (2004) 1.77
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Morphine-Induced mu-opioid receptor desensitization. Mol Pharmacol (2005) 1.18
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Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. Br J Pharmacol (2005) 1.16
Chronic morphine treatment reduces recovery from opioid desensitization. J Neurosci (2004) 1.14
Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization. Mol Pharmacol (2008) 1.13
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A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct Funct (2014) 1.00
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Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation. Gastroenterology (2010) 0.96
Novel GPCR paradigms at the μ-opioid receptor. Br J Pharmacol (2014) 0.93
Influence of agonist intrinsic activity on the desensitisation of beta2-adrenoceptor-mediated responses in mast cells. Br J Pharmacol (2004) 0.92
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Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling. Neuropsychopharmacology (2012) 0.91
The long-acting beta-adrenoceptor agonist, indacaterol, inhibits IgE-dependent responses of human lung mast cells. Br J Pharmacol (2009) 0.91
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Efficacy and ligand bias at the μ-opioid receptor. Br J Pharmacol (2013) 0.87
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Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1). Br J Pharmacol (2014) 0.81
Muscarinic acetylcholine receptor modulation of mu (mu) opioid receptors in adult rat sphenopalatine ganglion neurons. J Neurophysiol (2009) 0.81
Electroacupuncture modulation of reflex hypertension in rats: role of cholecystokinin octapeptide. Am J Physiol Regul Integr Comp Physiol (2013) 0.81
β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons. Br J Pharmacol (2014) 0.80
Effects of chronic opioid exposure on guinea pig mu opioid receptor in Chinese hamster ovary cells: comparison with human and rat receptor. Biochem Pharmacol (2007) 0.80
In vivo opioid receptor heteromerization: where do we stand? Br J Pharmacol (2014) 0.80
Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. PLoS One (2014) 0.79
In vivo regulation of the μ opioid receptor: role of the endogenous opioid agents. Mol Med (2013) 0.79
Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment. Int J Neuropsychopharmacol (2016) 0.78
Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice. J Pharmacol Exp Ther (2011) 0.78
Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance. Behav Brain Res (2015) 0.77
Mu-opioid receptor redistribution in the locus coeruleus upon precipitation of withdrawal in opiate-dependent rats. Anat Rec (Hoboken) (2009) 0.77
Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors. Br J Pharmacol (2014) 0.77
Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor. Br J Pharmacol (2014) 0.77
Ligand-induced μ opioid receptor internalization in enteric neurons following chronic treatment with the opiate fentanyl. J Neurosci Res (2013) 0.76
Characterization of methadone as a β-arrestin-biased μ-opioid receptor agonist. Mol Pain (2016) 0.75
Agonist Binding and Desensitization of the μ-Opioid Receptor Is Modulated by Phosphorylation of the C-Terminal Tail Domain. Mol Pharmacol (2015) 0.75
Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo. Pharmacol Res (2017) 0.75
A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro. Br J Pharmacol (2015) 0.75
Striatal dopamine D1 and D2 receptors are differentially regulated following buprenorphine or methadone treatment. Psychopharmacology (Berl) (2014) 0.75
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell (2010) 7.52
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells. J Exp Med (2013) 2.04
Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res (2006) 1.90
Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells. Hum Pathol (2007) 1.84
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Conus venom peptide pharmacology. Pharmacol Rev (2012) 1.69
Immunohistochemical analysis of neuron types in the mouse small intestine. Cell Tissue Res (2008) 1.66
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Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine. Gastroenterology (2011) 1.59
Correlation of electrophysiological and morphological characteristics of enteric neurons in the mouse colon. J Comp Neurol (2004) 1.36
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. J Neurosci (2005) 1.35
Transplanted progenitors generate functional enteric neurons in the postnatal colon. J Clin Invest (2013) 1.32
Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area. J Physiol (2011) 1.30
Characterization of neurons in the rat central nucleus of the amygdala: cellular physiology, morphology, and opioid sensitivity. J Comp Neurol (2006) 1.29
Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. J Physiol (2002) 1.29
Coexpression of prodynorphin and corticotrophin-releasing hormone in the rat central amygdala: evidence of two distinct endogenous opioid systems in the lateral division. J Comp Neurol (2007) 1.25
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro. Neuropharmacology (2003) 1.22
The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system. Auton Neurosci (2002) 1.18
Pathobiology of dynorphins in trauma and disease. Front Biosci (2005) 1.17
Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. Br J Pharmacol (2005) 1.16
GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron (2005) 1.15
Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. J Neurosci (2009) 1.13
Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. Br J Pharmacol (2002) 1.11
Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br J Pharmacol (2002) 1.11
Myenteric neurons of the mouse small intestine undergo significant electrophysiological and morphological changes during postnatal development. J Physiol (2012) 1.11
Analysis of whole-cell currents by patch clamp of guinea-pig myenteric neurones in intact ganglia. J Physiol (2002) 1.11
Cellular morphine tolerance produced by βarrestin-2-dependent impairment of μ-opioid receptor resensitization. J Neurosci (2011) 1.09
Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes. J Neurosci (2002) 1.09
17beta-estradiol activates estrogen receptor beta-signalling and inhibits transient receptor potential vanilloid receptor 1 activation by capsaicin in adult rat nociceptor neurons. Endocrinology (2008) 1.08
Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human. Br J Pharmacol (2011) 1.07
The distribution of purine P2X(2) receptors in the guinea-pig enteric nervous system. Histochem Cell Biol (2002) 1.06
Identification of neuron types in the submucosal ganglia of the mouse ileum. Cell Tissue Res (2009) 1.05
Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat. J Physiol (2006) 1.04
Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. J Neurophysiol (2004) 1.02
Identification of neurons that express 5-hydroxytryptamine4 receptors in intestine. Cell Tissue Res (2006) 1.01
The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment. Neurosignals (2005) 1.01
Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine. Br J Pharmacol (2009) 1.01
Inhibition of recombinant human T-type calcium channels by Delta9-tetrahydrocannabinol and cannabidiol. J Biol Chem (2008) 1.00
Phenotypic changes of morphologically identified guinea-pig myenteric neurons following intestinal inflammation. J Physiol (2007) 0.98
Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol (2013) 0.97
Novel therapeutic targets for enteric nervous system disorders. Trends Pharmacol Sci (2007) 0.97
Prostaglandin E(2) inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. J Physiol (2002) 0.96
TEA- and apamin-resistant K(Ca) channels in guinea-pig myenteric neurons: slow AHP channels. J Physiol (2002) 0.95
Intermediate-conductance calcium-activated potassium channels in enteric neurones of the mouse: pharmacological, molecular and immunochemical evidence for their role in mediating the slow afterhyperpolarization. J Neurochem (2004) 0.94
Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nat Neurosci (2011) 0.93
ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis. Neuroreport (2006) 0.92
Damaging effects of ischemia/reperfusion on intestinal muscle. Cell Tissue Res (2010) 0.92
Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn. J Physiol (2007) 0.92
Effects of compounds that influence IK (KCNN4) channels on afterhyperpolarizing potentials, and determination of IK channel sequence, in guinea pig enteric neurons. J Neurophysiol (2007) 0.91
Identification of enteroendocrine cells that express TRPA1 channels in the mouse intestine. Cell Tissue Res (2014) 0.90
Morphological and functional changes in guinea-pig neurons projecting to the ileal mucosa at early stages after inflammatory damage. J Physiol (2010) 0.90
Structural changes in the epithelium of the small intestine and immune cell infiltration of enteric ganglia following acute mucosal damage and local inflammation. Virchows Arch (2009) 0.90
Controlling the excitability of IPANs: a possible route to therapeutics. Curr Opin Pharmacol (2002) 0.90
Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons. Cell Tissue Res (2002) 0.90
Acute and chronic changes in dorsal horn innervation by primary afferents and descending supraspinal pathways after spinal cord injury. J Comp Neurol (2007) 0.89
Extrinsic and intrinsic sources of calcitonin gene-related peptide immunoreactivity in the lamb ileum: a morphometric and neurochemical investigation. Cell Tissue Res (2005) 0.89
Regulation of the slow afterhyperpolarization in enteric neurons by protein kinase A. Auton Neurosci (2006) 0.89
A continuous, fluorescence-based assay of μ-opioid receptor activation in AtT-20 cells. J Biomol Screen (2012) 0.89
Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. Eur J Pharmacol (2006) 0.89
Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels. J Physiol (2012) 0.89
P2X(2) purine receptor immunoreactivity of intraganglionic laminar endings in the mouse gastrointestinal tract. Cell Tissue Res (2003) 0.89
Effects of pre- and postnatal protein deprivation and postnatal refeeding on myenteric neurons of the rat large intestine: a quantitative morphological study. Cell Tissue Res (2002) 0.89
The evolving science of cochlear implants. JAMA (2013) 0.89
Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. Br J Pharmacol (2003) 0.88
Regulation of K+ channels underlying the slow afterhyperpolarization in enteric afterhyperpolarization-generating myenteric neurons: role of calcium and phosphorylation. Clin Exp Pharmacol Physiol (2002) 0.88
PKA-mediated inhibition of a novel K+ channel underlies the slow after-hyperpolarization in enteric AH neurons. J Physiol (2003) 0.87
Protein kinases expressed by interstitial cells of Cajal. Histochem Cell Biol (2003) 0.87
Learning-related translocation of δ-opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions. J Neurosci (2013) 0.87
TRPV1 antagonists as a potential treatment for hyperalgesia. Recent Pat CNS Drug Discov (2006) 0.87
Correlation of electrophysiology, shape and synaptic properties of myenteric AH neurons of the guinea pig distal colon. Auton Neurosci (2003) 0.87
Multiple mechanisms of microglia: a gatekeeper's contribution to pain states. Exp Neurol (2012) 0.87
Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons. Gastroenterology (2007) 0.86
The reactions of specific neuron types to intestinal ischemia in the guinea pig enteric nervous system. Acta Neuropathol (2009) 0.86
Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey. Mol Pain (2008) 0.86
Opioid receptor modulation of GABAergic and serotonergic spinally projecting neurons of the rostral ventromedial medulla in mice. J Neurophysiol (2011) 0.86
The roles of purinergic signaling during gastrointestinal inflammation. Curr Opin Pharmacol (2012) 0.86
Expression of mRNA and functional alpha(1)-adrenoceptors that suppress the GIRK conductance in adult rat locus coeruleus neurons. Br J Pharmacol (2002) 0.85
The distribution of intermediate-conductance, calcium-activated, potassium (IK) channels in epithelial cells. J Anat (2006) 0.85
Characterisation of neurons expressing calbindin immunoreactivity in the ileum of the unweaned and mature sheep. Cell Tissue Res (2004) 0.85
Spinal cord compression injury in adult rats initiates changes in dorsal horn remodeling that may correlate with development of neuropathic pain. J Comp Neurol (2009) 0.85
PKC delta-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle. Am J Physiol Gastrointest Liver Physiol (2006) 0.84
Anatomical evidence for ileal Peyer's patches innervation by enteric nervous system: a potential route for prion neuroinvasion? Cell Tissue Res (2008) 0.84
The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse. ACS Chem Neurosci (2013) 0.84
Decreased mu-opioid receptor signalling and a reduction in calcium current density in sensory neurons from chronically morphine-treated mice. Br J Pharmacol (2006) 0.84
Deleterious effects of intestinal ischemia/reperfusion injury in the mouse enteric nervous system are associated with protein nitrosylation. Cell Tissue Res (2011) 0.83
Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors. J Comp Neurol (2010) 0.83
Rhythm of digestion: keeping time in the gastrointestinal tract. Clin Exp Pharmacol Physiol (2009) 0.83
Sites of action of ghrelin receptor ligands in cardiovascular control. Am J Physiol Heart Circ Physiol (2012) 0.83
Prominent contribution of L-type Ca2+ channels to cutaneous neurovascular transmission that is revealed after spinal cord injury augments vasoconstriction. Am J Physiol Heart Circ Physiol (2011) 0.83
Glutamate transporter dysfunction associated with nerve injury-induced pain in mice. J Neurophysiol (2011) 0.82
Somatostatin and nociceptin inhibit neurons in the central nucleus of amygdala that project to the periaqueductal grey. Neuropharmacology (2010) 0.82
Lack of functional expression of NMDA receptors in PC12 cells. Neurotoxicology (2007) 0.81
Pharmacological characterization of a recombinant, fluorescent somatostatin receptor agonist. Bioconjug Chem (2011) 0.81