Published in J Physiol on March 01, 2002
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. J Physiol (2003) 1.27
Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. Br J Pharmacol (2002) 1.11
Ionic mechanisms underlying inflammatory mediator-induced sensitization of dural afferents. J Neurosci (2010) 1.04
BKCa currents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neurons. Eur J Neurosci (2010) 0.98
Prostaglandin E2 depresses solitary tract-mediated synaptic transmission in the nucleus tractus solitarius. Neuroscience (2007) 0.90
The action of prostaglandins on ion channels. Curr Neuropharmacol (2006) 0.90
COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ. Am J Physiol Heart Circ Physiol (2013) 0.89
Tumour necrosis factor alpha activates nuclear factor kappaB signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons. J Physiol (2009) 0.85
Prostaglandin E2-induced modification of tetrodotoxin-resistant Na+ currents involves activation of both EP2 and EP4 receptors in neonatal rat nodose ganglion neurones. Br J Pharmacol (2005) 0.85
Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway. Biochem Pharmacol (2007) 0.85
Decreased mu-opioid receptor signalling and a reduction in calcium current density in sensory neurons from chronically morphine-treated mice. Br J Pharmacol (2006) 0.84
Airway inflammation and central respiratory control: results from in vivo and in vitro neonatal rat. Respir Physiol Neurobiol (2011) 0.83
Prostaglandin E2 potentiates the excitability of small diameter trigeminal root ganglion neurons projecting onto the superficial layer of the cervical dorsal horn in rats. Exp Brain Res (2007) 0.82
Sex differences in the inflammatory mediator-induced sensitization of dural afferents. J Neurophysiol (2011) 0.78
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
Prostanoid receptors: structures, properties, and functions. Physiol Rev (1999) 8.60
Prostaglandins, aspirin-like drugs and analgesia. Nat New Biol (1972) 4.91
Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunits. Nature (1996) 4.01
Modulation of Ca2+ channels by G-protein beta gamma subunits. Nature (1996) 3.79
Parallel assay of prostaglandin-like activity in rat inflammatory exudate by means of cascade superfusion. J Pharm Pharmacol (1969) 3.59
Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors. Proc Natl Acad Sci U S A (1996) 2.84
PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J Physiol (1996) 2.46
Recovery of prostaglandins in human cutaneous inflammation. Br Med J (1971) 2.20
The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology (2000) 2.08
The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies. J Neurosci (1998) 2.02
Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat Neurosci (1999) 1.90
Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. J Neurosci (1998) 1.88
Tetrodotoxin-resistant sodium and calcium components of action potentials in dorsal root ganglion cells of the adult mouse. J Neurophysiol (1978) 1.83
Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic ganglia and brain. Neuron (1997) 1.58
Some rat sensory neurons in culture express characteristics of differentiated pain sensory cells. Proc Natl Acad Sci U S A (1983) 1.57
I - Prostaglandin hyperalgesia, a cAMP/Ca2+ dependent process. Prostaglandins (1979) 1.52
Modulation of the hyperpolarization-activated current (Ih) by cyclic nucleotides in guinea-pig primary afferent neurons. J Physiol (1996) 1.48
Decay of prepulse facilitation of N type calcium channels during G protein inhibition is consistent with binding of a single Gbeta subunit. Proc Natl Acad Sci U S A (1998) 1.46
Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins. J Biol Chem (1993) 1.37
Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3',5'-cyclic monophosphate transduction cascade. J Neurosci (1995) 1.34
Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons. J Biol Chem (2001) 1.34
Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase. Eur J Biochem (1993) 1.33
In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs. Br J Pharmacol (1995) 1.33
Sensitization of group IV muscle receptors to bradykinin by 5-hydroxytryptamine and prostaglandin E2. Brain Res (1981) 1.28
Prostaglandins suppress an outward potassium current in embryonic rat sensory neurons. J Neurophysiol (1997) 1.28
Opioid inhibition of Ih via adenylyl cyclase. Neuron (1994) 1.23
The cAMP transduction cascade mediates the PGE2-induced inhibition of potassium currents in rat sensory neurones. J Physiol (1999) 1.22
Prostaglandin modulation of Ca2+ channels in rat sympathetic neurones is mediated by guanine nucleotide binding proteins. J Physiol (1992) 1.21
Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture. J Neurosci (1994) 1.17
Presynaptic inhibitory action of enkephalin on excitatory transmission in superficial dorsal horn of rat spinal cord. J Physiol (1992) 1.16
Transient low-threshold Ca2+ current triggers burst firing through an afterdepolarizing potential in an adult mammalian neuron. Proc Natl Acad Sci U S A (1989) 1.16
Cyclic AMP mediates the prostaglandin E2-induced potentiation of bradykinin excitation in rat sensory neurons. Neuroscience (1995) 1.12
Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse. J Physiol (2001) 1.10
Involvement of primary afferent C-fibres in touch-evoked pain (allodynia) induced by prostaglandin E2. Eur J Neurosci (1999) 1.07
Prostaglandins sensitize nociceptors in cell culture. Neurosci Lett (1991) 1.07
Isolation and culture of rat sensory neurons having distinct sensory modalities. J Neurosci Methods (1997) 1.04
The effects of bradykinin and prostaglandin E1 on rat cutaneous afferent nerve activity. Br J Pharmacol (1977) 1.04
Calcium channel gating and modulation by transmitters depend on cellular compartmentalization. Nat Neurosci (2000) 1.01
VIP inhibits N-type Ca2+ channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway. Neuron (1994) 1.00
Calcium channel beta subunits differentially regulate the inhibition of N-type channels by individual Gbeta isoforms. J Biol Chem (2001) 1.00
Interaction between G proteins and accessory subunits in the regulation of 1B calcium channels in Xenopus oocytes. J Physiol (2000) 0.99
Prostaglandin E2 increases calcium conductance and stimulates release of substance P in avian sensory neurons. J Neurosci (1992) 0.98
Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats. J Pharmacol Exp Ther (1995) 0.96
Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G protein subunit isoforms. J Physiol (2000) 0.96
betagamma dimers derived from Go and Gi proteins contribute different components of adrenergic inhibition of Ca2+ channels in rat sympathetic neurones. J Physiol (1999) 0.95
Selective activation of the prostanoid EP(3) receptor reduces myocardial infarct size in rodents. Arterioscler Thromb Vasc Biol (1999) 0.92
Prostaglandins block a Ca2+-dependent slow spike afterhyperpolarization independent of effects on Ca2+ influx in visceral afferent neurons. Brain Res (1985) 0.91
Neurotransmitters acting via different G proteins inhibit N-type calcium current by an identical mechanism in rat sympathetic neurons. J Neurophysiol (1995) 0.88
Voltage-dependent, pertussis toxin insensitive inhibition of calcium currents by histamine in bovine adrenal chromaffin cells. J Neurophysiol (2000) 0.88
Ectopic alpha2-adrenoceptors couple to N-type Ca2+ channels in axotomized rat sensory neurons. J Neurosci (1997) 0.88
Expression and regulation of prostaglandin E receptor subtype mRNAs in rat sensory ganglia and spinal cord in response to peripheral inflammation. Prostaglandins Other Lipid Mediat (2001) 0.86
Inhibition of voltage-dependent calcium channels by prostaglandin E2 in rat melanotrophs. Endocrinology (1998) 0.79
The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia. Neuropharmacology (2000) 0.78
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell (2010) 7.52
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature (2007) 4.14
Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med (2010) 2.12
Immunopathogenesis of cerebral malaria. Int J Parasitol (2006) 2.08
Opioids: cellular mechanisms of tolerance and physical dependence. Curr Opin Pharmacol (2005) 1.82
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors. J Biol Chem (2003) 1.78
Conus venom peptide pharmacology. Pharmacol Rev (2012) 1.69
Mu-opioid receptor desensitization: is morphine different? Br J Pharmacol (2004) 1.64
Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. J Immunol (2008) 1.42
Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. Int J Parasitol (2006) 1.35
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. J Neurosci (2005) 1.35
Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun (2005) 1.32
Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area. J Physiol (2011) 1.30
Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. J Physiol (2002) 1.29
Mechanisms of glutamate transport. Physiol Rev (2013) 1.24
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro. Neuropharmacology (2003) 1.22
Targeting glutamine transport to suppress melanoma cell growth. Int J Cancer (2014) 1.21
Pathobiology of dynorphins in trauma and disease. Front Biosci (2005) 1.17
Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. Br J Pharmacol (2005) 1.16
GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron (2005) 1.15
Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. J Neurosci (2009) 1.13
Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1. PLoS One (2012) 1.13
Anandamide is a partial agonist at native vanilloid receptors in acutely isolated mouse trigeminal sensory neurons. Br J Pharmacol (2002) 1.11
Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br J Pharmacol (2002) 1.11
Cellular morphine tolerance produced by βarrestin-2-dependent impairment of μ-opioid receptor resensitization. J Neurosci (2011) 1.09
Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes. J Neurosci (2002) 1.09
Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human. Br J Pharmacol (2011) 1.07
Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. FASEB J (2004) 1.06
Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. J Clin Invest (2010) 1.04
Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. Int J Parasitol (2010) 1.03
Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. J Neurophysiol (2004) 1.02
The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment. Neurosignals (2005) 1.01
Inhibition of human recombinant T-type calcium channels by the endocannabinoid N-arachidonoyl dopamine. Br J Pharmacol (2009) 1.01
Inhibition of recombinant human T-type calcium channels by Delta9-tetrahydrocannabinol and cannabidiol. J Biol Chem (2008) 1.00
Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium. Int J Parasitol (2004) 0.98
Slips, leaks and channels in glutamate transporters. Channels (Austin) (2008) 0.98
Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids (2013) 0.98
Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol (2013) 0.97
Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine (2007) 0.96
Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nat Neurosci (2011) 0.93
1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan. Comp Biochem Physiol B Biochem Mol Biol (2010) 0.93
Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis. J Immunol (2012) 0.93
ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis. Neuroreport (2006) 0.92
Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn. J Physiol (2007) 0.92
Differential microRNA expression in experimental cerebral and noncerebral malaria. Infect Immun (2011) 0.91
A role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. J Neuroimmunol (2006) 0.91
Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1. Amino Acids (2014) 0.90
Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. Eur J Pharmacol (2006) 0.89
Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. Int J Parasitol (2010) 0.89
Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels. J Physiol (2012) 0.89
A continuous, fluorescence-based assay of μ-opioid receptor activation in AtT-20 cells. J Biomol Screen (2012) 0.89
Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. Br J Pharmacol (2003) 0.88
Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One (2008) 0.88
Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis. Infect Immun (2008) 0.88
Learning-related translocation of δ-opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions. J Neurosci (2013) 0.87
TRPV1 antagonists as a potential treatment for hyperalgesia. Recent Pat CNS Drug Discov (2006) 0.87
Multiple mechanisms of microglia: a gatekeeper's contribution to pain states. Exp Neurol (2012) 0.87
Opioid receptor modulation of GABAergic and serotonergic spinally projecting neurons of the rostral ventromedial medulla in mice. J Neurophysiol (2011) 0.86
Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey. Mol Pain (2008) 0.86
Expression of mRNA and functional alpha(1)-adrenoceptors that suppress the GIRK conductance in adult rat locus coeruleus neurons. Br J Pharmacol (2002) 0.85
The role of cation binding in determining substrate selectivity of glutamate transporters. J Biol Chem (2008) 0.85
Decreased mu-opioid receptor signalling and a reduction in calcium current density in sensory neurons from chronically morphine-treated mice. Br J Pharmacol (2006) 0.84
Molecular determinants for functional differences between alanine-serine-cysteine transporter 1 and other glutamate transporter family members. J Biol Chem (2013) 0.84
The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse. ACS Chem Neurosci (2013) 0.84
Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. J Biol Chem (2009) 0.83
Indoleamine 2,3-dioxygenases with very low catalytic activity are well conserved across kingdoms: IDOs of Basidiomycota. Fungal Genet Biol (2013) 0.83
Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials. Comp Biochem Physiol B Biochem Mol Biol (2009) 0.83
Somatostatin and nociceptin inhibit neurons in the central nucleus of amygdala that project to the periaqueductal grey. Neuropharmacology (2010) 0.82
The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis. Stem Cells (2015) 0.82
Glutamate transporter dysfunction associated with nerve injury-induced pain in mice. J Neurophysiol (2011) 0.82
Behavioral consequences of delta-opioid receptor activation in the periaqueductal gray of morphine tolerant rats. Neural Plast (2009) 0.81
Pharmacological characterization of a recombinant, fluorescent somatostatin receptor agonist. Bioconjug Chem (2011) 0.81
Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro. Neuropharmacology (2007) 0.81
Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1). Br J Pharmacol (2014) 0.81
Cellular actions of somatostatin on rat periaqueductal grey neurons in vitro. Br J Pharmacol (2004) 0.81
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorg Med Chem Lett (2012) 0.81
Molecular evolution and characterization of fungal indoleamine 2,3-dioxygenases. J Mol Evol (2010) 0.81
Lack of functional expression of NMDA receptors in PC12 cells. Neurotoxicology (2007) 0.81
Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties. Amino Acids (2008) 0.81
Prolonged stimulation of μ-opioid receptors produces β-arrestin-2-mediated heterologous desensitization of α(2)-adrenoceptor function in locus ceruleus neurons. Mol Pharmacol (2012) 0.80
A real-time, fluorescence-based assay for measuring μ-opioid receptor modulation of adenylyl cyclase activity in Chinese hamster ovary cells. J Biomol Screen (2013) 0.80
MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors. Biochemistry (2013) 0.80
The evolution of three types of indoleamine 2,3 dioxygenases in fungi with distinct molecular and biochemical characteristics. Gene (2012) 0.79
Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. Int J Parasitol (2008) 0.79
Chemical synthesis and structure of the prokineticin Bv8. Chembiochem (2010) 0.79
Developmental changes in the alpha-adrenergic responses of rat periaqueductal grey neurons. Neuroreport (2003) 0.79
Molecular evolution of bacterial indoleamine 2,3-dioxygenase. Gene (2011) 0.79
Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT. Br J Pharmacol (2012) 0.79
The results of an experimental indoor hydroponic Cannabis growing study, using the 'Screen of Green' (ScrOG) method-Yield, tetrahydrocannabinol (THC) and DNA analysis. Forensic Sci Int (2010) 0.78
Buprenorphine signalling is compromised at the N40D polymorphism of the human μ opioid receptor in vitro. Br J Pharmacol (2014) 0.78
Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.78
Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials. Comp Biochem Physiol B Biochem Mol Biol (2009) 0.78
Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria. PLoS One (2013) 0.78
μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons. Br J Pharmacol (2014) 0.78